ATE414781T1 - Verbessertes verfahren zur herstellung des coenzyms q-10 - Google Patents

Verbessertes verfahren zur herstellung des coenzyms q-10

Info

Publication number
ATE414781T1
ATE414781T1 AT04740419T AT04740419T ATE414781T1 AT E414781 T1 ATE414781 T1 AT E414781T1 AT 04740419 T AT04740419 T AT 04740419T AT 04740419 T AT04740419 T AT 04740419T AT E414781 T1 ATE414781 T1 AT E414781T1
Authority
AT
Austria
Prior art keywords
improved process
producing coenzyme
coenzyme
producing
coq10
Prior art date
Application number
AT04740419T
Other languages
English (en)
Inventor
Alan Berry
Markus Huembelin
Rual Lopez-Ulibarri
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE414781T1 publication Critical patent/ATE414781T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04740419T 2003-07-08 2004-06-29 Verbessertes verfahren zur herstellung des coenzyms q-10 ATE414781T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03015367 2003-07-08

Publications (1)

Publication Number Publication Date
ATE414781T1 true ATE414781T1 (de) 2008-12-15

Family

ID=34042818

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04740419T ATE414781T1 (de) 2003-07-08 2004-06-29 Verbessertes verfahren zur herstellung des coenzyms q-10

Country Status (8)

Country Link
US (2) US20060154349A1 (de)
EP (1) EP1641931B1 (de)
JP (1) JP4528297B2 (de)
KR (1) KR101060384B1 (de)
CN (1) CN100558889C (de)
AT (1) ATE414781T1 (de)
DE (1) DE602004017867D1 (de)
WO (1) WO2005005650A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101519681B (zh) * 2009-04-01 2012-11-07 宜都东阳光生化制药有限公司 一种辅酶q10的生产发酵工艺
EP2336310A1 (de) 2009-12-16 2011-06-22 Isobionics B.V. Valencensynthase
CN102168115A (zh) * 2010-12-23 2011-08-31 内蒙古金达威药业有限公司 一种辅酶q10工业化生产方法
EP2537926A1 (de) 2011-06-21 2012-12-26 Isobionics B.V. Valencensynthase
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase
NL2019473B1 (en) 2017-09-01 2019-03-11 Isobionics B V Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
CN111699247A (zh) 2017-12-07 2020-09-22 齐默尔根公司 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径
EP3728212A1 (de) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol-oxidoreduktasen, nepetalactol-synthasen und nebalacton produzierende mikroben
CN110229840A (zh) * 2019-06-04 2019-09-13 兰州天禾生物催化技术有限公司 一种构建高产辅酶q10工程菌的方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4809800A (en) * 1984-12-10 1989-03-07 Yamaha Hatsudoki Kabushiki Kaisha Exhaust system for vehicle
JP4401471B2 (ja) * 1998-04-14 2010-01-20 協和発酵バイオ株式会社 微生物によるイソプレノイド化合物の製造方法
DE60038565T2 (de) * 1999-10-14 2009-06-10 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von ubiquinon-10
EP2292776A1 (de) * 2000-07-31 2011-03-09 Danisco US Inc. Manipulation der in der Mevalonsäure- und Isoprenoid-Biosynthese verantwortlichen Gene zur Herstellung von geänderten Merkmalen in Transgenen Organismen
DE60132498T2 (de) * 2000-09-29 2009-01-15 Cargill, Inc., Wayzata Isoprenoidproduktion
KR100704072B1 (ko) * 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
US6998471B2 (en) * 2001-07-25 2006-02-14 E.I. Du Pont De Nemours And Company Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods
JP2007008442A (ja) * 2005-03-11 2007-01-18 Yamaha Motor Co Ltd 自動二輪車の排気装置

Also Published As

Publication number Publication date
KR101060384B1 (ko) 2011-08-29
US20060154349A1 (en) 2006-07-13
KR20060060657A (ko) 2006-06-05
EP1641931B1 (de) 2008-11-19
CN100558889C (zh) 2009-11-11
US20090226986A1 (en) 2009-09-10
JP4528297B2 (ja) 2010-08-18
JP2009513104A (ja) 2009-04-02
DE602004017867D1 (de) 2009-01-02
CN1820077A (zh) 2006-08-16
WO2005005650A1 (en) 2005-01-20
EP1641931A1 (de) 2006-04-05

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