ATE413416T1 - Verfahren zur herstellung von niedermolekularem heparin - Google Patents

Verfahren zur herstellung von niedermolekularem heparin

Info

Publication number: ATE413416T1
Authority: AT; Austria
Prior art keywords: low molecular; molecular weight; weight heparin; comprised; heparin
Prior art date: 2004-07-29

Application number

AT05769509T

Other languages

English (en)

Inventor

Stefania Sacchi

Mauro Montorsi

Egidio Marchi

Original Assignee

Biofer Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-29

Filing date

2005-07-27

Publication date

2008-11-15

2005-07-27 Application filed by Biofer Spa filed Critical Biofer Spa

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE413416T1 publication Critical patent/ATE413416T1/de

Links

239000003055 low molecular weight heparin Substances 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title abstract 2
229940127215 low-molecular weight heparin Drugs 0.000 abstract 5
230000009935 nitrosation Effects 0.000 abstract 2
238000007034 nitrosation reaction Methods 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
VQTGUFBGYOIUFS-UHFFFAOYSA-N nitrosylsulfuric acid Chemical group OS(=O)(=O)ON=O VQTGUFBGYOIUFS-UHFFFAOYSA-N 0.000 abstract 1
XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
230000005855 radiation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT05769509T 2004-07-29 2005-07-27 Verfahren zur herstellung von niedermolekularem heparin ATE413416T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000199A ITMO20040199A1 (it)	2004-07-29	2004-07-29	Procedimento per la purificazione da gruppi e n no rsidui di eparine a basso peso molecolare ottentite tramite nitrosazione.

Publications (1)

Publication Number	Publication Date
ATE413416T1 true ATE413416T1 (de)	2008-11-15

Family

ID=35253814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05769509T ATE413416T1 (de)	2004-07-29	2005-07-27	Verfahren zur herstellung von niedermolekularem heparin

Country Status (8)

Country	Link
EP (1)	EP1773890B1 (de)
AT (1)	ATE413416T1 (de)
DE (1)	DE602005010873D1 (de)
ES (1)	ES2317280T3 (de)
IT (1)	ITMO20040199A1 (de)
PL (1)	PL1773890T3 (de)
PT (1)	PT1773890E (de)
WO (1)	WO2006011179A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2481466A1 (de) *	2011-01-31	2012-08-01	Siemens Aktiengesellschaft	Vorrichtung und Verfahren zum Aufreinigen eines mit Nitrosamin verunreinigten Produktes einer Prozessanlage
ES2390063B1 (es) *	2011-04-13	2014-04-11	Bioibérica, S.A.	Glicosaminoglicanos con muy bajo contenido de metanol.
CN104072635B (zh) *	2014-03-07	2016-09-28	常山生化药业（江苏）有限公司	一种用阴离子交换树脂纯化制备达肝素钠的方法
CN104045744B (zh) *	2014-06-26	2016-01-06	常州千红生化制药股份有限公司	达肝素钠的制备方法
CN104086673B (zh) *	2014-07-28	2016-07-06	常州千红生化制药股份有限公司	一种那屈肝素钙的制备工艺
CN107011463A (zh) *	2017-05-31	2017-08-04	广元市海天实业有限责任公司	一种低分子量肝素钠的生产方法
JP2021513593A (ja)	2018-02-14	2021-05-27	バイオロジカルイーリミテッド	ダルテパリンナトリウムを調製する改善された方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2440376A1 (fr) *	1978-11-06	1980-05-30	Choay Sa	Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4351938A (en) *	1980-05-19	1982-09-28	Riker Laboratories, Inc.	Anticoagulant substance
FR2503714B1 (fr) *	1981-04-10	1986-11-21	Choay Sa	Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2704861B1 (fr) *	1993-05-07	1995-07-28	Sanofi Elf	Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.

2004
- 2004-07-29 IT IT000199A patent/ITMO20040199A1/it unknown
2005
- 2005-07-27 AT AT05769509T patent/ATE413416T1/de not_active IP Right Cessation
- 2005-07-27 EP EP05769509A patent/EP1773890B1/de not_active Expired - Lifetime
- 2005-07-27 PL PL05769509T patent/PL1773890T3/pl unknown
- 2005-07-27 ES ES05769509T patent/ES2317280T3/es not_active Expired - Lifetime
- 2005-07-27 WO PCT/IT2005/000448 patent/WO2006011179A1/en not_active Ceased
- 2005-07-27 DE DE602005010873T patent/DE602005010873D1/de not_active Expired - Lifetime
- 2005-07-27 PT PT05769509T patent/PT1773890E/pt unknown

Also Published As

Publication number	Publication date
EP1773890A1 (de)	2007-04-18
DE602005010873D1 (de)	2008-12-18
ITMO20040199A1 (it)	2004-10-29
ES2317280T3 (es)	2009-04-16
EP1773890B1 (de)	2008-11-05
PT1773890E (pt)	2009-02-12
WO2006011179A1 (en)	2006-02-02
PL1773890T3 (pl)	2009-04-30

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Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties