ATE407217T1 - Hochexpression und herstellung von recombinanter s-adenosyl homocysteinase mit hochspezifischer aktivität und verbesserte testverfahren für s- adenosylmethionine (sam) - Google Patents
Hochexpression und herstellung von recombinanter s-adenosyl homocysteinase mit hochspezifischer aktivität und verbesserte testverfahren für s- adenosylmethionine (sam)Info
- Publication number
- ATE407217T1 ATE407217T1 AT01900999T AT01900999T ATE407217T1 AT E407217 T1 ATE407217 T1 AT E407217T1 AT 01900999 T AT01900999 T AT 01900999T AT 01900999 T AT01900999 T AT 01900999T AT E407217 T1 ATE407217 T1 AT E407217T1
- Authority
- AT
- Austria
- Prior art keywords
- adenosylmethionine
- sam
- recombinant
- production
- specific activity
- Prior art date
Links
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title 2
- 229960001570 ademetionine Drugs 0.000 title 2
- 230000000694 effects Effects 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 108010079916 homocysteinase Proteins 0.000 title 1
- 230000001976 improved effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000012360 testing method Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17644400P | 2000-01-14 | 2000-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE407217T1 true ATE407217T1 (de) | 2008-09-15 |
Family
ID=22644371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01900999T ATE407217T1 (de) | 2000-01-14 | 2001-01-12 | Hochexpression und herstellung von recombinanter s-adenosyl homocysteinase mit hochspezifischer aktivität und verbesserte testverfahren für s- adenosylmethionine (sam) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6713273B2 (de) |
| EP (2) | EP1997508B1 (de) |
| JP (1) | JP5058422B2 (de) |
| KR (1) | KR20020065925A (de) |
| CN (2) | CN101298627A (de) |
| AT (1) | ATE407217T1 (de) |
| AU (2) | AU2001226397B2 (de) |
| CA (1) | CA2390057C (de) |
| DE (1) | DE60135632D1 (de) |
| WO (1) | WO2001051651A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7774492B2 (en) * | 2001-07-26 | 2010-08-10 | Citrix Systems, Inc. | System, method and computer program product to maximize server throughput while avoiding server overload by controlling the rate of establishing server-side net work connections |
| GB2394770A (en) * | 2002-10-10 | 2004-05-05 | Axis Shield Asa | Assay for s-adenosyl methionine (SAM) and s-adenosyl homocysteine (SAH) |
| WO2005070014A2 (en) * | 2004-01-23 | 2005-08-04 | Anticancer, Inc. | Enzymatic methionine assay |
| US7504234B2 (en) * | 2006-03-24 | 2009-03-17 | The Regents Of The University Of Michigan | Assays for S-adenosylmethionine (AdoMet)-dependent methyltransferase activity |
| KR100883530B1 (ko) * | 2007-07-30 | 2009-02-13 | 한국과학기술연구원 | 대장암 진단용 단백질 마커 아데노실호모시스테이나제 및이에 대한 항체를 포함하는 대장암 진단키트 |
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| CN103710324B (zh) * | 2013-12-09 | 2018-02-09 | 中国科学院微生物研究所 | 利用半胱氨酸水解酶家族成员制备(‑)γ内酰胺的方法 |
| CN114544826B (zh) * | 2020-11-24 | 2023-12-08 | 重庆医科大学 | 检测血浆中组氨酸的试剂在制备抑郁症检测试剂盒中的用途 |
| CN117045661B (zh) * | 2023-10-11 | 2024-01-30 | 广东医科大学附属医院 | Sahh可逆型抑制剂的应用、药物组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148888A (en) | 1978-03-13 | 1979-04-10 | The United States Of America As Represented By The Department Of Health, Education And Welfare | 3-Deazaadenosine as an inhibitor of adenosylhomocysteine hydrolase with antiviral activity |
| US5985540A (en) | 1997-07-24 | 1999-11-16 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| JP5462427B2 (ja) * | 1999-04-16 | 2014-04-02 | アンチキャンサー インコーポレーテッド | 生物学的流体のアッセイ方法 |
-
2001
- 2001-01-12 WO PCT/US2001/001114 patent/WO2001051651A2/en not_active Ceased
- 2001-01-12 DE DE60135632T patent/DE60135632D1/de not_active Expired - Lifetime
- 2001-01-12 CN CNA2008100900029A patent/CN101298627A/zh active Pending
- 2001-01-12 JP JP2001551225A patent/JP5058422B2/ja not_active Expired - Fee Related
- 2001-01-12 EP EP08015464.4A patent/EP1997508B1/de not_active Expired - Lifetime
- 2001-01-12 CN CN01803726A patent/CN1416472A/zh active Pending
- 2001-01-12 US US09/759,990 patent/US6713273B2/en not_active Expired - Fee Related
- 2001-01-12 EP EP01900999A patent/EP1250448B1/de not_active Expired - Lifetime
- 2001-01-12 KR KR1020027009060A patent/KR20020065925A/ko not_active Ceased
- 2001-01-12 CA CA2390057A patent/CA2390057C/en not_active Expired - Fee Related
- 2001-01-12 AT AT01900999T patent/ATE407217T1/de not_active IP Right Cessation
- 2001-01-12 AU AU2001226397A patent/AU2001226397B2/en not_active Ceased
- 2001-01-12 AU AU2639701A patent/AU2639701A/xx active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1416472A (zh) | 2003-05-07 |
| EP1250448B1 (de) | 2008-09-03 |
| EP1997508A3 (de) | 2009-07-01 |
| US6713273B2 (en) | 2004-03-30 |
| AU2001226397B2 (en) | 2006-06-01 |
| WO2001051651A3 (en) | 2002-01-10 |
| CN101298627A (zh) | 2008-11-05 |
| KR20020065925A (ko) | 2002-08-14 |
| CA2390057A1 (en) | 2001-07-19 |
| DE60135632D1 (de) | 2008-10-16 |
| WO2001051651A2 (en) | 2001-07-19 |
| US20020119491A1 (en) | 2002-08-29 |
| JP2004508005A (ja) | 2004-03-18 |
| JP5058422B2 (ja) | 2012-10-24 |
| EP1997508B1 (de) | 2013-07-24 |
| EP1997508A2 (de) | 2008-12-03 |
| EP1250448A2 (de) | 2002-10-23 |
| AU2639701A (en) | 2001-07-24 |
| CA2390057C (en) | 2012-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |