ATE40570T1 - Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon. - Google Patents

Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon.

Info

Publication number
ATE40570T1
ATE40570T1 AT84307297T AT84307297T ATE40570T1 AT E40570 T1 ATE40570 T1 AT E40570T1 AT 84307297 T AT84307297 T AT 84307297T AT 84307297 T AT84307297 T AT 84307297T AT E40570 T1 ATE40570 T1 AT E40570T1
Authority
AT
Austria
Prior art keywords
dihydroxyphenyl
serine
protected derivative
preparation
optically active
Prior art date
Application number
AT84307297T
Other languages
English (en)
Inventor
Hamao Umezawa
Tomio Takeuchi
Toshiharu Nagatsu
Masa Hamada
Shuichi Iwadare
Ikuo Matsumoto
Hajime Morishima
Original Assignee
Microbial Chem Res Found
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found, Banyu Pharma Co Ltd filed Critical Microbial Chem Res Found
Application granted granted Critical
Publication of ATE40570T1 publication Critical patent/ATE40570T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/38—Cyclopentanone- or cyclopentadione-containing products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/826—Actinomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/908—Streptovirticillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT84307297T 1983-11-04 1984-10-24 Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon. ATE40570T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58205859A JPS6098995A (ja) 1983-11-04 1983-11-04 光学活性３−（３，４−ジヒドロキシフエニル）セリン，およびその誘導体の製造法
EP84307297A EP0141613B1 (de) 1983-11-04 1984-10-24 Verfahren zur Herstellung eines optisch aktiven 3-(3,4-Dihydroxyphenyl)-Serins und ein geschütztes Derivat davon

Publications (1)

Publication Number Publication Date
ATE40570T1 true ATE40570T1 (de) 1989-02-15

Family

ID=16513892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84307297T ATE40570T1 (de) 1983-11-04 1984-10-24 Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon.

Country Status (8)

Country Link
US (1) US4699879A (de)
EP (1) EP0141613B1 (de)
JP (1) JPS6098995A (de)
KR (1) KR850003572A (de)
AT (1) ATE40570T1 (de)
CA (1) CA1241612A (de)
DE (1) DE3476560D1 (de)
HU (1) HU193234B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920701469A (ko) * 1989-05-15 1992-08-11 스테이너 브이. 캔스태드 향균성 화합물 및 이의 중간물질의 제조방법
AU6052090A (en) * 1989-07-07 1991-02-06 Schering Corporation Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates
US5707836A (en) * 1995-03-10 1998-01-13 Nitto Chemical Industry Co., Ltd. Production of alkylene or phenylenediamine disuccinic acid from fumaric acid and a diamine using lyase from microbes
CA2388050C (en) * 1999-08-12 2008-03-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antibiotic caprazamycins and process for producing the same
US20040050682A1 (en) * 2000-12-27 2004-03-18 George Paskalov Activated water apparatus and methods and products
ITPD20010031A1 (it) * 2001-02-09 2002-08-09 Fidia Farmaceutici Procedimento per la preparazione di fosfatidi puri e loro impiego in campo cosmetico, farmaceutico ed alimentare.
US6635456B2 (en) 2001-02-09 2003-10-21 Fidia Farmaceutici S.P.A. Procedure for the preparation of pure phosphatides with phospholipase D
JP2005278401A (ja) * 2002-09-09 2005-10-13 Nippon Kayaku Co Ltd 光学活性−エリスロ−３−シクロヘキシルセリンの製造方法
WO2004100929A1 (en) 2003-05-12 2004-11-25 Synergia Pharma, Inc. Threo-dops controlled release formulation
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
US20070010584A1 (en) * 2003-09-04 2007-01-11 Peroutka Stephen J Compositions and methods for orthostatic intolerance
US7687435B2 (en) * 2003-12-19 2010-03-30 Basf Aktiengesellschaft Benzoyl-substituted phenylalanineamides
WO2008003028A2 (en) 2006-06-28 2008-01-03 Chelsea Therapeutics, Inc. Pharmaceutical compositions comprising droxidopa
ES2500053T3 (es) 2007-03-09 2014-09-29 Chelsea Therapeutics, Inc. Composición farmacéutica que comprende droxidopa para el tratamiento de la fibromialgia
JP2010526820A (ja) * 2007-05-07 2010-08-05 チェルシー・セラピューティクス，インコーポレイテッド 気分障害、睡眠障害、または注意欠陥障害を治療するドロキシドパおよびその医薬組成物
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状（姿勢反射異常）の治療剤
CN103086906B (zh) * 2011-11-03 2015-04-01 重庆圣华曦药业股份有限公司 屈昔多巴的晶型及其制备方法
CA2863585A1 (en) 2012-01-31 2013-08-08 Lundbeck Na Ltd. Improving postural stability administering droxidopa
US9920342B2 (en) 2016-05-17 2018-03-20 Divi's Laboratories Limited Process for the preparation of Droxidopa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493643A1 (de) * 1963-04-26 1969-02-06 Merck & Co Inc Verfahren zur Spaltung von D,L-alpha-Methyl-beta-(3,4-dihydroxyphenyl)-alanin in seine optischen Antipoden
US3347752A (en) * 1965-03-26 1967-10-17 Merck & Co Inc Microbiological cleavage process for resolving racemic alpha-methyl-beta-(3, 4,-dihydroxyphenyl)-alanine
US3386888A (en) * 1965-07-15 1968-06-04 Tanabe Seiyaku Co Resolution of racemic amino acids
DE1543323A1 (de) * 1965-11-02 1969-08-07 Ajinomoto Kk Verfahren zur Herstellung von L-Serin
US3669837A (en) * 1970-03-30 1972-06-13 Parke Davis & Co Process for producing 3-(3,4-dimethoxyphenyl)l-alanine by resolution
GB1369462A (en) * 1971-11-23 1974-10-09 Beecham Group Ltd Enzymic resolution of racemic n-acyl-dl-amino acids
US3812009A (en) * 1972-01-10 1974-05-21 Owens Illinois Inc Stereospecific process for the preparation of l-3,4-dihydroxyphenylalanine (l-dopa)and analogs thereof
JPS5037277B2 (de) * 1972-08-31 1975-12-01
JPS57186495A (en) * 1981-05-14 1982-11-16 Ube Ind Ltd Preparation of l-alpha-methylphenylalanine

Also Published As

Publication number Publication date
KR850003572A (ko) 1985-06-20
CA1241612A (en) 1988-09-06
DE3476560D1 (en) 1989-03-09
HU193234B (en) 1987-08-28
US4699879A (en) 1987-10-13
EP0141613B1 (de) 1989-02-01
HUT38393A (en) 1986-05-28
JPS6098995A (ja) 1985-06-01
EP0141613A2 (de) 1985-05-15
JPH0559719B2 (de) 1993-08-31
EP0141613A3 (en) 1985-09-11

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee