ATE403741T1 - 7-alkoxycumarinverbindungen als cytochrom p450- substrate - Google Patents

7-alkoxycumarinverbindungen als cytochrom p450- substrate

Info

Publication number
ATE403741T1
ATE403741T1 AT99923518T AT99923518T ATE403741T1 AT E403741 T1 ATE403741 T1 AT E403741T1 AT 99923518 T AT99923518 T AT 99923518T AT 99923518 T AT99923518 T AT 99923518T AT E403741 T1 ATE403741 T1 AT E403741T1
Authority
AT
Austria
Prior art keywords
cytochrome
substrates
alkoxycumarine
compounds
enzyme
Prior art date
Application number
AT99923518T
Other languages
English (en)
Inventor
Stephen Clarke
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE403741T1 publication Critical patent/ATE403741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99923518T 1998-05-08 1999-04-28 7-alkoxycumarinverbindungen als cytochrom p450- substrate ATE403741T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9810016.7A GB9810016D0 (en) 1998-05-08 1998-05-08 Compounds

Publications (1)

Publication Number Publication Date
ATE403741T1 true ATE403741T1 (de) 2008-08-15

Family

ID=27772877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99923518T ATE403741T1 (de) 1998-05-08 1999-04-28 7-alkoxycumarinverbindungen als cytochrom p450- substrate

Country Status (8)

Country Link
US (1) US6617124B1 (de)
EP (1) EP1075539B1 (de)
JP (1) JP2002514438A (de)
AT (1) ATE403741T1 (de)
DE (1) DE69939257D1 (de)
ES (1) ES2312207T3 (de)
GB (1) GB9810016D0 (de)
WO (1) WO1999058710A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420130B1 (en) 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6143492A (en) * 1998-12-14 2000-11-07 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
DK1140888T3 (da) * 1998-12-14 2003-08-25 Vertex Pharma San Diego Llc Optiske molekylære sensorer for cytochrom P450-aktivitet
US6514687B1 (en) 1998-12-14 2003-02-04 Vertex Pharmaceuticals (San Diego), Llc Optical molecular sensors for cytochrome P450 activity
EP1210342A1 (de) * 1999-08-19 2002-06-05 Gentest Corporation Verwendung von fluorescein aryl äthern für hohen durchsatz cytochrom p450 hemmtest
US6207404B1 (en) 1999-09-30 2001-03-27 Gentest Corporation Coumarin-based CYP3A fluorescent assay reagents
US7056654B2 (en) 1999-12-13 2006-06-06 Smithkline Beecham Corporation Screening assay for inhibitors of human cytochrome P-450
WO2001044494A2 (en) * 1999-12-13 2001-06-21 Smithkline Beecham P.L.C. P450 enzyme substrate
WO2002004660A2 (en) * 2000-07-12 2002-01-17 Wyeth Method for testing for inhibition of drug-metabolizing cytochrome p450 isozymes
CN115023222A (zh) * 2019-10-25 2022-09-06 J·夸克 神经系统病症的治疗

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE734121A (de) * 1968-06-14 1969-11-17

Also Published As

Publication number Publication date
EP1075539B1 (de) 2008-08-06
JP2002514438A (ja) 2002-05-21
EP1075539A1 (de) 2001-02-14
ES2312207T3 (es) 2009-02-16
GB9810016D0 (en) 1998-07-08
WO1999058710A1 (en) 1999-11-18
US6617124B1 (en) 2003-09-09
DE69939257D1 (de) 2008-09-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties