ATE407202T1 - Enzymvarianten von subtilisin (subtilasen) - Google Patents
Enzymvarianten von subtilisin (subtilasen)Info
- Publication number
- ATE407202T1 ATE407202T1 AT04731310T AT04731310T ATE407202T1 AT E407202 T1 ATE407202 T1 AT E407202T1 AT 04731310 T AT04731310 T AT 04731310T AT 04731310 T AT04731310 T AT 04731310T AT E407202 T1 ATE407202 T1 AT E407202T1
- Authority
- AT
- Austria
- Prior art keywords
- subtilases
- subtilisin
- enzyme variants
- compositions
- egg stains
- Prior art date
Links
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000787 Subtilisin Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 101710135785 Subtilisin-like protease Proteins 0.000 abstract 2
- 239000003599 detergent Substances 0.000 abstract 2
- 238000004140 cleaning Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38681—Chemically modified or immobilised enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300690 | 2003-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE407202T1 true ATE407202T1 (de) | 2008-09-15 |
Family
ID=33426922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04731310T ATE407202T1 (de) | 2003-05-07 | 2004-05-06 | Enzymvarianten von subtilisin (subtilasen) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7507569B2 (de) |
| EP (1) | EP1623029B1 (de) |
| JP (1) | JP4819670B2 (de) |
| CN (2) | CN102766545B (de) |
| AT (1) | ATE407202T1 (de) |
| AU (1) | AU2004236308B2 (de) |
| BR (1) | BRPI0409992A (de) |
| CA (1) | CA2526341C (de) |
| DE (1) | DE602004016314D1 (de) |
| WO (1) | WO2004099401A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6682924B1 (en) * | 1995-05-05 | 2004-01-27 | Novozymes A/S | Protease variants and compositions |
| BR9811248B1 (pt) * | 1997-08-29 | 2011-10-04 | variante de enzima subtilase derivada de uma subtilase originária selecionada a partir do sub-grupo i-s1 ou do sub-grupo i-s2, dita variante tendo melhorado desempenho de lavagem em detergentes em comparação com a subtilase originária, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processo para produzir uma variante, composição, uso de uma variante de subtilase. | |
| WO2001083559A2 (en) * | 2000-04-28 | 2001-11-08 | Novozymes A/S | Production and use of protein variants having modified immunogenecity |
| JP2009534022A (ja) | 2006-04-20 | 2009-09-24 | ノボザイムス アクティーゼルスカブ | 卵のシミに対する洗浄能力が向上したサビナーゼ変異体 |
| KR20150115023A (ko) * | 2006-07-18 | 2015-10-13 | 다니스코 유에스 인크. | 광범위한 온도에 걸쳐 활성인 프로테아제 변이형 |
| CN101522878B (zh) * | 2006-10-06 | 2012-11-14 | 诺维信公司 | 洗涤剂组合物及其中酶组合的使用 |
| DE102007038031A1 (de) * | 2007-08-10 | 2009-06-04 | Henkel Ag & Co. Kgaa | Mittel enthaltend Proteasen |
| DE102007044415A1 (de) * | 2007-09-17 | 2009-03-19 | Henkel Ag & Co. Kgaa | Leistungsverbesserte Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen |
| US7781387B2 (en) * | 2008-01-22 | 2010-08-24 | Access Business Group International, Llc. | Automatic phosphate-free dishwashing detergent providing improved spotting and filming performance |
| EP2245060B1 (de) | 2008-02-01 | 2017-11-01 | Novozymes A/S | Flüssige enzymzusammensetzung |
| BRPI0909084B1 (pt) | 2008-03-26 | 2020-11-03 | Novozymes A/S | peptídeo aldeído, e, composição líquida |
| EP2362902B1 (de) * | 2008-11-11 | 2012-10-24 | Danisco US, Inc., Genencor Division | Zusammensetzungen und verfahren mit einer subtilisinvariante |
| GB0915572D0 (en) * | 2009-09-07 | 2009-10-07 | Reckitt Benckiser Nv | Detergent composition |
| EP2480650B1 (de) * | 2009-09-25 | 2017-03-22 | Novozymes A/S | Subtilasevarianten |
| US9085750B2 (en) | 2011-07-01 | 2015-07-21 | Novozymes A/S | Stabilized subtilisin composition |
| MX350874B (es) | 2011-07-01 | 2017-09-19 | Novozymes As | Composicion de detergente liquido. |
| US20140147895A1 (en) | 2011-07-22 | 2014-05-29 | Novozymes A/S | Processes for Pretreating Cellulosic Material and Improving Hydrolysis Thereof |
| DE102011118027A1 (de) * | 2011-09-12 | 2013-03-14 | Henkel Ag & Co. Kgaa | Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente |
| JP2015500006A (ja) | 2011-11-25 | 2015-01-05 | ノボザイムス アクティーゼルスカブ | サブチラーゼ変異体およびこれをコードするポリヌクレオチド |
| EP2607468A1 (de) | 2011-12-20 | 2013-06-26 | Henkel AG & Co. KGaA | Reinigungsmittelzusammensetzungen mit Subtilasevarianten |
| JP2015504660A (ja) | 2011-12-20 | 2015-02-16 | ノボザイムス アクティーゼルスカブ | サブチラーゼ変異体およびそれをコードするポリヌクレオチド |
| BR112014017919A2 (pt) | 2012-01-26 | 2017-06-27 | Novozymes As | uso de um poliptídeo variante, composição, polinucleotídeo isolado, constructo de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos de produção do pilipeptídeo, para melhoria do valor nutricional de uma ração animal, e para o tratamento de proteínas, planta, parte de planta ou célula de planta transgênica, aditivo de ração animal, ração animal, e, composição de ração animal ou detergente |
| EP2628785B1 (de) | 2012-02-17 | 2016-05-18 | Henkel AG & Co. KGaA | Reinigungsmittelzusammensetzungen mit Subtilasevarianten |
| US10093911B2 (en) | 2012-02-17 | 2018-10-09 | Novozymes A/S | Subtilisin variants and polynucleotides encoding same |
| WO2013167581A1 (en) | 2012-05-07 | 2013-11-14 | Novozymes A/S | Polypeptides having xanthan degrading activity and polynucleotides encoding same |
| CN105189724A (zh) | 2013-03-14 | 2015-12-23 | 诺维信公司 | 含有酶和抑制剂的水溶性膜 |
| EP3569611A1 (de) | 2013-04-23 | 2019-11-20 | Novozymes A/S | Flüssige reinigungszusammensetzungen für automatische geschirrspüler |
| US20160075976A1 (en) | 2013-05-03 | 2016-03-17 | Novozymes A/S | Microencapsulation of Detergent Enzymes |
| EP2832853A1 (de) | 2013-07-29 | 2015-02-04 | Henkel AG&Co. KGAA | Waschmittelzusammensetzung mit Proteasevarianten |
| US9613906B2 (en) * | 2014-06-23 | 2017-04-04 | GlobalFoundries, Inc. | Integrated circuits including modified liners and methods for fabricating the same |
| US20170121646A1 (en) | 2014-07-03 | 2017-05-04 | Novozymes A/S | Improved Stabilization of Non-Protease Enzyme |
| WO2016079305A1 (en) | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| CA2975814C (en) | 2015-03-30 | 2023-06-27 | Nestec S.A. | Milk-based protein hydrolysates and compositions made thereof |
| EP4234693A3 (de) * | 2015-06-17 | 2023-11-01 | Danisco US Inc | Bacillus-gibboni-clade-serin-proteasen |
| WO2017117089A1 (en) | 2015-12-28 | 2017-07-06 | Novozymes Bioag A/S | Heat priming of bacterial spores |
| US20190218479A1 (en) | 2016-05-31 | 2019-07-18 | Novozymes A/S | Stabilized Liquid Peroxide Compositions |
| CN109563451A (zh) | 2016-08-24 | 2019-04-02 | 汉高股份有限及两合公司 | 包含gh9内切葡聚糖酶变体i的洗涤剂组合物 |
| US11512300B2 (en) | 2016-08-24 | 2022-11-29 | Novozymes A/S | Xanthan lyase variants and polynucleotides encoding same |
| WO2018037064A1 (en) | 2016-08-24 | 2018-03-01 | Henkel Ag & Co. Kgaa | Detergent compositions comprising xanthan lyase variants i |
| CA3031609A1 (en) | 2016-08-24 | 2018-03-01 | Novozymes A/S | Gh9 endoglucanase variants and polynucleotides encoding same |
| US20190284647A1 (en) | 2016-09-29 | 2019-09-19 | Novozymes A/S | Spore Containing Granule |
| EP3401385A1 (de) | 2017-05-08 | 2018-11-14 | Henkel AG & Co. KGaA | Tensidzusammensetzungen enthaltend polypeptide enthaltend eine carbohydrate binding domain |
| WO2018206535A1 (en) | 2017-05-08 | 2018-11-15 | Novozymes A/S | Carbohydrate-binding domain and polynucleotides encoding the same |
| CN111108183A (zh) | 2017-06-30 | 2020-05-05 | 诺维信公司 | 酶浆液组合物 |
| CN111278971A (zh) | 2017-08-24 | 2020-06-12 | 诺维信公司 | Gh9内切葡聚糖酶变体以及编码它们的多核苷酸 |
| US11624059B2 (en) | 2017-08-24 | 2023-04-11 | Henkel Ag & Co. Kgaa | Detergent compositions comprising GH9 endoglucanase variants II |
| CA3071078A1 (en) | 2017-08-24 | 2019-02-28 | Novozymes A/S | Xanthan lyase variants and polynucleotides encoding same |
| US20210130744A1 (en) | 2017-08-24 | 2021-05-06 | Henkel Ag & Co. Kgaa | Detergent composition comprising xanthan lyase variants ii |
| EP4567094A3 (de) | 2017-09-27 | 2026-01-07 | Novozymes A/S | Lipasevarianten und mikrokapselzusammensetzungen mit solchen lipasevarianten |
| EP3740591A4 (de) | 2018-01-19 | 2022-02-23 | Bio-Rad Laboratories, Inc. | Mutierte dna-polymerasen |
| WO2019154955A1 (en) | 2018-02-08 | 2019-08-15 | Novozymes A/S | Lipase variants and compositions thereof |
| US20210123033A1 (en) | 2018-02-08 | 2021-04-29 | Novozymes A/S | Lipases, Lipase Variants and Compositions Thereof |
| EP3755793A1 (de) | 2018-02-23 | 2020-12-30 | Henkel AG & Co. KGaA | Waschmittelzusammensetzung mit xanthan lyase und endoglucanasevarianten |
| CN111770788B (zh) | 2018-03-13 | 2023-07-25 | 诺维信公司 | 使用氨基糖低聚物进行微囊化 |
| EP3799601A1 (de) * | 2018-06-19 | 2021-04-07 | Danisco US Inc. | Subtilisinvarianten |
| MX2021015894A (es) | 2019-07-01 | 2022-02-03 | Basf Se | Peptidos acetales para estabilizar enzimas. |
| EP3994255A1 (de) | 2019-07-02 | 2022-05-11 | Novozymes A/S | Lipasevarianten und zusammensetzungen davon |
| EP3907271A1 (de) | 2020-05-07 | 2021-11-10 | Novozymes A/S | Reinigungszusammensetzung, verwendung und verfahren zum reinigen |
| EP4039806A1 (de) | 2021-02-04 | 2022-08-10 | Henkel AG & Co. KGaA | Reinigungsmittelzusammensetzung mit xanthan-lyase- und endoglucanase-varianten mit verbesserter stabilität |
| CA3257053A1 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | COMPOSITIONS AND METHODS FOR THE PREVENTION, TREATMENT, SUPPRESSION AND/OR ELIMINATION OF PHYTOPATHOGENIC INFESTATIONS AND INFECTIONS |
| CN120712348A (zh) * | 2023-03-06 | 2025-09-26 | 丹尼斯科美国公司 | 枯草杆菌蛋白酶变体和使用方法 |
| WO2025085351A1 (en) * | 2023-10-20 | 2025-04-24 | Danisco Us Inc. | Subtilisin variants and methods of use |
| DE102024207057A1 (de) * | 2024-07-26 | 2026-01-29 | Henkel Ag & Co. Kgaa | Protease-varianten mit verbesserter lagerstabilität |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ208612A (en) | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
| DE3527913A1 (de) | 1985-08-03 | 1987-02-12 | Henkel Kgaa | Alkalische protease, verfahren zur herstellung von hybridvektoren und genetisch transformierte mikroorganismen |
| JP2599946B2 (ja) | 1986-01-15 | 1997-04-16 | アムジェン,インコーポレイテツド | ズブチリシン類似体 |
| US4990452A (en) * | 1986-02-12 | 1991-02-05 | Genex Corporation | Combining mutations for stabilization of subtilisin |
| JPS63502959A (ja) | 1986-02-12 | 1988-11-02 | ジェネックス、コ−ポレ−ション | 突然変異誘発及びスクリ−ニング方法並びに生成物 |
| IE65767B1 (en) | 1986-04-30 | 1995-11-15 | Genencor Int | Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| US5260207A (en) * | 1987-04-06 | 1993-11-09 | Enzon Labs Inc. | Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins |
| DE353250T1 (de) | 1987-04-06 | 1998-05-28 | Novonordisk As | Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen. |
| US4914031A (en) * | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US5543302A (en) * | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
| JPH03505976A (ja) * | 1989-05-17 | 1991-12-26 | アムジエン・インコーポレーテツド | 多重突然変異スブチリシン |
| DK316989D0 (da) | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
| US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| US5340735A (en) * | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
| DE4224125A1 (de) | 1991-07-27 | 1993-01-28 | Solvay Enzymes Gmbh & Co Kg | Verfahren zur verbesserung der stabilitaet von enzymen und stabilisierte enzyme |
| JP4028592B2 (ja) | 1992-07-17 | 2007-12-26 | ジェネンコー インターナショナル インコーポレイテッド | 高アルカリ性セリンプロテアーゼ |
| US6436690B1 (en) | 1993-09-15 | 2002-08-20 | The Procter & Gamble Company | BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
| MA23346A1 (fr) * | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
| ES2287931T3 (es) * | 1993-10-14 | 2007-12-16 | THE PROCTER & GAMBLE COMPANY | Composiciones limpiadoras que contienen proteasa. |
| ATE245185T1 (de) * | 1993-10-14 | 2003-08-15 | Procter & Gamble | Proteasen enthaltende bleichmittelzusammensetzungen |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE4411223A1 (de) | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren |
| US6599730B1 (en) | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
| ZA952220B (en) | 1994-05-02 | 1995-12-14 | Procter & Gamble | Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
| US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
| DE69637907D1 (de) | 1995-05-05 | 2009-06-04 | Novozymes As | Protease-varianten und verbindungen |
| US6777218B1 (en) * | 2000-03-14 | 2004-08-17 | Novozymes A/S | Subtilase enzymes having an improved wash performance on egg stains |
| DE60144145D1 (de) * | 2000-04-03 | 2011-04-14 | Maxygen Inc | Subtilisin-variante |
| AU2002223020B2 (en) | 2000-11-27 | 2006-07-06 | Novozymes A/S | Automated mechanical stress assay for screening cleaning ingredients |
| DK200101090A (da) * | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
| DE10162728A1 (de) * | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
-
2004
- 2004-05-06 BR BRPI0409992-3A patent/BRPI0409992A/pt not_active Application Discontinuation
- 2004-05-06 JP JP2006504372A patent/JP4819670B2/ja not_active Expired - Fee Related
- 2004-05-06 CA CA2526341A patent/CA2526341C/en not_active Expired - Fee Related
- 2004-05-06 EP EP04731310A patent/EP1623029B1/de not_active Expired - Lifetime
- 2004-05-06 WO PCT/DK2004/000312 patent/WO2004099401A1/en not_active Ceased
- 2004-05-06 AU AU2004236308A patent/AU2004236308B2/en not_active Ceased
- 2004-05-06 AT AT04731310T patent/ATE407202T1/de not_active IP Right Cessation
- 2004-05-06 CN CN201210213501.9A patent/CN102766545B/zh not_active Expired - Fee Related
- 2004-05-06 DE DE602004016314T patent/DE602004016314D1/de not_active Expired - Lifetime
- 2004-05-06 US US10/555,484 patent/US7507569B2/en not_active Expired - Fee Related
- 2004-05-06 CN CNA2004800118934A patent/CN1784490A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004016314D1 (de) | 2008-10-16 |
| CN1784490A (zh) | 2006-06-07 |
| BRPI0409992A (pt) | 2006-05-09 |
| US7507569B2 (en) | 2009-03-24 |
| JP2006524998A (ja) | 2006-11-09 |
| AU2004236308A1 (en) | 2004-11-18 |
| EP1623029B1 (de) | 2008-09-03 |
| CN102766545A (zh) | 2012-11-07 |
| CA2526341C (en) | 2013-02-19 |
| CN102766545B (zh) | 2014-08-06 |
| WO2004099401A1 (en) | 2004-11-18 |
| EP1623029A1 (de) | 2006-02-08 |
| CA2526341A1 (en) | 2004-11-18 |
| JP4819670B2 (ja) | 2011-11-24 |
| US20070015677A1 (en) | 2007-01-18 |
| AU2004236308B2 (en) | 2010-09-09 |
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