ATE532072T1 - Verfahren und vorrichtung zur beurteilung von polypeptidaggregation - Google Patents

Verfahren und vorrichtung zur beurteilung von polypeptidaggregation

Info

Publication number
ATE532072T1
ATE532072T1 AT04791642T AT04791642T ATE532072T1 AT E532072 T1 ATE532072 T1 AT E532072T1 AT 04791642 T AT04791642 T AT 04791642T AT 04791642 T AT04791642 T AT 04791642T AT E532072 T1 ATE532072 T1 AT E532072T1
Authority
AT
Austria
Prior art keywords
aggregation
sequence
propensities
polypeptide aggregation
predicted
Prior art date
Application number
AT04791642T
Other languages
English (en)
Inventor
Christopher Dobson
Fabrizio Chiti
Jesus Zurdo
Michele Vendruscolo
Kateri Dubay
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Application granted granted Critical
Publication of ATE532072T1 publication Critical patent/ATE532072T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Theoretical Computer Science (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04791642T 2003-11-05 2004-10-01 Verfahren und vorrichtung zur beurteilung von polypeptidaggregation ATE532072T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0325817.5A GB0325817D0 (en) 2003-11-05 2003-11-05 Method and apparatus for assessing polypeptide aggregation
PCT/GB2004/050015 WO2005045442A1 (en) 2003-11-05 2004-10-01 Method and apparatus for assessing polypeptide aggregation

Publications (1)

Publication Number Publication Date
ATE532072T1 true ATE532072T1 (de) 2011-11-15

Family

ID=29725985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04791642T ATE532072T1 (de) 2003-11-05 2004-10-01 Verfahren und vorrichtung zur beurteilung von polypeptidaggregation

Country Status (7)

Country Link
US (2) US7698070B2 (de)
EP (2) EP2261670B1 (de)
AT (1) ATE532072T1 (de)
DK (1) DK1680681T3 (de)
ES (1) ES2376463T3 (de)
GB (1) GB0325817D0 (de)
WO (1) WO2005045442A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1586059T3 (da) 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation
US8290713B2 (en) 2006-08-04 2012-10-16 Lonza Biologics PLLC Method for predicting protein aggregation and designing aggregation inhibitors
JP5302212B2 (ja) * 2006-12-18 2013-10-02 コヴァルクス・アーゲー 治療タンパク質の凝集体の直接質量分光分析
GB2455102A (en) * 2007-11-28 2009-06-03 Cambridge Entpr Ltd Protein Aggregation Prediction Systems
PL2310970T3 (pl) 2008-06-20 2013-10-31 Novartis Ag Metody identyfikacji w białkach regionów wiązania makrocząsteczek i regionów podatności na agregację i zastosowanie tych metod
ES2669591T3 (es) 2008-06-20 2018-05-28 Novartis Ag Inmunoglobulinas con agregación reducida
EP2896404B1 (de) 2009-06-04 2017-08-02 Novartis AG Verfahren zur Identifizierung von Stellen für IgG-Konjugation
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
US8717023B2 (en) * 2011-04-21 2014-05-06 Mark Griswold Relaxometry quantification self-justification fitting
US10431325B2 (en) 2012-08-03 2019-10-01 Novartis Ag Methods to identify amino acid residues involved in macromolecular binding and uses therefor
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CN120695169A (zh) 2013-12-20 2025-09-26 博德研究所 使用新抗原疫苗的联合疗法
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
WO2016100977A1 (en) 2014-12-19 2016-06-23 The Broad Institute Inc. Methods for profiling the t-cel- receptor repertoire
GB201809341D0 (en) * 2018-06-07 2018-07-25 Ucb Biopharma Sprl Multi-domain proteins with increased native state colloidal stability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1255209A3 (de) 1997-04-11 2009-02-11 California Institute Of Technology Gerät und Verfahren für automatischen Protein-Entwurf
AU751331B2 (en) 1997-04-11 2002-08-15 California Institute Of Technology Apparatus and method for automated protein design
EP1115845A2 (de) 1998-09-21 2001-07-18 Isis Innovation Limited Fibrillen
GB9924484D0 (en) * 1999-10-15 1999-12-15 Isis Innovation Altered polypeptide aggregation
AU2002223886A1 (en) 2000-11-24 2002-06-03 Isis Innovation Limited Mixed fibrils
GB0109438D0 (en) 2001-04-17 2001-06-06 Isis Innovation Peptides
JP3802416B2 (ja) * 2001-12-27 2006-07-26 セレスター・レキシコ・サイエンシズ株式会社 相互作用部位予測装置、相互作用部位予測方法、プログラム、および、記録媒体
DK1586059T3 (da) * 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation

Also Published As

Publication number Publication date
US8155888B2 (en) 2012-04-10
US20100261882A1 (en) 2010-10-14
EP1680681A1 (de) 2006-07-19
EP2261670A3 (de) 2011-03-23
US7698070B2 (en) 2010-04-13
EP1680681B1 (de) 2011-11-02
GB0325817D0 (en) 2003-12-10
DK1680681T3 (da) 2012-02-27
EP2261670A2 (de) 2010-12-15
WO2005045442A1 (en) 2005-05-19
US20060271306A1 (en) 2006-11-30
ES2376463T3 (es) 2012-03-14
EP2261670B1 (de) 2014-08-20

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