ATE371029T1 - Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen - Google Patents

Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen

Info

Publication number
ATE371029T1
ATE371029T1 AT98610039T AT98610039T ATE371029T1 AT E371029 T1 ATE371029 T1 AT E371029T1 AT 98610039 T AT98610039 T AT 98610039T AT 98610039 T AT98610039 T AT 98610039T AT E371029 T1 ATE371029 T1 AT E371029T1
Authority
AT
Austria
Prior art keywords
metal ion
regulation
ion binding
binding sites
electrostatic interactions
Prior art date
Application number
AT98610039T
Other languages
English (en)
Inventor
Michael W Pantoliano
Philip N Bryan
Barry C Finzel
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21879773&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE371029(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE371029T1 publication Critical patent/ATE371029T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Laminated Bodies (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
AT98610039T 1987-04-06 1988-04-06 Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen ATE371029T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3496587A 1987-04-06 1987-04-06

Publications (1)

Publication Number Publication Date
ATE371029T1 true ATE371029T1 (de) 2007-09-15

Family

ID=21879773

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98610039T ATE371029T1 (de) 1987-04-06 1988-04-06 Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen
AT88904113T ATE184316T1 (de) 1987-04-06 1988-04-06 Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT88904113T ATE184316T1 (de) 1987-04-06 1988-04-06 Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen

Country Status (6)

Country Link
EP (2) EP0353250B1 (de)
JP (2) JP3155984B2 (de)
AT (2) ATE371029T1 (de)
DE (3) DE3856362T2 (de)
DK (1) DK175917B1 (de)
WO (1) WO1988008028A1 (de)

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US5324653A (en) * 1988-02-11 1994-06-28 Gist-Brocades N.V. Recombinant genetic means for the production of serine protease muteins
US6287841B1 (en) 1988-02-11 2001-09-11 Genencor International, Inc. High alkaline serine protease
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WO1990014420A1 (en) * 1989-05-17 1990-11-29 Amgen Inc. Multiply mutated subtilisins
US5665587A (en) 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
BR9006827A (pt) * 1989-06-26 1991-08-06 Unilever Nv Composicoes detergentes enzimaticas
JPH04500384A (ja) * 1989-06-26 1992-01-23 ユニリーバー・ナームローゼ・ベンノートシヤープ 酵素洗剤組成物
US5115102A (en) * 1989-07-21 1992-05-19 Monsanto Company Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices
US6271012B1 (en) * 1989-10-11 2001-08-07 Genencor International, Inc. Protease muteins and their use in detergents
FI102543B (fi) * 1990-01-04 1998-12-31 Plant Genetic Systems Nv Mutantti glukoosi-isomeraasit
DE69133491T2 (de) * 1990-01-04 2006-07-27 Genencor International, Inc., Palo Alto Glucose-Isomerase mit geändertem pH-Optimum
US5340735A (en) * 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
US5567601A (en) * 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
US6436690B1 (en) * 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US6440717B1 (en) * 1993-09-15 2002-08-27 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
ES2287931T3 (es) * 1993-10-14 2007-12-16 THE PROCTER & GAMBLE COMPANY Composiciones limpiadoras que contienen proteasa.
AU1253695A (en) * 1993-10-14 1995-05-04 Procter & Gamble Company, The Bleaching compositions comprising protease enzymes
US6599730B1 (en) * 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
EP0687733A1 (de) * 1994-06-16 1995-12-20 The Procter & Gamble Company Detergenzusammensetzung die Wolle-kompatible-hochalkalische Proteasen enthält
US5922082A (en) 1994-06-16 1999-07-13 Procter & Gamble Company Detergent composition containing wool compatible high alkaline proteases
US6066611A (en) * 1994-10-13 2000-05-23 The Procter & Gamble Company Bleaching compositions comprising protease enzymes
US6455295B1 (en) * 1995-03-08 2002-09-24 The Procter & Gamble Company Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
US6475765B1 (en) * 1995-03-09 2002-11-05 Procter & Gamble Company Subtilisin DY variants having decreased adsorption and increased hydrolysis
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US6682924B1 (en) * 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
EP0948610B1 (de) 1996-11-04 2011-05-25 Novozymes A/S Subtilase-varianten und verbindungen
BR9712878A (pt) 1996-11-04 2000-02-01 Novo Nordisk As Variante de enzima subtilase, processos para a identificação de uma variante de protease apresentando estabilidade autoproteolìtica e paraq a produção de uma enzima subtilase mutante e de uma variante de subtilase, sequência de dna, vetor, célula hospedeira microbiana, composição e uso de uma variante de subtilase.
JP2001514846A (ja) 1997-08-29 2001-09-18 ノボ ノルディスク アクティーゼルスカブ プロテアーゼ変異体及び組成物
JP5095884B2 (ja) 1997-08-29 2012-12-12 ノボザイムス アクティーゼルスカブ プロテアーゼ変異体及び組成物
US6773907B2 (en) 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
CA2310454C (en) 1997-11-21 2012-01-24 Novo Nordisk A/S Protease variants and compositions
US6780629B2 (en) 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
CN1301305A (zh) 1998-03-26 2001-06-27 宝洁公司 具有氨基酸取代的丝氨酸蛋白酶变体
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
EP1082443A1 (de) * 1998-03-26 2001-03-14 The Procter & Gamble Company Serinproteasevarianten mit deletierten und substituierten aminosäuren
AU4392500A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 132 and 133
EP1183342B2 (de) 1999-05-20 2012-06-13 Novozymes A/S Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129
EP1183341B2 (de) 1999-05-20 2012-05-02 Novozymes A/S Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 127 und 128
ATE408678T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 129 und 130
AU4392800A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 126 and 127
ATE402996T1 (de) 1999-05-20 2008-08-15 Novozymes As Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurerest zwischen positionen 125 und 126
JP2003505067A (ja) 1999-07-22 2003-02-12 ザ、プロクター、エンド、ギャンブル、カンパニー 特定のエピトープ領域にアミノ酸欠失及び置換を有するサブチリシンプロテアーゼの変異体
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
MXPA02000840A (es) 1999-07-22 2002-07-30 Procter & Gamble Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
EP1196548A2 (de) 1999-07-22 2002-04-17 The Procter & Gamble Company Proteasekonjugaten mit sterisch geschützten hydrolysierbaren stellen
EP1644471A2 (de) * 1999-10-14 2006-04-12 Novozymes A/S Waschmittelzusammensetzungen mit verbesserter waschleistung enthaltend eine subtilase-variante und ein tensid
US6727085B2 (en) 1999-12-15 2004-04-27 Fanoe Tina Sejersgaard Subtilase variants having an improved wash performance on egg stains
US6777218B1 (en) 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
GB0013643D0 (en) * 2000-05-31 2000-07-26 Unilever Plc Targeted moieties for use in bleach catalysts
DE10153792A1 (de) 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
BRPI0409992A (pt) 2003-05-07 2006-05-09 Novozymes As enzima subtilase, polinucleotìdeo isolado, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, método para produzir a subtilase, composição limpadora ou detergente, usos de uma subtilase e de uma composição limpadora ou detergente, e, métodos para limpar ou lavar louças, lavar uma superfìcie dura ou lavar roupas e para remover manchas de ovo de uma superfìcie dura ou de roupas para lavar
EP1678296B1 (de) 2003-10-23 2011-07-13 Novozymes A/S Protease mit verbesserter stabilität in detergentien
DE10360805A1 (de) 2003-12-23 2005-07-28 Henkel Kgaa Neue Alkalische Protease und Wasch- und Reinigungsmittel, enthaltend diese neue Alkalische Protease
WO2005078074A2 (en) 2004-02-13 2005-08-25 Novozymes A/S Protease variants
DE102004019751A1 (de) 2004-04-23 2005-11-17 Henkel Kgaa Neue Alkalische Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Alkalischen Proteasen
EP1598367A1 (de) * 2004-05-18 2005-11-23 ZLB Behring GmbH Modifizierte Gerinnungsfaktoren mit erhöhter Stabilität und deren Derivate
US20100029538A1 (en) 2006-04-14 2010-02-04 Anna-Liisa Auterinen One-Step Treatment of Textiles
WO2007122175A1 (en) 2006-04-20 2007-11-01 Novozymes A/S Savinase variants having an improved wash performance on egg stains
BRPI0810863A2 (pt) 2007-04-30 2014-10-07 Danisco Us Inc Genencor Div Uso de hidrolisados de proteína para estabilizar formulações de detergente de metaloprotease.
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DE102007032111B4 (de) 2007-07-09 2017-07-20 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen
DE102007036756A1 (de) 2007-08-03 2009-02-05 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen
US20130224757A1 (en) 2010-08-19 2013-08-29 Novozymes A/S Induced sporulation screening method
MX350874B (es) 2011-07-01 2017-09-19 Novozymes As Composicion de detergente liquido.
CN105189724A (zh) 2013-03-14 2015-12-23 诺维信公司 含有酶和抑制剂的水溶性膜
CN105164244B (zh) 2013-05-03 2019-08-20 诺维信公司 洗涤剂酶的微囊化
EP3397061A1 (de) 2015-12-28 2018-11-07 Novozymes BioAG A/S Wärmebehandlung von bakteriensporen
JP7317811B2 (ja) 2017-09-27 2023-07-31 ノボザイムス アクティーゼルスカブ リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物
WO2019154952A1 (en) 2018-02-08 2019-08-15 Novozymes A/S Lipase variants and compositions thereof
US20210123033A1 (en) 2018-02-08 2021-04-29 Novozymes A/S Lipases, Lipase Variants and Compositions Thereof
US20210002588A1 (en) 2018-03-13 2021-01-07 Novozymes A/S Microencapsulation Using Amino Sugar Oligomers
WO2020099491A1 (en) 2018-11-14 2020-05-22 Novozymes A/S Oral care composition comprising a polypeptide having dnase activity
WO2021001400A1 (en) 2019-07-02 2021-01-07 Novozymes A/S Lipase variants and compositions thereof
JP7425459B2 (ja) * 2019-10-11 2024-01-31 株式会社シノテスト 安定化されたｈｍｇｂ１含有溶液
EP4199897A2 (de) 2020-08-24 2023-06-28 Novozymes A/S Mundpflegezusammensetzung mit einer fructanase

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WO1990014420A1 (en) * 1989-05-17 1990-11-29 Amgen Inc. Multiply mutated subtilisins

Also Published As

Publication number Publication date
EP0353250B1 (de) 1999-09-08
EP0353250A1 (de) 1990-02-07
WO1988008028A1 (en) 1988-10-20
DK496489A (da) 1989-10-06
DK496489D0 (da) 1989-10-06
EP0353250A4 (en) 1990-09-05
ATE184316T1 (de) 1999-09-15
JP3155984B2 (ja) 2001-04-16
EP0916732A1 (de) 1999-05-19
DE3856362D1 (de) 1999-10-14
DE3856362T2 (de) 2000-05-18
JP2001029076A (ja) 2001-02-06
DE3856593D1 (de) 2007-10-04
DE353250T1 (de) 1998-05-28
EP0916732B1 (de) 2007-08-22
DK175917B1 (da) 2005-06-27
JPH02502874A (ja) 1990-09-13

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