NO20074861L - Fremgangsmate for fremstilling av docetaxel - Google Patents

Fremgangsmate for fremstilling av docetaxel

Info

Publication number
NO20074861L
NO20074861L NO20074861A NO20074861A NO20074861L NO 20074861 L NO20074861 L NO 20074861L NO 20074861 A NO20074861 A NO 20074861A NO 20074861 A NO20074861 A NO 20074861A NO 20074861 L NO20074861 L NO 20074861L
Authority
NO
Norway
Prior art keywords
hydroxy groups
iii
positions
docetaxel
protected hydroxy
Prior art date
Application number
NO20074861A
Other languages
English (en)
Inventor
Antoine Paul Gaston Leze
Regis Perion
Original Assignee
Seripharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35106645&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20074861(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seripharm filed Critical Seripharm
Publication of NO20074861L publication Critical patent/NO20074861L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Fremgangsmåte for fremstilling av docetaxel fra paclitaxel, hvori man utfører følgende trinn:. a) acetylering av paclitaxel. b) beskyttelse av de frie hydroksyfunksjonene henholdsvis i stilling -7,-10 og -2', c) avbenzoylering av amin i stilling -3' til et primæramin avledet fra 10-deacetylbaccatin, hvorav hydroksyfunksj onene i stilling -7, -10 og -2' er beskyttet, d) funksjonalisering av aminet ved et t-butoksykarbonylradikal for å oppnå et du docetaxelderivat med generell formel: hvori X representerer beskyttende radikaler eller hydrogenatomer, deretter eventuelt, e) frigjøring av hydroksyfunksj onene først beskyttet for å oppnå docetaxel.
NO20074861A 2005-02-24 2007-09-24 Fremgangsmate for fremstilling av docetaxel NO20074861L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0501882A FR2882363B1 (fr) 2005-02-24 2005-02-24 Procede de preparation du docetaxel
PCT/FR2006/000386 WO2006090056A1 (fr) 2005-02-24 2006-02-21 Procede de preparation du docetaxel

Publications (1)

Publication Number Publication Date
NO20074861L true NO20074861L (no) 2007-11-26

Family

ID=35106645

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074861A NO20074861L (no) 2005-02-24 2007-09-24 Fremgangsmate for fremstilling av docetaxel

Country Status (16)

Country Link
US (1) US20080200699A1 (no)
EP (1) EP1856080B1 (no)
JP (1) JP2008531527A (no)
KR (1) KR20070108188A (no)
CN (1) CN101128449A (no)
AT (1) ATE490245T1 (no)
AU (1) AU2006217803A1 (no)
BR (1) BRPI0607989A2 (no)
CA (1) CA2596696A1 (no)
DE (1) DE602006018584D1 (no)
FR (1) FR2882363B1 (no)
IL (1) IL185464A0 (no)
MX (1) MX2007010331A (no)
NO (1) NO20074861L (no)
RU (1) RU2007134454A (no)
WO (1) WO2006090056A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2914642B1 (fr) * 2007-04-03 2009-10-16 Seripharm Procede de preparation de taxanes 3'-n-substitues a partir du paclitaxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN103808851A (zh) * 2012-11-15 2014-05-21 刘胜远 一种红豆杉中10-去乙酰基紫杉醇的薄层色谱检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679807A (en) * 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US20040132991A1 (en) * 2002-10-09 2004-07-08 Phytogen Life Sciences Inc. Novel taxanes and methods related to use and preparation thereof

Also Published As

Publication number Publication date
EP1856080B1 (fr) 2010-12-01
JP2008531527A (ja) 2008-08-14
CA2596696A1 (fr) 2006-08-31
EP1856080A1 (fr) 2007-11-21
IL185464A0 (en) 2008-01-06
US20080200699A1 (en) 2008-08-21
FR2882363A1 (fr) 2006-08-25
AU2006217803A1 (en) 2006-08-31
DE602006018584D1 (de) 2011-01-13
BRPI0607989A2 (pt) 2009-10-27
WO2006090056A1 (fr) 2006-08-31
KR20070108188A (ko) 2007-11-08
FR2882363B1 (fr) 2007-05-11
CN101128449A (zh) 2008-02-20
RU2007134454A (ru) 2009-03-27
ATE490245T1 (de) 2010-12-15
MX2007010331A (es) 2008-03-04

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application