ATE412742T1 - Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren - Google Patents

Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren

Info

Publication number
ATE412742T1
ATE412742T1 AT03731662T AT03731662T ATE412742T1 AT E412742 T1 ATE412742 T1 AT E412742T1 AT 03731662 T AT03731662 T AT 03731662T AT 03731662 T AT03731662 T AT 03731662T AT E412742 T1 ATE412742 T1 AT E412742T1
Authority
AT
Austria
Prior art keywords
small molecules
methods
methods according
cells
functionalities
Prior art date
Application number
AT03731662T
Other languages
English (en)
Inventor
Neil Goldsmith
Soeren Nielsen
Alexandra Soerensen
Curt Nielsen
Original Assignee
Evolva Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2002/000057 external-priority patent/WO2002059290A2/en
Application filed by Evolva Ag filed Critical Evolva Ag
Application granted granted Critical
Publication of ATE412742T1 publication Critical patent/ATE412742T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5097—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03731662T 2002-01-25 2003-01-24 Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren ATE412742T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK2002/000057 WO2002059290A2 (en) 2001-01-25 2002-01-25 A method for evolving a cell having desired phenotype and envolved cells
DKPA200201174 2002-08-01

Publications (1)

Publication Number Publication Date
ATE412742T1 true ATE412742T1 (de) 2008-11-15

Family

ID=32992148

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03731662T ATE412742T1 (de) 2002-01-25 2003-01-24 Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren

Country Status (8)

Country Link
US (1) US20050164162A1 (de)
EP (1) EP1472349B1 (de)
JP (1) JP4472345B2 (de)
AT (1) ATE412742T1 (de)
AU (1) AU2003237662B2 (de)
CA (1) CA2511229A1 (de)
DE (1) DE60324385D1 (de)
WO (1) WO2003062419A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE501251T1 (de) 2001-01-25 2011-03-15 Evolva Ltd Zellbibliothek
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
ATE527366T1 (de) * 2002-08-01 2011-10-15 Evolva Ltd Verfahren zur mischung von vielen heterologen genen
EP1718765A2 (de) * 2004-01-26 2006-11-08 Isis Innovation Limited Molekularanalyse
CN101218352B (zh) 2005-03-18 2013-09-04 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
WO2008073166A2 (en) * 2006-08-23 2008-06-19 Xcellerex, Inc. Multi-variant cell indication technique
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
WO2008157358A1 (en) * 2007-06-15 2008-12-24 University Of Medicine And Dentistry Of New Jersey Methods for treating neoplasia and for identifying compositions useful in such therapy
JP5676837B2 (ja) * 2007-11-02 2015-02-25 丸善製薬株式会社 毛乳頭細胞増殖促進剤、線維芽細胞増殖因子−７（ｆｇｆ−７）産生促進剤、血管内皮増殖因子（ｖｅｇｆ）産生促進剤、抗男性ホルモン剤、育毛剤及び頭髪化粧料
AU2009220203B2 (en) * 2008-03-04 2014-02-20 Crystal Bioscience Inc. Gel microdrop composition and method of using the same
JP4918582B2 (ja) * 2009-09-28 2012-04-18 富山県 グルクロン酸転移酵素の製造方法
WO2011118231A1 (ja) * 2010-03-26 2011-09-29 国立大学法人三重大学 マラリア原虫人工染色体を用いた薬剤耐性遺伝子の迅速同定法および組換えマラリア原虫作製法
WO2011146833A1 (en) 2010-05-20 2011-11-24 Evolva Inc. Method of producing isoprenoid compounds in yeast
WO2017130059A1 (en) 2016-01-25 2017-08-03 Bio-Rad Innovations Digital microbiology
EP3589741A1 (de) * 2017-03-03 2020-01-08 Biomillenia SAS Mikropartikel zur kultivierung und prüfung von zellen
WO2018229018A1 (en) * 2017-06-12 2018-12-20 Biomillenia Sas Method of measuring viscosity in a microfluidic system
CN114868678A (zh) * 2022-04-28 2022-08-09 淮阴师范学院 一种加州鲈鱼水槽养殖方法
WO2024173944A1 (en) * 2023-02-17 2024-08-22 Carnegie Mellon University Prioritizing candidate cell type-specific enhancers through comparative genomics

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316922A (en) * 1992-04-15 1994-05-31 The United States Of America As Represented By Department Of Health And Human Services Method for indentifying and expressing proteins that recognize and adhere to specific probes
US6268140B1 (en) * 1994-02-03 2001-07-31 Neugenesis Combinatorial metabolic libraries
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) * 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5824485A (en) * 1995-04-24 1998-10-20 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US6030779A (en) * 1995-07-18 2000-02-29 Diversa Corporation Screening for novel bioactivities
US5958672A (en) * 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US6004788A (en) * 1995-07-18 1999-12-21 Diversa Corporation Enzyme kits and libraries
US5939250A (en) * 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
US20010041333A1 (en) * 1997-06-16 2001-11-15 Short Jay M. High throughput screening for a bioactivity or biomolecule
GB9603803D0 (en) * 1996-02-22 1996-04-24 Zeneca Ltd Production of proteins, plasmids coding therefor and organisms containing such plasmids
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US5783431A (en) * 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5763239A (en) * 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
AU5217599A (en) * 1998-07-27 2000-02-21 Genotypes, Inc. Automatic eukaryotic artificial chromosome vector
GB9908814D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Process
EP1276861A2 (de) * 2000-03-24 2003-01-22 Maxygen, Inc. Methoden zur modulation zellulärer und organismenspezifischer phenotypen
EP1360327A4 (de) * 2001-01-24 2005-07-13 Galileo Pharmaceuticals Inc Verfahren zur identifizierung von gewünschte zellphänotypen regulierenden genen
US8008459B2 (en) * 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
CA2474146C (en) * 2001-01-25 2012-09-18 Evolva Ltd. A method for evolving a cell having desired phenotype and evolved cells
ATE501251T1 (de) * 2001-01-25 2011-03-15 Evolva Ltd Zellbibliothek
US20030235823A1 (en) * 2002-06-24 2003-12-25 The University Of Alabama Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
ATE527366T1 (de) * 2002-08-01 2011-10-15 Evolva Ltd Verfahren zur mischung von vielen heterologen genen

Also Published As

Publication number Publication date
JP4472345B2 (ja) 2010-06-02
US20050164162A1 (en) 2005-07-28
JP2005514947A (ja) 2005-05-26
EP1472349B1 (de) 2008-10-29
WO2003062419A1 (en) 2003-07-31
DE60324385D1 (de) 2008-12-11
EP1472349A1 (de) 2004-11-03
AU2003237662B2 (en) 2008-04-24
CA2511229A1 (en) 2003-07-31

Similar Documents

Publication Publication Date Title
ATE412742T1 (de) Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren
Graudal et al. Global to local genetic diversity indicators of evolutionary potential in tree species within and outside forests
Díaz-Ramírez et al. Environmental assessment of electrochemical energy storage device manufacturing to identify drivers for attaining goals of sustainable materials 4.0
Ashworth et al. Crop rotations and poultry litter affect dynamic soil chemical properties and soil biota long term
Borisov et al. Stable relativistic/charge-displacement channels in ultrahigh power density (≈ 1021 W/cm3) plasmas
Basdevant et al. Peak Locations and Relative Phase of Different Decay Modes of the a 1 Axial Vector Resonance in Diffractive Production
Eiben et al. Competing crossovers in an adaptive GA framework
Langschied et al. Quest for orthologs in the era of biodiversity genomics
Clark et al. Reexamination of the N= 90 transitional nuclei 150 Nd and 152 Sm
Savee et al. The role of excited-state topology in three-body dissociation of sym-triazine
ATE527366T1 (de) Verfahren zur mischung von vielen heterologen genen
EP1601687A4 (de) Verfahren zur erhöhung der ausbreitung von b-zellen
Le et al. Optimized phage display-based selection for the development of heterodimerizing optogenetic tools
May et al. Temporal binding of sound emerges out of anatomical structure and synaptic dynamics of auditory cortex
Srivastava et al. Spectra of produced particles at CERN SPS heavy-ion collisions from a parton cascade model
WO2007079291A3 (en) Generation of set coverings with free riders, and generation of ordered sets of meeting points, in systems which include, but are not limited to, systems for broadcast encryption and systems for certificate revocation
ATE512576T1 (de) Abschirmgehäuse mit einpresspins sowie verfahren zu dessen herstellung
Ingrassia et al. The legal framework for the management of animal genetic resources
Petersen Latin American Pentecostalism: Social Capital, Networks, and Politics
WO2007072051A3 (en) Data tracking system
Kolar et al. Towards key performance indicators of research infrastructures
Song et al. Overmodulation causes a variation in the number of jumps in the Duffing system
Verma et al. Ab Initio Simulations Predict Highly Efficient Transfer of Hot Electrons from Noble-Metal Nanoclusters to Degrade Per-and Polyfluoroalkyl Substances
Chen Dynamics of burst synchronization induced by excitatory inputs on midbrain dopamine neurons
Kasbun et al. A Decade of E-Waste Unplugged: Decoding the Landscape of Global Research and Challenges

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties