ATE410459T1 - Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung - Google Patents
Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendungInfo
- Publication number
- ATE410459T1 ATE410459T1 AT03707375T AT03707375T ATE410459T1 AT E410459 T1 ATE410459 T1 AT E410459T1 AT 03707375 T AT03707375 T AT 03707375T AT 03707375 T AT03707375 T AT 03707375T AT E410459 T1 ATE410459 T1 AT E410459T1
- Authority
- AT
- Austria
- Prior art keywords
- chiral
- polyketals
- methods
- biodegradable biocompatible
- polyketal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G16/00—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00
- C08G16/02—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes
- C08G16/04—Chemically modified polycondensates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
- C08L59/02—Polyacetals containing polyoxymethylene sequences only
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34833302P | 2002-01-14 | 2002-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE410459T1 true ATE410459T1 (de) | 2008-10-15 |
Family
ID=23367539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03707375T ATE410459T1 (de) | 2002-01-14 | 2003-01-14 | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7838619B2 (de) |
| EP (1) | EP1468036B1 (de) |
| AT (1) | ATE410459T1 (de) |
| AU (1) | AU2003209227A1 (de) |
| DE (1) | DE60323936D1 (de) |
| WO (1) | WO2003059988A2 (de) |
Families Citing this family (65)
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|---|---|---|---|---|
| CA2374003C (en) * | 1999-05-17 | 2008-02-12 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| DE60323936D1 (de) | 2002-01-14 | 2008-11-20 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
| WO2003070823A2 (en) * | 2002-02-20 | 2003-08-28 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
| EP1534269B1 (de) * | 2002-07-19 | 2013-10-30 | The General Hospital Corporation | Oxim-konjugate und verfahren zu ihrer bildung und verwendung |
| CA2493764C (en) * | 2002-08-01 | 2011-05-24 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
| ATE507845T1 (de) * | 2003-09-05 | 2011-05-15 | Gen Hospital Corp | Polyacetal-arzneimittelkonjugate als freisetzungssystem |
| WO2006122223A2 (en) * | 2005-05-10 | 2006-11-16 | Emory University | Strategies for delivery of active agents using micelles and particles |
| EP1954140B1 (de) | 2005-11-22 | 2013-05-29 | Segetis, Inc. | Glycerinlevulinatketale und ihre verwendung |
| US7741375B2 (en) | 2006-02-17 | 2010-06-22 | Medtronic, Inc | Polyketal polymers, and methods of making and using same |
| US7850382B2 (en) * | 2007-01-18 | 2010-12-14 | Sanford, L.P. | Valve made from two materials and writing utensil with retractable tip incorporating same |
| US7488130B2 (en) | 2007-02-01 | 2009-02-10 | Sanford, L.P. | Seal assembly for retractable instrument |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| WO2009032905A1 (en) | 2007-09-04 | 2009-03-12 | Segetis, Inc. | Ketal compounds from polyols and oxocarboxylates |
| BRPI0820229A2 (pt) * | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| US8226312B2 (en) * | 2008-03-28 | 2012-07-24 | Sanford, L.P. | Valve door having a force directing component and retractable instruments comprising same |
| WO2009146202A2 (en) * | 2008-04-16 | 2009-12-03 | Segetis, Inc. | Transketalized compositions, synthesis, and applications |
| US8399600B2 (en) * | 2008-08-07 | 2013-03-19 | Sigma-Aldrich Co. Llc | Preparation of low molecular weight polylysine and polyornithine in high yield |
| WO2010036884A1 (en) | 2008-09-25 | 2010-04-01 | Segetis, Inc. | Ketal ester derivatives |
| US8221012B2 (en) * | 2008-11-07 | 2012-07-17 | Sanford, L.P. | Retractable instruments comprising a one-piece valve door actuating assembly |
| AR074584A1 (es) | 2008-12-10 | 2011-01-26 | Mersana Therapeutics Inc | Formulaciones farmaceuticas de conjugados camtotecina-polimero biocompatibles biodegradables |
