ATE412415T1 - Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie - Google Patents

Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie

Info

Publication number: ATE412415T1
Authority: AT; Austria
Prior art keywords: cyclic nucleotide; nucleotide phosphodiesterase; benzodiazepin; therapy; phosphodiesterase inhibitors
Prior art date: 2002-10-30

Application number

AT03780257T

Other languages

English (en)

Inventor

Jean-Jacques Bourguignon

Claire Lugnier

Mustapha Abarghaz

Yan Lagouge

Patrick Wagner

Cesare Mondadori

Jean-Paul Macher

Dominique Schultz

Pierre Raboisson

Original Assignee

Via Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-30

Filing date

2003-10-30

Publication date

2008-11-15

2002-10-30 Priority claimed from FR0213607A external-priority patent/FR2846653B1/fr

2003-10-30 Application filed by Via Pharmaceuticals Inc filed Critical Via Pharmaceuticals Inc

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE412415T1 publication Critical patent/ATE412415T1/de

Links

101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 title abstract 2
SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical group N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title 1
229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
ZHYMGSPDEVXULU-UHFFFAOYSA-N 1,2-benzodiazepin-3-one Chemical class N1=NC(=O)C=CC2=CC=CC=C21 ZHYMGSPDEVXULU-UHFFFAOYSA-N 0.000 abstract 1
229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
210000001428 peripheral nervous system Anatomy 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03780257T 2002-10-30 2003-10-30 Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie ATE412415T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0213607A FR2846653B1 (fr)	2002-10-30	2002-10-30	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US45587403P	2003-03-20	2003-03-20

Publications (1)

Publication Number	Publication Date
ATE412415T1 true ATE412415T1 (de)	2008-11-15

Family

ID=32313949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03780257T ATE412415T1 (de)	2002-10-30	2003-10-30	Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie

Country Status (10)

Country	Link
US (1)	US20060128695A1 (de)
EP (1)	EP1556055B1 (de)
JP (1)	JP2006509832A (de)
AT (1)	ATE412415T1 (de)
AU (1)	AU2003288352A1 (de)
CA (1)	CA2503716A1 (de)
DE (1)	DE60324449D1 (de)
ES (1)	ES2315546T3 (de)
NZ (1)	NZ540167A (de)
WO (1)	WO2004041258A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2513170A1 (en) *	2003-01-17	2004-08-05	Takeda Pharmaceutical Company Limited	Skeletal muscle protecting agent
EP1749824A1 (de)	2005-08-03	2007-02-07	Neuro3D	Benzodiazepinederivate, Herstellung und Verwendung als Arzneimittel
TW200918519A (en) *	2007-09-19	2009-05-01	Lundbeck & Co As H	Cyanoisoquinoline
US7858620B2 (en)	2007-09-19	2010-12-28	H. Lundbeck A/S	Cyanoisoquinoline
WO2010145668A1 (en)	2009-06-19	2010-12-23	H. Lundbeck A/S	Novel phenylimidazole derivative as pde10a enzyme inhibitor
US9062024B2 (en)	2009-09-28	2015-06-23	Nippon Soda Co., Ltd.	Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use
TWI481607B (zh)	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh)	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TW201200516A (en)	2009-12-17	2012-01-01	Lundbeck & Co As H	Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
NZ601967A (en)	2010-03-12	2015-03-27	Omeros Corp	Pde10 inhibitors and related compositions and methods
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en)	2010-12-02	2016-02-02	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2705039B1 (de)	2011-05-04	2017-07-26	Constellation Pharmaceuticals, Inc.	Bromodomainhemmer und ihre verwendung
US9328117B2 (en)	2011-06-17	2016-05-03	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2803662B1 (de) *	2012-01-13	2017-03-01	Nippon Chemiphar Co., Ltd.	P2x4-rezeptor-antagonisten
CN102690239B (zh) *	2012-04-01	2015-01-28	浙江工业大学	一种1,5-苯并二氮卓类衍生物的合成方法
MY173949A (en)	2012-04-25	2020-02-28	Takeda Pharmaceuticals Co	Nitrogenated heterocyclic compound
US9624244B2 (en)	2012-06-06	2017-04-18	Constellation Pharmaceuticals, Inc.	Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
RU2657540C2 (ru) *	2012-06-26	2018-06-14	Янссен Фармацевтика Нв	Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств
US9527841B2 (en)	2012-07-13	2016-12-27	Takeda Pharmaceutical Company Limited	Substituted pyrido[2,3-b]pyrazines as phosphodiesterase 2A inhibitors
JP6280912B2 (ja)	2013-03-14	2018-02-14	武田薬品工業株式会社	複素環化合物
ES2950424T3 (es)	2013-07-03	2023-10-09	Takeda Pharmaceuticals Co	Compuesto de amida
WO2015002231A1 (ja)	2013-07-03	2015-01-08	武田薬品工業株式会社	複素環化合物
US9873683B2 (en)	2013-07-12	2018-01-23	Nippon Chemiphar Co., Ltd	P2X4 receptor antagonist
EP3091983B1 (de)	2014-01-08	2019-10-02	Intra-Cellular Therapies, Inc.	Pharmazeutische zusammensetzungen enthaltend einen pde-1-hemmer und einen pde-2-hemmer
NZ716494A (en)	2014-04-28	2017-07-28	Omeros Corp	Processes and intermediates for the preparation of a pde10 inhibitor
NZ716462A (en)	2014-04-28	2017-11-24	Omeros Corp	Optically active pde10 inhibitor
PL3157928T3 (pl)	2014-06-20	2019-07-31	Constellation Pharmaceuticals, Inc.	Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu
AU2015357498B2 (en)	2014-12-06	2019-09-12	Intra-Cellular Therapies, Inc.	Organic compounds
US10300064B2 (en)	2014-12-06	2019-05-28	Intra-Cellular Therapies, Inc.	Organic compounds
CN107530313A (zh)	2015-04-24	2018-01-02	奥默罗斯公司	Pde10抑制剂以及相关组合物和方法
WO2017079678A1 (en)	2015-11-04	2017-05-11	Omeros Corporation	Solid state forms of a pde10 inhibitor
PT3713572T (pt)	2017-11-23	2025-08-28	Oslo Univ Hospital Hf	Tratamento da taquicardia
CN110511259B (zh) *	2019-08-22	2022-08-16	陕西师范大学	环二核苷酸人工金属酶及其制备和催化不对称Friedel-Crafts反应的应用
US20250313537A1 (en) *	2022-05-13	2025-10-09	University Of Cincinnati	Benzodiazepine analogs and methods of use in treating cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1145626B (de) *	1959-12-10	1963-03-21	Hoffmann La Roche	Verfahren zur Herstellung von 3H-1, 4-Benzodiazepin-2(1H)-on-derivaten
DE1136709B (de) *	1959-12-10	1962-09-20	Hoffmann La Roche	Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
US3515755A (en) *	1968-06-18	1970-06-02	Hoffmann La Roche	Lower alkanoyl amido benzophenones
US3609146A (en) *	1968-11-01	1971-09-28	Sandoz Ag	Substituted benzodiazepinone derivatives
US3573282A (en) *	1969-03-27	1971-03-30	Upjohn Co	4h-(1,3)oxazino(3,2-d)(1,4)benzodiazepine-4,7(6h)-diones
DE1942744A1 (de) *	1969-08-22	1971-03-04	Cassella Farbwerke Mainkur Ag	2-Imino-1,2-dihydro-3H-1,4-benzodiazepine und Verfahren zu ihrer Herstellung
US3778433A (en) *	1969-04-18	1973-12-11	Sumitomo Chemical Co	Process for producing benzodiazepine derivatives
GB1346176A (en) *	1970-08-25	1974-02-06	American Home Prod	Benzodiazepines
US3803129A (en) *	1972-08-10	1974-04-09	American Home Prod	1,5-dihydro-3-alkoxy-5-phenyl-2h-1,4-benzodiazepin-2-ones
US4056525A (en) *	1975-06-02	1977-11-01	American Home Products Corporation	2,3-dialkoxy-3h-1,4-benzodiazepines
JPS54157585A (en) *	1978-05-30	1979-12-12	Yasumitsu Tamura	Manufacture of 1*44benzodiazepin
IL93401A (en) *	1989-03-08	1994-08-26	Kali Chemie Pharma Gmbh	H1 - Indole - 2 - Carboxylic acid 1, 7 - Consolidated N -) 1, 4 - Benzodiazepine - 3 - Il (amides, their preparation and drugs containing them
WO1999058117A1 (fr) *	1998-05-13	1999-11-18	Sanofi-Synthelabo	Utilisation de composes reduisant l'apoptose
EP1392663A2 (de) *	2001-06-07	2004-03-03	Neuro3D	Benzodiazepinon-derivate als zyklische nukleotidphosphodiesterase-hemmer sowie deren herstellungsverfahren und verwendung

2003
- 2003-10-30 WO PCT/FR2003/003247 patent/WO2004041258A2/fr not_active Ceased
- 2003-10-30 ES ES03780257T patent/ES2315546T3/es not_active Expired - Lifetime
- 2003-10-30 US US10/533,157 patent/US20060128695A1/en not_active Abandoned
- 2003-10-30 NZ NZ540167A patent/NZ540167A/en unknown
- 2003-10-30 JP JP2005502123A patent/JP2006509832A/ja active Pending
- 2003-10-30 CA CA002503716A patent/CA2503716A1/fr not_active Abandoned
- 2003-10-30 AU AU2003288352A patent/AU2003288352A1/en not_active Abandoned
- 2003-10-30 AT AT03780257T patent/ATE412415T1/de not_active IP Right Cessation
- 2003-10-30 EP EP03780257A patent/EP1556055B1/de not_active Expired - Lifetime
- 2003-10-30 DE DE60324449T patent/DE60324449D1/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2503716A1 (fr)	2004-05-21
EP1556055A2 (de)	2005-07-27
US20060128695A1 (en)	2006-06-15
NZ540167A (en)	2007-06-29
JP2006509832A (ja)	2006-03-23
WO2004041258A3 (fr)	2004-09-23
WO2004041258A8 (fr)	2005-06-23
DE60324449D1 (de)	2008-12-11
ES2315546T3 (es)	2009-04-01
WO2004041258A2 (fr)	2004-05-21
AU2003288352A1 (en)	2004-06-07
EP1556055B1 (de)	2008-10-29

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60324449D1 (de)	2008-12-11	Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapie
ATE348808T1 (de)	2007-01-15	Azacyclische verbindungen zur verwendung in der behandlung von mit serotonin verwandten krankheiten
DK1632483T3 (da)	2009-03-02	Heterocykliske, substituerede carbonylderivater og deres anvendelse som dopamin-D3-receptorligander
CR6620A (es)	2004-02-02	Amino acidos biciclicos como agentes farmaceuticos
EE200100619A (et)	2003-02-17	Asendatud bensimidasoolid, nende saamine ning kasutamine ravimi valmistamiseks, mis on ette nähtud NFkB aktiivsuse suurenemisest tingitud haiguste profülaktikaks ja raviks
MX2007004882A (es)	2007-05-09	Derivados de xantina con actividad de receptor de hm74a.
CY1106645T1 (el)	2012-01-25	Παραγωγα 1,2,4 τριαμινοβενζολης χρησιμα για τη θεραπευτικη αντιμετωπιση διαταραχων του κεντρικου νευρικου συστηματος
NO306779B1 (no)	1999-12-20	Naftalamider, anvendelse derav og farmasöytisk preparat
NO990433L (no)	1999-03-25	Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet
PL313716A1 (en)	1996-07-22	Tetrachloropyridino-(or 4-hydroxypiperidino) alkyloazoles exhibiting activity in respect to sigma and/or 5ht1a receptor
ATE247639T1 (de)	2003-09-15	Arylsubstituierte cyclische amine als selektive dopamin-d3-liganden
HRP20041179B1 (hr)	2012-11-30	Prekursorski oblici lijekova za aminokiseline s pobuđivačkom aktivnosti
WO2003092617A3 (en)	2004-05-13	Combinations for the treatment of inflammatory skin disorders
ATE224718T1 (de)	2002-10-15	Verwendung eines k-252a derivats zur behandlung von periphärer oder zentraler nervenerkrankungen und übermässiger cytokinbildung
ATE345342T1 (de)	2006-12-15	1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung
DE60304695D1 (de)	2006-05-24	7-ARYLSULFONAMID-2,3,4,5-TETRAHYDRO-1H-BENZOiDöAZEPINE MIT 5-HT6 REZEPTOR AFFINITÄT ZUR BEHANDLUNG VON ZENTRALNERVENSYSTEMERKRANKUNGEN
DE69837322D1 (de)	2007-04-26	Verfahren zur therapeutischen verabreichung von anti-cd40l-mitteln
UY29077A1 (es)	2006-03-31	Amidas sustituidas de ácido tienopirrolcarboxílico, amidas del ácido pirrolotiazolcarboxílico y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon)
ATE286883T1 (de)	2005-01-15	Isochinolin und chinazolinderivate mit kombinierter 5ht1a, 5ht1b und 5ht1d rezeptor aktivität
BR0307504A (pt)	2004-12-07	Composto ou sal farmaceuticamente aceitável, composição farmacêutica, métodos tratar doenças, para potencializar um efeito terapêutico de um agente para o snc, para melhorar a memória de curto prazo em um paciente, para determinar a presença ou ausência de receptores gabaa em uma amostra, e para alterar a atividade transdutora de sinal do receptor gabaa, embalagem, e, uso de um composto ou sal
DE602004022284D1 (de)	2009-09-10	Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid-neurotoxizität und mikrogliosis
DE60041399D1 (de)	2009-03-05	Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
IL157363A0 (en)	2004-02-19	Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
TW200510437A (en)	2005-03-16	Phosphinane compound with immunomodulating activity
DE60039579D1 (de)	2008-09-04	Humane adulte astrozyten, sowie deren herstellung und verwendung