ATE405644T1 - Verfahren zur herstellung und reinigung von erythropoietin - Google Patents

Verfahren zur herstellung und reinigung von erythropoietin

Info

Publication number: ATE405644T1
Authority: AT; Austria
Prior art keywords: producing; purifying; purifying erythropoietin; erythropoietin; glycoproteins
Prior art date: 2002-12-13

Application number

AT02027952T

Other languages

English (en)

Inventor

Michael Bavand

Horst Blasey

Original Assignee

Bioceuticals Arzneimittel Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-13

Filing date

2002-12-13

Publication date

2008-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32319603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE405644(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-13 Application filed by Bioceuticals Arzneimittel Ag filed Critical Bioceuticals Arzneimittel Ag

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE405644T1 publication Critical patent/ATE405644T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
102000003951 Erythropoietin Human genes 0.000 title 1
108090000394 Erythropoietin Proteins 0.000 title 1
229940105423 erythropoietin Drugs 0.000 title 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
102000003886 Glycoproteins Human genes 0.000 abstract 2
108090000288 Glycoproteins Proteins 0.000 abstract 2
101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 1
101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
102000044890 human EPO Human genes 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT02027952T 2002-12-13 2002-12-13 Verfahren zur herstellung und reinigung von erythropoietin ATE405644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02027952A EP1428878B1 (de)	2002-12-13	2002-12-13	Verfahren zur Herstellung und Reinigung von Erythropoietin

Publications (1)

Publication Number	Publication Date
ATE405644T1 true ATE405644T1 (de)	2008-09-15

Family

ID=32319603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02027952T ATE405644T1 (de)	2002-12-13	2002-12-13	Verfahren zur herstellung und reinigung von erythropoietin

Country Status (8)

Country	Link
EP (1)	EP1428878B1 (de)
AT (1)	ATE405644T1 (de)
CY (1)	CY1108571T1 (de)
DE (1)	DE60228460D1 (de)
DK (1)	DK1428878T3 (de)
ES (1)	ES2312523T3 (de)
PT (1)	PT1428878E (de)
SI (1)	SI1428878T1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US8008252B2 (en)	2001-10-10	2011-08-30	Novo Nordisk A/S	Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en)	2001-10-10	2010-09-14	Novo Nordisk A/S	Protein remodeling methods and proteins/peptides produced by the methods
US7157277B2 (en)	2001-11-28	2007-01-02	Neose Technologies, Inc.	Factor VIII remodeling and glycoconjugation of Factor VIII
US7696163B2 (en)	2001-10-10	2010-04-13	Novo Nordisk A/S	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
DE60336555D1 (de)	2002-06-21	2011-05-12	Novo Nordisk Healthcare Ag	Pegylierte glykoformen von faktor vii
NZ542094A (en)	2003-03-14	2008-12-24	Neose Technologies Inc	Branched polymer conjugates comprising a peptide and water-soluble polymer chains
US8791070B2 (en)	2003-04-09	2014-07-29	Novo Nordisk A/S	Glycopegylated factor IX
PL1615945T3 (pl)	2003-04-09	2012-03-30	Ratiopharm Gmbh	Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
JP2007523630A (ja)	2003-05-09	2007-08-23	ネオステクノロジーズインコーポレイテッド	ヒト成長ホルモングリコシル化突然変異体の組成と調合法
US9005625B2 (en)	2003-07-25	2015-04-14	Novo Nordisk A/S	Antibody toxin conjugates
US7842661B2 (en)	2003-11-24	2010-11-30	Novo Nordisk A/S	Glycopegylated erythropoietin formulations
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
US8633157B2 (en)	2003-11-24	2014-01-21	Novo Nordisk A/S	Glycopegylated erythropoietin
US20060040856A1 (en)	2003-12-03	2006-02-23	Neose Technologies, Inc.	Glycopegylated factor IX
US7956032B2 (en)	2003-12-03	2011-06-07	Novo Nordisk A/S	Glycopegylated granulocyte colony stimulating factor
NZ548123A (en)	2004-01-08	2010-05-28	Novo Nordisk As	O-linked glycosylation of peptides
DE102004027816A1 (de) *	2004-06-08	2006-01-05	Bioceuticals Arzneimittel Ag	Verfahren zur Reinigung von Erythropoietin
US20080300173A1 (en)	2004-07-13	2008-12-04	Defrees Shawn	Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
WO2006031811A2 (en)	2004-09-10	2006-03-23	Neose Technologies, Inc.	Glycopegylated interferon alpha
WO2006050247A2 (en)	2004-10-29	2006-05-11	Neose Technologies, Inc.	Remodeling and glycopegylation of fibroblast growth factor (fgf)
US9029331B2 (en)	2005-01-10	2015-05-12	Novo Nordisk A/S	Glycopegylated granulocyte colony stimulating factor
CA2595676A1 (en) *	2005-01-25	2006-08-03	Apollo Life Sciences Limited	Molecules and chimeric molecules thereof
JP2008538181A (ja) *	2005-03-30	2008-10-16	ネオステクノロジーズインコーポレイテッド	昆虫細胞系において増殖させたペプチドを生産するための製造方法
WO2006121569A2 (en)	2005-04-08	2006-11-16	Neose Technologies, Inc.	Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP2975135A1 (de)	2005-05-25	2016-01-20	Novo Nordisk A/S	Glykopegylierter Faktor IX
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en)	2005-11-03	2007-05-18	Neose Technologies, Inc.	Nucleotide sugar purification using membranes
EP2013224A2 (de) *	2006-04-27	2009-01-14	Syddansk Universitet	Verfahren zur isolierung und analyse von sialylierten und phosphorylierten peptiden
EP2049144B8 (de)	2006-07-21	2015-02-18	ratiopharm GmbH	Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
EP2054521A4 (de) *	2006-10-03	2012-12-19	Novo Nordisk As	Verfahren zur reinigung von polypeptid-konjugate
EP2089424B1 (de) *	2006-12-06	2015-07-01	JCR PHARMACEUTICALS Co., LTD.	Verfahren zur herstellung von humanem erythropoietin
HRP20130382T1 (hr)	2007-04-03	2013-05-31	Biogenerix Ag	Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
US20100129932A1 (en) *	2007-06-05	2010-05-27	Loennberg Maria	Determination of Isoerythropoietins
CA2690611C (en)	2007-06-12	2015-12-08	Novo Nordisk A/S	Improved process for the production of nucleotide sugars
US8207112B2 (en)	2007-08-29	2012-06-26	Biogenerix Ag	Liquid formulation of G-CSF conjugate
PL2257311T3 (pl)	2008-02-27	2014-09-30	Novo Nordisk As	Koniugaty cząsteczek czynnika VIII
DE102008002209A1 (de)	2008-06-04	2009-12-10	Evonik Degussa Gmbh	Verfahren zur Aufreinigung von Erythropoietin
CN102164954B (zh) *	2008-09-23	2018-04-06	弗·哈夫曼-拉罗切有限公司	促红细胞生成素的纯化
EA022396B1 (ru)	2009-09-23	2015-12-30	Ратиофарм Гмбх	Способ очистки рекомбинантного эритропоэтина человека (epo), эритропоэтин, очищенный данным способом, и фармацевтические композиции, содержащие такой эритропоэтин
WO2011063195A2 (en) *	2009-11-20	2011-05-26	Dr. Reddy's Laboratories Ltd.	Purification of modified cytokines
WO2011073235A1 (en)	2009-12-18	2011-06-23	Csl Ltd.	Method of purifying polypeptides
CN107915769A (zh)	2011-03-29	2018-04-17	葛兰素史密斯克莱有限责任公司	用于蛋白纯化的缓冲液体系
KR101443257B1 (ko) *	2011-10-18	2014-09-19	주식회사 종근당	낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
US20150065689A1 (en) *	2012-04-10	2015-03-05	Dr. Reddy's Laboratories Limited	Single step fractionation method
US10066001B2 (en)	2013-03-15	2018-09-04	Apotex Inc.	Enhanced liquid formulation stability of erythropoietin alpha through purification processing
CN115032317B (zh) *	2022-06-29	2024-03-26	科兴生物制药股份有限公司	重组人促红细胞生成素的检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL79176A (en) *	1985-06-20	1992-06-21	Kirin Amgen Inc	Process for the recovery of erythropoietin from a fluid
CA2171832C (en) *	1993-09-15	2001-01-02	Harutyun Eran	Alpha1-acid glycoprotein purification process and product
IL117849A (en) *	1995-04-14	2002-07-25	Lepetit Spa	Chromatographic process for clearing glycoproteins
IL118201A (en) *	1995-05-11	2004-12-15	Roche Diagnostics Gmbh	Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
RU2145610C1 (ru) *	1998-12-09	2000-02-20	Общество с ограниченной ответственностью "Протеиновый контур"	Способ очистки рекомбинантного эритропоэтина человека
EP1453857B1 (de) *	2001-11-28	2014-08-13	Sandoz AG	Chromatografische aufreinigung von recombinanter humaner erythropoietin

2002
- 2002-12-13 DE DE60228460T patent/DE60228460D1/de not_active Expired - Lifetime
- 2002-12-13 ES ES02027952T patent/ES2312523T3/es not_active Expired - Lifetime
- 2002-12-13 SI SI200230761T patent/SI1428878T1/sl unknown
- 2002-12-13 AT AT02027952T patent/ATE405644T1/de active
- 2002-12-13 EP EP02027952A patent/EP1428878B1/de not_active Revoked
- 2002-12-13 DK DK02027952T patent/DK1428878T3/da active
- 2002-12-13 PT PT02027952T patent/PT1428878E/pt unknown
2008
- 2008-11-17 CY CY20081101319T patent/CY1108571T1/el unknown

Also Published As

Publication number	Publication date
EP1428878A1 (de)	2004-06-16
CY1108571T1 (el)	2014-04-09
ES2312523T3 (es)	2009-03-01
PT1428878E (pt)	2008-11-18
DE60228460D1 (de)	2008-10-02
EP1428878B1 (de)	2008-08-20
SI1428878T1 (sl)	2009-02-28
DK1428878T3 (da)	2008-12-08

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2009-04-15

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