ATE411335T1 - Östrogen-sulfamate als sulfataseinhibitoren - Google Patents

Östrogen-sulfamate als sulfataseinhibitoren

Info

Publication number: ATE411335T1
Authority: AT; Austria
Prior art keywords: group; ring; sulfatase inhibitors; compound; estrogen sulfamates
Prior art date: 1996-12-05

Application number

AT02080557T

Other languages

English (en)

Inventor

Michael J Reed

Barry V L Potter

Original Assignee

Sterix Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-05

Filing date

1997-12-04

Publication date

2008-10-15

1997-12-04 Application filed by Sterix Ltd filed Critical Sterix Ltd

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE411335T1 publication Critical patent/ATE411335T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
102000005262 Sulfatase Human genes 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
108060007951 sulfatase Proteins 0.000 title 1
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229960003399 estrone Drugs 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

AT02080557T 1996-12-05 1997-12-04 Östrogen-sulfamate als sulfataseinhibitoren ATE411335T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9625334.9A GB9625334D0 (en)	1996-12-05	1996-12-05	Compound

Publications (1)

Publication Number	Publication Date
ATE411335T1 true ATE411335T1 (de)	2008-10-15

Family

ID=10804019

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT97947778T ATE240968T1 (de)	1996-12-05	1997-12-04	Sulfataseinhibitoren
AT02080557T ATE411335T1 (de)	1996-12-05	1997-12-04	Östrogen-sulfamate als sulfataseinhibitoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT97947778T ATE240968T1 (de)	1996-12-05	1997-12-04	Sulfataseinhibitoren

Country Status (10)

Country	Link
EP (2)	EP1310508B1 (de)
JP (1)	JP2001505221A (de)
AT (2)	ATE240968T1 (de)
AU (1)	AU5402398A (de)
DE (2)	DE69722240T2 (de)
DK (1)	DK0942919T3 (de)
ES (2)	ES2314020T3 (de)
GB (1)	GB9625334D0 (de)
PT (1)	PT942919E (de)
WO (1)	WO1998024802A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6903084B2 (en)	1991-08-28	2005-06-07	Sterix Limited	Steroid sulphatase inhibitors
US6476011B1 (en)	1991-08-28	2002-11-05	Sterix Limited	Methods for introducing an estrogenic compound
US6011024A (en)	1991-08-28	2000-01-04	Imperial College Of Science Technology & Medicine	Steroid sulphatase inhibitors
GB9118478D0 (en) *	1991-08-29	1991-10-16	Imperial College	Steroid sulphatase inhibitors
GB2331988B (en)	1997-12-04	2003-04-16	Imperial College	Polycyclic sulphamate inhibitors or oestrone sulphatase
GB2331987B (en) *	1997-12-04	2002-11-27	Imperial College	Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) *	1997-12-24	2000-04-04	Sri International	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
JP2002517449A (ja) *	1998-06-10	2002-06-18	ステリックスリミテッド	エストロンスルファターゼの阻害のための腫瘍壊死因子ａおよび２−メトキシエストロン−３−ｏ−スルファメートを有する薬学的組成物
JP2000309599A (ja)	1999-04-13	2000-11-07	Kyowa Hakko Kogyo Co Ltd	エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en)	1999-06-16	2006-07-18	Sterix Limited	Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
JP5042411B2 (ja) *	1999-04-30	2012-10-03	ステリックスリミテッド	抗腫瘍剤としてのエストロン誘導体の使用
AU2005225148B2 (en) *	1999-04-30	2008-04-03	Sterix Limited	Use
GB9913536D0 (en) *	1999-06-10	1999-08-11	Sterix Ltd	Use
ATE308556T1 (de)	1999-12-13	2005-11-15	Sterix Ltd	Halogenierte sulphamat-, phosphonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
US7335650B2 (en)	2000-01-14	2008-02-26	Sterix Limited	Composition
JPWO2001081364A1 (ja)	2000-04-24	2004-01-08	協和醗酵工業株式会社	エストラ−１，３，５（１０）−トリエン誘導体
AU2001279955A1 (en)	2000-08-18	2002-03-04	Sterix Limited	2-substituted estradiol derivative for inhibiting superoxid dismutase
GB0020498D0 (en) *	2000-08-18	2000-10-11	Sterix Ltd	Compound
GB0025788D0 (en) *	2000-10-20	2000-12-06	Sterix Ltd	Use
US8026229B2 (en)	2001-08-13	2011-09-27	Sterix Limited	Antitumor-active 2-alkoxyestradiol sulfamates
DE10307104A1 (de) *	2003-02-19	2004-09-23	Schering Ag	Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) *	2003-02-19	2004-09-09	Schering Ag	Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) *	2003-02-19	2004-09-09	Schering Ag	Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
CA2698814A1 (en)	2007-09-17	2009-03-26	Preglem S.A.	Treatment of oestrogen dependant conditions in pre-menopausal women

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668668A (en) *	1984-03-20	1987-05-26	Wayne State University	Compositions inhibiting murine MXT ductal carcinoma
GB9118478D0 (en) *	1991-08-29	1991-10-16	Imperial College	Steroid sulphatase inhibitors
DE4429398C2 (de) *	1994-08-09	1997-09-11	Jenapharm Gmbh	Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption

1996
- 1996-12-05 GB GBGB9625334.9A patent/GB9625334D0/en active Pending
1997
- 1997-12-04 AU AU54023/98A patent/AU5402398A/en not_active Abandoned
- 1997-12-04 EP EP02080557A patent/EP1310508B1/de not_active Expired - Lifetime
- 1997-12-04 JP JP52535898A patent/JP2001505221A/ja active Pending
- 1997-12-04 WO PCT/GB1997/003352 patent/WO1998024802A2/en not_active Ceased
- 1997-12-04 ES ES02080557T patent/ES2314020T3/es not_active Expired - Lifetime
- 1997-12-04 AT AT97947778T patent/ATE240968T1/de active
- 1997-12-04 EP EP97947778A patent/EP0942919B1/de not_active Expired - Lifetime
- 1997-12-04 DE DE69722240T patent/DE69722240T2/de not_active Expired - Lifetime
- 1997-12-04 DE DE69739051T patent/DE69739051D1/de not_active Expired - Lifetime
- 1997-12-04 PT PT97947778T patent/PT942919E/pt unknown
- 1997-12-04 AT AT02080557T patent/ATE411335T1/de not_active IP Right Cessation
- 1997-12-04 ES ES97947778T patent/ES2200201T3/es not_active Expired - Lifetime
- 1997-12-04 DK DK97947778T patent/DK0942919T3/da active

Also Published As

Publication number	Publication date
DK0942919T3 (da)	2003-09-15
EP0942919B1 (de)	2003-05-21
EP0942919A2 (de)	1999-09-22
EP1310508A2 (de)	2003-05-14
JP2001505221A (ja)	2001-04-17
PT942919E (pt)	2003-10-31
DE69739051D1 (de)	2008-11-27
ES2314020T3 (es)	2009-03-16
DE69722240T2 (de)	2004-04-01
WO1998024802A2 (en)	1998-06-11
EP1310508B1 (de)	2008-10-15
WO1998024802A3 (en)	1998-08-27
DE69722240D1 (de)	2003-06-26
EP1310508A3 (de)	2004-12-08
ATE240968T1 (de)	2003-06-15
GB9625334D0 (en)	1997-01-22
ES2200201T3 (es)	2004-03-01
AU5402398A (en)	1998-06-29

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69739051D1 (de)	2008-11-27	Östrogen-Sulfamate als Sulfataseinhibitoren
ATE293614T1 (de)	2005-05-15	Nicht-steroidale polyzyklische sulfamat-derivate, deren herstellung und deren verwendung als östron sulfatase inhibitoren
ES2134847T3 (es)	1999-10-16	Derivados de taxol.
FI941832A7 (fi)	1994-10-24	Menetelmiä NMR:llä havaittavien ksenobioottisten yhdisteiden in vivo määrittämiseksi
GB2331988B (en)	2003-04-16	Polycyclic sulphamate inhibitors or oestrone sulphatase
DE69841374D1 (de)	2010-01-21	3-o-sulfamatsteroidderivate als hemmer von estronsulfatase
PT82945A (pt)	1986-08-01	Processo para a preparacao de novos derivados de 2,3-di-hidro-benzofurano
WO1998002149A3 (en)	1998-06-04	Use of idebenone and analogues against beta amyloid induced cytotoxicity
DK288686A (da)	1986-06-19	Farmaceutiske praeparater
ES2099879T3 (es)	1997-06-01	5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.
MX170732B (es)	1993-09-10	Composicion de derivados de succinimida y su uso
FR2501676B1 (de)	1985-05-17
ATE77744T1 (de)	1992-07-15	Verwendung von pyrrothinderivaten.
EP0139907A3 (en)	1985-06-05	Estrane derivatives
MY122562A (en)	2006-04-29	Antibacterial composition
TR199701011A2 (xx)	1998-04-21	1-karba-(detia)-sefalosforin t�revleri.
ES462764A1 (es)	1978-05-16	Procedimiento para la obtencion de derivados de 1,6-anhidri-do-beta-d-hexopiranosa.
ATE130308T1 (de)	1995-12-15	14alpha,17alpha-(propano- und 17,2-propeno)- estratriene.