ATE414180T1 - Verwendung der gene kir2.3 und drd2 als molekulare marker zur diagnose von schizophrenie - Google Patents

Verwendung der gene kir2.3 und drd2 als molekulare marker zur diagnose von schizophrenie

Info

Publication number: ATE414180T1
Authority: AT; Austria
Prior art keywords: drd2; pcr; genes; schizophrenia; qrt
Prior art date: 2004-04-30

Application number

AT05741102T

Other languages

English (en)

Inventor

Laszlo Puskas

Agnes Zvara

Miklos Santha

Gyoergy Szekeres

Zoltan Janka

Original Assignee

Biolog Res Ct Of The Hungarian

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-30

Filing date

2005-05-02

Publication date

2008-11-15

2005-05-02 Application filed by Biolog Res Ct Of The Hungarian filed Critical Biolog Res Ct Of The Hungarian

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE414180T1 publication Critical patent/ATE414180T1/de

Links

101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 title abstract 4
101000944267 Homo sapiens Inward rectifier potassium channel 4 Proteins 0.000 title abstract 4
102100033057 Inward rectifier potassium channel 4 Human genes 0.000 title abstract 4
201000000980 schizophrenia Diseases 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 5
238000000034 method Methods 0.000 abstract 4
102100020756 D(2) dopamine receptor Human genes 0.000 abstract 3
238000011529 RT qPCR Methods 0.000 abstract 3
229940079593 drug Drugs 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
230000000698 schizophrenic effect Effects 0.000 abstract 2
238000009007 Diagnostic Kit Methods 0.000 abstract 1
108010009983 Inwardly Rectifying Potassium Channels Proteins 0.000 abstract 1
102000009855 Inwardly Rectifying Potassium Channels Human genes 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
230000009977 dual effect Effects 0.000 abstract 1
108020004999 messenger RNA Proteins 0.000 abstract 1
238000002493 microarray Methods 0.000 abstract 1
238000010208 microarray analysis Methods 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Pathology (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT05741102T 2004-04-30 2005-05-02 Verwendung der gene kir2.3 und drd2 als molekulare marker zur diagnose von schizophrenie ATE414180T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0400904A HU227246B1 (en)	2004-04-30	2004-04-30	Use of genes as molecular markers in diagnosis of schizophrenia and diagnostic kit

Publications (1)

Publication Number	Publication Date
ATE414180T1 true ATE414180T1 (de)	2008-11-15

Family

ID=89982187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05741102T ATE414180T1 (de)	2004-04-30	2005-05-02	Verwendung der gene kir2.3 und drd2 als molekulare marker zur diagnose von schizophrenie

Country Status (6)

Country	Link
US (1)	US20080274455A1 (de)
EP (1)	EP1761642B1 (de)
AT (1)	ATE414180T1 (de)
DE (1)	DE602005011008D1 (de)
HU (1)	HU227246B1 (de)
WO (1)	WO2005106026A1 (de)

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US20080075789A1 (en) *	2006-02-28	2008-03-27	The Regents Of The University Of California	Genes differentially expressed in bipolar disorder and/or schizophrenia
EP4512526A3 (de)	2008-09-23	2025-06-04	Bio-Rad Laboratories, Inc.	Tropfenbasiertes assaysystem
US8951939B2 (en)	2011-07-12	2015-02-10	Bio-Rad Laboratories, Inc.	Digital assays with multiplexed detection of two or more targets in the same optical channel
US9417190B2 (en)	2008-09-23	2016-08-16	Bio-Rad Laboratories, Inc.	Calibrations and controls for droplet-based assays
US9492797B2 (en)	2008-09-23	2016-11-15	Bio-Rad Laboratories, Inc.	System for detection of spaced droplets
US9132394B2 (en)	2008-09-23	2015-09-15	Bio-Rad Laboratories, Inc.	System for detection of spaced droplets
US9764322B2 (en)	2008-09-23	2017-09-19	Bio-Rad Laboratories, Inc.	System for generating droplets with pressure monitoring
US10512910B2 (en)	2008-09-23	2019-12-24	Bio-Rad Laboratories, Inc.	Droplet-based analysis method
WO2011120020A1 (en)	2010-03-25	2011-09-29	Quantalife, Inc.	Droplet transport system for detection
US8633015B2 (en)	2008-09-23	2014-01-21	Bio-Rad Laboratories, Inc.	Flow-based thermocycling system with thermoelectric cooler
US9399215B2 (en)	2012-04-13	2016-07-26	Bio-Rad Laboratories, Inc.	Sample holder with a well having a wicking promoter
US12162008B2 (en)	2008-09-23	2024-12-10	Bio-Rad Laboratories, Inc.	Partition-based method of analysis
US8663920B2 (en)	2011-07-29	2014-03-04	Bio-Rad Laboratories, Inc.	Library characterization by digital assay
US9156010B2 (en)	2008-09-23	2015-10-13	Bio-Rad Laboratories, Inc.	Droplet-based assay system
US8709762B2 (en)	2010-03-02	2014-04-29	Bio-Rad Laboratories, Inc.	System for hot-start amplification via a multiple emulsion
US11130128B2 (en)	2008-09-23	2021-09-28	Bio-Rad Laboratories, Inc.	Detection method for a target nucleic acid
US12090480B2 (en)	2008-09-23	2024-09-17	Bio-Rad Laboratories, Inc.	Partition-based method of analysis
KR101062167B1 (ko) *	2008-10-23	2011-09-05	사회복지법인 삼성생명공익재단	Ｋｉｒ2.2 억제제를 포함하는 암 치료용 조성물
US8346485B2 (en)	2008-11-25	2013-01-01	Quest Diagnostics Investments Incorporated	Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction
CA2767056C (en)	2009-09-02	2018-12-04	Bio-Rad Laboratories, Inc.	System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en)	2010-03-02	2013-03-19	Bio-Rad Laboratories, Inc.	Assays with droplets transformed into capsules
JP2013524169A (ja)	2010-03-25	2013-06-17	クァンタライフ・インコーポレーテッド	液滴によるアッセイ用の検出システム
CA2767182C (en)	2010-03-25	2020-03-24	Bio-Rad Laboratories, Inc.	Droplet generation for droplet-based assays
EP3574990B1 (de)	2010-11-01	2022-04-06	Bio-Rad Laboratories, Inc.	System zur formung von emulsionen
US12097495B2 (en)	2011-02-18	2024-09-24	Bio-Rad Laboratories, Inc.	Methods and compositions for detecting genetic material
CN103534360A (zh)	2011-03-18	2014-01-22	伯乐生命医学产品有限公司	借助对信号的组合使用进行的多重数字分析
EP3395957B1 (de)	2011-04-25	2020-08-12	Bio-Rad Laboratories, Inc.	Verfahren und zusammensetzungen zur nukleinsäureanalyse
CN110396541A (zh) *	2019-05-07	2019-11-01	中国人民解放军联勤保障部队第九0四医院	精神分裂症小鼠模型海马lncRNA测序分析及试剂盒

Family Cites Families (5)

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Publication number	Priority date	Publication date	Assignee	Title
US4931270A (en) *	1988-07-07	1990-06-05	Nelson Research & Development	Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands
JP3507884B2 (ja) *	2000-03-07	2004-03-15	新潟大学長	遺伝子発現を指標とする統合失調症の客観的診断法
IL137865A0 (en) *	2000-08-15	2001-10-31	Yeda Res & Dev	Method for the diagnosis and follow-up of schizophrenia
US20020133839A1 (en) *	2000-11-15	2002-09-19	Allen Keith D.	Transgenic mice containing Kir2.3 potassium channel gene disruptions
EP1348963A1 (de) *	2002-03-28	2003-10-01	Mitsubishi Pharma Corporation	Mit Schizophrenie in Zusammenhang stehendes Gen

2004
- 2004-04-30 HU HU0400904A patent/HU227246B1/hu not_active IP Right Cessation
2005
- 2005-05-02 AT AT05741102T patent/ATE414180T1/de not_active IP Right Cessation
- 2005-05-02 DE DE602005011008T patent/DE602005011008D1/de not_active Expired - Lifetime
- 2005-05-02 EP EP05741102A patent/EP1761642B1/de not_active Expired - Lifetime
- 2005-05-02 WO PCT/HU2005/000044 patent/WO2005106026A1/en not_active Ceased
- 2005-05-02 US US11/568,467 patent/US20080274455A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2005106026B1 (en)	2006-01-19
HUP0400904A2 (en)	2006-02-28
US20080274455A1 (en)	2008-11-06
EP1761642A1 (de)	2007-03-14
WO2005106026A1 (en)	2005-11-10
DE602005011008D1 (de)	2008-12-24
EP1761642B1 (de)	2008-11-12
HU0400904D0 (en)	2004-07-28
HU227246B1 (en)	2010-12-28

Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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