ATE486841T1 - Verfahren zur herstellung von pregabalin und salzen daraus - Google Patents
Verfahren zur herstellung von pregabalin und salzen darausInfo
- Publication number
- ATE486841T1 ATE486841T1 AT06759589T AT06759589T ATE486841T1 AT E486841 T1 ATE486841 T1 AT E486841T1 AT 06759589 T AT06759589 T AT 06759589T AT 06759589 T AT06759589 T AT 06759589T AT E486841 T1 ATE486841 T1 AT E486841T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- pregabalin
- producing
- producing pregabalin
- preparing
- Prior art date
Links
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title abstract 2
- 229960001233 pregabalin Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67978405P | 2005-05-10 | 2005-05-10 | |
| US68969905P | 2005-06-09 | 2005-06-09 | |
| PCT/US2006/018272 WO2006122258A1 (en) | 2005-05-10 | 2006-05-10 | Method for the preparation of pregabalin and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486841T1 true ATE486841T1 (de) | 2010-11-15 |
Family
ID=36940110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06759589T ATE486841T1 (de) | 2005-05-10 | 2006-05-10 | Verfahren zur herstellung von pregabalin und salzen daraus |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7763749B2 (de) |
| EP (1) | EP1879851B1 (de) |
| KR (1) | KR100893312B1 (de) |
| AT (1) | ATE486841T1 (de) |
| CA (1) | CA2604602A1 (de) |
| DE (1) | DE602006017995D1 (de) |
| IL (1) | IL185031A0 (de) |
| MX (1) | MX2007000524A (de) |
| WO (1) | WO2006122258A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101160281A (zh) * | 2005-04-06 | 2008-04-09 | 特瓦制药工业有限公司 | 结晶形态的普瑞巴林 |
| EP1768950A2 (de) * | 2005-04-11 | 2007-04-04 | Teva Pharmaceutical Industries Ltd. | Herstellungsverfahren für (s)-pregabalin |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| DE602006017995D1 (de) | 2005-05-10 | 2010-12-16 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
| WO2006122255A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Pregabalin free of isobutylglutaric acid and a process for preparation thereof |
| US20070043241A1 (en) * | 2005-05-10 | 2007-02-22 | Lilach Hedvati | Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid |
| ES2398579T3 (es) * | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| WO2007139933A2 (en) * | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
| EP1912931A2 (de) * | 2006-05-31 | 2008-04-23 | Teva Pharmaceutical Industries Ltd. | (s)-prägabalin-nitril-präparat |
| US20080026433A1 (en) * | 2006-05-31 | 2008-01-31 | Lilach Hedvati | Use of enzymatic resolution for the preparation of intermediates of pregabalin |
| KR101036536B1 (ko) | 2007-03-22 | 2011-05-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성 |
| KR100846419B1 (ko) * | 2007-08-10 | 2008-07-15 | 한국과학기술원 | 프레가발린의 신규한 제조 방법 |
| KR20090101462A (ko) * | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| EP2294207B1 (de) | 2008-05-21 | 2012-09-26 | Sandoz AG | Verfahren zur stereoselektiven enzymatischen Hydrolyse von 5-methyl-3-nitromethylhexansäureester |
| EP2297090A1 (de) * | 2008-06-23 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Stereoselektive enzymatische synthese von (s)- bzw. (r)-iso-butyl-glutarsäure |
| ES2362913B1 (es) | 2009-12-24 | 2012-05-24 | Moehs Iberica S.L. | Nuevo método para la preparación de (s)-pregabalina. |
| US20140243412A1 (en) * | 2013-02-28 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Process for preparation of pregabalin |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| CN117865853A (zh) * | 2023-11-24 | 2024-04-12 | 迪嘉药业集团股份有限公司 | 一种普瑞巴林杂质的制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2053582T3 (es) | 1986-08-13 | 1994-08-01 | Ciba Geigy Ag | Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico. |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US5616793A (en) | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| DE19530637A1 (de) | 1995-08-21 | 1997-02-27 | Bayer Ag | Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden |
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| ES2130079B1 (es) | 1997-07-10 | 2000-01-16 | Esteve Labor Dr | Resolucion de aminas |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| FR2781793B1 (fr) | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
| US6642398B2 (en) | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
| BRPI0107863B8 (pt) | 2000-01-27 | 2017-04-25 | Warner-Lambert Company | método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina |
| WO2001074741A2 (en) | 2000-04-04 | 2001-10-11 | Brandeis University | Catalytic asymmetric desymmetrization of meso compounds |
| DE10203122A1 (de) | 2002-01-25 | 2003-07-31 | Gruenenthal Gmbh | Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren |
| US20030225149A1 (en) | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
| ES2292107T3 (es) | 2004-03-12 | 2008-03-01 | Warner-Lambert Company Llc | Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina. |
| EP1735324B1 (de) | 2004-04-01 | 2008-08-20 | Warner-Lambert Company LLC | Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese |
| UA82292C2 (uk) | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
| HRP20100054T1 (hr) | 2004-06-21 | 2010-05-31 | Warner-Lambert Company Llc | Dobivanje pregabalina i njemu sličnih spojeva |
| WO2006008640A1 (en) | 2004-07-15 | 2006-01-26 | Pharmacia & Upjohn Company Llc | Non-aqueous suspension containing a drug having an unpleasant taste |
| CN1634869A (zh) | 2004-12-06 | 2005-07-06 | 北京阜康仁生物制药科技有限公司 | 普瑞巴林新晶型及其制备方法 |
| EP1768950A2 (de) | 2005-04-11 | 2007-04-04 | Teva Pharmaceutical Industries Ltd. | Herstellungsverfahren für (s)-pregabalin |
| WO2006122255A1 (en) | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Pregabalin free of isobutylglutaric acid and a process for preparation thereof |
| DE602006017995D1 (de) | 2005-05-10 | 2010-12-16 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
| US20060270871A1 (en) | 2005-05-30 | 2006-11-30 | Khanduri Chandra H | Polymorphic form i of pregabalin and processes for its preparation |
| CN100410242C (zh) | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
| CZ297970B6 (cs) | 2005-08-10 | 2007-05-09 | Zentiva, A. S | Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu) |
| ES2398579T3 (es) | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| ITMI20061297A1 (it) | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi |
| US20090286880A1 (en) | 2006-07-12 | 2009-11-19 | Generics [Uk] Limited | Novel process |
| GB0614133D0 (en) | 2006-07-15 | 2006-08-23 | Pliva Istrazivanje I Razvoj D | Process for preparing a pharmaceutical compound |
| US20080014280A1 (en) | 2006-07-17 | 2008-01-17 | Glenmark Pharmaceuticals Limited | Amorphous pregabalin and process for the preparation thereof |
| WO2008062460A2 (en) | 2006-10-06 | 2008-05-29 | Cadila Healthcare Limited | Crystalline forms of pregabalin |
| EP1992609A1 (de) | 2007-05-14 | 2008-11-19 | Dipharma Francis S.r.l. | Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure |
| EP2017273A1 (de) | 2007-07-18 | 2009-01-21 | Laboratorios del Dr. Esteve S.A. | Verfahren zur enantioselektiven Herstellung von Pregabalin |
-
2006
- 2006-05-10 DE DE602006017995T patent/DE602006017995D1/de active Active
- 2006-05-10 KR KR1020077025956A patent/KR100893312B1/ko not_active Expired - Fee Related
- 2006-05-10 US US11/432,721 patent/US7763749B2/en not_active Expired - Fee Related
- 2006-05-10 AT AT06759589T patent/ATE486841T1/de not_active IP Right Cessation
- 2006-05-10 WO PCT/US2006/018272 patent/WO2006122258A1/en not_active Ceased
- 2006-05-10 MX MX2007000524A patent/MX2007000524A/es active IP Right Grant
- 2006-05-10 CA CA002604602A patent/CA2604602A1/en not_active Abandoned
- 2006-05-10 EP EP06759589A patent/EP1879851B1/de not_active Revoked
-
2007
- 2007-08-02 IL IL185031A patent/IL185031A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007000524A (es) | 2007-03-28 |
| KR20070118306A (ko) | 2007-12-14 |
| WO2006122258A1 (en) | 2006-11-16 |
| EP1879851A1 (de) | 2008-01-23 |
| CA2604602A1 (en) | 2006-11-16 |
| EP1879851B1 (de) | 2010-11-03 |
| DE602006017995D1 (de) | 2010-12-16 |
| US7763749B2 (en) | 2010-07-27 |
| IL185031A0 (en) | 2007-12-03 |
| KR100893312B1 (ko) | 2009-04-15 |
| US20070073085A1 (en) | 2007-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |