|
CA2141427C
(en)
*
|
1992-07-31 |
2008-07-22 |
Mohammed Anjam Khan |
Expression of recombinant fusion proteins in attenuated bacteria
|
|
US8791237B2
(en)
*
|
1994-11-08 |
2014-07-29 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of non-hodgkins lymphoma
|
|
US7820180B2
(en)
*
|
2004-09-24 |
2010-10-26 |
The Trustees Of The University Of Pennsylvania |
Listeria-based and LLO-based vaccines
|
|
US7662396B2
(en)
*
|
2001-03-26 |
2010-02-16 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for enhancing the immunogenicity of antigens
|
|
US8956621B2
(en)
|
1994-11-08 |
2015-02-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of cervical dysplasia
|
|
US20070264279A1
(en)
*
|
1994-11-08 |
2007-11-15 |
Claudia Gravekamp |
Compositions and methods comprising a MAGE-b antigen
|
|
US7794729B2
(en)
*
|
1994-11-08 |
2010-09-14 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for immunotherapy of cancer
|
|
US8114414B2
(en)
*
|
1994-11-08 |
2012-02-14 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of cervical cancer
|
|
FR2728170A1
(fr)
*
|
1994-12-15 |
1996-06-21 |
Pasteur Institut |
Vaccin de type acellulaire anti-bordetella
|
|
US6682729B1
(en)
|
1995-05-03 |
2004-01-27 |
University Of Maryland, Baltimore |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
|
|
US6150170A
(en)
*
|
1998-05-03 |
2000-11-21 |
University Of Maryland At Baltimore |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
|
|
US7045336B1
(en)
|
1995-09-06 |
2006-05-16 |
The United States Of America As Represented By The Secretary Of The Army |
Bacterial delivery system
|
|
US5980898A
(en)
*
|
1996-11-14 |
1999-11-09 |
The United States Of America As Represented By The U.S. Army Medical Research & Material Command |
Adjuvant for transcutaneous immunization
|
|
US20060002949A1
(en)
*
|
1996-11-14 |
2006-01-05 |
Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. |
Transcutaneous immunization without heterologous adjuvant
|
|
US20060002959A1
(en)
*
|
1996-11-14 |
2006-01-05 |
Government Of The United States |
Skin-sctive adjuvants for transcutaneous immuization
|
|
US6797276B1
(en)
|
1996-11-14 |
2004-09-28 |
The United States Of America As Represented By The Secretary Of The Army |
Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
|
|
CA2218754A1
(en)
*
|
1996-11-15 |
1998-05-15 |
Eli Lilly And Company |
Recombinant psa expression vectors and assays using the same
|
|
AU6868198A
(en)
*
|
1997-03-28 |
1998-10-22 |
Jason C. Grove |
Antimicrobial mediated bacterial dna delivery
|
|
ES2253789T3
(es)
|
1997-04-18 |
2006-06-01 |
Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) |
Cepa de salmonella atenuada usada como vehiculo para inmunizacion oral.
|
|
US20030125278A1
(en)
*
|
1997-08-13 |
2003-07-03 |
Tang De-Chu C. |
Immunization of animals by topical applications of a salmonella-based vector
|
|
US20030045492A1
(en)
*
|
1997-08-13 |
2003-03-06 |
Tang De-Chu C. |
Vaccination by topical application of recombinant vectors
|
|
US6080849A
(en)
*
|
1997-09-10 |
2000-06-27 |
Vion Pharmaceuticals, Inc. |
Genetically modified tumor-targeted bacteria with reduced virulence
|
|
JP2002500001A
(ja)
*
|
1997-09-10 |
2002-01-08 |
ヴァイオン ファーマシューティカルズ、インコーポレーテッド |
低下した毒性を有する遺伝子改変腫瘍標的化細菌
|
|
JP2001519162A
(ja)
*
|
1997-10-07 |
2001-10-23 |
ユニバーシティ・オブ・メリーランド・バイオテクノロジー・インスティチュート |
動物細胞にrnaを導入して発現させる方法
|
|
US20040258703A1
(en)
*
|
1997-11-14 |
2004-12-23 |
The Government Of The Us, As Represented By The Secretary Of The Army |
Skin-active adjuvants for transcutaneous immunization
|
|
DE19754938B4
(de)
*
|
1997-12-11 |
2006-04-20 |
Christoph von Dr. Eichel-Streiber |
TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität
|
|
US6143551A
(en)
*
|
1997-12-29 |
2000-11-07 |
Schering Aktiengesellschaft |
Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
|
|
US6585975B1
(en)
*
|
1998-04-30 |
2003-07-01 |
Acambis, Inc. |
Use of Salmonella vectors for vaccination against helicobacter infection
|
|
US6004815A
(en)
|
1998-08-13 |
1999-12-21 |
The Regents Of The University Of California |
Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells
|
|
MXPA01005615A
(es)
*
|
1998-12-04 |
2004-08-19 |
Univ Manitoba |
Procedimiento de inmunizacion en dos pasos para proteger contra infeccion por chlamydia.
|
|
WO2000061184A2
(en)
*
|
1999-04-08 |
2000-10-19 |
Glenn Gregory M |
Dry formulation for transcutaneous immunization
|
|
US20040138168A1
(en)
*
|
1999-04-21 |
2004-07-15 |
Wyeth |
Methods and compositions for inhibiting the function of polynucleotide sequences
|
|
IL145778A0
(en)
*
|
1999-04-21 |
2002-07-25 |
American Home Prod |
Methods and compositions for inhibiting the function of polynucleotide sequences
|
|
US20040009936A1
(en)
*
|
1999-05-03 |
2004-01-15 |
Tang De-Chu C. |
Vaccine and drug delivery by topical application of vectors and vector extracts
|
|
GB9918283D0
(en)
*
|
1999-08-03 |
1999-10-06 |
Int Centre Genetic Eng & Bio |
Hsv vaccines
|
|
US7994278B1
(en)
|
1999-08-06 |
2011-08-09 |
Nobel Biosciences Llc |
Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
|
|
US6759241B1
(en)
|
1999-10-04 |
2004-07-06 |
University Of Maryland Biotechnology Institute |
Adjuvant comprising a lipopolysaccharide antagonist
|
|
US6962696B1
(en)
*
|
1999-10-04 |
2005-11-08 |
Vion Pharmaceuticals Inc. |
Compositions and methods for tumor-targeted delivery of effector molecules
|
|
JP2003512077A
(ja)
*
|
1999-10-26 |
2003-04-02 |
インターナショナル エイズ バクシーン イニシアティブ |
アルファウイルスレプリコンを発現する侵襲性細菌
|
|
EP1244687A4
(de)
*
|
1999-12-22 |
2005-06-15 |
Univ Ohio State Res Found |
Schutzma nahmen gegen die tödliche infektion durch i bacillus anthracis
|
|
US9012141B2
(en)
|
2000-03-27 |
2015-04-21 |
Advaxis, Inc. |
Compositions and methods comprising KLK3 of FOLH1 antigen
|
|
JP2004500405A
(ja)
*
|
2000-03-29 |
2004-01-08 |
ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルヴァニア |
抗原の免疫原性を増強するための組成物および方法
|
|
US7083858B1
(en)
|
2000-07-26 |
2006-08-01 |
Worthen Industries, Inc. |
Thermally activated adhesive films for the collation of wire staples
|
|
EP2329846B1
(de)
|
2000-09-08 |
2014-11-12 |
University Of Maryland, Baltimore |
Genetisch veränderte Koexpressions-DNA-Impfstoffe, Herstellungsverfahren und Verwendungen davon
|
|
GB0024203D0
(en)
*
|
2000-10-03 |
2000-11-15 |
Peptide Therapeutics Ltd |
Stabilisation of plasmid inheritance in bacteria
|
|
US6872547B1
(en)
|
2000-10-11 |
2005-03-29 |
Washington University |
Functional balanced-lethal host-vector systems
|
|
EP1372708B1
(de)
*
|
2001-02-13 |
2008-06-18 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE ARMY |
Impstoffe zur transkutanen immunisierung gegen reisediarrhö
|
|
US8771702B2
(en)
|
2001-03-26 |
2014-07-08 |
The Trustees Of The University Of Pennsylvania |
Non-hemolytic LLO fusion proteins and methods of utilizing same
|
|
US7700344B2
(en)
*
|
2001-03-26 |
2010-04-20 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for enhancing the immunogenicity of antigens
|
|
US7396822B2
(en)
|
2001-05-24 |
2008-07-08 |
Vaxiion Therapeutics, Inc. |
Immunogenic minicells and methods of use
|
|
US20030194798A1
(en)
*
|
2001-05-24 |
2003-10-16 |
Surber Mark W. |
Minicell compositions and methods
|
|
US20050180985A9
(en)
*
|
2001-10-04 |
2005-08-18 |
Vladoianu Ion R. |
Live attenuated salmonella strains for producing monovalent or multivalent vaccines
|
|
US20030224369A1
(en)
*
|
2002-02-25 |
2003-12-04 |
Surber Mark W. |
Reverse screening and target identification with minicells
|
|
US20030207833A1
(en)
*
|
2002-02-25 |
2003-11-06 |
Neil Berkley |
Pharmaceutical compositions with minicells
|
|
US20030224444A1
(en)
*
|
2002-02-25 |
2003-12-04 |
Sabbadini Roger A. |
Antibodies to native conformations of membrane proteins
|
|
CA2380471A1
(en)
*
|
2002-02-28 |
2003-08-28 |
The University Of Hong Kong |
Oral dna vaccine composition for hepatitis b virus chronic infection
|
|
US20040005700A1
(en)
*
|
2002-05-28 |
2004-01-08 |
Surber Mark W. |
Poroplasts
|
|
JP2006507800A
(ja)
*
|
2002-06-07 |
2006-03-09 |
ラージ・スケール・バイオロジー・コーポレイション |
可撓性ワクチンアセンブリおよびワクチン送達プラットフォーム
|
|
US7018835B2
(en)
*
|
2002-08-20 |
2006-03-28 |
David Michael Hone |
Recombinant double-stranded RNA phage, and use of the same
|
|
WO2004020643A2
(en)
*
|
2002-09-01 |
2004-03-11 |
Washington University |
Regulated bacterial lysis for gene vaccine vector delivery and antigen release
|
|
US7695725B2
(en)
|
2003-02-06 |
2010-04-13 |
Aduro Biotech |
Modified free-living microbes, vaccine compositions and methods of use thereof
|
|
KR101173871B1
(ko)
*
|
2003-02-06 |
2012-08-16 |
앤저 테라퓨틱스 인코퍼레이티드 |
변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법
|
|
ATE552843T1
(de)
*
|
2003-02-06 |
2012-04-15 |
Aduro Biotech |
Listerien deren eindringen in nicht-phagozytische zellen abgeschwächt ist, impfstoffe, die diese listerien enthalten und deren verwendungen
|
|
DE10326189A1
(de)
*
|
2003-06-06 |
2005-01-05 |
MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH |
Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe
|
|
DK2270162T3
(en)
|
2003-06-12 |
2019-01-21 |
Alnylam Pharmaceuticals Inc |
PRESERVED HBV AND HCV SEQUENCES USED FOR GEN-SILENCING
|
|
CA2536026A1
(en)
*
|
2003-08-22 |
2005-05-06 |
Nucleonics Inc. |
Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments
|
|
EP1687022A4
(de)
|
2003-11-12 |
2008-02-13 |
Medical Res Council |
Renta: hiv-immunogen und seine anwendungen
|
|
WO2006055024A2
(en)
*
|
2004-04-05 |
2006-05-26 |
Vaxiion Therapeutics, Inc. |
Minicells as vaccines
|
|
US8029777B2
(en)
|
2004-08-13 |
2011-10-04 |
Marshall Barry J |
Helicobacter system and uses thereof
|
|
CA2576280A1
(en)
|
2004-08-13 |
2006-02-16 |
Barry J. Marshall |
Helicobacter pylori-based delivery system
|
|
EP2169072A1
(de)
|
2004-08-23 |
2010-03-31 |
Alnylam Pharmaceuticals, Inc |
Expressionskonstrukte mit mehreren RNA-Polymerase-III-Promotoren
|
|
CA2824308A1
(en)
|
2004-09-24 |
2006-04-06 |
Alnylam Pharmaceuticals, Inc. |
Targeting opposite strand replication intermediates of single-stranded viruses by rnai
|
|
CA2585098C
(en)
|
2004-10-22 |
2018-12-18 |
Revivicor, Inc. |
Porcine genomic kappa and lambda light chain sequences
|
|
WO2006050394A2
(en)
|
2004-11-01 |
2006-05-11 |
Novartis Vaccines And Diagnostics Inc. |
Combination approaches for generating immune responses
|
|
WO2006069064A2
(en)
|
2004-12-22 |
2006-06-29 |
Nucleonics, Inc. |
Conserved hbv and hcv sequences useful for gene silencing
|
|
WO2006076517A1
(en)
*
|
2005-01-12 |
2006-07-20 |
Albert Einstein College Of Medicine Of Yeshiva University |
Attenuated mycobacteria as vectors for gene delivery to mammalian cells
|
|
AR053385A1
(es)
|
2005-05-12 |
2007-05-02 |
Novartis Ag |
Genes y proteinas novedosos de brachyspira hyodysenteriae y uso de los mismos para diagnostico y terapia
|
|
WO2007039454A1
(en)
|
2005-09-20 |
2007-04-12 |
Basf Plant Science Gmbh |
Methods for controlling gene expression using ta-siran
|
|
EP2056849A4
(de)
*
|
2006-08-04 |
2010-09-08 |
Univ Pennsylvania |
Verfahren und zusammensetzungen zur behandlung von ige-vermittelten erkrankungen
|
|
US8268326B2
(en)
*
|
2006-08-15 |
2012-09-18 |
The Trustees Of The University Of Pennsylvania |
Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
|
|
US8241636B2
(en)
*
|
2006-08-15 |
2012-08-14 |
The Trustees Of The University Of Pennsylvania |
Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
|
|
US20080124355A1
(en)
|
2006-09-22 |
2008-05-29 |
David Gordon Bermudes |
Live bacterial vaccines for viral infection prophylaxis or treatment
|
|
AU2007283667B2
(en)
|
2007-08-03 |
2014-09-04 |
Boehringer Ingelheim Vetmedica Gmbh |
Genes and proteins of Brachyspira hyodysenteriae and uses thereof
|
|
CN101139616B
(zh)
*
|
2007-08-16 |
2011-04-06 |
湖北大学 |
一种高通量的通过细菌直接侵染将外源基因导入昆虫细胞的方法
|
|
BRPI0817090A2
(pt)
|
2007-09-12 |
2014-11-25 |
Intervet Int Bv |
Método de cultura e uma espécie bacteriana da família anaplasmataceae, e, composição.
|
|
US9051557B2
(en)
*
|
2007-09-12 |
2015-06-09 |
Intervet International B.V. |
Method for continuously culturing Ehrlichia canis
|
|
GB0720250D0
(en)
|
2007-10-17 |
2007-11-28 |
Univ Edinburgh |
Immunogenic compositions containing escherichia coli h7 flagella and methods of use thereof
|
|
EP2363407A1
(de)
|
2008-02-28 |
2011-09-07 |
Murdoch University |
Neuartige Brachyspira-Sequenzen, immunogene Zusammensetzungen, Herstellungsverfahren dafür und Verwendung davon
|
|
AU2009227986C1
(en)
|
2008-03-27 |
2014-06-19 |
Murdoch University |
Novel sequences of Brachyspira, immunogenic compositions, methods for preparation and use thereof
|
|
US9650639B2
(en)
|
2008-05-19 |
2017-05-16 |
Advaxis, Inc. |
Dual delivery system for heterologous antigens
|
|
US9017660B2
(en)
|
2009-11-11 |
2015-04-28 |
Advaxis, Inc. |
Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
|
|
JP5757863B2
(ja)
|
2008-05-19 |
2015-08-05 |
アドバクシス インコーポレイテッド |
異種抗原のための二重送達システム
|
|
DK2348827T3
(en)
|
2008-10-27 |
2015-07-20 |
Revivicor Inc |
IMMUNICIPLY COMPROMATED PETS
|
|
US8241623B1
(en)
|
2009-02-09 |
2012-08-14 |
David Bermudes |
Protease sensitivity expression system
|
|
US8778329B2
(en)
|
2009-03-04 |
2014-07-15 |
The Trustees Of The University Of Pennsylvania |
Compositions comprising angiogenic factors and methods of use thereof
|
|
US10016617B2
(en)
|
2009-11-11 |
2018-07-10 |
The Trustees Of The University Of Pennsylvania |
Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
|
|
US8771669B1
(en)
|
2010-02-09 |
2014-07-08 |
David Gordon Bermudes |
Immunization and/or treatment of parasites and infectious agents by live bacteria
|
|
US8524220B1
(en)
|
2010-02-09 |
2013-09-03 |
David Gordon Bermudes |
Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
|
|
US9597379B1
(en)
|
2010-02-09 |
2017-03-21 |
David Gordon Bermudes |
Protease inhibitor combination with therapeutic proteins including antibodies
|
|
BRPI1003750A2
(pt)
|
2010-07-22 |
2012-04-10 |
Univ Sao Paulo |
microrganismos recombinantes, métodos de preparação de linhagens vacinais, antìgenos, composições vacinais vetorizadas, seus usos, anticorpos, kit de diagnóstico e métodos de tratamento e/ou profilaxia
|
|
CN107412756A
(zh)
|
2010-10-01 |
2017-12-01 |
宾夕法尼亚大学理事会 |
李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途
|
|
EP2447277A1
(de)
|
2010-10-28 |
2012-05-02 |
Laboratorios Del. Dr. Esteve, S.A. |
Impfstoffzusammensetzungen auf Basis von modifizierten gp41-Immunogenen
|
|
DK2675474T3
(en)
|
2011-02-15 |
2019-04-23 |
Vaxiion Therapeutics Llc |
THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES
|
|
CA2829960A1
(en)
|
2011-03-11 |
2012-09-20 |
John Rothman |
Listeria-based adjuvants
|
|
US10183069B2
(en)
|
2011-03-21 |
2019-01-22 |
Altimmune Inc. |
Rapid and prolonged immunologic-therapeutic
|
|
DK3205353T3
(da)
|
2011-03-21 |
2021-04-06 |
Altimmune Inc |
Hurtig- og langtidsvirkende immunologisk terapeutisk middel
|
|
BR112014022662A2
(pt)
|
2012-03-12 |
2017-10-03 |
Advaxis Inc |
Inibição da função de célula supressora seguindo tratamento de vacina de listeria
|
|
US9730991B2
(en)
*
|
2012-09-06 |
2017-08-15 |
Eveliqure Biotechnologies Gmbh |
Live attenuated Shigella vaccine
|
|
US9593339B1
(en)
|
2013-02-14 |
2017-03-14 |
David Gordon Bermudes |
Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
UY36990A
(es)
|
2015-11-21 |
2017-11-30 |
Fundació Privada Inst De Recerca De La Sida-Caixa (Irsicaixa) |
Derivados de anticuerpos contra el vih con actividad dual antiviral e inmunomodulatoria
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US20200157192A1
(en)
|
2017-05-10 |
2020-05-21 |
Albajuna Therapeutics, S.L. |
Fc-fusion protein derivatives with high dual hiv antiviral and immunomodulatory activity
|
|
US11471497B1
(en)
|
2019-03-13 |
2022-10-18 |
David Gordon Bermudes |
Copper chelation therapeutics
|
|
US10973908B1
(en)
|
2020-05-14 |
2021-04-13 |
David Gordon Bermudes |
Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
|
|
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