ATE411525T1 - Nachweis einer histonmodifikation in zellfreien nukleosomen - Google Patents
Nachweis einer histonmodifikation in zellfreien nukleosomenInfo
- Publication number
- ATE411525T1 ATE411525T1 AT04768123T AT04768123T ATE411525T1 AT E411525 T1 ATE411525 T1 AT E411525T1 AT 04768123 T AT04768123 T AT 04768123T AT 04768123 T AT04768123 T AT 04768123T AT E411525 T1 ATE411525 T1 AT E411525T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- free nucleosomes
- detection
- nucleosomes
- histone modification
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Geophysics And Detection Of Objects (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0319376.0A GB0319376D0 (en) | 2003-08-18 | 2003-08-18 | Histone modification detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411525T1 true ATE411525T1 (de) | 2008-10-15 |
Family
ID=28052702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04768123T ATE411525T1 (de) | 2003-08-18 | 2004-08-18 | Nachweis einer histonmodifikation in zellfreien nukleosomen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9128086B2 (de) |
| EP (1) | EP1668368B1 (de) |
| AT (1) | ATE411525T1 (de) |
| DE (1) | DE602004017201D1 (de) |
| DK (1) | DK1668368T3 (de) |
| ES (1) | ES2315697T3 (de) |
| GB (1) | GB0319376D0 (de) |
| SI (1) | SI1668368T1 (de) |
| WO (1) | WO2005019826A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| WO2006119264A2 (en) * | 2005-04-29 | 2006-11-09 | The Regents Of The University Of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
| US8119572B2 (en) * | 2005-10-24 | 2012-02-21 | Wisconsin Alumni Research Foundation | Methods for determining protein binding specificity using peptide libraries |
| US9035068B2 (en) | 2010-09-24 | 2015-05-19 | The Rockefeller University | Phosphohistidine analogs |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115099D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes |
| PT2788767T (pt) * | 2011-12-07 | 2017-12-06 | Belgian Volition Sprl | Método de detecção de adutos de nucleosoma |
| GB201303576D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for predicting therapy efficacy using nucleosome structure biomarkers |
| GB201303575D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for detecting histone modifications in nucleosomes |
| EP2775304A1 (de) * | 2013-03-07 | 2014-09-10 | Universitätsspital Basel | Verfahren zum Nachweis einer entzündlichen Störung |
| EP3736344A1 (de) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| CN107209190B (zh) | 2014-10-29 | 2021-07-16 | 比利时意志有限责任公司 | 用于富集循环肿瘤dna的方法 |
| GB201518674D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for detecting nuleosomes containing histone modifications and variants |
| GB201518665D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for enrichment of cell free nucleosomes |
| CN109415431A (zh) | 2016-04-20 | 2019-03-01 | 爱兰细胞技术公司 | 与k180二甲基化h1.0蛋白相关的组合物和方法 |
| TWI726009B (zh) * | 2016-11-28 | 2021-05-01 | 比利時商比利時意志有限公司 | 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途 |
| WO2019053243A1 (en) | 2017-09-18 | 2019-03-21 | Santersus Sa | METHOD AND DEVICE FOR PURIFYING BLOOD OF FREE CIRCULATING DNA |
| CN111770761B (zh) | 2017-10-25 | 2024-07-09 | 爱兰细胞技术公司 | H1.0k180me2抗体、其制造方法和用途 |
| GB201721569D0 (en) | 2017-12-21 | 2018-02-07 | Belgian Volition Sprl | Method for the detection and treatment of colorectal adenomas |
| JP2021510306A (ja) * | 2018-01-10 | 2021-04-22 | エピサイファー，インコーポレイテッド | ゲノム遺伝子座におけるヌクレオソーム修飾及び変異の定量化のための方法並びにその臨床応用 |
| ES2960550T3 (es) * | 2018-03-01 | 2024-03-05 | Epicypher Inc | Cuantificación de modificaciones de nucleosoma utilizando nucleosomas recombinantes definidos químicamente |
| CN112119166B (zh) * | 2018-03-13 | 2025-08-22 | 耶路撒冷希伯来大学伊萨姆研发有限公司 | 无细胞dna染色质免疫沉淀的诊断应用 |
| DE202019005627U1 (de) | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
| WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| US12571051B2 (en) | 2019-08-27 | 2026-03-10 | Belgian Volition Srl | Method of isolating circulating nucleosomes |
| IL293342B1 (en) | 2019-12-02 | 2026-01-01 | Belgian Volition Srl | Using cell-free nucleosomes as biomarkers |
| CA3175171A1 (en) | 2020-03-20 | 2021-09-23 | Mark Edward Eccleston | Triaging method using cell free nucleosome levels |
| JP7839784B2 (ja) | 2020-09-21 | 2026-04-02 | ベルジアン ボリション エスアールエル | 血液中の遊離ヌクレオソームのインラインモニタリングのための装置 |
| EP4237850A4 (de) * | 2020-11-02 | 2024-09-18 | Epicypher, Inc. | Verbesserte assays zur quantifizierung von chromatinzielen mittels antikörpergerichtetem enzymabbau |
| TW202238131A (zh) | 2020-11-25 | 2022-10-01 | 比利時商比利時意志有限公司 | 測量無細胞核蛋白染色質片段之方法 |
| TW202238132A (zh) | 2020-12-08 | 2022-10-01 | 比利時商比利時意志有限公司 | 多發性硬化症之診斷方法 |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| TW202242146A (zh) | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| GB202108452D0 (en) | 2021-06-14 | 2021-07-28 | Belgian Volition Sprl | Triaging method using cell free nucleosome levels |
| JP2024542996A (ja) | 2021-10-29 | 2024-11-19 | ベルジアン ボリション エスアールエル | 均一系免疫アッセイ法 |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| WO2023126672A1 (en) | 2021-12-27 | 2023-07-06 | Santersus Ag | Method and device for removal of circulating cell free dna |
| EP4490323A1 (de) | 2022-03-11 | 2025-01-15 | Belgian Volition SRL | Differentialdiagnoseverfahren |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| WO2024042210A1 (en) | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
| IL319155A (en) | 2022-08-25 | 2025-04-01 | Belgian Volition Srl | A method for detecting dementia |
| EP4639173A1 (de) | 2022-12-19 | 2025-10-29 | Belgian Volition SRL | Kalibrierung |
| WO2024133222A1 (en) | 2022-12-19 | 2024-06-27 | Belgian Volition Srl | Assessment of biological samples for nucleic acid analysis |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| GB202303562D0 (en) | 2023-03-10 | 2023-04-26 | Belgian Volition Sprl | Sample collection for liquid biopsy |
| WO2024213795A1 (en) | 2023-04-14 | 2024-10-17 | Belgian Volition Srl | Diagnosis method using cell free nucleosome levels |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025012440A1 (en) | 2023-07-13 | 2025-01-16 | Belgian Volition Srl | Method for detection of the potential of a body fluid sample to produce extracellular traps |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
| WO2025181348A1 (en) | 2024-03-01 | 2025-09-04 | Belgian Volition Srl | Method for determining the origin of circulating dna |
| WO2025253002A1 (en) | 2024-06-07 | 2025-12-11 | Belgian Volition Srl | Sample collection for liquid biopsy |
| WO2026052765A1 (en) | 2024-09-05 | 2026-03-12 | Belgian Volition Srl | Method using nucleosome levels |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE329264T1 (de) * | 1998-03-18 | 2006-06-15 | Roche Diagnostics Gmbh | Nachweis von produkten von apoptosis |
| JP2005506973A (ja) * | 2001-08-03 | 2005-03-10 | ユニバーシティ オブ バージニア パテント ファウンデーション | アポトーシスのマーカーとしてのリン酸化ヒストンｈ２ｂ |
| WO2003046218A1 (en) | 2001-11-30 | 2003-06-05 | Pfizer Products Inc. | Methods for detecting cells with numerical chromosomal abnormalities |
| CA2476835A1 (en) * | 2002-02-20 | 2003-08-28 | University Of Virginia Patent Foundation | A non-invasive diagnostic test utilizing histone modification markers |
