ATE409749T1 - Verfahren zur reinigung von alphaviralen replikon partikeln - Google Patents
Verfahren zur reinigung von alphaviralen replikon partikelnInfo
- Publication number
- ATE409749T1 ATE409749T1 AT01941874T AT01941874T ATE409749T1 AT E409749 T1 ATE409749 T1 AT E409749T1 AT 01941874 T AT01941874 T AT 01941874T AT 01941874 T AT01941874 T AT 01941874T AT E409749 T1 ATE409749 T1 AT E409749T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- purifying
- replicon particles
- purification
- disclosed
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 3
- 241000710929 Alphavirus Species 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36151—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Powder Metallurgy (AREA)
- Disintegrating Or Milling (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20837600P | 2000-05-31 | 2000-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409749T1 true ATE409749T1 (de) | 2008-10-15 |
Family
ID=22774372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01941874T ATE409749T1 (de) | 2000-05-31 | 2001-05-31 | Verfahren zur reinigung von alphaviralen replikon partikeln |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6767699B2 (de) |
| EP (1) | EP1285080B1 (de) |
| AT (1) | ATE409749T1 (de) |
| AU (1) | AU2001275191A1 (de) |
| CA (1) | CA2410948C (de) |
| DE (1) | DE60135983D1 (de) |
| DK (1) | DK1285080T3 (de) |
| ES (1) | ES2312447T3 (de) |
| WO (1) | WO2001092552A2 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| ES2624854T3 (es) | 2001-05-31 | 2017-07-17 | Glaxosmithkline Biologicals Sa | Partículas de replicón de alfavirus quimérico |
| ES2330202T5 (es) * | 2001-09-06 | 2014-01-20 | Alphavax, Inc. | Sistemas vectores basados en replicones de alfavirus |
| US7195905B2 (en) * | 2001-12-10 | 2007-03-27 | Baxter Healthcare S.A. | Enveloped virus vaccine and method for production |
| MXPA04010603A (es) | 2002-04-30 | 2004-12-13 | Oncolytics Biotech Inc | Metodos mejorados de purificacion viral. |
| WO2004030631A2 (en) | 2002-10-01 | 2004-04-15 | Chiron Corporation | Anti-cancer and anti-infectious disease compositions and methods for using same |
| CA2509973C (en) * | 2002-12-13 | 2013-02-26 | Alphavax, Inc. | Multi-antigenic alphavirus replicon particles and methods |
| DK3246399T3 (da) * | 2002-12-13 | 2021-10-04 | Alphavax Inc | Alfavirus-partikler og fremgangsmåder til fremstilling |
| MXPA05010007A (es) * | 2003-03-20 | 2006-03-10 | Alphavax Inc | Replicones de alfavirus y construcciones auxiliares mejorados. |
| PT1651666E (pt) * | 2003-07-11 | 2009-08-28 | Alphavax Inc | Vacinas de citomegalovírus à base de alfavírus |
| MXPA06013124A (es) | 2004-05-18 | 2007-05-23 | Alphavax Inc | Vectores de alfavirus derivados de tc-83, particulas y metodos. |
| US20090104226A1 (en) | 2004-05-21 | 2009-04-23 | Novartis Vaccines And Diagnostics Inc. | Alphavirus Vectors for Respiratory Pathogen Vaccines |
| US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
| EP1736538A1 (de) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Prozess für die preparative Reinigung von Virus-ähnlichen Partikeln (VLPs) |
| KR100760525B1 (ko) * | 2006-04-13 | 2007-10-04 | 김재만 | 병원성 미생물의 무증폭 다중 정량 검출킷트 및 검출방법 |
| US20090022760A1 (en) * | 2006-09-12 | 2009-01-22 | Alphavax | Alphavirus Replicon Particles Matched to Protein Antigens as Immunological Adjuvants |
| ES2746960T3 (es) | 2006-09-12 | 2020-03-09 | Alphavax Inc | Partículas de replicón de alfavirus que codifican IL-12 como adyuvantes inmunológicos |
| US20090047255A1 (en) * | 2006-11-03 | 2009-02-19 | Alphavax, Inc. | Alphavirus and Alphavirus Replicon Particle Formulations and Methods |
| WO2008156829A2 (en) * | 2007-06-21 | 2008-12-24 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
| ES2525707T3 (es) | 2008-12-01 | 2014-12-29 | Alphavax, Inc. | Uso de microRNAs para el control de ácidos nucleicos colaboradores de virus |
| CN105056229A (zh) | 2009-01-05 | 2015-11-18 | 埃皮托吉尼西斯股份有限公司 | 佐剂组合物及使用方法 |
| US10072307B1 (en) | 2009-01-23 | 2018-09-11 | Colorado State University Research Foundation | Isolation of viruses using anionic resin beads |
| ES2540958T3 (es) | 2009-04-08 | 2015-07-15 | Alphavax, Inc. | Partículas de replicón de alfavirus que expresan TRP2 |
| EP2598223B1 (de) | 2010-07-30 | 2022-04-06 | EMD Millipore Corporation | Chromatographiemedien und verfahren |
| EP2625264B1 (de) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem mit steuerungsbedingungen |
| BR112013032410A2 (pt) | 2011-06-24 | 2017-01-17 | Epitogenesis Inc | composições farmacêuticas compreendendo uma combinação de veículos, vitaminas, taninos e flavonoides de seleção como imunomoduladores específicos de antígeno |
| EP3068866B1 (de) | 2013-11-16 | 2018-04-25 | Terumo BCT, Inc. | Zellenexpansion in einem bioreaktor |
| JP6783143B2 (ja) | 2014-03-25 | 2020-11-11 | テルモ ビーシーティー、インコーポレーテッド | 培地の受動的補充 |
| CN106794389A (zh) | 2014-09-02 | 2017-05-31 | Emd密理博公司 | 具有纳米原纤化表面特征的高表面积纤维介质 |
| CN106715676A (zh) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
| CN107001410A (zh) | 2014-12-08 | 2017-08-01 | Emd密理博公司 | 混合床离子交换吸附剂 |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| CA3009278A1 (en) | 2015-12-23 | 2017-06-29 | Valneva Austria Gmbh | Zika virus vaccine |
| CN109415696A (zh) | 2016-05-25 | 2019-03-01 | 泰尔茂比司特公司 | 细胞扩增 |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| EP3684404A1 (de) | 2017-09-21 | 2020-07-29 | Valneva SE | Verfahren zur herstellung von pharmazeutischen zusammensetzungen mit immunogenem chikungunya-virus chikv-delta5nsp3 |
| NL2022538B1 (en) | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
| US12043823B2 (en) | 2021-03-23 | 2024-07-23 | Terumo Bct, Inc. | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| AU2024208643A1 (en) | 2023-01-12 | 2025-06-26 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE |
| WO2024163370A1 (en) * | 2023-01-30 | 2024-08-08 | Thermo Finnigan Llc | Separation of long oligonucleotides |
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| ES8800988A1 (es) | 1985-04-05 | 1987-12-16 | Meloy Lab | Procedimiento de producir interferona humana. |
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| WO1998026084A1 (en) | 1996-12-09 | 1998-06-18 | Wolfgang Andreas Renner | Expression of active interferon beta 1 using recombinant rna replicons |
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| US5811407A (en) | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
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-
2001
- 2001-05-31 AU AU2001275191A patent/AU2001275191A1/en not_active Abandoned
- 2001-05-31 EP EP01941874A patent/EP1285080B1/de not_active Expired - Lifetime
- 2001-05-31 CA CA2410948A patent/CA2410948C/en not_active Expired - Fee Related
- 2001-05-31 US US09/872,086 patent/US6767699B2/en not_active Expired - Fee Related
- 2001-05-31 DK DK01941874T patent/DK1285080T3/da active
- 2001-05-31 DE DE60135983T patent/DE60135983D1/de not_active Expired - Lifetime
- 2001-05-31 ES ES01941874T patent/ES2312447T3/es not_active Expired - Lifetime
- 2001-05-31 AT AT01941874T patent/ATE409749T1/de active
- 2001-05-31 WO PCT/US2001/018021 patent/WO2001092552A2/en not_active Ceased
-
2004
- 2004-06-29 US US10/881,575 patent/US20050112752A1/en not_active Abandoned
-
2008
- 2008-09-18 US US12/212,978 patent/US20100055128A1/en not_active Abandoned
-
2012
- 2012-03-27 US US13/430,920 patent/US20120231526A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100055128A1 (en) | 2010-03-04 |
| EP1285080B1 (de) | 2008-10-01 |
| DK1285080T3 (da) | 2008-12-01 |
| US20120231526A1 (en) | 2012-09-13 |
| CA2410948A1 (en) | 2001-12-06 |
| CA2410948C (en) | 2012-07-17 |
| EP1285080A2 (de) | 2003-02-26 |
| AU2001275191A1 (en) | 2001-12-11 |
| US20050112752A1 (en) | 2005-05-26 |
| WO2001092552A2 (en) | 2001-12-06 |
| US20020015945A1 (en) | 2002-02-07 |
| US6767699B2 (en) | 2004-07-27 |
| ES2312447T3 (es) | 2009-03-01 |
| DE60135983D1 (de) | 2008-11-13 |
| WO2001092552A3 (en) | 2002-05-23 |
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