ATE409694T1 - Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii - Google Patents

Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii

Info

Publication number: ATE409694T1
Authority: AT; Austria
Prior art keywords: dihydro; semi; taxan; acetylbaccatin iii; iii
Prior art date: 2003-10-27

Application number

AT04796503T

Other languages

English (en)

Inventor

Ragina Naidu

Original Assignee

Chatham Biotec Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-27

Filing date

2004-10-27

Publication date

2008-10-15

2004-10-27 Application filed by Chatham Biotec Ltd filed Critical Chatham Biotec Ltd

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE409694T1 publication Critical patent/ATE409694T1/de

Links

WPPPFZJNKLMYBW-FAEUQDRCSA-N 13-acetyl-9-dihydrobaccatin iii Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(C)=O)[C@H](O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]31)OC(C)=O)C2(C)C)C)OC(=O)C)C(=O)C1=CC=CC=C1 WPPPFZJNKLMYBW-FAEUQDRCSA-N 0.000 title abstract 4
FFCWRLFQIKDRNO-UHFFFAOYSA-N 9-dihydro-13-acetyl baccatin III Natural products CC(=O)OC1C2C(O)CC(OC(=O)C)C3(CO3)C2C(OC(=O)C)C4(O)CC(OC(=O)C)C(=C(C1OC(=O)C)C4(C)C)C FFCWRLFQIKDRNO-UHFFFAOYSA-N 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 3
239000013067 intermediate product Substances 0.000 title 1
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 2
229960003668 docetaxel Drugs 0.000 abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
HOJZAHQWDXAPDJ-UHFFFAOYSA-N 3-anilino-2-hydroxypropanoic acid Chemical group OC(=O)C(O)CNC1=CC=CC=C1 HOJZAHQWDXAPDJ-UHFFFAOYSA-N 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
125000003834 baccatin III group Chemical group 0.000 abstract 1
238000003780 insertion Methods 0.000 abstract 1
230000037431 insertion Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

AT04796503T 2003-10-27 2004-10-27 Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii ATE409694T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/695,416 US7202370B2 (en)	2003-10-27	2003-10-27	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III

Publications (1)

Publication Number	Publication Date
ATE409694T1 true ATE409694T1 (de)	2008-10-15

Family

ID=34549976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04796503T ATE409694T1 (de)	2003-10-27	2004-10-27	Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii

Country Status (7)

Country	Link
US (1)	US7202370B2 (de)
EP (2)	EP2003124B1 (de)
AT (1)	ATE409694T1 (de)
CA (1)	CA2583366C (de)
DE (1)	DE602004016888D1 (de)
TW (1)	TW200608958A (de)
WO (1)	WO2005044811A2 (de)

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US7893283B2 (en) *	2004-06-04	2011-02-22	Chatham Biotec, Limited	Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
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US7847111B2 (en) *	2006-06-19	2010-12-07	Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
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CN101835769A (zh) *	2007-08-22	2010-09-15	6570763加拿大有限公司	将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
CN101735179B (zh) *	2008-11-19	2012-09-12	上海百灵医药科技有限公司	一种多烯紫杉醇的制备方法，其中间体及制备方法
KR101096282B1 (ko) *	2009-04-24	2011-12-20	주식회사 삼양제넥스	탁산 유도체를 제조하는 방법
CN102408397B (zh)	2011-10-19	2014-08-20	上海贝美医药科技有限公司	紫杉烷类衍生物及其制备方法
CN104592173A (zh) *	2014-12-31	2015-05-06	宁波绿之健药业有限公司	一种由9-dhb合成10-dab的制备方法

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2003
- 2003-10-27 US US10/695,416 patent/US7202370B2/en not_active Expired - Fee Related
2004
- 2004-09-07 TW TW093126988A patent/TW200608958A/zh unknown
- 2004-10-27 AT AT04796503T patent/ATE409694T1/de not_active IP Right Cessation
- 2004-10-27 CA CA2583366A patent/CA2583366C/en not_active Expired - Fee Related
- 2004-10-27 EP EP08165422.0A patent/EP2003124B1/de not_active Expired - Lifetime
- 2004-10-27 DE DE602004016888T patent/DE602004016888D1/de not_active Expired - Lifetime
- 2004-10-27 EP EP04796503A patent/EP1727810B1/de not_active Expired - Lifetime
- 2004-10-27 WO PCT/US2004/035583 patent/WO2005044811A2/en not_active Ceased

Also Published As

Publication number	Publication date
EP2003124A1 (de)	2008-12-17
US20050101789A1 (en)	2005-05-12
CA2583366A1 (en)	2005-05-19
WO2005044811A3 (en)	2005-09-29
EP1727810A2 (de)	2006-12-06
DE602004016888D1 (de)	2008-11-13
EP1727810B1 (de)	2008-10-01
TW200608958A (en)	2006-03-16
WO2005044811A2 (en)	2005-05-19
US7202370B2 (en)	2007-04-10
EP2003124B1 (de)	2015-02-25
CA2583366C (en)	2012-06-12

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE409694T1 (de)	2008-10-15	Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii
NO20071835L (no)	2007-05-07	Semisynteseprosess for fremstillingen av 10-deacetyl-N-debenzoyl-paklitaxel.
AR047683A1 (es)	2006-02-01	Pirazoles para el tratamiento de obesidad y trastornos psiquiatricos
FR2696463B1 (fr)	1994-11-25	Procédé d'obtention de la désacétyl-10 baccatine III.
ATE398114T1 (de)	2008-07-15	Eintopfsynthese von taxanderivaten und deren umwandlung in paclitaxel und docetaxel
RU2000104089A (ru)	2001-11-27	Способ превращения 9-дигидро-13-ацетилбаккатина iii в таксол и его производные
ATE431343T1 (de)	2009-05-15	Thio-analoga von paclitaxel und deren vorprodukte
CY1113176T1 (el)	2016-04-13	Παρασκευη ταξανων απο 9-διυδρο-13-ακετυλοβακκατινη iii
DE60001265D1 (de)	2003-02-27	Verfahren zu herstellung von taxanen aus 10-desacetylbaccatin iii
TW200604153A (en)	2006-02-01	Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
WO2005082875A3 (en)	2005-11-17	Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
DK0981358T3 (da)	2003-09-22	Dolastatin-15-derivater i kombinationer med taxaner
NO20002600L (no)	2000-07-17	Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
ZA200006004B (en)	2002-05-03	Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-CBZ 10-Deacetylbaccatin III.
WO2008054233A3 (en)	2008-10-02	Process for the preparation of docetaxel
NZ514407A (en)	2004-12-24	C10 carbamoyloxy substituted taxanes as antitumor agents
DE60133600D1 (de)	2008-05-29	C7-carbamoyloxysubstituierte taxane als antitumormittel
DE60144113D1 (de)	2011-04-07	Verfahren zur herstellung von taxanderivaten
TR200003168T2 (tr)	2001-06-21	C-7, C-10 DI-CBZ bakkatin III'ten paklitaksel sentezi için yararlı aracılar ve yöntemler
DK1495011T3 (da)	2006-05-15	Semisyntetisk fremgangsmåde til fremstilling af N-debenzoylpaclitaxel
HUP0103246A2 (hu)	2003-07-28	C10 karbonát szubsztituált taxánok