ATE414090T1 - Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit - Google Patents

Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit

Info

Publication number
ATE414090T1
ATE414090T1 AT04803724T AT04803724T ATE414090T1 AT E414090 T1 ATE414090 T1 AT E414090T1 AT 04803724 T AT04803724 T AT 04803724T AT 04803724 T AT04803724 T AT 04803724T AT E414090 T1 ATE414090 T1 AT E414090T1
Authority
AT
Austria
Prior art keywords
disease
treatment
alzheimer
indolhydroxyethylamine
tricyclic
Prior art date
Application number
AT04803724T
Other languages
English (en)
Inventor
Sally Redshaw
Emmanuel Hubert Demont
Daryl Simon Walter
David Vesey
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE414090T1 publication Critical patent/ATE414090T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04803724T 2003-12-12 2004-12-09 Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit ATE414090T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0328900.6A GB0328900D0 (en) 2003-12-12 2003-12-12 Novel compounds

Publications (1)

Publication Number Publication Date
ATE414090T1 true ATE414090T1 (de) 2008-11-15

Family

ID=30130158

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04803724T ATE414090T1 (de) 2003-12-12 2004-12-09 Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit

Country Status (17)

Country Link
US (1) US20070073060A1 (de)
EP (1) EP1692143B1 (de)
JP (1) JP2007513913A (de)
KR (1) KR20060121164A (de)
CN (1) CN1914214A (de)
AT (1) ATE414090T1 (de)
AU (1) AU2004299231A1 (de)
BR (1) BRPI0417476A (de)
CA (1) CA2549072A1 (de)
DE (1) DE602004017777D1 (de)
GB (1) GB0328900D0 (de)
IL (1) IL175819A0 (de)
IS (1) IS8521A (de)
MA (1) MA28241A1 (de)
NO (1) NO20063137L (de)
RU (1) RU2006124863A (de)
WO (1) WO2005058915A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2558034A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
US7385085B2 (en) 2004-07-09 2008-06-10 Elan Pharmaceuticals, Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
BRPI0515383A (pt) * 2004-09-21 2008-07-22 Pfizer Prod Inc n-etil hidroxietilamina útil no tratamento de condições do snc
GB0422766D0 (en) * 2004-10-13 2004-11-17 Glaxo Group Ltd Novel compounds
GB0422765D0 (en) * 2004-10-13 2004-11-17 Glaxo Group Ltd Novel compounds
WO2007047305A1 (en) * 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
US7872009B2 (en) * 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
FR2919288B1 (fr) * 2007-07-27 2009-09-04 Sanofi Aventis Sa Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique.
FR2919286A1 (fr) 2007-07-27 2009-01-30 Sanofi Aventis Sa Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
HRP20110650T1 (hr) * 2007-07-27 2011-10-31 Sanofi DERIVATI 1,2,3,4-TETRAHIDROPIROLO[1,2-a]PIRAZIN-6-KARBOKSAMIDA I 2,3,4,5-TETRAHIDROPIROLO[1,2-a]DIAZEPIN-7-KARBOKSAMIDA, NJIHOVO DOBIVANJE I UPOTREBA U TERAPIJI
FR2919289B1 (fr) * 2007-07-27 2009-09-04 Sanofi Aventis Sa Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique.
FR2919285B1 (fr) 2007-07-27 2012-08-31 Sanofi Aventis Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
CA2724449C (en) * 2008-05-29 2017-05-30 Albany Molecular Research, Inc. 5-ht3 receptor modulators, methods of making, and use thereof
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
EP2575815A4 (de) 2010-06-04 2013-12-25 Albany Molecular Res Inc Glycin-transporter-1-hemmer, verfahren zu ihrer herstellung und ihre verwendung
KR102046499B1 (ko) * 2012-08-24 2019-11-19 트레벤티스 코포레이션 벤조푸라잔 항아밀로이드 화합물 및 방법
US12043631B2 (en) 2017-10-13 2024-07-23 Purdue Research Foundation BACE1 inhibitors for the treatment of Alzheimer's disease
US11214579B2 (en) * 2017-10-13 2022-01-04 Purdue Research Foundation BACE1 inhibitors for the treatment of Alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU749281B2 (en) * 1997-02-04 2002-06-20 Regents Of The University Of California, The Nanomolar, non-peptide inhibitors of cathepsin D
US6207664B1 (en) * 1998-11-25 2001-03-27 Pfizer Inc. Squalene synthetase inhibitor agents
AU2001252958A1 (en) * 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
DE60116313T2 (de) * 2000-06-30 2006-08-31 Elan Pharmaceuticals, Inc., San Francisco Verbindungen zur behandlung der alzheimerischen krankheit
EP1453789A2 (de) * 2001-11-08 2004-09-08 Elan Pharmaceuticals, Inc. N,n'-substituierte 1,3-diamino-2-hydroxypropanderivate
GB0228410D0 (en) * 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
GB0309221D0 (en) * 2003-04-23 2003-06-04 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
IL175819A0 (en) 2006-10-05
GB0328900D0 (en) 2004-01-14
EP1692143A1 (de) 2006-08-23
MA28241A1 (fr) 2006-10-02
AU2004299231A1 (en) 2005-06-30
DE602004017777D1 (de) 2008-12-24
IS8521A (is) 2006-06-26
JP2007513913A (ja) 2007-05-31
EP1692143B1 (de) 2008-11-12
CN1914214A (zh) 2007-02-14
US20070073060A1 (en) 2007-03-29
KR20060121164A (ko) 2006-11-28
RU2006124863A (ru) 2008-01-20
NO20063137L (no) 2006-08-31
WO2005058915A1 (en) 2005-06-30
CA2549072A1 (en) 2005-06-30
BRPI0417476A (pt) 2007-05-08

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