ATE409176T1 - 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen - Google Patents

1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen

Info

Publication number
ATE409176T1
ATE409176T1 AT04712483T AT04712483T ATE409176T1 AT E409176 T1 ATE409176 T1 AT E409176T1 AT 04712483 T AT04712483 T AT 04712483T AT 04712483 T AT04712483 T AT 04712483T AT E409176 T1 ATE409176 T1 AT E409176T1
Authority
AT
Austria
Prior art keywords
treatment
acid derivatives
neurodegenerative diseases
phenylalkanecarboxylic acid
phenylalkanecarboxylic
Prior art date
Application number
AT04712483T
Other languages
English (en)
Inventor
Luca Raveglia
Ilaria Peretto
Stefano Radaelli
Bruno Imbimbo
Andrea Rizzi
Gino Villetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20030311 external-priority patent/ITMI20030311A1/it
Priority claimed from ITMI20032068 external-priority patent/ITMI20032068A1/it
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Application granted granted Critical
Publication of ATE409176T1 publication Critical patent/ATE409176T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/12—Polycyclic non-condensed hydrocarbons
    • C07C15/14—Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT04712483T 2003-02-21 2004-02-19 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen ATE409176T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20030311 ITMI20030311A1 (it) 2003-02-21 2003-02-21 Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
ITMI20032068 ITMI20032068A1 (it) 2003-10-23 2003-10-23 Derivati dell'acido 1-fenilcicloalcancarbossilico per il trattamento delle malattie neurodegenerative.

Publications (1)

Publication Number Publication Date
ATE409176T1 true ATE409176T1 (de) 2008-10-15

Family

ID=32910543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04712483T ATE409176T1 (de) 2003-02-21 2004-02-19 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen

Country Status (16)

Country Link
US (3) US7662995B2 (de)
EP (1) EP1594833B1 (de)
JP (1) JP4472691B2 (de)
KR (2) KR101088272B1 (de)
AT (1) ATE409176T1 (de)
AU (1) AU2004213145B2 (de)
BR (1) BRPI0407662B8 (de)
CA (1) CA2514384C (de)
CY (1) CY1108514T1 (de)
DE (1) DE602004016729D1 (de)
DK (1) DK1594833T3 (de)
ES (1) ES2312964T3 (de)
NO (1) NO333118B1 (de)
PT (1) PT1594833E (de)
SI (1) SI1594833T1 (de)
WO (1) WO2004074232A1 (de)

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AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
CA2532207A1 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
MXPA06012165A (es) * 2004-04-29 2007-01-17 Keystone Retaining Wall System Chapas para muros, muros de contencion y similares.
DE602005007912D1 (de) 2004-08-03 2008-08-14 Chiesi Farma Spa Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten
BRPI0514303A (pt) * 2004-08-11 2008-06-10 Myriad Genetics Inc composição farmacêutica e método para tratar distúrbios neurodegenerativos
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
KR20080039876A (ko) * 2005-07-22 2008-05-07 미리어드 제네틱스, 인크. 높은 약물 충진 제형 및 투여형
EP2046119A2 (de) * 2006-07-07 2009-04-15 Myriad Genetics, Inc. Behandlung von psychiatrischen störungen
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
EP2133322A1 (de) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Verfahren zur Herstellung von Derivaten aus 1-(2-Halobiphenyl-4-yl)-Cyclopopancarboxy-Säure
SI2462098T1 (sl) * 2009-08-04 2014-01-31 Chiesi Farmaceutici S.P.A. Postopek priprave derivatov 1-(2-halobifenil-4-il)-ciklopropankarboksilne kisline
EP2531511A1 (de) 2010-02-03 2012-12-12 Infinity Pharmaceuticals, Inc. Fettsäureamidhydrolase-hemmer
WO2011120778A1 (en) 2010-04-01 2011-10-06 Chiesi Farmaceutici S.P.A. Novel polymorphs and salts
KR20130079353A (ko) 2010-04-21 2013-07-10 키에시 파르마슈티시 엣스. 피. 에이. 트랜스티레틴 아밀로이드증 치료용 1-(2-플루오로비페닐-4-일)-알킬 카복실산 유도체
KR20130080795A (ko) 2010-06-04 2013-07-15 키에시 파르마슈티시 엣스. 피. 에이. 프리온 질환의 치료를 위한 1-(2-플루오로비페닐-4-일)-시클로프로판카복실산 유도체
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
CN104169251A (zh) * 2012-04-04 2014-11-26 奇斯药制品公司 用于治疗神经退行性疾病的1-(2-卤代-联苯-4-基)-烷羧酸的衍生物
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (de) 2013-03-15 2016-01-20 Pfizer Inc. Indolverbindungen zur ampk-aktivierung
RU2015153818A (ru) 2013-06-24 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Усовершенствованный способ получения производных 1-(2-фтор[1, 1-бифенил]-4-ил)-циклопропанкарбоновой кислоты
EP2818460A1 (de) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation von substituierten Phenylacetonitrilen oder Phenylacetaten
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2015173133A1 (en) 2014-05-12 2015-11-19 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
WO2015181094A1 (en) 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof
WO2023034184A1 (en) 2021-08-31 2023-03-09 Cerespir Incorporated Co-crystals

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JPS4994680A (de) 1973-01-22 1974-09-09
JPS5046669A (de) 1973-03-28 1975-04-25
JPS58177977A (ja) 1982-04-09 1983-10-18 Grelan Pharmaceut Co Ltd ４−フエニルピラゾ−ル類
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JP2006517925A (ja) * 2003-01-14 2006-08-03 メルク　エンド　カムパニー　インコーポレーテッド Ａβ４２低下薬としてのジェミナル二置換ＮＳＡＩＤ誘導体
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
DE602005007912D1 (de) 2004-08-03 2008-08-14 Chiesi Farma Spa Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten
EP2133322A1 (de) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Verfahren zur Herstellung von Derivaten aus 1-(2-Halobiphenyl-4-yl)-Cyclopopancarboxy-Säure

Also Published As

Publication number Publication date
JP4472691B2 (ja) 2010-06-02
BRPI0407662A (pt) 2006-03-01
AU2004213145A1 (en) 2004-09-02
AU2004213145B2 (en) 2010-05-13
KR101088272B1 (ko) 2011-11-30
SI1594833T1 (sl) 2008-12-31
CA2514384A1 (en) 2004-09-02
US7662995B2 (en) 2010-02-16
WO2004074232A8 (en) 2005-09-09
WO2004074232A1 (en) 2004-09-02
JP2006518351A (ja) 2006-08-10
US20070060752A1 (en) 2007-03-15
NO333118B1 (no) 2013-03-04
US20100099768A1 (en) 2010-04-22
EP1594833B1 (de) 2008-09-24
PT1594833E (pt) 2008-12-03
US8314268B2 (en) 2012-11-20
KR20050104369A (ko) 2005-11-02
NO20053855L (no) 2005-11-21
NO20053855D0 (no) 2005-08-18
ES2312964T3 (es) 2009-03-01
EP1594833A1 (de) 2005-11-16
US20110288175A1 (en) 2011-11-24
KR101152448B1 (ko) 2012-07-02
DK1594833T3 (da) 2008-12-15
CA2514384C (en) 2012-04-10
CY1108514T1 (el) 2014-04-09
BRPI0407662B1 (pt) 2019-11-12
DE602004016729D1 (de) 2008-11-06
BRPI0407662B8 (pt) 2021-05-25
US8022250B2 (en) 2011-09-20
KR20110057227A (ko) 2011-05-31
HK1087398A1 (zh) 2006-10-13

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