ATE405572T1 - Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese - Google Patents
Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen syntheseInfo
- Publication number
- ATE405572T1 ATE405572T1 AT05718265T AT05718265T ATE405572T1 AT E405572 T1 ATE405572 T1 AT E405572T1 AT 05718265 T AT05718265 T AT 05718265T AT 05718265 T AT05718265 T AT 05718265T AT E405572 T1 ATE405572 T1 AT E405572T1
- Authority
- AT
- Austria
- Prior art keywords
- chirogenic
- phospholanes
- asymmetric synthesis
- production
- disclosed
- Prior art date
Links
- 150000004850 phospholanes Chemical class 0.000 title abstract 3
- 238000011914 asymmetric synthesis Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- GWLJTAJEHRYMCA-UHFFFAOYSA-N phospholane Chemical class C1CCPC1 GWLJTAJEHRYMCA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65683—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55904304P | 2004-04-01 | 2004-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405572T1 true ATE405572T1 (de) | 2008-09-15 |
Family
ID=34962295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05718265T ATE405572T1 (de) | 2004-04-01 | 2005-03-23 | Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7390931B2 (de) |
| EP (1) | EP1735324B1 (de) |
| JP (1) | JP2007530657A (de) |
| AT (1) | ATE405572T1 (de) |
| BR (1) | BRPI0508998A (de) |
| CA (1) | CA2561755A1 (de) |
| DE (1) | DE602005009161D1 (de) |
| ES (1) | ES2309731T3 (de) |
| WO (1) | WO2005095424A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001876A (en) | 1996-07-24 | 1999-12-14 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| US7417165B2 (en) * | 2005-04-06 | 2008-08-26 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of pregabalin |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| WO2006110783A2 (en) * | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
| KR20070067077A (ko) | 2005-05-10 | 2007-06-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법 |
| WO2006122259A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
| KR100893312B1 (ko) * | 2005-05-10 | 2009-04-15 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린 및 이의 염의 제조 방법 |
| WO2007035890A1 (en) | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid |
| WO2007127309A2 (en) * | 2006-04-24 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 3-isobutylglutaric acid |
| WO2007139933A2 (en) * | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
| EP2071032A3 (de) * | 2006-05-31 | 2009-07-08 | Teva Pharmaceutical Industries Ltd | Enzymatische Auflösung für die Herstellung von Pregablin-Zwischenprodukten |
| US20080015385A1 (en) * | 2006-05-31 | 2008-01-17 | Lilach Hedvati | Preparation of (S)-pregabalin-nitrile |
| WO2008118427A2 (en) * | 2007-03-22 | 2008-10-02 | Teva Pharmaceutical Industries Ltd. | Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid |
| KR20090101462A (ko) * | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| CN103788133A (zh) * | 2014-01-22 | 2014-05-14 | 常州大学 | 一种含磷五元杂环类化合物及其合成方法 |
| CN109776486A (zh) * | 2019-02-26 | 2019-05-21 | 武汉松石科技股份有限公司 | 一种硫酸亚丙酯的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US6001876A (en) * | 1996-07-24 | 1999-12-14 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| US6329429B1 (en) * | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
| US6194459B1 (en) * | 1997-08-19 | 2001-02-27 | Warner-Lambert Company | Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants |
| US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| AU8668598A (en) * | 1997-08-20 | 1999-03-08 | University Of Oklahoma, The | Gaba analogs to prevent and treat gastrointestinal damage |
| JP2002520286A (ja) * | 1998-07-09 | 2002-07-09 | ワーナー−ランバート・カンパニー | Ｇａｂａ類縁体及びカフェインを含んでなる組成物 |
| US6306910B1 (en) * | 1998-07-09 | 2001-10-23 | Warner-Lambert Company | Use of Gaba-analogues for treating insomnia |
| KR100697734B1 (ko) * | 1998-10-16 | 2007-03-22 | 워너-램버트 캄파니 엘엘씨 | 조증 및 양극성 장애 치료용 제약 조성물 |
| JP4037756B2 (ja) * | 2000-12-13 | 2008-01-23 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Ｐ−キラルビスホスホランリガンド、それらの遷移金属錯体 |
-
2005
- 2005-03-23 ES ES05718265T patent/ES2309731T3/es not_active Expired - Lifetime
- 2005-03-23 EP EP05718265A patent/EP1735324B1/de not_active Expired - Lifetime
- 2005-03-23 AT AT05718265T patent/ATE405572T1/de not_active IP Right Cessation
- 2005-03-23 WO PCT/IB2005/000768 patent/WO2005095424A1/en not_active Ceased
- 2005-03-23 CA CA002561755A patent/CA2561755A1/en not_active Abandoned
- 2005-03-23 DE DE602005009161T patent/DE602005009161D1/de not_active Expired - Fee Related
- 2005-03-23 BR BRPI0508998-0A patent/BRPI0508998A/pt not_active IP Right Cessation
- 2005-03-23 JP JP2007505651A patent/JP2007530657A/ja not_active Withdrawn
- 2005-03-31 US US11/095,044 patent/US7390931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005095424A1 (en) | 2005-10-13 |
| EP1735324A1 (de) | 2006-12-27 |
| DE602005009161D1 (de) | 2008-10-02 |
| US20050222464A1 (en) | 2005-10-06 |
| US7390931B2 (en) | 2008-06-24 |
| ES2309731T3 (es) | 2008-12-16 |
| WO2005095424A8 (en) | 2005-12-15 |
| JP2007530657A (ja) | 2007-11-01 |
| CA2561755A1 (en) | 2005-10-13 |
| BRPI0508998A (pt) | 2007-09-04 |
| EP1735324B1 (de) | 2008-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |