FR2960876B1 - Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. - Google Patents

Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Info

Publication number: FR2960876B1
Authority: FR; France
Prior art keywords: dihydropyrrolo; pyrazine; preparation; therapeutic use; dicarboxamide derivatives
Prior art date: 2010-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR1054372A

Other languages

English (en)

Other versions

FR2960876A1 (fr

Inventor

Jacques Froissant

Jean Francois Gibert

Frank Marguet

Christophe Pacaud

Frederic Puech

Antoine Ravet

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-03

Filing date

2010-06-03

Publication date

2012-07-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2960876(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-06-03 Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France

2010-06-03 Priority to FR1054372A priority Critical patent/FR2960876B1/fr

2011-06-01 Priority to BR112012030697A priority patent/BR112012030697A2/pt

2011-06-01 Priority to PT117815902T priority patent/PT2588480T/pt

2011-06-01 Priority to AU2011268651A priority patent/AU2011268651B2/en

2011-06-01 Priority to KR1020127031424A priority patent/KR20130113928A/ko

2011-06-01 Priority to CN201180038277.8A priority patent/CN103168041B/zh

2011-06-01 Priority to CA2801154A priority patent/CA2801154C/fr

2011-06-01 Priority to JP2013513006A priority patent/JP5995841B2/ja

2011-06-01 Priority to PL11781590T priority patent/PL2588480T3/pl

2011-06-01 Priority to LTEP11781590.2T priority patent/LT2588480T/lt

2011-06-01 Priority to EP11781590.2A priority patent/EP2588480B1/fr

2011-06-01 Priority to MA35524A priority patent/MA34360B1/fr

2011-06-01 Priority to PH1/2012/502353A priority patent/PH12012502353A1/en

2011-06-01 Priority to ES11781590.2T priority patent/ES2603420T3/es

2011-06-01 Priority to HUE11781590A priority patent/HUE030650T2/en

2011-06-01 Priority to NZ603947A priority patent/NZ603947A/en

2011-06-01 Priority to SI201131022A priority patent/SI2588480T1/sl

2011-06-01 Priority to PE2012002257A priority patent/PE20130259A1/es

2011-06-01 Priority to HRP20161494TT priority patent/HRP20161494T1/hr

2011-06-01 Priority to EA201291364A priority patent/EA201291364A1/ru

2011-06-01 Priority to DK11781590.2T priority patent/DK2588480T3/en

2011-06-01 Priority to MX2012014084A priority patent/MX2012014084A/es

2011-06-01 Priority to PCT/IB2011/001594 priority patent/WO2011161537A2/fr

2011-06-01 Priority to SG2012088795A priority patent/SG186143A1/en

2011-06-02 Priority to ARP110101901A priority patent/AR081832A1/es

2011-06-03 Priority to TW100119696A priority patent/TWI487707B/zh

2011-06-03 Priority to UY0001033428A priority patent/UY33428A/es

2011-12-09 Publication of FR2960876A1 publication Critical patent/FR2960876A1/fr

2012-07-27 Application granted granted Critical

2012-07-27 Publication of FR2960876B1 publication Critical patent/FR2960876B1/fr

2012-10-31 Priority to TNP2012000520A priority patent/TN2012000520A1/en

2012-11-22 Priority to DO2012000296A priority patent/DOP2012000296A/es

2012-11-26 Priority to CR20120595A priority patent/CR20120595A/es

2012-11-27 Priority to GT201200319A priority patent/GT201200319A/es

2012-11-29 Priority to IL223364A priority patent/IL223364A/en

2012-11-29 Priority to US13/688,916 priority patent/US8791119B2/en

2012-11-30 Priority to ZA2012/09071A priority patent/ZA201209071B/en

2012-11-30 Priority to NI201200176A priority patent/NI201200176A/es

2012-11-30 Priority to CL2012003360A priority patent/CL2012003360A1/es

2012-12-03 Priority to ECSP12012322 priority patent/ECSP12012322A/es

2012-12-03 Priority to CO12218640A priority patent/CO6602113A2/es

2014-07-23 Priority to US14/339,112 priority patent/US9233965B2/en

2016-11-16 Priority to CY20161101179T priority patent/CY1118512T1/el

Status Expired - Fee Related legal-status Critical Current

2030-06-03 Anticipated expiration legal-status Critical

Links

IXCDDTCRURYHQM-UHFFFAOYSA-N 3,4-dihydro-1h-pyrrolo[1,2-a]pyrazine-2,8-dicarboxamide Chemical class C1N(C(=O)N)CCN2C=CC(C(N)=O)=C21 IXCDDTCRURYHQM-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FR1054372A 2010-06-03 2010-06-03 Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. Expired - Fee Related FR2960876B1 (fr)

Priority Applications (40)

Application Number	Priority Date	Filing Date	Title
FR1054372A FR2960876B1 (fr)	2010-06-03	2010-06-03	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
DK11781590.2T DK2588480T3 (en)	2010-06-03	2011-06-01	3,4-dihydro-pyrrolo [1,2-a] pyrazine-2,8 (1H) -DICARBOXAMIDDERIVATER PREPARATION AND THERAPEUTIC USE THEREOF
PT117815902T PT2588480T (pt)	2010-06-03	2011-06-01	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)dicarboxamida, sua preparação e sua utilização terapêutica
AU2011268651A AU2011268651B2 (en)	2010-06-03	2011-06-01	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
KR1020127031424A KR20130113928A (ko)	2010-06-03	2011-06-01	3,4-디히드로피롤로[1,2-ａ]피라진-2,8(1Ｈ)-디카르복스아미드 유도체, 그의 제조법 및 그의 치료 용도
CN201180038277.8A CN103168041B (zh)	2010-06-03	2011-06-01	3,4-二氢吡咯并[1,2-a]吡嗪-2,8(1h)-二甲酰胺衍生物、其制备方法及其治疗用途
CA2801154A CA2801154C (fr)	2010-06-03	2011-06-01	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide, leur preparation et leur utilisation therapeutique
JP2013513006A JP5995841B2 (ja)	2010-06-03	2011-06-01	３，４−ジヒドロピロロ［１，２−ａ］ピラジン−２，８（１Ｈ）−ジカルボキサミド誘導体、その調製、およびその治療的使用
PL11781590T PL2588480T3 (pl)	2010-06-03	2011-06-01	Pochodne 3,4-dihydropirolo[1,2-a]pirazyno-2,8(1H)-dikarboksyamidowe, ich otrzymywanie i zastosowania terapeutyczne
LTEP11781590.2T LT2588480T (lt)	2010-06-03	2011-06-01	3,4-dihidropolo[1,2-a]pirazin-2,8(1h)-dikarboksamido dariniai, jų gamyba ir terapinis panaudojimas
EP11781590.2A EP2588480B1 (fr)	2010-06-03	2011-06-01	Dérivés de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide, leur préparation et leur utilisation thérapeutique
MA35524A MA34360B1 (fr)	2010-06-03	2011-06-01	Dérivés de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide, préparation de ceux-ci et utilisation thérapeutique de ceux-ci et utilisation thérapeutique de ceux-ci
PH1/2012/502353A PH12012502353A1 (en)	2010-06-03	2011-06-01	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
ES11781590.2T ES2603420T3 (es)	2010-06-03	2011-06-01	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1H)-dicarboxamida, su preparación y uso terapéutico de los mismos
HUE11781590A HUE030650T2 (en)	2010-06-03	2011-06-01	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
NZ603947A NZ603947A (en)	2010-06-03	2011-06-01	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
SI201131022A SI2588480T1 (sl)	2010-06-03	2011-06-01	Derivati 3,4-dihidropirolo(1,2-a)pirazina-2,8(1H)-dikarboksamida, njihova priprava in terapevtska uporaba
PE2012002257A PE20130259A1 (es)	2010-06-03	2011-06-01	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparacion y su uso terapeutico
HRP20161494TT HRP20161494T1 (hr)	2010-06-03	2011-06-01	Derivati 3,4-dihidropirolo[1,2-a]pirazin-2,8(1h)-dikaboksamida, njihova priprava i terapijska primjena
EA201291364A EA201291364A1 (ru)	2010-06-03	2011-06-01	Производные 3,4-дигидропирроло[1,2-а]пиразин-2,8(1н)-дикарбоксамида, их получение и применение в терапии
BR112012030697A BR112012030697A2 (pt)	2010-06-03	2011-06-01	derivados de 3,4-di-hidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida, preparação destes e emprego terapêutico destes
PCT/IB2011/001594 WO2011161537A2 (fr)	2010-06-03	2011-06-01	Dérivés de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide, leur préparation et leur utilisation thérapeutique
SG2012088795A SG186143A1 (en)	2010-06-03	2011-06-01	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
MX2012014084A MX2012014084A (es)	2010-06-03	2011-06-01	Deivados de 3, 4-dihidropirrolo [1, 2-a] pirazina-2, 8 (1h) -dicarboxamida su preparacion y sus uso terapeutico.
ARP110101901A AR081832A1 (es)	2010-06-03	2011-06-02	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida, su preparacion y su aplicacion en terapeutica
TW100119696A TWI487707B (zh)	2010-06-03	2011-06-03	３，４－二氫吡咯并［１，２－ａ］吡－２，８（１ｈ）－二碳醯胺衍生物及其製備與治療用途
UY0001033428A UY33428A (es)	2010-06-03	2011-06-03	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparacion y su aplicacion en terapeutica
TNP2012000520A TN2012000520A1 (en)	2010-06-03	2012-10-31	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
DO2012000296A DOP2012000296A (es)	2010-06-03	2012-11-22	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico
CR20120595A CR20120595A (es)	2010-06-03	2012-11-26	Derivados de 3,4-dihidropirrolo[1,2-a] pirazina-2,8 (1h)-dicarboxamida su preparación y su uso terapéutico
GT201200319A GT201200319A (es)	2010-06-03	2012-11-27	Derivados de 3, 4-dihidropirrolo [1, 2 -a ] pirazina - 2, 8(1h)- dicarboxamida su preparacion y su uso terapèutico
IL223364A IL223364A (en)	2010-06-03	2012-11-29	Derivatives of 4,3-Dihydro-pyrrolo [2,1-a] pyrene 2,8 (1 h) - dicarboxamide, their preparation, and their medical use
US13/688,916 US8791119B2 (en)	2010-06-03	2012-11-29	3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta
NI201200176A NI201200176A (es)	2010-06-03	2012-11-30	Derivados de 3, 4 - dihidropirrolo [ 1, 2 - a] pirazina - 2, 8 (1h) - dicarboxamida su preparación y su uso terapéutico.
ZA2012/09071A ZA201209071B (en)	2010-06-03	2012-11-30	3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof
CL2012003360A CL2012003360A1 (es)	2010-06-03	2012-11-30	Compuestos derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida, inhibidores de caseína quinasa 1 épsilon y/o 1 delta; procedimiento de preparación; medicamento que los comprende; composición farmacéutica; y su uso para prevenir o tratar trastornos del sueño y del ritmo circadíano, y enfermedades inflamatorias.
CO12218640A CO6602113A2 (es)	2010-06-03	2012-12-03	Derivados de 3.4-dihidropirrolo[1.2-a]pirazina -2.8(1h)-dicarboxamida su preparación y su uso terapéutico
ECSP12012322 ECSP12012322A (es)	2010-06-03	2012-12-03	Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico
US14/339,112 US9233965B2 (en)	2010-06-03	2014-07-23	3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta
CY20161101179T CY1118512T1 (el)	2010-06-03	2016-11-16	Παραγωγα 3,4-διϋδροπυρρολο[1,2-α]πυραζινο-2,8(1η)-δικαρβοξαμιδιου, παρασκευη αυτων και θεραπευτικη χρηση αυτων

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR1054372A FR2960876B1 (fr)	2010-06-03	2010-06-03	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Publications (2)

Publication Number	Publication Date
FR2960876A1 FR2960876A1 (fr)	2011-12-09
FR2960876B1 true FR2960876B1 (fr)	2012-07-27

Family

ID=42697541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR1054372A Expired - Fee Related FR2960876B1 (fr)	2010-06-03	2010-06-03	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Country Status (39)

Country	Link
US (2)	US8791119B2 (fr)
EP (1)	EP2588480B1 (fr)
JP (1)	JP5995841B2 (fr)
KR (1)	KR20130113928A (fr)
CN (1)	CN103168041B (fr)
AR (1)	AR081832A1 (fr)
AU (1)	AU2011268651B2 (fr)
BR (1)	BR112012030697A2 (fr)
CA (1)	CA2801154C (fr)
CL (1)	CL2012003360A1 (fr)
CO (1)	CO6602113A2 (fr)
CR (1)	CR20120595A (fr)
CY (1)	CY1118512T1 (fr)
DK (1)	DK2588480T3 (fr)
DO (1)	DOP2012000296A (fr)
EA (1)	EA201291364A1 (fr)
EC (1)	ECSP12012322A (fr)
ES (1)	ES2603420T3 (fr)
FR (1)	FR2960876B1 (fr)
GT (1)	GT201200319A (fr)
HR (1)	HRP20161494T1 (fr)
HU (1)	HUE030650T2 (fr)
IL (1)	IL223364A (fr)
LT (1)	LT2588480T (fr)
MA (1)	MA34360B1 (fr)
MX (1)	MX2012014084A (fr)
NI (1)	NI201200176A (fr)
NZ (1)	NZ603947A (fr)
PE (1)	PE20130259A1 (fr)
PH (1)	PH12012502353A1 (fr)
PL (1)	PL2588480T3 (fr)
PT (1)	PT2588480T (fr)
SG (1)	SG186143A1 (fr)
SI (1)	SI2588480T1 (fr)
TN (1)	TN2012000520A1 (fr)
TW (1)	TWI487707B (fr)
UY (1)	UY33428A (fr)
WO (1)	WO2011161537A2 (fr)
ZA (1)	ZA201209071B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2960876B1 (fr) *	2010-06-03	2012-07-27	Sanofi Aventis	Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
AR098414A1 (es) *	2013-11-14	2016-05-26	Bristol Myers Squibb Co	PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e
JP6307989B2 (ja) *	2014-04-02	2018-04-11	住友化学株式会社	塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
WO2018191389A1 (fr) *	2017-04-12	2018-10-18	Roche Sequencing Solutions, Inc.	Méthode pour réaction de séquençage avec un nucléoside marqué obtenu par réaction de pictet spengler
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Publication number	Publication date
US20130090340A1 (en)	2013-04-11
US9233965B2 (en)	2016-01-12
US20140336189A1 (en)	2014-11-13
MX2012014084A (es)	2013-01-29
CN103168041B (zh)	2015-08-26
CN103168041A (zh)	2013-06-19
TW201202248A (en)	2012-01-16
US8791119B2 (en)	2014-07-29
PL2588480T3 (pl)	2017-08-31
JP2013527226A (ja)	2013-06-27
PE20130259A1 (es)	2013-03-22
FR2960876A1 (fr)	2011-12-09
MA34360B1 (fr)	2013-07-03
NI201200176A (es)	2013-02-06
JP5995841B2 (ja)	2016-09-21
AR081832A1 (es)	2012-10-24
CO6602113A2 (es)	2013-01-18
HUE030650T2 (en)	2017-05-29
EP2588480A2 (fr)	2013-05-08
CA2801154C (fr)	2018-01-09
LT2588480T (lt)	2016-12-12
AU2011268651A1 (en)	2012-12-20
TWI487707B (zh)	2015-06-11
WO2011161537A3 (fr)	2012-03-01
CY1118512T1 (el)	2017-07-12
PH12012502353A1 (en)	2014-10-22
AU2011268651B2 (en)	2016-09-01
ZA201209071B (en)	2014-02-26
DOP2012000296A (es)	2013-02-28
CL2012003360A1 (es)	2013-04-01
IL223364A (en)	2015-06-30
EA201291364A1 (ru)	2013-05-30
ES2603420T3 (es)	2017-02-27
BR112012030697A2 (pt)	2019-09-24
WO2011161537A2 (fr)	2011-12-29
GT201200319A (es)	2014-01-17
CR20120595A (es)	2013-01-03
HRP20161494T1 (hr)	2016-12-16
KR20130113928A (ko)	2013-10-16
DK2588480T3 (en)	2016-12-12
PT2588480T (pt)	2016-11-21
ECSP12012322A (es)	2013-03-28
NZ603947A (en)	2014-12-24
SI2588480T1 (sl)	2016-12-30
EP2588480B1 (fr)	2016-08-17
TN2012000520A1 (en)	2014-04-01
CA2801154A1 (fr)	2011-12-29
SG186143A1 (en)	2013-01-30
UY33428A (es)	2011-12-30

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Publication	Publication Date	Title
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FR2915199B1 (fr)	2010-01-22	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
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FR2925901B1 (fr)	2011-03-04	DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
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