ATE406371T1 - Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung - Google Patents

Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung

Info

Publication number: ATE406371T1
Authority: AT; Austria
Prior art keywords: methods; decrease; infection; treatment; active ingredients
Prior art date: 2000-11-02

Application number

AT01989211T

Other languages

English (en)

Inventor

Nigel Greig

Karen Shaw

Qiang-Sheng Yu

Harold Holloway

Tada Utsuki

Timothy Soncrant

Donald Ingram

Arnold Brossi

Anthony Giordano

Gordon Powers

Diane Davidson

Michael Sturgess

Original Assignee

Us Gov Health & Human Serv

Torreypines Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-02

Filing date

2001-11-02

Publication date

2008-09-15

2001-11-02 Application filed by Us Gov Health & Human Serv, Torreypines Therapeutics Inc filed Critical Us Gov Health & Human Serv

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE406371T1 publication Critical patent/ATE406371T1/de

Links

238000000034 method Methods 0.000 title abstract 3
101710137189 Amyloid-beta A4 protein Proteins 0.000 title 1
101710151993 Amyloid-beta precursor protein Proteins 0.000 title 1
102100022704 Amyloid-beta precursor protein Human genes 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
208000015181 infectious disease Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
150000004657 carbamic acid derivatives Chemical class 0.000 abstract 2
231100000331 toxic Toxicity 0.000 abstract 2
230000002588 toxic effect Effects 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/345—Nitrofurans
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

AT01989211T 2000-11-02 2001-11-02 Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung ATE406371T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24532900P	2000-11-02	2000-11-02

Publications (1)

Publication Number	Publication Date
ATE406371T1 true ATE406371T1 (de)	2008-09-15

Family

ID=22926225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01989211T ATE406371T1 (de)	2000-11-02	2001-11-02	Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung

Country Status (7)

Country	Link
US (5)	US7153882B2 (de)
EP (1)	EP1349858B1 (de)
AT (1)	ATE406371T1 (de)
AU (2)	AU4332302A (de)
CA (1)	CA2465534C (de)
DE (1)	DE60135579D1 (de)
WO (1)	WO2002048150A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002048150A2 (en) *	2000-11-02	2002-06-20	The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof
US20040024043A1 (en) *	2002-03-22	2004-02-05	Nigel Greig	Method for treating cognitive disorders
US9068234B2 (en)	2003-01-21	2015-06-30	Ptc Therapeutics, Inc.	Methods and agents for screening for compounds capable of modulating gene expression
CA2514184C (en)	2003-01-21	2016-04-12	Ptc Therapeutics, Inc.	Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
US8426194B2 (en)	2003-01-21	2013-04-23	Ptc Therapeutics, Inc.	Methods and agents for screening for compounds capable of modulating VEGF expression
US7521481B2 (en)	2003-02-27	2009-04-21	Mclaurin Joanne	Methods of preventing, treating and diagnosing disorders of protein aggregation
JP4769718B2 (ja) *	2003-08-07	2011-09-07	メルクシャープエンドドームリミテッド	アルツハイマー病及び関連症状の治療
CA2546363A1 (en) *	2003-11-17	2005-06-02	Anuradha Mehta	Methods and agents for screening for compounds capable of modulating her2 expression
US20050182044A1 (en) *	2004-02-17	2005-08-18	Bruinsma Gosse B.	Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
GB0410238D0 (en) *	2004-05-07	2004-06-09	Merck Sharp & Dohme	Therapeutic agents
EP1604686A1 (de) *	2004-06-08	2005-12-14	Axonyx, Inc.	Verwendung von Phenserine und einem HMG CoA reduktase Hemmer zur Verzögerung der Alzheimer Krankheit
WO2006060082A1 (en) *	2004-10-22	2006-06-08	THE GOVERNMENT OF THE U.S.A. as represented by THE SEC., DEPT. OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH	Tricyclic compounds, preparation thereof and use thereof as cholinesterase activity inhibitors
US20060105940A1 (en) *	2004-11-03	2006-05-18	Axonyx, Inc.	Compound useful in the treatment or prevention of cognitive disorders associated with diabetes and associated methods
JP2008519988A (ja) *	2004-11-12	2008-06-12	ファイザー・インク	アミロイド−ベータペプチドを測定する方法
US9095573B2 (en) *	2005-08-01	2015-08-04	University Of Central Florida Research Foundation, Inc.	Method of biasing implanted human neural stem cells away from differentiation into glial cells by (+)phenserine to modulate the concentration of soluble βAPP in tissue or CSF
US8283115B1 (en)	2007-06-20	2012-10-09	Ptc Therapeutics, Inc.	Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
US8283116B1 (en)	2007-06-22	2012-10-09	Ptc Therapeutics, Inc.	Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation
US8686024B2 (en)	2009-02-05	2014-04-01	Kyoto University	Indoline derivatives
US20100317730A1 (en) *	2009-06-12	2010-12-16	Shaya Elias K	Treatment for menopausal and perimenopausal vasomotor symptons
WO2012058031A2 (en) *	2010-10-28	2012-05-03	Qr Pharma, Inc.	Novel method for preparation of bisnorcymerine and salts thereof
US20120225922A1 (en)	2011-03-04	2012-09-06	Qr Pharma	Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
TW201717938A (zh)	2015-08-14	2017-06-01	Ｑｒ製藥股份有限公司	治療或預防急性腦部或神經損傷的方法
US10864192B2 (en)	2016-01-15	2020-12-15	Aristea Translational Medicine Corporation	Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
US10111860B1 (en)	2016-01-15	2018-10-30	Aristea Translational Medicine Corporation	Compositions and methods for treating concussion
US10751340B2 (en)	2016-06-06	2020-08-25	University Of Central Florida Research Foundation, Inc.	Combination therapy to improve brain function or promote neurogenesis for treating neurodegenerative conditions
EP3654957A4 (de)	2017-05-24	2021-06-23	Annovis Bio, Inc.	Prävention oder behandlung von krankheitszuständen aufgrund von metall-dis-homöostase durch verabreichung von posiphen an gesunde oder kranke menschen
US12297244B2 (en)	2019-06-05	2025-05-13	Rensselaer Polytechnic Institute	Systems and methods for inhibiting γ-secretase production of amyloid-β peptides
EP3753923A1 (de)	2019-06-19	2020-12-23	GH Research Limited	Umkristallisierung von 5-methoxy-n,n-dimethyltryptamin (5-meo-dmt) in methyl tert.-butyl ether (mtbe) ohne zugabe eines antilösungsmittels
EP3868364A1 (de)	2020-02-24	2021-08-25	GH Research Limited	Aerosol enthaltend 5-methoxy-n,n-dimethyltryptamine
CA3201913A1 (en)	2020-12-09	2022-06-16	Andrew R. Chadeayne	Dialkyl trytamines and their therapeutic uses
WO2022245843A1 (en)	2021-05-18	2022-11-24	Annovis Bio, Inc.	Inhibition of neurological injuries due to infections via administration of butanetap and analogs thereof
WO2025017530A1 (en)	2023-07-19	2025-01-23	Assia Chemical Industries Ltd.	Solid state forms of buntanetap and process for preparation thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2890223A (en) *	1956-03-22	1959-06-09	Research Corp	1-benzyl, 2-methyl, 5-methoxy tryptamine
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4900748A (en) *	1988-03-04	1990-02-13	The United States Of America As Represented By The Department Of Health And Human Services	Carbamates related to (-)-physostigmine as cholinergic agents
US5260452A (en) *	1989-11-03	1993-11-09	Hoechst-Roussel Pharmaceuticals Inc.	4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
FR2674522B1 (fr)	1991-03-26	1993-07-16	Lipha	Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
US5171750A (en) *	1991-09-26	1992-12-15	The United States Of America As Represented By The Department Of Health And Human Services	Substituted phenserines as specific inhibitors of acetylcholinesterase
EP0605474B1 (de) *	1991-09-26	2003-11-26	THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES	Carbamatanalogen von thiaphysovenin, pharmazeutische zusammensetzungen und verfahren zur hemmung von cholinesterasen
FR2707639B1 (fr)	1993-06-30	1995-10-13	Pf Medicament	Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
JPH07271066A (ja)	1994-03-29	1995-10-20	Mitsubishi Paper Mills Ltd	電子写真感光体
US5403851A (en) *	1994-04-05	1995-04-04	Interneuron Pharmaceuticals, Inc.	Substituted tryptamines, phenalkylamines and related compounds
MX9700696A (es)	1994-07-27	1997-04-30	Sankyo Co	Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos.
WO1999002154A1 (en) *	1997-07-09	1999-01-21	Axonyx	Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias
GEP20032920B (en)	1998-02-25	2003-03-25	Genetics Inst	Inhibitors of Phospholipase Enzymes
US20020004198A1 (en) *	1998-12-16	2002-01-10	Hardwicke Mary Ann	Novel anti-infectives
US20010007877A1 (en) *	1998-12-16	2001-07-12	George O. Burton	Novel anti-infectives
GB9918962D0 (en) *	1999-08-11	1999-10-13	Cerebrus Ltd	Chemical compounds xxii
WO2001034146A1 (en)	1999-11-08	2001-05-17	Smithkline Beecham Corporation	Novel anti-infectives
AU5702201A (en)	2000-04-13	2001-10-30	Mayo Foundation	Abeta<sub>42</sub> lowering agents
WO2002048150A2 (en) *	2000-11-02	2002-06-20	The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof

2001
- 2001-11-02 WO PCT/US2001/048175 patent/WO2002048150A2/en not_active Ceased
- 2001-11-02 US US10/415,765 patent/US7153882B2/en not_active Expired - Lifetime
- 2001-11-02 EP EP01989211A patent/EP1349858B1/de not_active Expired - Lifetime
- 2001-11-02 CA CA002465534A patent/CA2465534C/en not_active Expired - Lifetime
- 2001-11-02 AU AU4332302A patent/AU4332302A/xx active Pending
- 2001-11-02 DE DE60135579T patent/DE60135579D1/de not_active Expired - Lifetime
- 2001-11-02 AU AU2002243323A patent/AU2002243323B2/en not_active Expired
- 2001-11-02 AT AT01989211T patent/ATE406371T1/de active
2006
- 2006-06-20 US US11/455,959 patent/US20060270729A1/en not_active Abandoned
2009
- 2009-01-21 US US12/357,115 patent/US7786162B2/en not_active Expired - Lifetime
2010
- 2010-07-22 US US12/841,888 patent/US8258172B2/en not_active Expired - Fee Related
2012
- 2012-07-26 US US13/559,186 patent/US8691864B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2002048150A3 (en)	2003-08-07
WO2002048150A2 (en)	2002-06-20
US20110021594A1 (en)	2011-01-27
US8258172B2 (en)	2012-09-04
EP1349858B1 (de)	2008-08-27
US20090131501A1 (en)	2009-05-21
US7786162B2 (en)	2010-08-31
AU2002243323B8 (en)	2002-06-24
US7153882B2 (en)	2006-12-26
US20120295946A1 (en)	2012-11-22
EP1349858A2 (de)	2003-10-08
US20060270729A1 (en)	2006-11-30
AU4332302A (en)	2002-06-24
US8691864B2 (en)	2014-04-08
US20040138282A1 (en)	2004-07-15
CA2465534C (en)	2009-10-27
DE60135579D1 (de)	2008-10-09
CA2465534A1 (en)	2002-06-20
AU2002243323B2 (en)	2007-07-12

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