ATE407140T1 - Verfahren zur herstellung von cyclosporin- derivaten - Google Patents

Verfahren zur herstellung von cyclosporin- derivaten

Info

Publication number
ATE407140T1
ATE407140T1 AT99957167T AT99957167T ATE407140T1 AT E407140 T1 ATE407140 T1 AT E407140T1 AT 99957167 T AT99957167 T AT 99957167T AT 99957167 T AT99957167 T AT 99957167T AT E407140 T1 ATE407140 T1 AT E407140T1
Authority
AT
Austria
Prior art keywords
cyclosporin
preparing
optionally
cyclosporine derivatives
derivatives
Prior art date
Application number
AT99957167T
Other languages
English (en)
Inventor
Christian Viskov
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE407140T1 publication Critical patent/ATE407140T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99957167T 1998-06-22 1999-06-21 Verfahren zur herstellung von cyclosporin- derivaten ATE407140T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9807846A FR2780061B1 (fr) 1998-06-22 1998-06-22 Nouveau procede de preparation de derives de cyclosporine

Publications (1)

Publication Number Publication Date
ATE407140T1 true ATE407140T1 (de) 2008-09-15

Family

ID=9527672

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99957167T ATE407140T1 (de) 1998-06-22 1999-06-21 Verfahren zur herstellung von cyclosporin- derivaten

Country Status (8)

Country Link
US (3) US7226905B2 (de)
EP (1) EP1098903B1 (de)
JP (1) JP4224213B2 (de)
AT (1) ATE407140T1 (de)
AU (1) AU4270099A (de)
DE (1) DE69939470D1 (de)
FR (1) FR2780061B1 (de)
WO (1) WO1999067280A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1154759T3 (da) 1998-12-30 2008-12-08 Dexcel Ltd Dispergerbart koncentrat til indgift af cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
TWI243826B (en) * 2001-07-19 2005-11-21 Akzo Nobel Nv Process for the preparation of peptides
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
US6987090B2 (en) * 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
EP1742652A2 (de) * 2004-04-08 2007-01-17 Novartis AG Verwendung von cyclosporinen zur behandlung von zerebralischämie und gehirn- und rückenmarksverletzungen
EP1804823A4 (de) 2004-09-29 2010-06-09 Amr Technology Inc Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP5139065B2 (ja) * 2004-10-01 2013-02-06 スシネキス インク Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
BRPI0616476A2 (pt) 2005-09-30 2011-06-21 Scynexis Inc uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
US8329658B2 (en) 2005-09-30 2012-12-11 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (de) * 2006-06-02 2009-02-25 Claude Annie Perrichon Verwaltung von aktieven elektronen
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
EP2376524B1 (de) 2008-12-31 2017-03-15 Cypralis Limited Derivate von cyclosporin a
AU2010254316A1 (en) * 2009-05-27 2011-12-22 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
AU2010339460A1 (en) 2009-12-30 2012-07-19 Scynexis Inc. Cyclosporine analogues
JP6144627B2 (ja) 2010-12-15 2017-06-07 コントラヴィア ファーマシューティカルズ、インク． アミノ酸１および３で修飾されたシクロスポリン類似体分子
WO2014049540A2 (en) 2012-09-29 2014-04-03 Novartis Ag Cyclic peptides and use as medicines
US10227877B2 (en) 2016-08-18 2019-03-12 General Electric Company Cooling circuit for a multi-wall blade
WO2020037530A1 (en) * 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (de) 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
JPH0267244A (ja) * 1988-09-01 1990-03-07 Wako Pure Chem Ind Ltd β−ヒドロキシ脂肪酸の製法
US4937355A (en) 1989-01-17 1990-06-26 E. R. Squibb & Sons, Inc. Process for preparing (trans)-4-substituted-dl-proline derivatives
ATE148469T1 (de) * 1990-11-02 1997-02-15 Sandoz Ag Zyklosporine
JPH0793927B2 (ja) * 1990-11-02 1995-10-11 富士通株式会社 超音波カラードプラ診断装置
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2772768B1 (fr) * 1997-12-19 2000-01-14 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine

Also Published As

Publication number Publication date
AU4270099A (en) 2000-01-10
FR2780061B1 (fr) 2001-09-07
US20010025025A1 (en) 2001-09-27
US7226905B2 (en) 2007-06-05
WO1999067280A1 (fr) 1999-12-29
US20070213260A1 (en) 2007-09-13
US7678766B2 (en) 2010-03-16
DE69939470D1 (de) 2008-10-16
EP1098903A1 (de) 2001-05-16
JP2002518519A (ja) 2002-06-25
JP4224213B2 (ja) 2009-02-12
FR2780061A1 (fr) 1999-12-24
EP1098903B1 (de) 2008-09-03
US20100173838A1 (en) 2010-07-08

Similar Documents

Publication Publication Date Title
DE69939470D1 (de) Verfahren zur herstellung von cyclosporin-derivaten
WO2003072026A3 (en) Method of reducing and treating uvb-induced immunosuppression
DE69916435D1 (de) Verfahren zur verbesserung der ductilität von nitinol
ATE469908T1 (de) Verfahren zur herstellung von pimecrolimus
CA2376596A1 (en) Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
IL189629A0 (en) Compositions containing human ctla-4 antibodies
PL328858A1 (en) Immunogenous peptides
DE60029799D1 (de) Verbindungen, verfahren und pharmazeutische zubereitungen zur behandlung von zellschäden wie zum beispiel schäden an nerven- oder kerzgefässgewebe
WO2003102153A3 (en) Cell migration inhibiting compositions and methods and compositions for treating cancer
DE69918799D1 (de) Verfahren zur herstellung und screening von inhibitoren des bakteriellen nad synthetase enzyms, verbindungen daraus und methoden zur behandlung bakterieller und mikrobieller infektionen mit diesen inhibitoren
ATE309353T1 (de) Verfahren zur herstellung von rekombinanten peptiden
ATE196083T1 (de) Verwendung von ferrioxamin-b zur behandlung septischen schocks
EP1401467A4 (de) Alpha-fetoprotein-peptide und ihre verwendung
EP1234049A4 (de) Verfahren zur herstellung von biopolymeren aus stickstoffarmem abwasser
DK1135163T3 (da) Topiske sammensætninger indeholdende ascomyciner
ES2191061T3 (es) Antibioticos sinteticos.
DE69735583D1 (de) Semisynthetisches verfahren zur herstellung von didemninanalogen
WO2000032765A3 (en) Ribozyme therapy for the treatment and/or prevention of restenosis
DE69906593D1 (de) Verfahren zur herstellung von 8-chinolinolato metallkomplexen
MX9707046A (es) Composiciones que comprenden nicotinilalanina y un inhibidor de conjugacion de glicina o vitamina b6.
AP2000001937A0 (en) Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway.
DE69616913D1 (de) Verfahren zur Herstellung von 3,7-Dimethyl-5,7-octadien-1-ol oder Rosenoxid
DE10082646D2 (de) Verfahren zur Herstellung bzw. Gewinnung von 2,6-Dichlortoluol
DE69617685D1 (de) Zusammensetzung und verfahren zur stabilisierung von radiomarkierten organischen verbindungen
EA200000247A1 (ru) Производные 4-циано-4-деформилсордарицина

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties