ATE407702T1 - Liposomale einkapselung von alphastrahlern, und deren verwendung - Google Patents

Liposomale einkapselung von alphastrahlern, und deren verwendung

Info

Publication number
ATE407702T1
ATE407702T1 AT01942205T AT01942205T ATE407702T1 AT E407702 T1 ATE407702 T1 AT E407702T1 AT 01942205 T AT01942205 T AT 01942205T AT 01942205 T AT01942205 T AT 01942205T AT E407702 T1 ATE407702 T1 AT E407702T1
Authority
AT
Austria
Prior art keywords
alphast
emitters
liposomal encapsulation
emitting
radionuclides
Prior art date
Application number
AT01942205T
Other languages
English (en)
Inventor
George Sgouros
James Louis Thomas
David Scheinberg
Michael R Mcdevitt
Original Assignee
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer
Application granted granted Critical
Publication of ATE407702T1 publication Critical patent/ATE407702T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Dental Preparations (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
AT01942205T 2000-06-16 2001-06-15 Liposomale einkapselung von alphastrahlern, und deren verwendung ATE407702T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21218600P 2000-06-16 2000-06-16

Publications (1)

Publication Number Publication Date
ATE407702T1 true ATE407702T1 (de) 2008-09-15

Family

ID=22789922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01942205T ATE407702T1 (de) 2000-06-16 2001-06-15 Liposomale einkapselung von alphastrahlern, und deren verwendung

Country Status (9)

Country Link
US (1) US20030175206A1 (de)
EP (1) EP1289570B1 (de)
JP (1) JP2003535913A (de)
AT (1) ATE407702T1 (de)
AU (2) AU2001275489B2 (de)
CA (1) CA2411826A1 (de)
DE (1) DE60135743D1 (de)
ES (1) ES2312448T3 (de)
WO (1) WO2001097859A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683162B2 (en) * 2000-09-15 2004-01-27 Sloan Kettering Institute Of Cancer Research Targeted alpha particle therapy using actinium-255 conjugates
US20080193372A1 (en) * 2004-02-10 2008-08-14 Barnes-Jewish Hospital Efficacy and Safety of Targeted Particulate Agents with Decoy Systems
GB0423565D0 (en) * 2004-10-22 2004-11-24 Algeta As Formulation
TW200922630A (en) * 2007-09-26 2009-06-01 Nat Health Research Institutes Liposome compositions useful for tumor imaging and treatment
US11798700B2 (en) 2018-03-26 2023-10-24 The University Of British Columbia Systems, apparatus and methods for separating actinium, radium, and thorium
WO2020160147A1 (en) * 2019-01-29 2020-08-06 The Johns Hopkins University Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance
US20230241256A1 (en) * 2020-06-30 2023-08-03 The Johns Hopkins University Non-intuitive combination of drug delivery carriers of the same drug for synergistic growth delay of solid tumors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
US4624846A (en) * 1983-07-29 1986-11-25 Immunomedics, Inc. Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
US4671256A (en) * 1984-05-25 1987-06-09 Lemelson Jerome H Medical scanning, monitoring and treatment system and method
US5328678A (en) * 1987-11-04 1994-07-12 Vestar, Inc. Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
AU629367B2 (en) * 1989-06-19 1992-10-01 Akzo N.V. Radioimmunotherapy using alpha-particles emission
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US5662929A (en) * 1994-12-23 1997-09-02 Universite De Montreal Therapeutic liposomal formulation
US6322810B1 (en) * 1997-07-14 2001-11-27 Hayat Alkan-Onyuksel Materials and methods for making improved micelle compositions
US6060315A (en) * 1997-12-01 2000-05-09 Lockheed Martin Energy Research Corporation Method for facilitating the introduction of material into cells
NO312708B1 (no) * 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi

Also Published As

Publication number Publication date
WO2001097859A1 (en) 2001-12-27
CA2411826A1 (en) 2001-12-27
EP1289570A1 (de) 2003-03-12
AU7548901A (en) 2002-01-02
US20030175206A1 (en) 2003-09-18
ES2312448T3 (es) 2009-03-01
JP2003535913A (ja) 2003-12-02
EP1289570B1 (de) 2008-09-10
EP1289570A4 (de) 2004-12-15
AU2001275489B2 (en) 2005-01-27
DE60135743D1 (de) 2008-10-23

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties