ATE414537T1 - Antikörper enthaltende stabilisierte zubereitungen - Google Patents

Antikörper enthaltende stabilisierte zubereitungen

Info

Publication number
ATE414537T1
ATE414537T1 AT02762901T AT02762901T ATE414537T1 AT E414537 T1 ATE414537 T1 AT E414537T1 AT 02762901 T AT02762901 T AT 02762901T AT 02762901 T AT02762901 T AT 02762901T AT E414537 T1 ATE414537 T1 AT E414537T1
Authority
AT
Austria
Prior art keywords
preparations containing
containing antibodies
stabilized preparations
stabilized
acetyltryptophan
Prior art date
Application number
AT02762901T
Other languages
English (en)
Inventor
Tadao Yamazaki
Hiroko Konishi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE414537T1 publication Critical patent/ATE414537T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT02762901T 2001-08-29 2002-08-29 Antikörper enthaltende stabilisierte zubereitungen ATE414537T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001258988 2001-08-29

Publications (1)

Publication Number Publication Date
ATE414537T1 true ATE414537T1 (de) 2008-12-15

Family

ID=19086420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02762901T ATE414537T1 (de) 2001-08-29 2002-08-29 Antikörper enthaltende stabilisierte zubereitungen

Country Status (6)

Country Link
US (1) US7682608B2 (de)
EP (1) EP1428537B1 (de)
JP (1) JP4342941B2 (de)
AT (1) ATE414537T1 (de)
DE (1) DE60229961D1 (de)
WO (1) WO2003018056A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150740A (en) * 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
WO2005063291A1 (ja) * 2003-12-25 2005-07-14 Kirin Beer Kabushiki Kaisha 抗体を含有する安定な水性医薬製剤
WO2008068885A1 (ja) * 2006-11-30 2008-06-12 Sanyo Chemical Industries, Ltd. 凍結乾燥用保護剤及び生理活性物質の製造方法
JP5419709B2 (ja) * 2007-01-09 2014-02-19 ワイス・エルエルシー 抗ｉｌ−１３抗体製剤およびその使用
EP2152312B1 (de) * 2007-05-16 2014-12-31 KTB Tumorforschungsgesellschaft mbH Niedrigviskose anthracyclinformulierung
JP4812807B2 (ja) * 2007-06-27 2011-11-09 三洋化成工業株式会社 タンパク質含有水溶液安定化剤及びタンパク質含有水溶液の安定化方法
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US20110086163A1 (en) * 2009-10-13 2011-04-14 Walbar Inc. Method for producing a crack-free abradable coating with enhanced adhesion
TWI603739B (zh) 2010-11-11 2017-11-01 艾伯維生物技術有限責任公司 具有增進高濃度之抗－ＴＮＦα抗體之液體調配物
SG11201507043SA (en) * 2013-03-13 2015-10-29 Genentech Inc Formulations with reduced oxidation
US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
CN104977408B (zh) * 2015-06-15 2016-09-14 暨南大学 一种筛选分泌特异性单克隆抗体杂交瘤细胞的方法与应用
SG10202103844WA (en) * 2015-12-30 2021-06-29 Genentech Inc Use of tryptophan derivatives for protein formulations
AR124914A1 (es) 2021-02-18 2023-05-17 Mitsubishi Tanabe Pharma Corp Nuevo anticuerpo anti-pad4

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157113A (en) 1987-08-10 1992-10-20 Miles Inc. Removal of nucleic acids from monoclonal antibody preparations
ES2045027T3 (es) 1987-08-10 1994-01-16 Miles Inc Igm purificadas.
CA2049342A1 (en) 1989-03-27 1990-09-28 Sally Bolmer Formulations for stabilizing of igm antibodies
JPH0768137B2 (ja) 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AUPO871997A0 (en) * 1997-08-25 1997-09-18 Csl Limited Dried biologically or therapeutically active preparations
SK14812000A3 (sk) * 1998-04-03 2001-08-06 Chugai Seiyaku Kabushiki Kaisha Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo
US7163671B2 (en) * 2000-02-29 2007-01-16 Chugai Seiyaku Kabushiki Kaisha Long-term stabilized formulations

Also Published As

Publication number Publication date
JPWO2003018056A1 (ja) 2004-12-09
WO2003018056A1 (fr) 2003-03-06
EP1428537B1 (de) 2008-11-19
EP1428537A1 (de) 2004-06-16
EP1428537A4 (de) 2005-11-09
US20040213785A1 (en) 2004-10-28
US7682608B2 (en) 2010-03-23
DE60229961D1 (de) 2009-01-02
JP4342941B2 (ja) 2009-10-14

Similar Documents

Publication Publication Date Title
DE60229961D1 (de) Antikörper enthaltende stabilisierte zubereitungen
DK2316852T3 (da) Stabiliserede enkeltdomæne-antistoffer
EP1674480A4 (de) Antikörper, der den die tgf-beta-aktivierung steuernden regionsabschnitt erkennt
NO2017028I2 (no) eftrenonacog alfa eller et biotilsvarende legemiddel ihht Artikkel 10(4) av Directive 2001/83/EC, som beskyttet av basispatentet.
DE69638269D1 (de) Hochaffine humane antikörper gegen tumorantigene
CY1114164T1 (el) Μεθοδος ελεγχου της δραστικοτητας ανοσολογικα λειτουργικου μοριου
ATE444308T1 (de) Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon
EP1698640A4 (de) Verfahren zur stabilisierung von antikörpern und stabilisierte antikörperzubereitung vom lösungstyp
EP1343880A4 (de) Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen ungulaten
ATE316982T1 (de) Mehrere zytokin-antikörper komplexen
CY1107652T1 (el) Μεθοδος ποσοτικης ανιχνευσης ζωντων επιθηλιακων κυτταρων ογκου σε ενα βιολογικο υγρο
EE200300408A (et) Aktiivsete valkude saagise suurendamine
DK1025227T3 (da) Humane TOLL-homologer
DE50209000D1 (de) PH-Wert-geregeltes Polyamidpulver
DK1645631T3 (da) Neisseria antigener og præparater
ITBO20010545A0 (it) Articolo per la coltivazione di specie orticole
WO2003038041A3 (en) Il-4 mutein proteins, antibodies, compositions, methods and uses
DE60322727D1 (de) Rückgefaltetes Membranprotein in monodisperser Form
EA200000016A1 (ru) Гидроксициклопентанон
WO2003057821A3 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
AU2002245255A1 (en) Regulation of target protein activity through modified proteins
BR0210575A (pt) Compostos de 2-(fenila 2,6-dissubstituìda)-4-aril-5-alquil-1,3-oxazolina úteis como inseticidas e acaricidas
DE69817915D1 (de) Harnstoff- und Thioharnstoffderivate von antibiotisch wirksamen Glykopeptiden
DE69513226D1 (de) Verwendung von Azolen als Virustötende Substanzen in Lösungen von biologisch aktiven Proteinen
DK1171470T3 (da) Antistoffer over for placentaprotein 13

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties