ATE404211T1 - Xenon als nmda-antogonist zur neuroprotektion - Google Patents
Xenon als nmda-antogonist zur neuroprotektionInfo
- Publication number
- ATE404211T1 ATE404211T1 AT00948171T AT00948171T ATE404211T1 AT E404211 T1 ATE404211 T1 AT E404211T1 AT 00948171 T AT00948171 T AT 00948171T AT 00948171 T AT00948171 T AT 00948171T AT E404211 T1 ATE404211 T1 AT E404211T1
- Authority
- AT
- Austria
- Prior art keywords
- xenon
- nmda
- antogonist
- neuroprotection
- modulating
- Prior art date
Links
- 229910052724 xenon Inorganic materials 0.000 title abstract 3
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 title abstract 3
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
- 230000004112 neuroprotection Effects 0.000 title 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 3
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9917822.0A GB9917822D0 (en) | 1999-07-29 | 1999-07-29 | Nmda antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404211T1 true ATE404211T1 (de) | 2008-08-15 |
Family
ID=10858166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948171T ATE404211T1 (de) | 1999-07-29 | 2000-07-28 | Xenon als nmda-antogonist zur neuroprotektion |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6274633B1 (de) |
| EP (1) | EP1200103B1 (de) |
| JP (1) | JP5088997B2 (de) |
| AT (1) | ATE404211T1 (de) |
| AU (1) | AU778097B2 (de) |
| CA (1) | CA2280310C (de) |
| DE (1) | DE60039878D1 (de) |
| ES (1) | ES2311466T3 (de) |
| GB (1) | GB9917822D0 (de) |
| PT (1) | PT1200103E (de) |
| RU (1) | RU2257902C2 (de) |
| WO (1) | WO2001008692A1 (de) |
| ZA (1) | ZA200200539B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| US7097849B2 (en) | 1998-08-19 | 2006-08-29 | Jagotec Ag | Injectable aqueous dispersions of propofol |
| DE19910986C2 (de) * | 1999-03-11 | 2001-06-07 | Aga Ab | Verwendung von Xenon bei der Behandlung von Neurointoxikationen |
| GB9913677D0 (en) * | 1999-06-11 | 1999-08-11 | Imperial College | Formulation |
| JP2005506292A (ja) * | 2001-03-08 | 2005-03-03 | エモリー ユニバーシティ | pHに依存するNMDAレセプターアンタゴニスト |
| GB0209998D0 (en) * | 2002-05-01 | 2002-06-12 | Protexeon Ltd | Use |
| GB0210021D0 (en) * | 2002-05-01 | 2002-06-12 | Air Prod & Chem | Ultrasonic gas analyser |
| GB0218153D0 (en) * | 2002-08-05 | 2002-09-11 | Ic Innovations Ltd | An analgesic agent for newborn or retal subjects |
| US7337776B2 (en) * | 2002-08-20 | 2008-03-04 | Aga Ab | Methods for easing pain and anxiety from atrial or ventricular defibrillation |
| US7681572B2 (en) * | 2002-08-20 | 2010-03-23 | Aga Ab | Method and devices for administration of therapeutic gases |
| FR2858233B1 (fr) * | 2003-07-30 | 2008-04-11 | Air Liquide Sante Int | Medicament gazeux inhalable a base de xenon et de protoxyde d'azote |
| PT1670489E (pt) * | 2003-10-10 | 2008-02-28 | Protexeon Ltd | Utilização de xénon com hipotermia para o tratamento de asfixia neonatal |
| US20080031971A1 (en) * | 2003-10-21 | 2008-02-07 | Aga Ab | Use Of Xenon For The Prevention Of Programmed Cell Death |
| FR2863169B1 (fr) * | 2003-12-08 | 2006-02-10 | Air Liquide Sante Int | Medicament gazeux inhalable a base d'argon pour le traitement des neuro-intoxications |
| GB0520176D0 (en) * | 2005-10-04 | 2005-11-09 | Imp College Innovations Ltd | Use |
| RU2346695C2 (ru) * | 2006-08-15 | 2009-02-20 | Общество с ограниченной ответственностью "Ксиан"(ООО "Ксиан") | Применение ксенона для коррекции патологических изменений в организме, связанных с нарушением антиоксидантного статуса |
| EP1980261A1 (de) | 2007-04-10 | 2008-10-15 | Nicholas Peter Franks | Verwendung von Helium mit Sauerstoff zur Bereitstellung von Neuroprotektion |
| EP1980260A1 (de) | 2007-04-10 | 2008-10-15 | Nicholas Peter Franks | Verwendung hyperbarischer Bedingungen zur Bereitstellung von Neuroprotektion |
| US8435569B2 (en) * | 2007-04-30 | 2013-05-07 | Nnoxe Pharmaceutiques Inc. | Pharmaceutical composition comprising at least one thrombolytic agent (A) and at least one gas (B) selected from the group consisting of nitrous oxide, argon, xenon, helium, neon |
| EA201070077A1 (ru) * | 2007-06-29 | 2010-08-30 | Эмори Юниверсити | Антагонисты nmda-рецепторов с нейропротективным действием |
| FR2952305B1 (fr) * | 2009-11-10 | 2012-04-27 | Air Liquide | Medicament inhalable a base de xenon pour traiter ou pour prevenir les dyskinesies |
| CN103565745A (zh) | 2012-08-10 | 2014-02-12 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
| JP6625966B2 (ja) | 2013-03-15 | 2019-12-25 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 希ガスが豊富な液体ならびにその調製及び使用の方法 |
| FR3022456B1 (fr) * | 2014-06-20 | 2016-07-15 | Air Liquide | Xenon associe a un antagoniste des recepteurs nmda pour lutter contre une proliferation tumorale dans le systeme nerveux central |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU120307A1 (ru) * | 1949-04-19 | 1958-11-30 | К.М. Салдадзе | Способ приготовлени искусственно-радиоактивных лечебных ванн |
| SU1075632A1 (ru) * | 1982-05-25 | 1985-06-30 | Ордена Трудового Красного Знамени Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср | Устройство дл моделировани нейрона |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| WO1997003677A1 (en) * | 1995-07-24 | 1997-02-06 | Trustees Of Boston University | Inhibition of nmda receptor activity by pregnenolone sulfate derivatives |
| DE19709704C2 (de) * | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| GB9706294D0 (en) * | 1997-03-26 | 1997-05-14 | Glaxo Wellcome Spa | Heterocyclic compound |
| ATE229004T1 (de) * | 1997-03-31 | 2002-12-15 | Korea Res Inst Chem Tech | Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung |
| JPH1171271A (ja) * | 1997-06-27 | 1999-03-16 | Shionogi & Co Ltd | グルコン酸又はその類縁体を含有するnmda受容体拮抗剤 |
| DE19910986C2 (de) * | 1999-03-11 | 2001-06-07 | Aga Ab | Verwendung von Xenon bei der Behandlung von Neurointoxikationen |
-
1999
- 1999-07-29 GB GBGB9917822.0A patent/GB9917822D0/en not_active Ceased
- 1999-08-13 CA CA002280310A patent/CA2280310C/en not_active Expired - Lifetime
- 1999-08-23 US US09/378,806 patent/US6274633B1/en not_active Expired - Lifetime
-
2000
- 2000-07-28 PT PT00948171T patent/PT1200103E/pt unknown
- 2000-07-28 EP EP00948171A patent/EP1200103B1/de not_active Revoked
- 2000-07-28 WO PCT/GB2000/002896 patent/WO2001008692A1/en not_active Ceased
- 2000-07-28 AU AU61735/00A patent/AU778097B2/en not_active Ceased
- 2000-07-28 ES ES00948171T patent/ES2311466T3/es not_active Expired - Lifetime
- 2000-07-28 JP JP2001513422A patent/JP5088997B2/ja not_active Expired - Lifetime
- 2000-07-28 AT AT00948171T patent/ATE404211T1/de not_active IP Right Cessation
- 2000-07-28 RU RU2002105377/15A patent/RU2257902C2/ru not_active IP Right Cessation
- 2000-07-28 DE DE60039878T patent/DE60039878D1/de not_active Expired - Lifetime
-
2002
- 2002-01-22 ZA ZA200200539A patent/ZA200200539B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2311466T3 (es) | 2009-02-16 |
| CA2280310C (en) | 2008-10-14 |
| ZA200200539B (en) | 2002-09-25 |
| US6274633B1 (en) | 2001-08-14 |
| PT1200103E (pt) | 2008-09-17 |
| GB9917822D0 (en) | 1999-09-29 |
| RU2257902C2 (ru) | 2005-08-10 |
| JP2003505512A (ja) | 2003-02-12 |
| CA2280310A1 (en) | 2001-01-29 |
| JP5088997B2 (ja) | 2012-12-05 |
| WO2001008692A1 (en) | 2001-02-08 |
| EP1200103A1 (de) | 2002-05-02 |
| EP1200103B1 (de) | 2008-08-13 |
| AU778097B2 (en) | 2004-11-18 |
| AU6173500A (en) | 2001-02-19 |
| DE60039878D1 (de) | 2008-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |