ATE411395T1 - Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren - Google Patents

Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren

Info

Publication number
ATE411395T1
ATE411395T1 AT03753198T AT03753198T ATE411395T1 AT E411395 T1 ATE411395 T1 AT E411395T1 AT 03753198 T AT03753198 T AT 03753198T AT 03753198 T AT03753198 T AT 03753198T AT E411395 T1 ATE411395 T1 AT E411395T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
validation
inhibitors
host cells
kinase activity
Prior art date
Application number
AT03753198T
Other languages
English (en)
Inventor
Tea Gunde
Catherine Berset
Alcide Barberis
Original Assignee
Oncalis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncalis Ag filed Critical Oncalis Ag
Application granted granted Critical
Publication of ATE411395T1 publication Critical patent/ATE411395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03753198T 2003-10-24 2003-10-24 Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren ATE411395T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2003/000694 WO2005040413A1 (en) 2003-10-24 2003-10-24 Method for the identification and/or validation of receptor tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE411395T1 true ATE411395T1 (de) 2008-10-15

Family

ID=34468779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03753198T ATE411395T1 (de) 2003-10-24 2003-10-24 Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren

Country Status (11)

Country Link
US (1) US7566528B2 (de)
EP (1) EP1675961B1 (de)
JP (1) JP2007508801A (de)
AT (1) ATE411395T1 (de)
AU (1) AU2003271489B2 (de)
CA (1) CA2544074A1 (de)
DE (1) DE60324207D1 (de)
DK (1) DK1675961T3 (de)
IL (1) IL175097A0 (de)
NZ (1) NZ547398A (de)
WO (1) WO2005040413A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1675961T3 (da) 2003-10-24 2009-02-23 Oncalis Ag Fremgangsmåde til identifikation og/eller validering af receptortyrosinkinaseinhibitorer
WO2005069872A2 (en) * 2004-01-15 2005-08-04 Washington University High throughput pharmaceutical screening using drosophila
US20060156421A1 (en) * 2004-06-18 2006-07-13 Cagan Ross L High throughput screening methods for anti-metastatic compounds
EP1715059A1 (de) * 2005-04-21 2006-10-25 Esbatech AG Verfahren zur Erkennung von möglichen gesundheitsgefährdenden Rezeptortyrosinkinase-Mutationen und von Inhibitoren oder Medikamenten gegen RTK-Mutanten
WO2006111035A1 (en) * 2005-04-21 2006-10-26 Oncalis Ag Method for the identification of possibly harmful receptor tyrosine kinase (rtk) mutations and of inhibitors or medication directed against rtk mutantstitle
SI2671954T1 (sl) * 2006-01-20 2018-11-30 Cell Signaling Technology, Inc. Translokacija in mutantna ROS kinaza v človeškem ne-drobnoceličnem karcinomu pljuč
JP5392992B2 (ja) * 2007-03-30 2014-01-22 アズワン株式会社 自己リン酸化受容体のアゴニスト、アンタゴニストのスクリーニング方法、遺伝子組換え酵母
MX2010008025A (es) * 2008-01-22 2010-08-04 Biogen Idec Inc Anticuerpos ron y usos de los mismos.
GB0900425D0 (en) * 2009-01-12 2009-02-11 Ucb Pharma Sa Biological products
KR101433057B1 (ko) 2012-03-07 2014-09-23 한국과학기술원 빛에 의해 ｒｔｋ 신호전달을 활성화하는 융합단백질 및 그의 용도
EP2789630A1 (de) 2013-04-09 2014-10-15 EngMab AG Bispezifische Antikörper gegen CD3e und ROR1
US10231965B2 (en) 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
US9777070B2 (en) 2014-04-30 2017-10-03 Pfizer Inc Anti-PTK7 antibody-drug conjugates
EP3204415B1 (de) 2014-10-09 2020-06-17 EngMab Sàrl Bispezifische antikörper gegen cd3epsilon und ror1
EP3227276B1 (de) 2014-12-02 2021-09-01 Ignyta, Inc. Kombinationen zur behandlung von neuroblastom
JP6929231B2 (ja) * 2015-05-29 2021-09-01 イグナイタ インコーポレイテッド Ｒｔｋ突然変異細胞を有する患者を処置するための組成物及び方法
BR112018012255A2 (pt) 2015-12-18 2018-12-04 Ignyta Inc método para tratar câncer
AU2018302170B2 (en) 2017-07-19 2024-02-29 Ignyta, Inc. Pharmaceutical compositions comprising entrectinib
CN111225662B (zh) 2017-10-17 2022-11-22 伊尼塔公司 药物组合物和剂型

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128722A1 (en) * 1992-01-22 1993-08-05 William I. Wood Novel protein tyrosine kinases
US6051397A (en) * 1993-11-16 2000-04-18 Max Planck Gesellschaft Zur Forderung Der Wissenschaften DNA encoding MCK-10, a novel receptor tyrosine kinase
US5573994A (en) 1994-05-13 1996-11-12 University Of Cincinnati Superabsorbent foams, and method for producing the same
US5573944A (en) * 1994-07-22 1996-11-12 President And Fellows Of Harvard College Yeast cell expressing heterologous receptor kinase
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
IL163515A0 (en) * 2002-03-01 2005-12-18 Bristol Myers Squibb Co Transgenic non-human mammals
EP1495329B1 (de) * 2002-04-18 2006-03-29 Esbatech AG Verfahren zum nachweis von modulatoren einer sekretaseaktivität
DK1675961T3 (da) 2003-10-24 2009-02-23 Oncalis Ag Fremgangsmåde til identifikation og/eller validering af receptortyrosinkinaseinhibitorer

Also Published As

Publication number Publication date
JP2007508801A (ja) 2007-04-12
EP1675961A1 (de) 2006-07-05
NZ547398A (en) 2008-10-31
CA2544074A1 (en) 2005-05-06
US20050239049A1 (en) 2005-10-27
WO2005040413A1 (en) 2005-05-06
US7566528B2 (en) 2009-07-28
AU2003271489A1 (en) 2005-05-11
AU2003271489B2 (en) 2009-02-19
DK1675961T3 (da) 2009-02-23
DE60324207D1 (de) 2008-11-27
IL175097A0 (en) 2006-08-20
EP1675961B1 (de) 2008-10-15

Similar Documents

Publication Publication Date Title
ATE411395T1 (de) Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren
Tee et al. Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs
DE602005021336D1 (de) Verfahren zur identifizierung von proteinen mit stärkephosphorylierender enzymatischer aktivität
DE60023936D1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
MY149161A (en) Methods using pores
ATE444377T1 (de) Nukleinsäurecharakterisierung
ATE494388T1 (de) Neues verfahren zum erschaffen von proteinkinase- inhibitoren
DE602004006764D1 (de) Verfahren zur Bestimmung der Identität einer unbekannten Nachbarzelle und Vorrichtung dafür
DE59912716D1 (de) Verfahren zur bestimmung der immunabwehraktivität des blutes sowie testkit hierfür
Kjellerup et al. Pro‐inflammatory cytokine release in keratinocytes is mediated through the MAPK signal‐integrating kinases
DE602004015791D1 (de) Screening-Verfahren zur Identifizierung von Tau-Protein modulierenden Substanzen.
ATE532072T1 (de) Verfahren und vorrichtung zur beurteilung von polypeptidaggregation
DE602004017884D1 (de) Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren
ATE433591T1 (de) Authentifizierungsverfahren für einen gegenstand oder stoff durch markierung oder chemische verfolgbarkeit
ATE391727T1 (de) Verfahren zur identifikation von modulatoren des humanen orexin-2-rezeptors
WO2002008280A3 (en) SCREENING METHODS BASED ON SUPERACTIVATED αVβ3 INTEGRIN
DE602005026811D1 (de) Verfahren zur inhibierung von tumorzellwachstum mit foxm1 sirns
ATE426806T1 (de) Verfahren zur prognose der wirksamkeit von chemotherapie
ATE385503T1 (de) Verfahren zur modulierung von integrin- vermittelter zellaktivitaet und hierfuer geeignete reagenzien
DE60326640D1 (de) Rekombinante biotincarboxylasedomänen zur identifizierung von acetyl-coa-carboxylase-inhibitoren
RU2008152780A (ru) Ген, вовлеченный в иммортализацию раковой клетки человека, и его применение
ATE359513T1 (de) Hochdurchsatzscreening von verbindungen für biologische wirksamkeit
DE602004019180D1 (de) Methode zur Identifizierung von unbekannten Proteinen mittels zwei-dimensionaler Auftrennung und Verwendung von Markern
DE60027895D1 (de) Verfahren zur identifizierung von inhibitoren von signalmolekülen
DE602005018808D1 (de) Odifizierung der supercoil-topologie von nukleinsäuren sowie modulatoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1675961

Country of ref document: EP

REN Ceased due to non-payment of the annual fee