DK1179537T3 - Fastfasepeptidsyntesefremgangsmåde - Google Patents

Fastfasepeptidsyntesefremgangsmåde

Info

Publication number: DK1179537T3
Authority: DK; Denmark
Prior art keywords: amino acids; solid phase; procedure; phase peptide; protecting
Prior art date: 1999-05-20

Application number

DK00925307T

Other languages

English (en)

Inventor

I Obiols Berta Ponsati

I Poblet Marc Canas

Rodriguez Javier Clemente

I Cabado Jordi Barcadit

I Farres Gemma Jodas

Original Assignee

Lipotec Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-20

Filing date

2000-05-05

Publication date

2008-12-01

2000-05-05 Application filed by Lipotec Sa filed Critical Lipotec Sa

2008-12-01 Application granted granted Critical

2008-12-01 Publication of DK1179537T3 publication Critical patent/DK1179537T3/da

Links

238000000034 method Methods 0.000 title abstract 4
238000010647 peptide synthesis reaction Methods 0.000 title abstract 2
239000007790 solid phase Substances 0.000 title abstract 2
150000001413 amino acids Chemical class 0.000 abstract 3
239000012467 final product Substances 0.000 abstract 2
BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK00925307T 1999-05-20 2000-05-05 Fastfasepeptidsyntesefremgangsmåde DK1179537T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009901090A ES2154590B1 (es)	1999-05-20	1999-05-20	Procedimiento de sintesis de peptidos en fase solida
PCT/ES2000/000169 WO2000071570A1 (es)	1999-05-20	2000-05-05	Procedimiento de sintesis de peptidos en fase solida

Publications (1)

Publication Number	Publication Date
DK1179537T3 true DK1179537T3 (da)	2008-12-01

Family

ID=8308492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00925307T DK1179537T3 (da)	1999-05-20	2000-05-05	Fastfasepeptidsyntesefremgangsmåde

Country Status (11)

Country	Link
US (1)	US6897289B1 (da)
EP (1)	EP1179537B1 (da)
JP (1)	JP5138845B2 (da)
AT (1)	ATE402946T1 (da)
AU (1)	AU4406400A (da)
CY (1)	CY1108465T1 (da)
DE (1)	DE60039692D1 (da)
DK (1)	DK1179537T3 (da)
ES (2)	ES2154590B1 (da)
PT (1)	PT1179537E (da)
WO (1)	WO2000071570A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL162780A0 (en) *	2002-04-11	2005-11-20	Kenji Kangawa	Method for producing modified peptide
CN101094867B (zh)	2004-10-19	2011-08-24	隆萨股份公司	用于固相肽合成的方法
ES2336826T3 (es) *	2005-05-03	2010-04-16	Novetide, Ltd.	Procedimientos para la produccion de un peptido que presenta una amida c-terminal.
CN100355773C (zh) *	2006-01-19	2007-12-19	九江石化波涛生化科技有限公司	高分子量多肽聚合物的合成方法
US8022181B2 (en) *	2006-05-03	2011-09-20	Mallinckrodt Llc	Composition and method for the release of protected peptides from a resin
KR101046846B1 (ko)	2006-10-12	2011-07-06	동국제약 주식회사	고체상 합성법을 이용한 펩타이드의 제조방법
WO2008044890A1 (en) *	2006-10-12	2008-04-17	Dong Kook Pharm. Co., Ltd	A method for preparing peptides using by solid phase synthesis
US20100311946A1 (en) *	2009-06-03	2010-12-09	Mallinckrodt Inc.	Solid Phase Peptide for the Production of Goserelin
WO2011066386A1 (en) *	2009-11-25	2011-06-03	Novetide, Ltd.	Process for production of degarelix
ES2531471T3 (es)	2011-02-25	2015-03-16	Lonza Ltd	Enlazador ramificado para conjugados de proteínas-fármacos
WO2014047822A1 (zh) *	2012-09-27	2014-04-03	深圳翰宇药业股份有限公司	一种制备布舍瑞林的方法
CN108264538B (zh) *	2017-01-04	2023-08-29	辽宁药联制药有限公司	门冬氨酸缩合物的固相合成方法
CN110922452B (zh) *	2018-09-20	2023-12-26	深圳翰宇药业股份有限公司	一种戈舍瑞林的合成方法
CN110922453B (zh) *	2018-09-20	2023-12-26	深圳翰宇药业股份有限公司	一种戈舍瑞林的合成方法
KR20210104460A (ko) *	2020-02-17	2021-08-25	주식회사 아이바이오코리아	고체상 합성법을 이용한 펩타이드의 제조 방법
CN114324669B (zh) *	2022-01-04	2023-11-14	宁波第二激素厂	一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2438350C3 (de)	1974-08-09	1979-06-13	Hoechst Ag, 6000 Frankfurt	Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
GB1524747A (en)	1976-05-11	1978-09-13	Ici Ltd	Polypeptide
TW295589B (da) *	1990-08-30	1997-01-11	Hoechst Ag
GB9112859D0 (en)	1991-06-14	1991-07-31	Ici Plc	Peptide process
GB9112825D0 (en) *	1991-06-14	1991-07-31	Ici Plc	Process for making peptides
CH682662A5 (de) *	1991-10-11	1993-10-29	Bachem Feinchemikalien Ag	Aminosäurederivate zur Peptidsynthese.
DE4306839A1 (de) *	1993-03-05	1994-09-08	Bayer Ernst Prof Dr	Tritylgruppe enthaltendes Festphasensystem, Verfahren zu seiner Herstellung und seine Verwendung in Festphasenreaktionen

1999
- 1999-05-20 ES ES009901090A patent/ES2154590B1/es not_active Expired - Fee Related
2000
- 2000-05-05 AT AT00925307T patent/ATE402946T1/de active
- 2000-05-05 US US09/979,293 patent/US6897289B1/en not_active Expired - Lifetime
- 2000-05-05 WO PCT/ES2000/000169 patent/WO2000071570A1/es not_active Ceased
- 2000-05-05 JP JP2000619825A patent/JP5138845B2/ja not_active Expired - Fee Related
- 2000-05-05 ES ES00925307T patent/ES2310993T3/es not_active Expired - Lifetime
- 2000-05-05 DE DE60039692T patent/DE60039692D1/de not_active Expired - Lifetime
- 2000-05-05 EP EP00925307A patent/EP1179537B1/en not_active Expired - Lifetime
- 2000-05-05 PT PT00925307T patent/PT1179537E/pt unknown
- 2000-05-05 DK DK00925307T patent/DK1179537T3/da active
- 2000-05-05 AU AU44064/00A patent/AU4406400A/en not_active Abandoned
2008
- 2008-10-30 CY CY20081101226T patent/CY1108465T1/el unknown

Also Published As

Publication number	Publication date
US6897289B1 (en)	2005-05-24
AU4406400A (en)	2000-12-12
ES2154590B1 (es)	2001-11-01
ES2154590A1 (es)	2001-04-01
JP2003500416A (ja)	2003-01-07
PT1179537E (pt)	2008-11-11
ATE402946T1 (de)	2008-08-15
EP1179537A1 (en)	2002-02-13
CY1108465T1 (el)	2014-04-09
ES2310993T3 (es)	2009-02-01
DE60039692D1 (de)	2008-09-11
EP1179537B1 (en)	2008-07-30
JP5138845B2 (ja)	2013-02-06
WO2000071570A1 (es)	2000-11-30
WO2000071570A8 (es)	2001-04-12

Publication	Publication Date	Title
CY1108465T1 (el)	2014-04-09	Μεθοδος συνθεσης πεπτιδιων στερεης φασης
DE69430312D1 (de)	2002-05-08	Peralkylierte oligopeptidmischungen
CO5040068A1 (es)	2001-05-29	Composiciones para cuidadod personal que contienen polimeros injertados endurecidos
DE69906128D1 (de)	2003-04-24	Reaktionsprodukte von hyaluronsäure und natürlichen aminosäuren sowie deren verwendung in kosmetischen und pharmazeutischen zusammensetzungen
WO2003091311A8 (en)	2004-02-26	Monomers containing polyoxyalkylenes and polymer supports therefrom
BR0013193A (pt)	2002-07-02	Polimerização de óxido de etileno usando catalisadores de cianeto metálico
ATE236218T1 (de)	2003-04-15	Ethylenpolymerzusammensetzungen und daraus hergestellte gegenstände
DE50006269D1 (de)	2004-06-03	Kombinationen zur einführung von nucleinsäuren in zellen
ES2159769T3 (es)	2001-10-16	Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes.
CA2295219A1 (en)	1999-01-21	Integrin binding peptide and use thereof
WO1996040708A3 (en)	1997-02-20	Improved methods for oligonucleotide synthesis
MX9704767A (es)	1997-10-31	Inhibidores de la adhesion de fibronectina.
DE69415829D1 (de)	1999-02-18	Katalysatorzusammensetzung für die copolymerisation von ethylen
BR9612115A (pt)	1999-02-17	Inibidor de proliferação de célula endotelial e processo de uso
AU2002366715A1 (en)	2003-07-09	Ph-sensitive polymeric conjugates of an anthracycline drug
ATE260337T1 (de)	2004-03-15	Neue oligomere konjugate zum transfer biologischer moleküle in zellen
DE59410132D1 (de)	2002-07-11	Humanes zirkulierendes cytokin cc-1
AU7334291A (en)	1991-08-21	Merosin, nucleic acids encoding, fragments and uses thereof
ES2137620T3 (es)	1999-12-16	Ligandos peptidicos para la region constante de las inmunoglobulinas.
PT714441E (pt)	2003-04-30	Alergenios recombinantes de cladosporium herbarum
TR199900147T2 (xx)	1999-03-22	Antifriz peptidlerine sahip dondurulmu� g�da maddesi.
EP1344784A4 (en)	2004-12-29	BUTEN OLIGOMER DERIVATIVES WITH FUNCTIONAL FINAL 1,4-BUTANEDIOL GROUP
EP0254905A3 (en)	1990-06-27	Shiga vaccine
ES2114170T3 (es)	1998-05-16	Peptidos con actividad organo-protectora, su procedimiento de preparacion y su utilizacion en la terapia.
IT1266553B1 (it)	1997-01-09	Supporto per la sintesi di peptidi carbossammidici e suo uso