ATE413401T1 - Neue purinderivate, deren herstellungsverfahren, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue verwendung - Google Patents

Neue purinderivate, deren herstellungsverfahren, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue verwendung

Info

Publication number: ATE413401T1
Authority: AT; Austria
Prior art keywords: optionally substituted; alkyl; aryl; new; upto
Prior art date: 2003-02-18

Application number

AT04710901T

Other languages

English (en)

Inventor

Florence Bordon-Pallier

Jean-Luc Haesslein

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-18

Filing date

2004-02-13

Publication date

2008-11-15

2004-02-13 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE413401T1 publication Critical patent/ATE413401T1/de

Links

229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
-1 dioxolyl Chemical group 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
101000628949 Homo sapiens Mitogen-activated protein kinase 10 Proteins 0.000 abstract 1
102100026931 Mitogen-activated protein kinase 10 Human genes 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002682 anti-psoriatic effect Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000000824 cytostatic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000000855 fungicidal effect Effects 0.000 abstract 1
239000000417 fungicide Substances 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
229940043355 kinase inhibitor Drugs 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
239000003909 protein kinase inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04710901T 2003-02-18 2004-02-13 Neue purinderivate, deren herstellungsverfahren, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue verwendung ATE413401T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0301915A FR2851248B1 (fr)	2003-02-18	2003-02-18	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Publications (1)

Publication Number	Publication Date
ATE413401T1 true ATE413401T1 (de)	2008-11-15

Family

ID=32749627

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04710901T ATE413401T1 (de)	2003-02-18	2004-02-13	Neue purinderivate, deren herstellungsverfahren, deren verwendung als arzneimittel, pharmazeutische zusammensetzungen und neue verwendung

Country Status (11)

Country	Link
EP (1)	EP1597258B1 (de)
JP (1)	JP2006517955A (de)
AT (1)	ATE413401T1 (de)
AU (1)	AU2004212733B2 (de)
BR (1)	BRPI0407578A (de)
CA (1)	CA2515610A1 (de)
DE (1)	DE602004017580D1 (de)
FR (1)	FR2851248B1 (de)
IL (1)	IL170318A (de)
MX (1)	MXPA05007519A (de)
WO (1)	WO2004073595A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0407723D0 (en) *	2004-04-05	2004-05-12	Novartis Ag	Organic compounds
WO2006090261A1 (en) *	2005-02-24	2006-08-31	Pfizer Products Inc.	Bicyclic heteroaromatic derivatives useful as anticancer agents
GB0519245D0 (en) *	2005-09-20	2005-10-26	Vernalis R&D Ltd	Purine compounds
CA2672213C (en) *	2006-12-22	2016-02-16	Astex Therapeutics Limited	Bicyclic amine derivatives as protein tyrosine kinase inhibitors
JP2010526027A (ja) *	2007-01-23	2010-07-29	パラウ・フアルマ・ソシエダツド・アノニマ	プリン誘導体
EP2134723B1 (de)	2007-03-07	2017-07-12	Boehringer Ingelheim International GmbH	2,6-diamino-9h-purin-derivate und ihre verwendung für die behandlung von proliferativen erkrankungen
CN104119336B (zh) *	2007-10-05	2016-08-24	维拉斯通股份有限公司	嘧啶取代的嘌呤衍生物
AU2009269087A1 (en) *	2008-07-07	2010-01-14	Xcovery Holding Company Llc	PI3K isoform selective inhibitors
WO2013123215A2 (en) *	2012-02-17	2013-08-22	Siga Technologies, Inc.	Antiviral drugs for treatment of arenavirus infection
TW201825465A (zh)	2016-09-23	2018-07-16	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh)	2016-09-23	2018-04-16	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh)	2016-09-23	2018-05-01	美商基利科學股份有限公司	磷脂醯肌醇3-激酶抑制劑
RU2760305C1 (ru) *	2021-04-26	2021-11-23	Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН)	4-[(Пурин-6-ил)аминополиметиленкарбонил]-производные 3,4-дигидро-3-метил-7,8-дифтор-2H-[1,4]бензоксазина, обладающие противоопухолевой активностью

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992012718A1 (en) *	1991-01-23	1992-08-06	Gensia, Inc.	Adenosine kinase inhibitors
DE69531558T2 (de) *	1995-06-07	2004-03-18	Pfizer Inc.	Heterocyclische kondensierte pyrimidin-derivate
WO2000044750A1 (en) *	1999-02-01	2000-08-03	Cv Therapeutics, Inc.	PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a)
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
MXPA03003774A (es) *	2000-10-31	2003-07-28	Aventis Pharm Prod Inc	Derivados de acilo y sulfonilo de 2-(trans-1, 4-diaminociclohexil)-purinas 6,9-disubstituidas y sus uso como agentes antiproliferativos.
FR2818642B1 (fr) *	2000-12-26	2005-07-15	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion

2003
- 2003-02-18 FR FR0301915A patent/FR2851248B1/fr not_active Expired - Fee Related
2004
- 2004-02-13 AT AT04710901T patent/ATE413401T1/de not_active IP Right Cessation
- 2004-02-13 BR BRPI0407578-1A patent/BRPI0407578A/pt not_active IP Right Cessation
- 2004-02-13 MX MXPA05007519A patent/MXPA05007519A/es active IP Right Grant
- 2004-02-13 AU AU2004212733A patent/AU2004212733B2/en not_active Ceased
- 2004-02-13 CA CA002515610A patent/CA2515610A1/fr not_active Abandoned
- 2004-02-13 EP EP04710901A patent/EP1597258B1/de not_active Expired - Lifetime
- 2004-02-13 WO PCT/FR2004/000330 patent/WO2004073595A2/fr not_active Ceased
- 2004-02-13 JP JP2006502145A patent/JP2006517955A/ja active Pending
- 2004-02-13 DE DE602004017580T patent/DE602004017580D1/de not_active Expired - Lifetime
2005
- 2005-08-16 IL IL170318A patent/IL170318A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2004073595A3 (fr)	2005-01-06
WO2004073595A2 (fr)	2004-09-02
EP1597258B1 (de)	2008-11-05
FR2851248B1 (fr)	2005-04-08
DE602004017580D1 (de)	2008-12-18
BRPI0407578A (pt)	2006-02-14
JP2006517955A (ja)	2006-08-03
FR2851248A1 (fr)	2004-08-20
CA2515610A1 (fr)	2004-09-02
AU2004212733A1 (en)	2004-09-02
IL170318A (en)	2011-02-28
EP1597258A2 (de)	2005-11-23
MXPA05007519A (es)	2005-09-21
AU2004212733B2 (en)	2009-12-24

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Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties