ATE405582T1 - P53 bindende t-zellrezeptormoleküle und deren verwendungen - Google Patents

P53 bindende t-zellrezeptormoleküle und deren verwendungen

Info

Publication number
ATE405582T1
ATE405582T1 AT02746470T AT02746470T ATE405582T1 AT E405582 T1 ATE405582 T1 AT E405582T1 AT 02746470 T AT02746470 T AT 02746470T AT 02746470 T AT02746470 T AT 02746470T AT E405582 T1 ATE405582 T1 AT E405582T1
Authority
AT
Austria
Prior art keywords
molecules
protein
tcr
cell receptor
binding
Prior art date
Application number
AT02746470T
Other languages
English (en)
Inventor
Linda Sherman
Kimberlyn Card
Jon Weidanz
Hing Wong
Elizabeth Thomson
Original Assignee
Altor Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altor Bioscience Corp filed Critical Altor Bioscience Corp
Application granted granted Critical
Publication of ATE405582T1 publication Critical patent/ATE405582T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02746470T 2001-06-05 2002-06-05 P53 bindende t-zellrezeptormoleküle und deren verwendungen ATE405582T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29632401P 2001-06-05 2001-06-05

Publications (1)

Publication Number Publication Date
ATE405582T1 true ATE405582T1 (de) 2008-09-15

Family

ID=31946570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02746470T ATE405582T1 (de) 2001-06-05 2002-06-05 P53 bindende t-zellrezeptormoleküle und deren verwendungen

Country Status (11)

Country Link
US (1) US7456263B2 (de)
EP (2) EP2009019A1 (de)
JP (1) JP4447456B2 (de)
CN (1) CN1692124B (de)
AT (1) ATE405582T1 (de)
AU (1) AU2002316190B8 (de)
CA (1) CA2487779C (de)
DE (1) DE60228504D1 (de)
DK (1) DK1546188T3 (de)
ES (1) ES2307770T3 (de)
WO (1) WO2004018619A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7524601A (en) * 2000-06-05 2001-12-17 Sunol Molecular Corp T cell receptor fusions and conjugates and methods of use thereof
US8772451B2 (en) * 2003-11-10 2014-07-08 Altor Bioscience Corporation Soluble TCR molecules and methods of use
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
EP2486049A1 (de) 2009-10-06 2012-08-15 The Board Of Trustees Of The UniversityOf Illinois Menschliche einkettige t-zell-rezeptoren
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
ES2719495T5 (en) 2012-05-07 2025-09-10 Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
MA50651A (fr) * 2017-09-29 2020-08-05 Us Health Récepteurs de lymphocytes t reconnaissant p53 mutée
KR20200063215A (ko) 2017-10-06 2020-06-04 오슬로 유니버시테시케후스 에이치에프 키메라 항원 수용체
CN108060135A (zh) * 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用
CA3095757A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
EP3773632A4 (de) 2018-04-06 2022-05-18 The Regents of The University of California Verfahren zur behandlung von egfrviii-exprimierenden glioblastomen

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867973A (en) 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
WO1988007553A1 (fr) 1987-03-26 1988-10-06 Teijin Limited Procede de preparation d'un complexe d'anticorps
JPH05504481A (ja) 1990-02-20 1993-07-15 クールター　コーポレイション 改良された抗体―酵素直接接合体及びその製造方法
GB9200417D0 (en) 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US6399368B1 (en) 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
ES2139012T3 (es) * 1992-05-26 2000-02-01 Univ Leiden Peptidos de la proteina p53 humana destinados para ser utilizados en composiciones que inducen una reaccion en los linfocitos t humanos, y linfocitos t citotoxicos especificos de la proteina p53 humana.
AU5670194A (en) 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
EP0997477B1 (de) 1994-07-29 2006-03-15 Sunol Molecular Corporation MHC-Komplexe und ihre Verwendung
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
EP0793501A4 (de) 1994-12-14 2000-05-03 Scripps Research Inst 'in vivo'aktivierung von tumorspezifischen-zytotoxischen t-zellen
US5830755A (en) 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
AU728794B2 (en) 1996-03-05 2001-01-18 Scripps Research Institute, The Recombinant constructs encoding T cell receptors specific for human HLA-restricted tumor antigens
US6127524A (en) 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
EP0977886A4 (de) 1997-03-07 2002-10-23 Sunol Molecular Corp Fusionsproteine, welche ein bakteriophagen-hüllprotein sowie einen einzelketten t-zell-rezeptor enthalten
JP2001519143A (ja) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
WO2000023087A1 (en) * 1998-10-21 2000-04-27 Sunol Molecular Corporation Polyspecific binding molecules and uses thereof
EP1287363A2 (de) 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation von wechselwirkungen in t-zellrezeptoren
AU7524601A (en) 2000-06-05 2001-12-17 Sunol Molecular Corp T cell receptor fusions and conjugates and methods of use thereof
DE10109855A1 (de) * 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung

Also Published As

Publication number Publication date
EP1546188A2 (de) 2005-06-29
ES2307770T3 (es) 2008-12-01
WO2004018619A2 (en) 2004-03-04
US7456263B2 (en) 2008-11-25
JP4447456B2 (ja) 2010-04-07
CA2487779A1 (en) 2004-03-04
CN1692124B (zh) 2012-05-30
EP2009019A1 (de) 2008-12-31
AU2002316190B2 (en) 2009-01-22
AU2002316190B8 (en) 2009-01-29
AU2002316190A8 (en) 2004-04-08
AU2002316190A1 (en) 2004-03-17
CA2487779C (en) 2012-10-02
EP1546188B1 (de) 2008-08-20
CN1692124A (zh) 2005-11-02
DE60228504D1 (de) 2008-10-02
WO2004018619A3 (en) 2005-05-06
DK1546188T3 (da) 2008-10-27
JP2005525128A (ja) 2005-08-25
EP1546188A4 (de) 2005-12-21
US20080269113A1 (en) 2008-10-30

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