ATE405644T1 - Verfahren zur herstellung und reinigung von erythropoietin - Google Patents

Verfahren zur herstellung und reinigung von erythropoietin

Info

Publication number: ATE405644T1
Authority: AT; Austria
Prior art keywords: producing; purifying; purifying erythropoietin; erythropoietin; glycoproteins
Prior art date: 2002-12-13

Application number

AT02027952T

Other languages

English (en)

Inventor

Michael Bavand

Horst Blasey

Original Assignee

Bioceuticals Arzneimittel Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-13

Filing date

2002-12-13

Publication date

2008-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32319603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE405644(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-13 Application filed by Bioceuticals Arzneimittel Ag filed Critical Bioceuticals Arzneimittel Ag

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE405644T1 publication Critical patent/ATE405644T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
102000003951 Erythropoietin Human genes 0.000 title 1
108090000394 Erythropoietin Proteins 0.000 title 1
229940105423 erythropoietin Drugs 0.000 title 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
102000003886 Glycoproteins Human genes 0.000 abstract 2
108090000288 Glycoproteins Proteins 0.000 abstract 2
101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 1
101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
102000044890 human EPO Human genes 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02027952T 2002-12-13 2002-12-13 Verfahren zur herstellung und reinigung von erythropoietin ATE405644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02027952A EP1428878B1 (de)	2002-12-13	2002-12-13	Verfahren zur Herstellung und Reinigung von Erythropoietin

Publications (1)

Publication Number	Publication Date
ATE405644T1 true ATE405644T1 (de)	2008-09-15

Family

ID=32319603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02027952T ATE405644T1 (de)	2002-12-13	2002-12-13	Verfahren zur herstellung und reinigung von erythropoietin

Country Status (8)

Country	Link
EP (1)	EP1428878B1 (de)
AT (1)	ATE405644T1 (de)
CY (1)	CY1108571T1 (de)
DE (1)	DE60228460D1 (de)
DK (1)	DK1428878T3 (de)
ES (1)	ES2312523T3 (de)
PT (1)	PT1428878E (de)
SI (1)	SI1428878T1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7157277B2 (en)	2001-11-28	2007-01-02	Neose Technologies, Inc.	Factor VIII remodeling and glycoconjugation of Factor VIII
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US8008252B2 (en)	2001-10-10	2011-08-30	Novo Nordisk A/S	Factor VII: remodeling and glycoconjugation of Factor VII
US7795210B2 (en)	2001-10-10	2010-09-14	Novo Nordisk A/S	Protein remodeling methods and proteins/peptides produced by the methods
US7696163B2 (en)	2001-10-10	2010-04-13	Novo Nordisk A/S	Erythropoietin: remodeling and glycoconjugation of erythropoietin
MXPA04012496A (es)	2002-06-21	2005-09-12	Novo Nordisk Healthcare Ag	Glicoformos del factor vii pegilados.
JP2006523211A (ja)	2003-03-14	2006-10-12	ネオステクノロジーズインコーポレイテッド	分岐水溶性ポリマーとその複合物
US8791070B2 (en)	2003-04-09	2014-07-29	Novo Nordisk A/S	Glycopegylated factor IX
WO2006127896A2 (en)	2005-05-25	2006-11-30	Neose Technologies, Inc.	Glycopegylated factor ix
NZ542586A (en)	2003-04-09	2009-11-27	Biogenerix Ag	Method of forming a covalent conjugate between a G-CSF peptide and PEG
AU2004240553A1 (en)	2003-05-09	2004-12-02	Neose Technologies, Inc.	Compositions and methods for the preparation of human growth hormone glycosylation mutants
US9005625B2 (en)	2003-07-25	2015-04-14	Novo Nordisk A/S	Antibody toxin conjugates
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
US8633157B2 (en)	2003-11-24	2014-01-21	Novo Nordisk A/S	Glycopegylated erythropoietin
US7956032B2 (en)	2003-12-03	2011-06-07	Novo Nordisk A/S	Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en)	2003-12-03	2006-02-23	Neose Technologies, Inc.	Glycopegylated factor IX
US7338933B2 (en)	2004-01-08	2008-03-04	Neose Technologies, Inc.	O-linked glycosylation of peptides
DE102004027816A1 (de)	2004-06-08	2006-01-05	Bioceuticals Arzneimittel Ag	Verfahren zur Reinigung von Erythropoietin
WO2006010143A2 (en)	2004-07-13	2006-01-26	Neose Technologies, Inc.	Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP1799249A2 (de)	2004-09-10	2007-06-27	Neose Technologies, Inc.	Glycopegyliertes interferon alpha
EP3061461A1 (de)	2004-10-29	2016-08-31	ratiopharm GmbH	Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
US9029331B2 (en)	2005-01-10	2015-05-12	Novo Nordisk A/S	Glycopegylated granulocyte colony stimulating factor
JP2008527980A (ja) *	2005-01-25	2008-07-31	アポロライフサイエンシズリミテッド	分子およびそのキメラ分子
EP1866427A4 (de) *	2005-03-30	2010-09-01	Novo Nordisk As	Herstellungsverfahren zur produktion von in insektenzelllinien entstandenen peptiden
EP1871795A4 (de)	2005-04-08	2010-03-31	Biogenerix Ag	Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
WO2006127910A2 (en)	2005-05-25	2006-11-30	Neose Technologies, Inc.	Glycopegylated erythropoietin formulations
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en)	2005-11-03	2007-05-18	Neose Technologies, Inc.	Nucleotide sugar purification using membranes
EP2013224A2 (de)	2006-04-27	2009-01-14	Syddansk Universitet	Verfahren zur isolierung und analyse von sialylierten und phosphorylierten peptiden
US20080242607A1 (en)	2006-07-21	2008-10-02	Neose Technologies, Inc.	Glycosylation of peptides via o-linked glycosylation sequences
US8969532B2 (en)	2006-10-03	2015-03-03	Novo Nordisk A/S	Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
EP2089424B1 (de) *	2006-12-06	2015-07-01	JCR PHARMACEUTICALS Co., LTD.	Verfahren zur herstellung von humanem erythropoietin
CN101796063B (zh)	2007-04-03	2017-03-22	拉蒂奥法姆有限责任公司	使用糖聚乙二醇化g‑csf的治疗方法
WO2008153462A1 (en) *	2007-06-14	2008-12-18	Maiia Ab	Determination of isoerythropoietins
US9493499B2 (en)	2007-06-12	2016-11-15	Novo Nordisk A/S	Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
US8207112B2 (en)	2007-08-29	2012-06-26	Biogenerix Ag	Liquid formulation of G-CSF conjugate
DK2257311T3 (da)	2008-02-27	2014-06-30	Novo Nordisk As	Konjugerede Faktor VIII-Molekyler
DE102008002209A1 (de)	2008-06-04	2009-12-10	Evonik Degussa Gmbh	Verfahren zur Aufreinigung von Erythropoietin
EP2334699B1 (de) *	2008-09-23	2013-09-11	F. Hoffmann-La Roche AG	Aufreinigung von erythropoietin
EA022396B1 (ru)	2009-09-23	2015-12-30	Ратиофарм Гмбх	Способ очистки рекомбинантного эритропоэтина человека (epo), эритропоэтин, очищенный данным способом, и фармацевтические композиции, содержащие такой эритропоэтин
WO2011063195A2 (en) *	2009-11-20	2011-05-26	Dr. Reddy's Laboratories Ltd.	Purification of modified cytokines
EP3715356B1 (de)	2009-12-18	2023-10-11	CSL Limited	Verfahren zur aufreinigung von polypeptiden
JP6147726B2 (ja)	2011-03-29	2017-06-14	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	タンパク質精製のためのバッファー系
KR101443257B1 (ko) *	2011-10-18	2014-09-19	주식회사 종근당	낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
US20150065689A1 (en) *	2012-04-10	2015-03-05	Dr. Reddy's Laboratories Limited	Single step fractionation method
EP2970420A4 (de) *	2013-03-15	2016-08-17	Apotex Inc	Erhöhte flüssigkeitsformulationsstabilität von erythropoietin-alpha durch aufreinigungsverarbeitung
CN115032317B (zh) *	2022-06-29	2024-03-26	科兴生物制药股份有限公司	重组人促红细胞生成素的检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL79176A (en) *	1985-06-20	1992-06-21	Kirin Amgen Inc	Process for the recovery of erythropoietin from a fluid
WO1995007703A1 (en) *	1993-09-15	1995-03-23	Alpha Therapeutic Corp.	Alpha1-acid glycoprotein purification process and product
IL117849A (en) *	1995-04-14	2002-07-25	Lepetit Spa	Chromatographic process for clearing glycoproteins
IL118201A (en) *	1995-05-11	2004-12-15	Roche Diagnostics Gmbh	Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
RU2145610C1 (ru) *	1998-12-09	2000-02-20	Общество с ограниченной ответственностью "Протеиновый контур"	Способ очистки рекомбинантного эритропоэтина человека
CN1596268A (zh) *	2001-11-28	2005-03-16	桑多斯有限公司	重组人红细胞生成素的层析纯化

2002
- 2002-12-13 DK DK02027952T patent/DK1428878T3/da active
- 2002-12-13 AT AT02027952T patent/ATE405644T1/de active
- 2002-12-13 ES ES02027952T patent/ES2312523T3/es not_active Expired - Lifetime
- 2002-12-13 SI SI200230761T patent/SI1428878T1/sl unknown
- 2002-12-13 PT PT02027952T patent/PT1428878E/pt unknown
- 2002-12-13 DE DE60228460T patent/DE60228460D1/de not_active Expired - Lifetime
- 2002-12-13 EP EP02027952A patent/EP1428878B1/de not_active Revoked
2008
- 2008-11-17 CY CY20081101319T patent/CY1108571T1/el unknown

Also Published As

Publication number	Publication date
CY1108571T1 (el)	2014-04-09
ES2312523T3 (es)	2009-03-01
PT1428878E (pt)	2008-11-18
EP1428878B1 (de)	2008-08-20
DE60228460D1 (de)	2008-10-02
SI1428878T1 (sl)	2009-02-28
DK1428878T3 (da)	2008-12-08
EP1428878A1 (de)	2004-06-16

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2009-04-15

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