ATE405572T1 - Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese - Google Patents
Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen syntheseInfo
- Publication number
- ATE405572T1 ATE405572T1 AT05718265T AT05718265T ATE405572T1 AT E405572 T1 ATE405572 T1 AT E405572T1 AT 05718265 T AT05718265 T AT 05718265T AT 05718265 T AT05718265 T AT 05718265T AT E405572 T1 ATE405572 T1 AT E405572T1
- Authority
- AT
- Austria
- Prior art keywords
- chirogenic
- phospholanes
- asymmetric synthesis
- production
- disclosed
- Prior art date
Links
- 150000004850 phospholanes Chemical class 0.000 title abstract 3
- 238000011914 asymmetric synthesis Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- GWLJTAJEHRYMCA-UHFFFAOYSA-N phospholane Chemical class C1CCPC1 GWLJTAJEHRYMCA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65683—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55904304P | 2004-04-01 | 2004-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405572T1 true ATE405572T1 (de) | 2008-09-15 |
Family
ID=34962295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05718265T ATE405572T1 (de) | 2004-04-01 | 2005-03-23 | Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7390931B2 (de) |
| EP (1) | EP1735324B1 (de) |
| JP (1) | JP2007530657A (de) |
| AT (1) | ATE405572T1 (de) |
| BR (1) | BRPI0508998A (de) |
| CA (1) | CA2561755A1 (de) |
| DE (1) | DE602005009161D1 (de) |
| ES (1) | ES2309731T3 (de) |
| WO (1) | WO2005095424A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| CN101160281A (zh) * | 2005-04-06 | 2008-04-09 | 特瓦制药工业有限公司 | 结晶形态的普瑞巴林 |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| EP1768950A2 (de) * | 2005-04-11 | 2007-04-04 | Teva Pharmaceutical Industries Ltd. | Herstellungsverfahren für (s)-pregabalin |
| WO2006122255A1 (en) | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Pregabalin free of isobutylglutaric acid and a process for preparation thereof |
| US20070043241A1 (en) * | 2005-05-10 | 2007-02-22 | Lilach Hedvati | Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid |
| DE602006017995D1 (de) * | 2005-05-10 | 2010-12-16 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
| ES2398579T3 (es) * | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| EP1904486A2 (de) * | 2006-04-24 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Verfahren zur synthese von 3-isobutylglutarsäure |
| WO2007139933A2 (en) * | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
| EP1912931A2 (de) * | 2006-05-31 | 2008-04-23 | Teva Pharmaceutical Industries Ltd. | (s)-prägabalin-nitril-präparat |
| US20080026433A1 (en) * | 2006-05-31 | 2008-01-31 | Lilach Hedvati | Use of enzymatic resolution for the preparation of intermediates of pregabalin |
| KR101036536B1 (ko) * | 2007-03-22 | 2011-05-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성 |
| KR20090101462A (ko) * | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| EP2297090A1 (de) * | 2008-06-23 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Stereoselektive enzymatische synthese von (s)- bzw. (r)-iso-butyl-glutarsäure |
| CN103788133A (zh) * | 2014-01-22 | 2014-05-14 | 常州大学 | 一种含磷五元杂环类化合物及其合成方法 |
| CN109776486A (zh) * | 2019-02-26 | 2019-05-21 | 武汉松石科技股份有限公司 | 一种硫酸亚丙酯的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| US6329429B1 (en) | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
| US6194459B1 (en) | 1997-08-19 | 2001-02-27 | Warner-Lambert Company | Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants |
| WO1999008670A1 (en) | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| US6127418A (en) | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| EP1094817A1 (de) | 1998-07-09 | 2001-05-02 | Warner-Lambert Company | Zusammensetzungen enthaltend gaba-analoge und koffein |
| JP2002520277A (ja) | 1998-07-09 | 2002-07-09 | ワーナー−ランバート・カンパニー | 不眠症を治療する方法 |
| EP1121114B1 (de) | 1998-10-16 | 2007-01-10 | Warner-Lambert Company Llc | Verwendung von gaba analogen zur herstellung eines arzneimittels zur behandlung von manie und bipolaren erkrankungen |
| WO2002048161A1 (en) * | 2000-12-13 | 2002-06-20 | Warner-Lambert Company Llc | P-chirale bisphospholane ligands, their transition metal complexes |
-
2005
- 2005-03-23 EP EP05718265A patent/EP1735324B1/de not_active Expired - Lifetime
- 2005-03-23 BR BRPI0508998-0A patent/BRPI0508998A/pt not_active IP Right Cessation
- 2005-03-23 WO PCT/IB2005/000768 patent/WO2005095424A1/en not_active Ceased
- 2005-03-23 JP JP2007505651A patent/JP2007530657A/ja not_active Withdrawn
- 2005-03-23 CA CA002561755A patent/CA2561755A1/en not_active Abandoned
- 2005-03-23 DE DE602005009161T patent/DE602005009161D1/de not_active Expired - Fee Related
- 2005-03-23 ES ES05718265T patent/ES2309731T3/es not_active Expired - Lifetime
- 2005-03-23 AT AT05718265T patent/ATE405572T1/de not_active IP Right Cessation
- 2005-03-31 US US11/095,044 patent/US7390931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005095424A8 (en) | 2005-12-15 |
| CA2561755A1 (en) | 2005-10-13 |
| US7390931B2 (en) | 2008-06-24 |
| US20050222464A1 (en) | 2005-10-06 |
| BRPI0508998A (pt) | 2007-09-04 |
| EP1735324A1 (de) | 2006-12-27 |
| JP2007530657A (ja) | 2007-11-01 |
| DE602005009161D1 (de) | 2008-10-02 |
| ES2309731T3 (es) | 2008-12-16 |
| WO2005095424A1 (en) | 2005-10-13 |
| EP1735324B1 (de) | 2008-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |