ATE402949T1 - Dipeptidtransglutaminaseinhibitoren und verfahren zu deren anwendung - Google Patents
Dipeptidtransglutaminaseinhibitoren und verfahren zu deren anwendungInfo
- Publication number
- ATE402949T1 ATE402949T1 AT04736919T AT04736919T ATE402949T1 AT E402949 T1 ATE402949 T1 AT E402949T1 AT 04736919 T AT04736919 T AT 04736919T AT 04736919 T AT04736919 T AT 04736919T AT E402949 T1 ATE402949 T1 AT E402949T1
- Authority
- AT
- Austria
- Prior art keywords
- medicament
- amino acid
- diseases
- inhibiting
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108060008539 Transglutaminase Proteins 0.000 title abstract 2
- 102000003601 transglutaminase Human genes 0.000 title abstract 2
- 108010016626 Dipeptides Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- -1 9-fluorenylmethyl Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- KTLIYLZKAKXBTG-UHFFFAOYSA-N CS(C)(C)(C)C=1NC=CN=1 Chemical group CS(C)(C)(C)C=1NC=CN=1 KTLIYLZKAKXBTG-UHFFFAOYSA-N 0.000 abstract 1
- 208000015943 Coeliac disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000037390 scarring Effects 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314262.7A GB0314262D0 (en) | 2003-06-19 | 2003-06-19 | Novel compounds and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402949T1 true ATE402949T1 (de) | 2008-08-15 |
Family
ID=27636894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04736919T ATE402949T1 (de) | 2003-06-19 | 2004-06-16 | Dipeptidtransglutaminaseinhibitoren und verfahren zu deren anwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7723307B2 (de) |
| EP (1) | EP1648924B1 (de) |
| AT (1) | ATE402949T1 (de) |
| CA (1) | CA2529938A1 (de) |
| DE (1) | DE602004015464D1 (de) |
| ES (1) | ES2314402T3 (de) |
| GB (1) | GB0314262D0 (de) |
| PL (1) | PL1648924T3 (de) |
| WO (1) | WO2004113363A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0515003D0 (en) | 2005-07-21 | 2005-08-31 | Univ Aston | Medical devices and coatings therefor |
| GB2490547A (en) * | 2011-05-06 | 2012-11-07 | Univ Aston | Tissue transglutaminase inhibitors for use in the treatment of angiogenesis |
| PT2794618T (pt) | 2011-12-20 | 2017-01-17 | Sanofi Sa | Isotiazolopiridina-2-carboxamidas e seu uso como produtos farmacêuticos |
| GB201209096D0 (en) | 2012-05-24 | 2012-07-04 | Medical Res Council Technology | Compounds |
| CA2994165A1 (en) * | 2015-07-31 | 2017-02-09 | The Johns Hopkins University | Methods for cancer and immunotherapy using glutamine analogues, including don |
| DK3328827T3 (da) * | 2015-07-31 | 2023-10-02 | Univ Johns Hopkins | Prodrugs af glutaminanaloger |
| US10842763B2 (en) | 2015-07-31 | 2020-11-24 | The Johns Hopkins University | Methods for cancer and immunotherapy using prodrugs of glutamine analogs |
| CN106074488B (zh) * | 2016-06-08 | 2018-07-27 | 天津大学 | 苯甲氧羰基-L-谷氨酸在制备BLyS拮抗剂的用途 |
| EP3924330A4 (de) | 2019-02-11 | 2022-11-09 | Dracen Pharmaceuticals, Inc. | Verfahren zur herstellung eines don-prodrugs aus l-glutaminsäure |
| CN116601140A (zh) | 2020-10-02 | 2023-08-15 | 羿尊生物医药股份有限公司 | 用于皮下施用的包含(s)-2-((s)-2-乙酰氨基-3-(1h-吲哚-3-基)丙酰氨基)-6-重氮基-5-氧代己酸异丙酯的冻干组合物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912120A (en) * | 1986-03-14 | 1990-03-27 | Syntex (U.S.A.) Inc. | 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors |
| US4968713A (en) * | 1989-07-31 | 1990-11-06 | Merck & Co., Inc. | Certain imidazole compounds as transglutaminase inhibitors |
| US5077285A (en) * | 1989-07-31 | 1991-12-31 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| WO1994010296A1 (en) * | 1992-11-03 | 1994-05-11 | Oklahoma Medical Research Foundation | Transglutaminase gene |
| ES2193615T3 (es) | 1995-10-25 | 2003-11-01 | Senju Pharma Co | .nhibidor de la angiogenesis. |
| JP2002501532A (ja) | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
-
2003
- 2003-06-19 GB GBGB0314262.7A patent/GB0314262D0/en not_active Ceased
-
2004
- 2004-06-16 PL PL04736919T patent/PL1648924T3/pl unknown
- 2004-06-16 DE DE602004015464T patent/DE602004015464D1/de not_active Expired - Lifetime
- 2004-06-16 US US10/561,425 patent/US7723307B2/en not_active Expired - Fee Related
- 2004-06-16 WO PCT/GB2004/002569 patent/WO2004113363A2/en not_active Ceased
- 2004-06-16 ES ES04736919T patent/ES2314402T3/es not_active Expired - Lifetime
- 2004-06-16 AT AT04736919T patent/ATE402949T1/de not_active IP Right Cessation
- 2004-06-16 EP EP04736919A patent/EP1648924B1/de not_active Expired - Lifetime
- 2004-06-16 CA CA002529938A patent/CA2529938A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1648924B1 (de) | 2008-07-30 |
| GB0314262D0 (en) | 2003-07-23 |
| PL1648924T3 (pl) | 2009-05-29 |
| EP1648924A2 (de) | 2006-04-26 |
| WO2004113363A3 (en) | 2005-02-24 |
| CA2529938A1 (en) | 2004-12-29 |
| WO2004113363A2 (en) | 2004-12-29 |
| DE602004015464D1 (de) | 2008-09-11 |
| ES2314402T3 (es) | 2009-03-16 |
| US7723307B2 (en) | 2010-05-25 |
| US20080200511A1 (en) | 2008-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |