ATE404587T1 - Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen - Google Patents

Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen

Info

Publication number
ATE404587T1
ATE404587T1 AT99912835T AT99912835T ATE404587T1 AT E404587 T1 ATE404587 T1 AT E404587T1 AT 99912835 T AT99912835 T AT 99912835T AT 99912835 T AT99912835 T AT 99912835T AT E404587 T1 ATE404587 T1 AT E404587T1
Authority
AT
Austria
Prior art keywords
inductors
inhibitors
identifying
compositions
proteolytic antibodies
Prior art date
Application number
AT99912835T
Other languages
English (en)
Inventor
Sudhir Paul
Gennady Gololobov
Larry Smith
Original Assignee
Univ Nebraska
Larry Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nebraska, Larry Smith filed Critical Univ Nebraska
Application granted granted Critical
Publication of ATE404587T1 publication Critical patent/ATE404587T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
AT99912835T 1998-03-23 1999-03-23 Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen ATE404587T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/046,373 US6235714B1 (en) 1998-03-23 1998-03-23 Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses

Publications (1)

Publication Number Publication Date
ATE404587T1 true ATE404587T1 (de) 2008-08-15

Family

ID=21943098

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99912835T ATE404587T1 (de) 1998-03-23 1999-03-23 Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen

Country Status (16)

Country Link
US (3) US6235714B1 (de)
EP (1) EP1064308B1 (de)
JP (2) JP2002507627A (de)
KR (1) KR100748920B1 (de)
CN (1) CN100358920C (de)
AT (1) ATE404587T1 (de)
AU (1) AU760648B2 (de)
BR (1) BR9909011A (de)
CA (1) CA2324340A1 (de)
DE (1) DE69939312D1 (de)
ES (1) ES2313780T3 (de)
IL (1) IL138424A (de)
PL (1) PL343245A1 (de)
RU (1) RU2226401C2 (de)
TR (1) TR200002731T2 (de)
WO (1) WO1999048925A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855804B2 (en) 1998-03-23 2005-02-15 Board Of Regents, The University Of Texas System Covalently reactive transition state analogs and methods of use thereof
WO2000051623A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US20050043262A1 (en) * 2000-03-29 2005-02-24 Weiss Robert H. Novel specific inhibitor of the cyclin kinase inhibitor p21Waf1/Cip1 and methods of using the inhibitor
WO2002079223A2 (en) * 2001-03-31 2002-10-10 Board Of Regents, The University Of Texas System Covalently reactive transition state analogs and methods of use thereof
RU2221873C2 (ru) * 2001-04-24 2004-01-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность
FR2825154B1 (fr) * 2001-05-22 2004-01-30 Univ Compiegne Tech Composes capables de moduler l'activite et de stimuler la production d'un anticorps catalytique
CA2463415C (en) 2001-10-25 2012-02-07 Emory University Catheter for modified perfusion
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
JP5253325B2 (ja) * 2002-09-04 2013-07-31 中外製薬株式会社 ＭＲＬ／ｌｐｒマウスを用いた抗体の作製
AU2003284062A1 (en) * 2002-10-09 2004-05-04 Integrigen, Inc. Recombinant catalytic polypeptides and their uses
EP1615946B1 (de) * 2003-03-26 2020-05-06 Sudhir Paul Proteolytische und kovalente antikörper
WO2004087059A2 (en) * 2003-03-26 2004-10-14 The University Of Texas Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding
CA2520382C (en) * 2003-03-27 2014-01-28 Sudhir Paul Lupus antibodies for passive immunotherapy of hiv/aids
US20050084488A1 (en) * 2003-04-10 2005-04-21 Mulkerrin Michael G. Asparagine deaminase catalytic antibodies
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US20090208451A1 (en) * 2003-10-17 2009-08-20 Integrigen, Inc. Halogen phosphonate monoesters
WO2005099772A2 (en) * 2004-04-13 2005-10-27 Boston Biomedical Research Institute Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death
CN101432001A (zh) 2004-08-20 2009-05-13 巴克年龄研究协会 取代或激动p53功能的小分子
US20080097385A1 (en) * 2004-12-22 2008-04-24 Jakob Vinten-Johansen Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
EP2091973A4 (de) * 2006-11-09 2010-08-04 Sudhir Paul Antikörper gegen binäre epitope und b-zellen-superantigen-immunstimulantien
EP2452947A1 (de) 2010-11-16 2012-05-16 Münch, Jan Eine Viralinfektion steigerndes Peptid
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
SG10201704846VA (en) 2012-03-14 2017-07-28 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
JP6993958B2 (ja) 2015-07-06 2022-02-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多重特異性抗原結合分子およびその使用
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
AU2018281280B2 (en) 2017-06-07 2024-12-19 Regeneron Pharmaceuticals, Inc. Compositions and methods for internalizing enzymes
JP7328990B2 (ja) 2018-04-30 2023-08-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｈｅｒ２及び／またはａｐｌｐ２に結合する抗体及び二重特異性抗原結合分子、ならびにそれらのコンジュゲート及び使用
EP3793591A1 (de) 2018-05-17 2021-03-24 Regeneron Pharmaceuticals, Inc. Anti-cd63-antikörper, konjugate und verwendungen davon
WO2020069005A1 (en) * 2018-09-28 2020-04-02 Harrow Health, Inc. Pharmaceutical compositions for prevention or treatment of cytokine release syndrome
CN112245563A (zh) * 2020-09-29 2021-01-22 古鲟（大连）生物科技发展有限公司 可降尿酸的鲟鱼肽复合粉

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658753A (en) * 1989-04-25 1997-08-19 Paul; Sudhir Catalytic antibody components
US5194585A (en) * 1989-04-25 1993-03-16 Igen, Inc. Inhibitors of catalytic antibodies
DE69025761T2 (de) * 1989-06-08 1996-07-18 Igen Inc Verfahren zur erhöhung der rate der modifikation metastabiler bindungen
US5948658A (en) * 1996-06-25 1999-09-07 The Trustees Of Columbia University In The City Of New York Anti-cocaine catalytic antibody

Also Published As

Publication number Publication date
WO1999048925A1 (en) 1999-09-30
RU2226401C2 (ru) 2004-04-10
EP1064308A4 (de) 2004-08-11
TR200002731T2 (tr) 2001-04-20
IL138424A (en) 2005-08-31
EP1064308A1 (de) 2001-01-03
IL138424A0 (en) 2001-10-31
CN100358920C (zh) 2008-01-02
CN1301271A (zh) 2001-06-27
US6855528B2 (en) 2005-02-15
CA2324340A1 (en) 1999-09-30
US20050214295A1 (en) 2005-09-29
DE69939312D1 (de) 2008-09-25
PL343245A1 (en) 2001-07-30
US20020013274A1 (en) 2002-01-31
AU3111399A (en) 1999-10-18
US6235714B1 (en) 2001-05-22
AU760648B2 (en) 2003-05-22
KR20010042123A (ko) 2001-05-25
JP2010031016A (ja) 2010-02-12
KR100748920B1 (ko) 2007-08-14
BR9909011A (pt) 2000-11-28
JP2002507627A (ja) 2002-03-12
EP1064308B1 (de) 2008-08-13
ES2313780T3 (es) 2009-03-01

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