ATE408698T1 - Kommerzielle herstellung von aprotinin in pflanzen - Google Patents

Kommerzielle herstellung von aprotinin in pflanzen

Info

Publication number: ATE408698T1
Authority: AT; Austria
Prior art keywords: aprotinin; plants; protein; commercial production; plant
Prior art date: 1995-11-06

Application number

AT96942722T

Other languages

English (en)

Inventor

John Howard

Chris Baszcynski

Thomas Czapla

Elizabeth Hood

Terry Meyer

David Peterson

A Rao

James Register

Derrick Witcher

Original Assignee

Prodigene Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-06

Filing date

1996-10-31

Publication date

2008-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24212272&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE408698(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-10-31 Application filed by Prodigene Inc filed Critical Prodigene Inc

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE408698T1 publication Critical patent/ATE408698T1/de

Links

108010039627 Aprotinin Proteins 0.000 title abstract 4
229960004405 aprotinin Drugs 0.000 title abstract 4
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 4
108090000623 proteins and genes Proteins 0.000 abstract 4
230000014509 gene expression Effects 0.000 abstract 3
102000004169 proteins and genes Human genes 0.000 abstract 3
230000002068 genetic effect Effects 0.000 abstract 2
230000010354 integration Effects 0.000 abstract 2
230000000749 insecticidal effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
210000000745 plant chromosome Anatomy 0.000 abstract 1
230000009261 transgenic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Insects & Arthropods (AREA)
Pest Control & Pesticides (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pretreatment Of Seeds And Plants (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96942722T 1995-11-06 1996-10-31 Kommerzielle herstellung von aprotinin in pflanzen ATE408698T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/554,161 US5824870A (en)	1995-11-06	1995-11-06	Commercial production of aprotinin in plants

Publications (1)

Publication Number	Publication Date
ATE408698T1 true ATE408698T1 (de)	2008-10-15

Family

ID=24212272

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96942722T ATE408698T1 (de)	1995-11-06	1996-10-31	Kommerzielle herstellung von aprotinin in pflanzen

Country Status (7)

Country	Link
US (1)	US5824870A (de)
EP (1)	EP0859852B1 (de)
AT (1)	ATE408698T1 (de)
AU (1)	AU1156797A (de)
CA (1)	CA2233538C (de)
DE (1)	DE69637685D1 (de)
WO (1)	WO1997017453A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7071384B2 (en)	1997-03-07	2006-07-04	Genencor International, Inc.	Methods for commercial production of heterologous laccase in plant tissue and extraction of the laccase from plant seed
CA2281830C (en)	1997-03-07	2007-06-19	Prodigene, Inc.	Methods of commercial production and extraction of protein from seed
WO1998039461A1 (en) *	1997-03-20	1998-09-11	Prodigene Inc.	Methods of commercial production and extraction of protein from seed
AR020090A1 (es) *	1998-06-15	2002-04-10	John Innes Ct	Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion
US6512162B2 (en)	1998-07-10	2003-01-28	Calgene Llc	Expression of eukaryotic peptides in plant plastids
JP2002520019A (ja) *	1998-07-10	2002-07-09	カルジーンエルエルシー	植物色素体における真核性ペプチドの発現
US6232527B1 (en) *	1998-12-15	2001-05-15	Pioneer Hi-Bred International, Inc.	Maize Rad2/FEN-1 orthologues and uses thereof
US7390936B1 (en) *	1999-08-23	2008-06-24	Sembiosys Genetics Inc.	Commercial production of chymosin in plants
CA2384828A1 (en) *	1999-09-21	2001-03-29	Zivko Nikolov	Methods for producing recombinant proteins
WO2002096923A1 (en)	2001-05-30	2002-12-05	Chromos Molecular Systems, Inc.	Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes
ES2348230T3 (es)	2002-06-07	2010-12-01	Dyax Corp.	Prevención y reducción de la isquemia.
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
CA2490781A1 (en)	2002-06-28	2004-01-08	University Of Guelph	Harvest-inducible genes from alfalfa (medicago sativa) and methods of use thereof
US7329798B2 (en) *	2002-06-28	2008-02-12	University Of Guelph	Harvest-inducible regulatory elements and methods of using same
US20040106198A1 (en) *	2002-07-16	2004-06-03	Large Scale Biology Corporation	Inhibition of peptide cleavage in plants
US7235530B2 (en) *	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006042327A2 (en) *	2004-10-12	2006-04-20	Large Scale Biology Corporation	Plant-produced recombinant aprotinin and aprotinin variants
US10150970B2 (en)	2011-07-27	2018-12-11	Applied Biotechnology Institute, Inc.	Methods to increase antigenicity of membrane-bound polypeptides produced in plants
US10428158B2 (en)	2014-03-27	2019-10-01	Dyax Corp.	Compositions and methods for treatment of diabetic macular edema
US11090380B2 (en)	2018-06-04	2021-08-17	Applied Biotechnology Institute, Inc.	Methods and compositions to increase immune response to vaccines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4956282A (en) *	1985-07-29	1990-09-11	Calgene, Inc.	Mammalian peptide expression in plant cells
US4914025A (en) *	1985-12-05	1990-04-03	Colin Manoil	Export of intra-cellular substances
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
DE58909876D1 (de) *	1988-06-20	2000-09-14	Novartis Ag	Verfahren zur Bekämpfung von Pflanzenschädlingen mit nicht-pflanzlichen Proteinase-Inhibitoren
WO1990001551A1 (en) *	1988-07-29	1990-02-22	Washington University School Of Medicine	Producing commercially valuable polypeptides with genetically transformed endosperm tissue
NL8901932A (nl) *	1989-07-26	1991-02-18	Mogen Int	Produktie van heterologe eiwitten in planten of plantecellen.
US5258302A (en) *	1990-07-03	1993-11-02	The Salk Institute Biotechnology/Industrial Associates, Inc.	DNA for expression of aprotinin in methylotrophic yeast cells
WO1993021320A1 (en) *	1991-02-22	1993-10-28	University Technologies International, Inc.	Oil-body proteins as carriers of high-value peptides in plants
WO1993020217A1 (fr) *	1992-03-31	1993-10-14	Kanebo Limited	Vecteur de virus vegetal, plasmide, procede d'expression d'un gene etranger, et procede de recuperation dudit gene etranger
US5460952A (en) *	1992-11-04	1995-10-24	National Science Counsil Of R.O.C.	Gene expression system comprising the promoter region of the α-amylase genes
BR9405668A (pt) *	1993-01-25	1995-11-21	Pioneer Hi Bred Int	Processo para a destruição insetos ou larvas processo para conferir a resistência ao caruncho europeu do milho e ao verme de raiz do milho do sul seqüència isolada de DNA cassete de expressão células bacterianas células vegetais transformadas cultura de células ou de tecido de milho planta de milho transformada composição larvicida e processo de destruição ou controle de pragas de insetos de material vegetal colhido
US5693506A (en) *	1993-11-16	1997-12-02	The Regents Of The University Of California	Process for protein production in plants

1995
- 1995-11-06 US US08/554,161 patent/US5824870A/en not_active Expired - Lifetime
1996
- 1996-10-31 AU AU11567/97A patent/AU1156797A/en not_active Abandoned
- 1996-10-31 WO PCT/US1996/017089 patent/WO1997017453A1/en not_active Ceased
- 1996-10-31 EP EP96942722A patent/EP0859852B1/de not_active Expired - Lifetime
- 1996-10-31 AT AT96942722T patent/ATE408698T1/de not_active IP Right Cessation
- 1996-10-31 CA CA2233538A patent/CA2233538C/en not_active Expired - Lifetime
- 1996-10-31 DE DE69637685T patent/DE69637685D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69637685D1 (de)	2008-10-30
US5824870A (en)	1998-10-20
AU1156797A (en)	1997-05-29
CA2233538C (en)	2010-05-25
WO1997017453A1 (en)	1997-05-15
CA2233538A1 (en)	1997-05-15
EP0859852B1 (de)	2008-09-17
EP0859852A1 (de)	1998-08-26

Legal Events

Date	Code	Title	Description
2009-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties
2010-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE408698T1 (de)	2008-10-15	Kommerzielle herstellung von aprotinin in pflanzen
WO1997017455A3 (en)	1997-09-12	Commercial production of avidin in plants
Hooykaas et al.	1984	The molecular genetics of crown gall tumorigenesis
EP1602729A3 (de)	2005-12-14	Verfahren zur Herstellung transgener Pflanzen
DK1034262T3 (da)	2005-11-28	Sammensætninger og fremgangsmåder til genetisk modifikation af planter
DE60041006D1 (de)	2009-01-15	Stress-gekoppelte kalium kanal proteine sowie methoden zu deren verwendung in pflanzen
AR072797A2 (es)	2010-09-22	Construccion de adn, su uso para el control de la expresion genetica en plantas y metodo para obtener una planta transgenica
DE69434308D1 (de)	2005-04-28	Isolierte DNA-Sequenz, die als Terminatorregion in chimären Genen zur Transformation von Pflanzen eingesetzt werden kann
AR089780A2 (es)	2014-09-17	Secuencias reguladoras para el control selectivo de la expresion de genes en plantas
AU631551B2 (en)	1992-12-03	Method of controlling plant pests
ATE466088T1 (de)	2010-05-15	Zufällige integration von polynukleotide nach in vivo linearisierung
WO1997017454A3 (en)	1997-12-24	COMMERCIAL PRODUCTION OF β-GLUCURONEDASE IN PLANTS
DE69636782D1 (de)	2007-02-01	Wurzelrinden spezifischer genpromoter
DE69432543D1 (de)	2003-05-28	Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
ATE328093T1 (de)	2006-06-15	Expression von phytase in pflanzen
ATE411391T1 (de)	2008-10-15	Verfahren zur herstellung stresstoleranter pflanzen
TW367365B (en)	1999-08-21	An improved method for obtaining plant somatic embryos about the somatic embryo suspension cultures and pro-embryogenic mass suspension cultures
DE60027570D1 (de)	2006-06-01	Verfahren zur herstellung künstlicher pflanzenchromosomen
EP0334539A3 (de)	1990-11-28	Genetische Manipulation
DE3575136D1 (de)	1990-02-08	Cyclohexenonderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses.
ATE263839T1 (de)	2004-04-15	Verfahren zur herstellung von proteinen in pflanzenflüssigkeiten
CA2305576A1 (en)	1999-04-15	A process for obtaining transgenic leguminous plants (leguminosae) containing exogenous dna
CA2422752A1 (en)	2002-02-14	Map-based genome mining method for identifying regulatory loci controlling the level of gene transcripts and products
EP0317509A3 (de)	1990-01-31	Gezielter Einbau von Genen ins pflanzliche Genom
DE69030306D1 (de)	1997-04-30	Verfahren zur ortsspezifischen integration von dna ins pflanzliche genom