ATE413882T1 - 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren - Google Patents

2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren

Info

Publication number: ATE413882T1
Authority: AT; Austria
Prior art keywords: sub; inhibitors; reuppose; phenylthiomethyl; morpholine derivatives
Prior art date: 2002-08-23

Application number

AT03751812T

Other languages

English (en)

Inventor

Magnus Wilhelm Walter

Barry Peter Clark

Peter Thaddeus Gallagher

Helen Louise Haughton

Helene C E Rudyk

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-23

Filing date

2003-08-18

Publication date

2008-11-15

2002-08-23 Priority claimed from GB0219690A external-priority patent/GB0219690D0/en

2003-08-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE413882T1 publication Critical patent/ATE413882T1/de

Links

SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title 1
BOQUBIQEFLRSNK-UHFFFAOYSA-N 2-(phenylsulfanylmethyl)morpholine Chemical class C1NCCOC1CSC1=CC=CC=C1 BOQUBIQEFLRSNK-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229960002748 norepinephrine Drugs 0.000 title 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229940124639 Selective inhibitor Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000966 norepinephrine reuptake Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT03751812T 2002-08-23 2003-08-18 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren ATE413882T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0219690A GB0219690D0 (en)	2002-08-23	2002-08-23	Benzyl morpholine derivatives
US41532802P	2002-10-01	2002-10-01

Publications (1)

Publication Number	Publication Date
ATE413882T1 true ATE413882T1 (de)	2008-11-15

Family

ID=31948037

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03751812T ATE413882T1 (de)	2002-08-23	2003-08-18	2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren

Country Status (7)

Country	Link
US (1)	US7384941B2 (de)
EP (1)	EP1534291B1 (de)
AT (1)	ATE413882T1 (de)
AU (1)	AU2003269923A1 (de)
DE (1)	DE60324685D1 (de)
ES (1)	ES2315525T3 (de)
WO (1)	WO2004017977A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7399775B2 (en)	2001-12-27	2008-07-15	Daiichi Pharmaceutical Co., Ltd.	β-amyloid protein production/secretion inhibitor
GB0219687D0 (en) *	2002-08-23	2002-10-02	Lilly Co Eli	Benzyl morpholine derivatives
EP1546123B1 (de)	2002-08-23	2006-05-31	Eli Lilly And Company	Benzylmorpholinderivate
PL379466A1 (pl) *	2003-06-30	2006-09-18	Daiichi Sankyo Company , Limited	Heterocykliczne pochodne metylosulfonu
GB0319793D0 (en) *	2003-08-22	2003-09-24	Lilly Co Eli	Pyridinylmorpholine derivatives
KR20060121178A (ko) *	2003-12-12	2006-11-28	일라이 릴리 앤드 캄파니	일과성 전신 열감, 충동 조절 장애 및 일반적인 의학상태로 인한 인격 변화 치료용 선택적 노르에피네프린재흡수 억제제
WO2005066144A1 (en) *	2003-12-23	2005-07-21	Eli Lilly And Company	Morpholine derivatives as norepinephrine reuptake inhibitors
GB0409744D0 (en) *	2004-04-30	2004-06-09	Pfizer Ltd	Novel compounds
AP2006003771A0 (en) *	2004-04-30	2006-10-31	Warner Lambert Co	Substituted morpholine compounds for the treatmentof central nervous system disorders
WO2007005935A2 (en) *	2005-07-06	2007-01-11	Molecular Neuroimaging, Llc	Norepinephrine transporter radiotracers and methods of syntheses thereof
ES2434250T3 (es)	2008-07-24	2013-12-16	Theravance, Inc.	Compuestos de 3-(fenoxifenilmetil)pirrolidina
SI2358676T1 (sl) *	2008-11-14	2013-01-31	Theravance, Inc.	Kristalinična oblika 4-(2-(2-fluorofenoksimetil)fenil)piperidinske spojine
EP2419405A1 (de) *	2009-04-15	2012-02-22	Theravance, Inc.	3-(phenoxypyrrolidin-3-ylmethyl)heteroaryl-, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl- und 3-(heteroarylpyrrolidin-3-ylmethoxy)heterarylverbindungen
AU2010273645B2 (en)	2009-07-13	2014-12-04	Theravance Biopharma R&D Ip, Llc	3-phenoxymethylpyrrolidine compounds
US8273786B2 (en) *	2009-07-21	2012-09-25	Theravance, Inc.	3-phenoxymethylpyrrolidine compounds
EP2523945A1 (de)	2010-01-11	2012-11-21	Theravance, Inc.	1-(2-phenoxymethylphenyl-)piperazinverbindungen als serotonin- und norepinephrin-wiederaufnahmehemmer
EP2550252B1 (de) *	2010-03-22	2015-05-06	Theravance Biopharma R&D IP, LLC	1-(2-phenoxymethylheteroaryl)piperidin und piperazinverbindungen
WO2012051103A1 (en)	2010-10-11	2012-04-19	Theravance, Inc.	Serotonin reuptake inhibitors
US8501964B2 (en)	2010-12-03	2013-08-06	Theravance, Inc.	Serotonin reuptake inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759013R (fr) *	1969-11-17	1971-05-17	Ici Ltd	Derives de la
GB1412546A (en) *	1973-08-08	1975-11-05	Ici Ltd	Morpholine derivatives
GB2167407B (en) *	1984-11-22	1988-05-11	Erba Farmitalia	Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
US5658590A (en)	1995-01-11	1997-08-19	Eli Lilly And Company	Treatment of attention-deficit/hyperactivity disorder
IL122984A0 (en)	1995-07-24	1998-08-16	Lilly Co Eli	Treatment of attention-deficit/ hyperactivity disorder
WO1999015177A1 (en)	1997-09-23	1999-04-01	Eli Lilly And Company	Treatment of attention-deficit/hyperactivity disorder
BR9907203A (pt)	1998-01-21	2000-10-17	Glaxo Group Ltd	"composto, composições farmacêuticas, uso de um composto, e, processo de tratametno de depressão, distúrbio de hiperatividade por deficiência de atenção (adhd), obesidade, enxaqueca, dor, disfunção sexual, doença de parkinson, doença de alzeheimer, ou vìcio de cocaìna ou de produtos contendo nicotina (especialmente tabaco) em um indivìduo animal ou humano. "
GB9812662D0 (en)	1998-06-11	1998-08-12	Merck Sharp & Dohme	Therapeutic use
US6503905B1 (en)	1998-12-29	2003-01-07	Pfizer Inc	3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
YU56301A (sh)	1999-02-23	2004-05-12	Pfizer Products Inc.	Inhibitori resorpcije monoamina za tretiranje poremećaja cns
ATE305788T1 (de)	1999-07-01	2005-10-15	Pharmacia & Upjohn Co Llc	(s,s)-reboxetin zur behandlung von inkontinenz

2003
- 2003-08-18 US US10/524,650 patent/US7384941B2/en not_active Expired - Fee Related
- 2003-08-18 AU AU2003269923A patent/AU2003269923A1/en not_active Abandoned
- 2003-08-18 ES ES03751812T patent/ES2315525T3/es not_active Expired - Lifetime
- 2003-08-18 DE DE60324685T patent/DE60324685D1/de not_active Expired - Fee Related
- 2003-08-18 WO PCT/US2003/023269 patent/WO2004017977A2/en not_active Ceased
- 2003-08-18 AT AT03751812T patent/ATE413882T1/de not_active IP Right Cessation
- 2003-08-18 EP EP03751812A patent/EP1534291B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2003269923A8 (en)	2004-03-11
US7384941B2 (en)	2008-06-10
EP1534291A2 (de)	2005-06-01
ES2315525T3 (es)	2009-04-01
DE60324685D1 (de)	2008-12-24
US20060035894A1 (en)	2006-02-16
WO2004017977A2 (en)	2004-03-04
EP1534291B1 (de)	2008-11-12
AU2003269923A1 (en)	2004-03-11
WO2004017977A3 (en)	2004-04-01

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Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties