ATE403740T1 - Verfahren, werkzeuge und reagenzien für zelltrennung - Google Patents

Verfahren, werkzeuge und reagenzien für zelltrennung

Info

Publication number
ATE403740T1
ATE403740T1 AT99939479T AT99939479T ATE403740T1 AT E403740 T1 ATE403740 T1 AT E403740T1 AT 99939479 T AT99939479 T AT 99939479T AT 99939479 T AT99939479 T AT 99939479T AT E403740 T1 ATE403740 T1 AT E403740T1
Authority
AT
Austria
Prior art keywords
cells
cell separation
reagents
tools
methods
Prior art date
Application number
AT99939479T
Other languages
English (en)
Inventor
De Saint Julien Jean- Bisconte
Patrizia Paterlini
Original Assignee
Inst Nat Sante Rech Med
Assist Publ Hopitaux De Paris
Univ Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Assist Publ Hopitaux De Paris, Univ Paris Descartes filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of ATE403740T1 publication Critical patent/ATE403740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT99939479T 1998-08-25 1999-08-23 Verfahren, werkzeuge und reagenzien für zelltrennung ATE403740T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9810696A FR2782730B1 (fr) 1998-08-25 1998-08-25 Procede de separation cellulaire pour l'isolation de cellules pathogeniques, notamment cancereuses rares, equipement et reactif pour la mise en oeuvre du procede et application du procede

Publications (1)

Publication Number Publication Date
ATE403740T1 true ATE403740T1 (de) 2008-08-15

Family

ID=9529872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99939479T ATE403740T1 (de) 1998-08-25 1999-08-23 Verfahren, werkzeuge und reagenzien für zelltrennung

Country Status (8)

Country Link
US (1) US7316897B2 (de)
EP (1) EP1108057B1 (de)
AT (1) ATE403740T1 (de)
AU (1) AU5376299A (de)
DE (1) DE69939265D1 (de)
ES (1) ES2312213T3 (de)
FR (1) FR2782730B1 (de)
WO (1) WO2000011210A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2824144B1 (fr) 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
AU2002365421A1 (en) 2001-07-10 2003-09-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of the multiple proteins in single cells
US7993908B2 (en) 2001-07-17 2011-08-09 Parsortix, Inc. Microstructure for particle and cell separation, identification, sorting, and manipulation
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
WO2004077021A2 (en) * 2003-02-27 2004-09-10 Lesko Stephen A Standardized evaluation of therapeutic efficacy based on cellular biomarkers
JP2007503597A (ja) * 2003-06-13 2007-02-22 ザ ジェネラル ホスピタル コーポレーション 血液から赤血球および血小板をサイズに基づいて除去するための微少流体システム
CA2557819A1 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
FR2880897B1 (fr) * 2005-01-18 2010-12-17 Inst Nat Sante Rech Med Methode de detection, non invasive, prenatale, in vitro de l'etat sain normal, de l'etat de porteur sain ou de l'etat de porteur malade de la mucoviscidose
FR2883488B1 (fr) * 2005-03-24 2010-12-10 Inst Nat Sante Rech Med Procede et dispositif pour separer par filtration verticale des particules biologiques contenues dans un liquide
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP2029779A4 (de) * 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2007147018A1 (en) * 2006-06-14 2007-12-21 Cellpoint Diagnostics, Inc. Analysis of rare cell-enriched samples
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
FR2926090B1 (fr) * 2008-01-09 2012-04-27 Metagenex Procede et dispositif pour isoler et cultiver des cellules vivantes sur un filtre.
US20090269800A1 (en) * 2008-04-29 2009-10-29 Todd Covey Device and method for processing cell samples
US20100014741A1 (en) * 2008-07-10 2010-01-21 Banville Steven C Methods and apparatus related to gate boundaries within a data space
US9183237B2 (en) 2008-07-10 2015-11-10 Nodality, Inc. Methods and apparatus related to gate boundaries within a data space
GB2474613A (en) * 2008-07-10 2011-04-20 Nodality Inc Methods and apparatus related to management of experiments
US8227202B2 (en) 2008-07-10 2012-07-24 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
SMT201700149T1 (it) 2008-09-20 2017-05-08 Univ Leland Stanford Junior Diagnosi non invasiva di aneuploidia fetale mediante sequenziamento
US20100099109A1 (en) * 2008-10-17 2010-04-22 Nodality, Inc., A Delaware Corporation Methods for Analyzing Drug Response
US9034257B2 (en) * 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
US20100209929A1 (en) * 2009-01-14 2010-08-19 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of jak/stat activity
US20100204973A1 (en) * 2009-01-15 2010-08-12 Nodality, Inc., A Delaware Corporation Methods For Diagnosis, Prognosis And Treatment
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
US20100215644A1 (en) * 2009-02-25 2010-08-26 Nodality, Inc. A Delaware Corporation Analysis of nodes in cellular pathways
US9459246B2 (en) 2009-09-08 2016-10-04 Nodality, Inc. Induced intercellular communication
CA2779750C (en) 2009-11-06 2019-03-19 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
EP2517013A4 (de) * 2009-12-23 2013-07-17 Artery Therapeutics Inc Diagnose und behandlung von erkrankungen im zusammenhang mit defizientem reversem cholesterintransport
ES2797448T3 (es) 2011-08-01 2020-12-02 Bio Rad Laboratories Sistema de captura de células
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
DE102013209718B4 (de) * 2012-06-22 2015-09-10 Human Med Ag Vorrichtung zum Separieren von adulten Stammzellen
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
WO2014144822A2 (en) 2013-03-15 2014-09-18 Immumetrix, Inc. Methods and compositions for tagging and analyzing samples
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
FR3012974B1 (fr) 2013-11-12 2016-01-15 Biocarecell Dispositif a filtration amelioree pour retenir des cellules contenues dans un echantillon liquide.
CN111295245B (zh) 2017-08-29 2021-03-16 伯乐实验室有限公司 用于分离和分析细胞的系统和方法
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
JP7413408B2 (ja) 2019-05-07 2024-01-15 バイオ－ラッド ラボラトリーズ インコーポレイテッド 自動化された単一細胞処理のためのシステムおよび方法
JP7356519B2 (ja) 2019-06-14 2023-10-04 バイオ－ラッド ラボラトリーズ インコーポレイテッド 自動化された単一細胞処理及び解析のためのシステム及び方法
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
EP4444910A4 (de) 2021-12-10 2025-11-05 Bio Rad Laboratories Inc Zusammensetzungen, verfahren und systeme zur probenverarbeitung mit morphologisch anpassbaren funktionalisierten partikeln

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561577A (en) * 1977-02-24 1980-02-27 Sanki Eng Co Ltd Cell fragility testing
US5070014A (en) * 1982-09-30 1991-12-03 Wadley Technologies, Inc. Stabilization of specimens for microbial analysis
US4937187A (en) * 1983-02-04 1990-06-26 Brown University Research Foundation Methods for separating malignant cells from clinical specimens
US4581331A (en) * 1983-09-29 1986-04-08 E. I. Du Pont De Nemours And Company Method for the rapid detection of virus and viral antigens
US4751179A (en) * 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US5057413A (en) * 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
DE69027686T2 (de) * 1989-09-20 1997-01-23 Vivorx, Inc., Santa Monica, Calif. Trennung von verschiedenen zellen
US5498336A (en) * 1991-02-22 1996-03-12 Terumo Kabushiki Kaisha Leukocyte-removing filter and leukocyte-removing apparatus furnished therewith
DK0667920T3 (da) * 1992-10-29 2003-04-14 Univ Jefferson Fremgangsmåder til påvisning af prostatacancermetastase
US5532139A (en) * 1992-10-30 1996-07-02 Micro-Med, Inc. Micro lysis-analysis process to measure cell characteristics and diagnose diseases
WO1994018828A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
NO180658C (no) * 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
US5648222A (en) * 1994-07-27 1997-07-15 The Trustees Of Columbia University In The City Of New York Method for preserving cells, and uses of said method
JP3322595B2 (ja) * 1996-03-28 2002-09-09 テルモ株式会社 フィルター装置および生体微細組織の分離・回収方法
US6190855B1 (en) * 1996-10-28 2001-02-20 Baxter International Inc. Systems and methods for removing viral agents from blood
BR9907852A (pt) * 1998-02-12 2000-10-24 Immunivest Corp Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes

Also Published As

Publication number Publication date
FR2782730B1 (fr) 2002-05-17
EP1108057A1 (de) 2001-06-20
WO2000011210A1 (fr) 2000-03-02
DE69939265D1 (de) 2008-09-18
US7316897B2 (en) 2008-01-08
FR2782730A1 (fr) 2000-03-03
ES2312213T3 (es) 2009-02-16
AU5376299A (en) 2000-03-14
US20020028431A1 (en) 2002-03-07
EP1108057B1 (de) 2008-08-06

Similar Documents

Publication Publication Date Title
ATE403740T1 (de) Verfahren, werkzeuge und reagenzien für zelltrennung
DE19681033D2 (de) Verfahren zur Quantifizierung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
AU6380001A (en) Porous ferro- or ferrimagnetic glass particles for isolating molecules
DE69427103D1 (de) Verfahren, Reagenzien und Kits zur Untersuchung von Neisseria gonorrhoeae und Chlamydia trachomatis
ATE179425T1 (de) Verfahren zur abreicherung oder entfernung von endotoxinen
DE60008252D1 (de) Verfahren zum aufbereiten von kärschlamm
DE69612973D1 (de) Verbesserung an der behandlung von proben
DE69006464D1 (de) An inorganischen Trägern gebundene, Pyridin enthaltende Alkoxysilane und Verfahren zu deren Verwendung zur Beseitigung und Konzentrierung von gewünschten Ionen in Flüssigkeiten.
ATE3726T1 (de) Verfahren und diagnostische mittel zum nachweis von redox-reaktionen.
ATE91708T1 (de) Verfahren zur freisetzung von rns und dns aus zellen.
ES8501531A1 (es) Un metodo y a unos reactivos para determinar ligandos en los fluidos biologicos
ATE373105T1 (de) Verbindungen und methoden zum nachweis von biomolekülen
ATE133206T1 (de) Verfahren zum nachweis von bakterien im harn
CU23095A1 (es) Proceso para la tipificación rápida de microorganismos y juego de reactivos empleado
DK1326963T3 (da) Mikroorganismer, som er gjort ikke-patogene
EP0659437A3 (de) Extraktionsverfahren für Mikroorganismenantigene.
ATE456799T1 (de) Verfahren zum identifizieren von präneoplastischen und neoplastischen stadien in säugern
ATE13558T1 (de) Mittel und verfahren zum nachweis von wasserstoffperoxid.
PT82940A (de) Mit uberzugen versehene formkorper zur bindung von bioaffinen substanzen verfahren zu ihrer herstellung sowie ihre verwendung
DE3765147D1 (de) Verfahren und reagenz zur bestimmung von gesamt-bilirubin.
ATE225859T1 (de) Nachweis von antibiotikumresistenzen in mikroorganismen
DE60140563D1 (de) Verfahren und zusammensetzungen zum aussortieren und/oder nachweis von mikroorganismen
ATE380584T1 (de) Hybridverfahren zur herstellung von trägern für die analytbestimmung
AU5326198A (en) Synthetic biepitope compounds which can be used as standards in the biological assays of troponin I
ATE180893T1 (de) Chromatographiematerial

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1108057

Country of ref document: EP