| US8393814B2 (en) | 2009-01-30 | 2013-03-12 | Sanford, L.P. | Retractable instrument having a two stage protraction/retraction sequence |
| BRPI1013943B1 (pt) | 2009-06-22 | 2020-03-17 | Segetis, Inc. | Composto, método para sintetizar o mesmo, composição e composição lubrificante |
| WO2011038117A2 (en) | 2009-09-23 | 2011-03-31 | The Regents Of The University Of California | Chemically amplified response strategies for medical sciences |
| WO2011041487A1 (en) | 2009-09-30 | 2011-04-07 | Innovotech, Llc | Biocompatible and biodegradable polymers from renewable natural polyphenols |
| EP2553019A1 (de) | 2010-03-26 | 2013-02-06 | Mersana Therapeutics, Inc. | Modifizierte polymere zur freisetzung von polynukleotiden, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung |
| AU2011250962B2 (en) | 2010-05-10 | 2015-09-03 | Gfbiochemicals Limited | Personal care formulations containing alkyl ketal esters and methods of manufacture |
| US9074065B2 (en) | 2010-08-12 | 2015-07-07 | Segetis, Inc. | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof |
| WO2012021824A2 (en) | 2010-08-12 | 2012-02-16 | Segetis, Inc. | Carboxy ester ketal removal compositions, methods of manufacture, and uses thereof |
| WO2012037122A2 (en) | 2010-09-13 | 2012-03-22 | Segetis, Inc. | Fabric softener compositions and methods of manufacture thereof |
| US8758778B2 (en) | 2010-09-16 | 2014-06-24 | The Regents Of The University Of California | Polymeric nano-carriers with a linear dual response mechanism and uses thereof |
| WO2012054505A2 (en) | 2010-10-18 | 2012-04-26 | Segetis, Inc. | Water reducible coating compositions including carboxy ester ketals, methods of manufacture, and uses thereof |
| KR20140009179A (ko) | 2010-11-11 | 2014-01-22 | 세게티스, 인코포레이티드. | 폴리케탈 부가물, 그의 제조방법 및 용도 |
| US8507718B2 (en) | 2010-11-11 | 2013-08-13 | Segetis, Inc. | Ketocarboxylic acids, methods of manufacture and uses thereof |
| US9187598B2 (en) | 2010-11-11 | 2015-11-17 | Segetis, Inc. | Polyhydroxy ketal ester adducts, methods of manufacture and uses thereof |
| US8728453B2 (en) | 2011-02-28 | 2014-05-20 | Innovotech, Llc | Combinatorial polymeric compositions for drug delivery |
| WO2012171020A1 (en) | 2011-06-10 | 2012-12-13 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| RU2633640C2 (ru) * | 2011-09-16 | 2017-10-16 | Ферринг Б.В. | Быстрорастворимая фармацевтическая композиция |
| EP2890372A4 (de) | 2012-08-28 | 2016-01-27 | Univ California | Polymere nanoträger mit einem durch licht ausgelösten-freisetzungsmechanismus |
| US9458414B2 (en) | 2012-09-21 | 2016-10-04 | Gfbiochemicals Limited | Cleaning, surfactant, and personal care compositions |
| JP2016506383A (ja) | 2012-11-29 | 2016-03-03 | サジティス・インコーポレイテッド | カルボキシエステルケタール、その製造方法および使用 |
| WO2014093379A1 (en) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| EP3046956B1 (de) | 2013-09-19 | 2019-08-28 | Microvention, Inc. | Polymerfilme |
| AU2014321277B2 (en) | 2013-09-19 | 2017-07-20 | Terumo Corporation | Polymer particles |
| ES2754397T3 (es) | 2013-10-11 | 2020-04-17 | Asana Biosciences Llc | Conjugados de proteína-polímero-fármaco |
| KR102087850B1 (ko) | 2013-10-11 | 2020-03-12 | 메르사나 테라퓨틱스, 인코포레이티드 | 단백질-고분자-약물 접합체 |
| EP3065719A4 (de) | 2013-11-08 | 2017-08-09 | Terumo Corporation | Polymerpartikel |
| EP3079668A1 (de) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit |
| US10464307B2 (en) | 2014-05-20 | 2019-11-05 | The Regents Of The University Of California | Layerless bioprinting via dynamic optical projection and uses thereof |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
| US9919058B2 (en) | 2014-07-15 | 2018-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer |
| US11324827B2 (en) | 2014-10-01 | 2022-05-10 | Xiamen Sinopeg Biotech Co., Ltd. | Multifunctionalized polyethylene glycol derivative and preparation method therefor |
| CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
| WO2016154592A1 (en) | 2015-03-26 | 2016-09-29 | Microvention, Inc. | Embiolic particles |
| JP7137474B2 (ja) | 2016-03-15 | 2022-09-14 | メルサナ セラピューティクス,インコーポレイティド | NaPi2b標的化抗体-薬物コンジュゲート及びその使用方法 |
| US11071714B2 (en) | 2016-04-29 | 2021-07-27 | Children's Medical Center Corporation | Poly(ketals) and related compositions and methods |
| WO2017210566A1 (en) * | 2016-06-03 | 2017-12-07 | Novacyte, Inc. | Polymer linkers and their uses |
| EP3518983B1 (de) | 2016-09-28 | 2024-04-24 | Terumo Corporation | Polymerpartikel |
| US20180271996A1 (en) | 2017-02-28 | 2018-09-27 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
| AU2018290330A1 (en) | 2017-06-22 | 2020-01-02 | Mersana Therapeutics, Inc. | Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates |
| US20210148918A1 (en) * | 2018-04-17 | 2021-05-20 | Purdue Research Foundation | Modifying surface of a live cell and the uses thereof |
| CN111545148B (zh) * | 2020-04-07 | 2022-06-07 | 华东交通大学 | 一种手性催化方法及其催化装置 |
| US11833742B2 (en) | 2020-06-26 | 2023-12-05 | The Regents Of The University Of California | High-fidelity 3D printing using flashing photopolymerization |
| CN116102002B (zh) * | 2021-11-09 | 2024-08-30 | 闽都创新实验室 | 一种金属-有机框架限域的手性碳纳米点及其制备方法和应用 |
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| DE2718254C3 (de) * | 1977-04-25 | 1980-04-10 | Hoechst Ag, 6000 Frankfurt | Strahlungsempfindliche Kopiermasse |
| US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4374953A (en) * | 1982-04-19 | 1983-02-22 | Dow Corning Corporation | Method for preparing polyacetals and polyketals by emulsion polymerization |
| US4882397A (en) * | 1986-12-05 | 1989-11-21 | Amoco Corporation | Method for converting polyketals to polyaryletherketones in the presence of a metal salt |
| US4793986A (en) * | 1987-02-25 | 1988-12-27 | Johnson Matthey, Inc. | Macromolecular platinum antitumor compounds |
| JPH01190636A (ja) | 1988-01-22 | 1989-07-31 | Green Cross Corp:The | 制癌作用物質複合体 |
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| DE60131177T2 (de) * | 2000-09-06 | 2008-08-07 | AP Pharma, Inc., Redwood | Abbaubare polyacetal-polymere |
| DE60323936D1 (de) * | 2002-01-14 | 2008-11-20 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
| WO2003070823A2 (en) * | 2002-02-20 | 2003-08-28 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
| EP1534269B1 (de) * | 2002-07-19 | 2013-10-30 | The General Hospital Corporation | Oxim-konjugate und verfahren zu ihrer bildung und verwendung |
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-
2003
- 2003-01-14 DE DE60323936T patent/DE60323936D1/de not_active Expired - Lifetime
- 2003-01-14 AT AT03707375T patent/ATE410459T1/de not_active IP Right Cessation
- 2003-01-14 WO PCT/US2003/001017 patent/WO2003059988A2/en not_active Ceased
- 2003-01-14 US US10/501,565 patent/US7838619B2/en not_active Expired - Fee Related
- 2003-01-14 AU AU2003209227A patent/AU2003209227A1/en not_active Abandoned
- 2003-01-14 EP EP03707375A patent/EP1468036B1/de not_active Expired - Lifetime
-
2009
- 2009-11-18 US US12/620,855 patent/US7951898B2/en not_active Expired - Fee Related
-
2011
- 2011-04-26 US US13/093,951 patent/US8383758B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7951898B2 (en) | 2011-05-31 |
| US7838619B2 (en) | 2010-11-23 |
| US20060069230A1 (en) | 2006-03-30 |
| WO2003059988A2 (en) | 2003-07-24 |
| EP1468036B1 (de) | 2008-10-08 |
| DE60323936D1 (de) | 2008-11-20 |
| AU2003209227A1 (en) | 2003-07-30 |
| US20110275700A1 (en) | 2011-11-10 |
| WO2003059988A3 (en) | 2003-12-18 |
| US8383758B2 (en) | 2013-02-26 |
| US20100150832A1 (en) | 2010-06-17 |
| EP1468036A2 (de) | 2004-10-20 |
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