| US20060073517A1 (en) * | 2003-03-10 | 2006-04-06 | Allis C D | Post-translational modifications of proteins as regulatory switches |
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| WO2006119264A2 (en) * | 2005-04-29 | 2006-11-09 | The Regents Of The University Of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
-
2003
- 2003-08-18 GB GBGB0319376.0A patent/GB0319376D0/en not_active Ceased
-
2004
- 2004-08-18 AT AT04768123T patent/ATE411525T1/de active
- 2004-08-18 EP EP04768123A patent/EP1668368B1/de not_active Expired - Lifetime
- 2004-08-18 DE DE602004017201T patent/DE602004017201D1/de not_active Expired - Lifetime
- 2004-08-18 WO PCT/GB2004/003564 patent/WO2005019826A1/en not_active Ceased
- 2004-08-18 ES ES04768123T patent/ES2315697T3/es not_active Expired - Lifetime
- 2004-08-18 SI SI200430992T patent/SI1668368T1/sl unknown
- 2004-08-18 DK DK04768123T patent/DK1668368T3/da active
- 2004-08-18 US US10/568,691 patent/US9128086B2/en active Active
-
2015
- 2015-08-03 US US14/816,329 patent/US10408831B2/en not_active Expired - Lifetime
-
2019
- 2019-07-26 US US16/523,096 patent/US20190353653A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10408831B2 (en) | 2019-09-10 |
| GB0319376D0 (en) | 2003-09-17 |
| US20150330996A1 (en) | 2015-11-19 |
| EP1668368B1 (de) | 2008-10-15 |
| EP1668368A1 (de) | 2006-06-14 |
| DE602004017201D1 (de) | 2008-11-27 |
| SI1668368T1 (sl) | 2009-04-30 |
| US20070160989A1 (en) | 2007-07-12 |
| US9128086B2 (en) | 2015-09-08 |
| ES2315697T3 (es) | 2009-04-01 |
| US20190353653A1 (en) | 2019-11-21 |
| WO2005019826A1 (en) | 2005-03-03 |
| DK1668368T3 (da) | 2009-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE411525T1 (de) | Nachweis einer histonmodifikation in zellfreien nukleosomen | |
| EP2275815A3 (de) | Verbesserte Immunoassayverfahren | |
| DE60228557D1 (de) | Candida-nachweis | |
| BRPI0618713B8 (pt) | cardiolipina modificada e seus usos | |
| ATE393914T1 (de) | Nachweis von biomolekülen unter verwendung poröser biosensoren und raman-spektroskopie | |
| ATE425266T1 (de) | Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten | |
| WO2002001230A3 (en) | Rapid and sensitive detection of protein aggregation | |
| BRPI0610092B8 (pt) | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado | |
| ATE474228T1 (de) | Reagenz für hämoglobinabbau | |
| WO2004057341A3 (en) | Cvd assay | |
| ATE412179T1 (de) | Nachweis von arzneistoffen der methamphetamingruppe | |
| WO2008054724A3 (en) | Monoclonal antibodies against osteopontin | |
| DE602005014386D1 (de) | Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome | |
| BRPI0416270A (pt) | método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra | |
| EP1560025A3 (de) | Marker spezifisch für Diabetes | |
| WO2005044989A3 (en) | Polynucleotides and polypeptides of anaplasma phagocytophilum and methods of using the same | |
| ATE503187T1 (de) | Nachweis eines therapeutischen antikörpers in einem versuchstier | |
| WO2005102938A3 (en) | Antibodies specific for bcr-abl fusion protein and uses thereof | |
| EP1476757A4 (de) | Verfahren und kit zur krebsvorhersage | |
| DE60140346D1 (de) | System zur internen, qualitativen und quantitativen überprüfung von zellmarker-indices | |
| CY1113013T1 (el) | Βελτιωμενες μεθοδοι ανοσολογικων δοκιμασιων | |
| EP2444812A3 (de) | Verbesserte Immunoassayverfahren | |
| DE602004001994D1 (de) | Verwendung des proteins masp als marker für kolorektale karzinome | |
| DE602005013430D1 (de) | Verwendung von asc als marker für kolorektalkarzinome | |
| WO2005037056A3 (en) | Method for the detection of a biomolecule in a test sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1668368 Country of ref document: EP |