ATE402946T1 - Methode festphasensynthese von peptiden - Google Patents

Methode festphasensynthese von peptiden

Info

Publication number: ATE402946T1
Authority: AT; Austria
Prior art keywords: amino acids; procedure; solid phase; protecting; peptides
Prior art date: 1999-05-20

Application number

AT00925307T

Other languages

English (en)

Inventor

I Obiols Berta Ponsati

I Poblet Marc Canas

I Farres Gemma Jodas

Rodriguez Javier Clemente

I Cabado Jordi Barcadit

Original Assignee

Lipotec Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-20

Filing date

2000-05-05

Publication date

2008-08-15

2000-05-05 Application filed by Lipotec Sa filed Critical Lipotec Sa

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE402946T1 publication Critical patent/ATE402946T1/de

Links

238000000034 method Methods 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
238000010532 solid phase synthesis reaction Methods 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 3
239000012467 final product Substances 0.000 abstract 2
BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 abstract 1
238000010647 peptide synthesis reaction Methods 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
239000007790 solid phase Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT00925307T 1999-05-20 2000-05-05 Methode festphasensynthese von peptiden ATE402946T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES009901090A ES2154590B1 (es)	1999-05-20	1999-05-20	Procedimiento de sintesis de peptidos en fase solida

Publications (1)

Publication Number	Publication Date
ATE402946T1 true ATE402946T1 (de)	2008-08-15

Family

ID=8308492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00925307T ATE402946T1 (de)	1999-05-20	2000-05-05	Methode festphasensynthese von peptiden

Country Status (11)

Country	Link
US (1)	US6897289B1 (de)
EP (1)	EP1179537B1 (de)
JP (1)	JP5138845B2 (de)
AT (1)	ATE402946T1 (de)
AU (1)	AU4406400A (de)
CY (1)	CY1108465T1 (de)
DE (1)	DE60039692D1 (de)
DK (1)	DK1179537T3 (de)
ES (2)	ES2154590B1 (de)
PT (1)	PT1179537E (de)
WO (1)	WO2000071570A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100491395C (zh) *	2002-04-11	2009-05-27	阿斯比奥制药株式会社	修饰肽的制造方法
PT1737889E (pt)	2004-10-19	2010-12-13	Lonza Ag	Método para síntese de péptidos em fase sólida
ES2336826T3 (es) *	2005-05-03	2010-04-16	Novetide, Ltd.	Procedimientos para la produccion de un peptido que presenta una amida c-terminal.
CN100355773C (zh) *	2006-01-19	2007-12-19	九江石化波涛生化科技有限公司	高分子量多肽聚合物的合成方法
CA2651070A1 (en) *	2006-05-03	2007-11-15	Mallinckrodt Inc.	Composition and method for the release of protected peptides from a resin
KR101046846B1 (ko)	2006-10-12	2011-07-06	동국제약 주식회사	고체상 합성법을 이용한 펩타이드의 제조방법
WO2008044890A1 (en) *	2006-10-12	2008-04-17	Dong Kook Pharm. Co., Ltd	A method for preparing peptides using by solid phase synthesis
WO2010141276A1 (en) *	2009-06-03	2010-12-09	Mallinckrodt Inc.	Solid phase peptide synthesis process for the production of goserelin
WO2011066386A1 (en) *	2009-11-25	2011-06-03	Novetide, Ltd.	Process for production of degarelix
WO2012113847A1 (en)	2011-02-25	2012-08-30	Lonza Ltd	Branched linker for protein drug conjugates
WO2014047822A1 (zh) *	2012-09-27	2014-04-03	深圳翰宇药业股份有限公司	一种制备布舍瑞林的方法
CN108264538B (zh) *	2017-01-04	2023-08-29	辽宁药联制药有限公司	门冬氨酸缩合物的固相合成方法
CN110922452B (zh) *	2018-09-20	2023-12-26	深圳翰宇药业股份有限公司	一种戈舍瑞林的合成方法
CN110922453B (zh) *	2018-09-20	2023-12-26	深圳翰宇药业股份有限公司	一种戈舍瑞林的合成方法
KR20210104460A (ko) *	2020-02-17	2021-08-25	주식회사 아이바이오코리아	고체상 합성법을 이용한 펩타이드의 제조 방법
CN114324669B (zh) *	2022-01-04	2023-11-14	宁波第二激素厂	一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2438350C3 (de)	1974-08-09	1979-06-13	Hoechst Ag, 6000 Frankfurt	Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
GB1524747A (en)	1976-05-11	1978-09-13	Ici Ltd	Polypeptide
TW295589B (de) *	1990-08-30	1997-01-11	Hoechst Ag
GB9112859D0 (en)	1991-06-14	1991-07-31	Ici Plc	Peptide process
GB9112825D0 (en) *	1991-06-14	1991-07-31	Ici Plc	Process for making peptides
CH682662A5 (de)	1991-10-11	1993-10-29	Bachem Feinchemikalien Ag	Aminosäurederivate zur Peptidsynthese.
DE4306839A1 (de) *	1993-03-05	1994-09-08	Bayer Ernst Prof Dr	Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen

1999
- 1999-05-20 ES ES009901090A patent/ES2154590B1/es not_active Expired - Fee Related
2000
- 2000-05-05 AT AT00925307T patent/ATE402946T1/de active
- 2000-05-05 US US09/979,293 patent/US6897289B1/en not_active Expired - Lifetime
- 2000-05-05 JP JP2000619825A patent/JP5138845B2/ja not_active Expired - Fee Related
- 2000-05-05 DE DE60039692T patent/DE60039692D1/de not_active Expired - Lifetime
- 2000-05-05 AU AU44064/00A patent/AU4406400A/en not_active Abandoned
- 2000-05-05 WO PCT/ES2000/000169 patent/WO2000071570A1/es not_active Ceased
- 2000-05-05 PT PT00925307T patent/PT1179537E/pt unknown
- 2000-05-05 EP EP00925307A patent/EP1179537B1/de not_active Expired - Lifetime
- 2000-05-05 DK DK00925307T patent/DK1179537T3/da active
- 2000-05-05 ES ES00925307T patent/ES2310993T3/es not_active Expired - Lifetime
2008
- 2008-10-30 CY CY20081101226T patent/CY1108465T1/el unknown

Also Published As

Publication number	Publication date
WO2000071570A8 (es)	2001-04-12
JP5138845B2 (ja)	2013-02-06
AU4406400A (en)	2000-12-12
EP1179537A1 (de)	2002-02-13
JP2003500416A (ja)	2003-01-07
ES2154590B1 (es)	2001-11-01
DE60039692D1 (de)	2008-09-11
PT1179537E (pt)	2008-11-11
CY1108465T1 (el)	2014-04-09
US6897289B1 (en)	2005-05-24
ES2310993T3 (es)	2009-02-01
DK1179537T3 (da)	2008-12-01
WO2000071570A1 (es)	2000-11-30
ES2154590A1 (es)	2001-04-01
EP1179537B1 (de)	2008-07-30

Legal Events

Date

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Title

Description

2009-02-15

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