ATE410459T1 - Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung - Google Patents
Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendungInfo
- Publication number
- ATE410459T1 ATE410459T1 AT03707375T AT03707375T ATE410459T1 AT E410459 T1 ATE410459 T1 AT E410459T1 AT 03707375 T AT03707375 T AT 03707375T AT 03707375 T AT03707375 T AT 03707375T AT E410459 T1 ATE410459 T1 AT E410459T1
- Authority
- AT
- Austria
- Prior art keywords
- chiral
- polyketals
- methods
- biodegradable biocompatible
- polyketal
- Prior art date
Links
- 229920001855 polyketal Polymers 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007800 oxidant agent Substances 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G16/00—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00
- C08G16/02—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes
- C08G16/04—Chemically modified polycondensates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
- C08L59/02—Polyacetals containing polyoxymethylene sequences only
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compounds Of Unknown Constitution (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34833302P | 2002-01-14 | 2002-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE410459T1 true ATE410459T1 (de) | 2008-10-15 |
Family
ID=23367539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03707375T ATE410459T1 (de) | 2002-01-14 | 2003-01-14 | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7838619B2 (de) |
| EP (1) | EP1468036B1 (de) |
| AT (1) | ATE410459T1 (de) |
| AU (1) | AU2003209227A1 (de) |
| DE (1) | DE60323936D1 (de) |
| WO (1) | WO2003059988A2 (de) |
Families Citing this family (65)
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| US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
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| EP1585817B1 (de) * | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| ES2405287T3 (es) * | 2002-08-01 | 2013-05-30 | Eisai Inc. | Tratamiento mejorado del cáncer con glutamina |
| ATE507845T1 (de) | 2003-09-05 | 2011-05-15 | Gen Hospital Corp | Polyacetal-arzneimittelkonjugate als freisetzungssystem |
| AU2006243960A1 (en) * | 2005-05-10 | 2006-11-16 | Emory University | Strategies for delivery of active agents using micelles and particles |
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| US7741375B2 (en) | 2006-02-17 | 2010-06-22 | Medtronic, Inc | Polyketal polymers, and methods of making and using same |
| US7850382B2 (en) * | 2007-01-18 | 2010-12-14 | Sanford, L.P. | Valve made from two materials and writing utensil with retractable tip incorporating same |
| US7488130B2 (en) | 2007-02-01 | 2009-02-10 | Sanford, L.P. | Seal assembly for retractable instrument |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
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| US8399512B2 (en) * | 2007-11-28 | 2013-03-19 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
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| US8221012B2 (en) * | 2008-11-07 | 2012-07-17 | Sanford, L.P. | Retractable instruments comprising a one-piece valve door actuating assembly |
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| US8393814B2 (en) | 2009-01-30 | 2013-03-12 | Sanford, L.P. | Retractable instrument having a two stage protraction/retraction sequence |
| BRPI1013943B1 (pt) | 2009-06-22 | 2020-03-17 | Segetis, Inc. | Composto, método para sintetizar o mesmo, composição e composição lubrificante |
| CN102686242B (zh) | 2009-09-23 | 2015-04-22 | 加利福尼亚大学董事会 | 用于医药科学的化学上放大的响应策略 |
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| US8758778B2 (en) | 2010-09-16 | 2014-06-24 | The Regents Of The University Of California | Polymeric nano-carriers with a linear dual response mechanism and uses thereof |
| KR20130131323A (ko) | 2010-10-18 | 2013-12-03 | 세게티스, 인코포레이티드. | 카복시 에스터 케탈을 포함하는 수희석성 코팅 조성물, 그리고 그의 제조방법 및 용도 |
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| EP2890372A4 (de) | 2012-08-28 | 2016-01-27 | Univ California | Polymere nanoträger mit einem durch licht ausgelösten-freisetzungsmechanismus |
| US9458414B2 (en) | 2012-09-21 | 2016-10-04 | Gfbiochemicals Limited | Cleaning, surfactant, and personal care compositions |
| BR112015012471B1 (pt) | 2012-11-29 | 2020-05-19 | Segetis Inc | cetais de carbóxi éster , métodos de fabricação e uso dos mesmos. |
| WO2014093379A1 (en) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
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| KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
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| EP3079668A1 (de) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit |
| EP3145689B1 (de) | 2014-05-20 | 2020-01-01 | The Regents of the University of California | Schichtloses bioprinting über dynamische optische projektion und verwendungen davon |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| WO2016010788A1 (en) | 2014-07-15 | 2016-01-21 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Polyketal particles including a cpg oligodeoxynucleotide for the treatment of lung cancer |
| WO2016050210A1 (zh) | 2014-10-01 | 2016-04-07 | 厦门赛诺邦格生物科技有限公司 | 一种多官能化聚乙二醇衍生物及其制备方法 |
| CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
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| AU2017234163B2 (en) | 2016-03-15 | 2023-01-19 | Mersana Therapeutics, Inc. | NaPi2b-targeted antibody-drug conjugates and methods of use thereof |
| US11071714B2 (en) | 2016-04-29 | 2021-07-27 | Children's Medical Center Corporation | Poly(ketals) and related compositions and methods |
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| US20210148918A1 (en) * | 2018-04-17 | 2021-05-20 | Purdue Research Foundation | Modifying surface of a live cell and the uses thereof |
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| DE2718254C3 (de) | 1977-04-25 | 1980-04-10 | Hoechst Ag, 6000 Frankfurt | Strahlungsempfindliche Kopiermasse |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
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| WO2003059988A2 (en) | 2002-01-14 | 2003-07-24 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
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| CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| KR101476067B1 (ko) | 2002-09-06 | 2014-12-23 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
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-
2003
- 2003-01-14 WO PCT/US2003/001017 patent/WO2003059988A2/en not_active Ceased
- 2003-01-14 AU AU2003209227A patent/AU2003209227A1/en not_active Abandoned
- 2003-01-14 US US10/501,565 patent/US7838619B2/en not_active Expired - Fee Related
- 2003-01-14 AT AT03707375T patent/ATE410459T1/de not_active IP Right Cessation
- 2003-01-14 EP EP03707375A patent/EP1468036B1/de not_active Expired - Lifetime
- 2003-01-14 DE DE60323936T patent/DE60323936D1/de not_active Expired - Lifetime
-
2009
- 2009-11-18 US US12/620,855 patent/US7951898B2/en not_active Expired - Fee Related
-
2011
- 2011-04-26 US US13/093,951 patent/US8383758B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8383758B2 (en) | 2013-02-26 |
| US20100150832A1 (en) | 2010-06-17 |
| WO2003059988A2 (en) | 2003-07-24 |
| AU2003209227A1 (en) | 2003-07-30 |
| US20110275700A1 (en) | 2011-11-10 |
| US7838619B2 (en) | 2010-11-23 |
| EP1468036B1 (de) | 2008-10-08 |
| EP1468036A2 (de) | 2004-10-20 |
| WO2003059988A3 (en) | 2003-12-18 |
| DE60323936D1 (de) | 2008-11-20 |
| US7951898B2 (en) | 2011-05-31 |
| US20060069230A1 (en) | 2006-03-30 |
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