DK1633779T3 - Oxidoreduktase fra Pichia capsulata - Google Patents
Oxidoreduktase fra Pichia capsulataInfo
- Publication number
- DK1633779T3 DK1633779T3 DK04735228.1T DK04735228T DK1633779T3 DK 1633779 T3 DK1633779 T3 DK 1633779T3 DK 04735228 T DK04735228 T DK 04735228T DK 1633779 T3 DK1633779 T3 DK 1633779T3
- Authority
- DK
- Denmark
- Prior art keywords
- pichia
- pichia capsulata
- oxidoreductase
- capsulata
- hydroxy compounds
- Prior art date
Links
- 241001304302 Kuraishia capsulata Species 0.000 title abstract 3
- 102000004316 Oxidoreductases Human genes 0.000 title abstract 2
- 108090000854 Oxidoreductases Proteins 0.000 title abstract 2
- 241000235648 Pichia Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10327454A DE10327454A1 (de) | 2003-06-18 | 2003-06-18 | Oxidoreduktase aus Pichia capsulata |
| PCT/EP2004/005831 WO2004111083A2 (de) | 2003-06-18 | 2004-05-28 | Oxidoreduktase aus pichia capsulata |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1633779T3 true DK1633779T3 (da) | 2011-01-31 |
Family
ID=33520692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04735228.1T DK1633779T3 (da) | 2003-06-18 | 2004-05-28 | Oxidoreduktase fra Pichia capsulata |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7575909B2 (da) |
| EP (1) | EP1633779B1 (da) |
| JP (2) | JP4845729B2 (da) |
| KR (1) | KR101085424B1 (da) |
| CN (1) | CN100567321C (da) |
| AT (1) | ATE484518T1 (da) |
| CA (1) | CA2529583C (da) |
| DE (2) | DE10327454A1 (da) |
| DK (1) | DK1633779T3 (da) |
| ES (1) | ES2357113T3 (da) |
| PL (1) | PL1633779T3 (da) |
| PT (1) | PT1633779E (da) |
| SI (1) | SI1633779T1 (da) |
| WO (1) | WO2004111083A2 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| AT413541B (de) * | 2004-05-10 | 2006-03-15 | Iep Gmbh | Verfahren zur herstellung von 2-butanol |
| AT501928B1 (de) * | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| DE102004055508A1 (de) * | 2004-11-17 | 2006-06-01 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| AT501496B1 (de) * | 2005-02-21 | 2007-03-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen |
| DE102005010804A1 (de) * | 2005-03-07 | 2006-09-14 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| AT502395B1 (de) * | 2005-07-27 | 2007-03-15 | Iep Gmbh | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| AT502185B1 (de) * | 2005-09-23 | 2007-02-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen |
| AT503017B1 (de) * | 2005-12-19 | 2007-07-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen |
| DE102006009744A1 (de) * | 2006-03-02 | 2007-09-06 | Wacker Chemie Ag | Herstellung von (S)-2-Butanol durch oxidative Racematspaltung |
| DE102006010994A1 (de) * | 2006-03-09 | 2007-09-13 | Wacker Chemie Ag | Verfahren zur enzymatischen Herstellung von chiralen Alkoholen |
| AT503486B1 (de) | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
| WO2008042876A2 (en) | 2006-10-02 | 2008-04-10 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| AT504542B1 (de) | 2006-12-07 | 2008-09-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten |
| TWI601825B (zh) * | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| EP2329013B1 (en) * | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| JP2010104239A (ja) * | 2008-10-28 | 2010-05-13 | Kagoshima Univ | １，５−ｄ−アンヒドログルシトールの製造法 |
| EP2226386A1 (de) | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| PL2445890T3 (pl) * | 2009-06-22 | 2016-02-29 | Sk Biopharmaceuticals Co Ltd | Sposób wytwarzania estru (R)-1-arylo-2-tetrazoliloetylowego kwasu karbaminowego |
| WO2011016102A1 (ja) | 2009-08-03 | 2011-02-10 | トヨタ自動車株式会社 | 変異型ギ酸脱水素酵素、これをコードする遺伝子及びnadhの製造方法 |
| ES2575560T3 (es) | 2009-08-19 | 2016-06-29 | Codexis, Inc. | Polipéptidos cetorreductasa para preparar fenilefrina |
| AU2010291208B2 (en) * | 2009-09-02 | 2015-04-09 | Purac Biochem B.V. | Polypeptides having oxidoreductase activity and their uses |
| US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| MY181812A (en) | 2010-01-20 | 2021-01-07 | Xyleco Inc | Dispersing feedstocks and processing materials |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| US9096825B2 (en) | 2010-05-27 | 2015-08-04 | Pharmazell Gmbh | 7 α-hydroxysteroid dehydrogenase knockout mutants and use therefor |
| EP2861750B1 (en) * | 2012-06-18 | 2016-11-23 | Laboratorio Chimico Internazionale S.p.A. | Process for producing chiral 1-substituted 3-piperidinols employing oxidoreductases |
| DE102012017026A1 (de) | 2012-08-28 | 2014-03-06 | Forschungszentrum Jülich GmbH | Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen |
| DE102013104418B4 (de) | 2013-04-30 | 2018-09-27 | Cambrex Iep Gmbh | Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol |
| CN104017780A (zh) * | 2014-05-28 | 2014-09-03 | 宁波酶赛生物工程有限公司 | 一种新的氧化还原酶ntro及其应用 |
| CN104560745B (zh) * | 2014-12-08 | 2017-12-01 | 上海应用技术学院 | 一种毕赤酵母菌Pichia sp.SIT2014及其培养方法和应用 |
| CN104561136B (zh) * | 2014-12-08 | 2018-07-06 | 上海应用技术学院 | 一种将消旋体芳基邻二醇转化为手性芳基邻二醇的方法 |
| CN108220261B (zh) * | 2017-12-29 | 2021-05-14 | 安徽联创生物医药股份有限公司 | 酮还原酶、核酸、重组表达载体、重组表达菌株及应用 |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523223A (en) * | 1992-03-13 | 1996-06-04 | Forschungszentrum Julich Gmbh | Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters |
| JP3574682B2 (ja) * | 1993-09-24 | 2004-10-06 | ダイセル化学工業株式会社 | 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法 |
| JP2000236883A (ja) * | 1998-12-21 | 2000-09-05 | Daicel Chem Ind Ltd | 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法 |
| US7094565B1 (en) * | 1999-12-15 | 2006-08-22 | Millennium Pharmaceuticals, Inc. | 21612, novel human dehydrogenases |
| DE10033902C1 (de) * | 2000-07-12 | 2001-11-22 | Vaw Ver Aluminium Werke Ag | Verfahren und Vorrichtung zum steigenden Giessen mit einem auf den Giesstisch aufgesetzten Schieberverschluss |
| JP2002233392A (ja) * | 2000-12-07 | 2002-08-20 | Sumitomo Chem Co Ltd | 光学活性４−ブロモ−３−ヒドロキシブタン酸エステルの製造法 |
| DE10119274A1 (de) | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
| JP2005512532A (ja) * | 2001-08-03 | 2005-05-12 | ディヴァーサ コーポレイション | Ｐ４５０酵素、それらをコードした核酸及びそれらの作製と使用 |
| DE60323215D1 (de) * | 2002-03-19 | 2008-10-09 | Mitsubishi Chem Corp | Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit |
| JP4426437B2 (ja) * | 2002-04-30 | 2010-03-03 | 株式会社カネカ | 新規カルボニル還元酵素、その遺伝子、およびその利用法 |
| US7220564B2 (en) * | 2002-09-19 | 2007-05-22 | Kaneka Corporation | Carbonyl reductase, gene thereof and method of using the same |
| JP4345425B2 (ja) * | 2002-10-07 | 2009-10-14 | ダイソー株式会社 | クロロヒドリン及びヒドロキシカルボン酸エステル不斉加水分解酵素遺伝子 |
| DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
-
2003
- 2003-06-18 DE DE10327454A patent/DE10327454A1/de not_active Withdrawn
-
2004
- 2004-05-28 SI SI200431579T patent/SI1633779T1/sl unknown
- 2004-05-28 AT AT04735228T patent/ATE484518T1/de active
- 2004-05-28 JP JP2006515804A patent/JP4845729B2/ja not_active Expired - Fee Related
- 2004-05-28 CA CA2529583A patent/CA2529583C/en not_active Expired - Lifetime
- 2004-05-28 PT PT04735228T patent/PT1633779E/pt unknown
- 2004-05-28 PL PL04735228T patent/PL1633779T3/pl unknown
- 2004-05-28 WO PCT/EP2004/005831 patent/WO2004111083A2/de not_active Ceased
- 2004-05-28 KR KR1020057024246A patent/KR101085424B1/ko not_active Expired - Fee Related
- 2004-05-28 CN CNB2004800238300A patent/CN100567321C/zh not_active Expired - Fee Related
- 2004-05-28 ES ES04735228T patent/ES2357113T3/es not_active Expired - Lifetime
- 2004-05-28 DE DE502004011781T patent/DE502004011781D1/de not_active Expired - Lifetime
- 2004-05-28 EP EP04735228A patent/EP1633779B1/de not_active Expired - Lifetime
- 2004-05-28 US US10/561,043 patent/US7575909B2/en not_active Expired - Lifetime
- 2004-05-28 DK DK04735228.1T patent/DK1633779T3/da active
-
2011
- 2011-08-02 JP JP2011169224A patent/JP2011244829A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1095336A1 (zh) | 2007-05-04 |
| CN100567321C (zh) | 2009-12-09 |
| PL1633779T3 (pl) | 2011-04-29 |
| CA2529583A1 (en) | 2004-12-23 |
| JP2007523617A (ja) | 2007-08-23 |
| JP2011244829A (ja) | 2011-12-08 |
| KR20060030478A (ko) | 2006-04-10 |
| WO2004111083A3 (de) | 2005-03-10 |
| KR101085424B1 (ko) | 2011-11-21 |
| SI1633779T1 (sl) | 2011-03-31 |
| WO2004111083A2 (de) | 2004-12-23 |
| JP4845729B2 (ja) | 2011-12-28 |
| CN1839153A (zh) | 2006-09-27 |
| EP1633779B1 (de) | 2010-10-13 |
| CA2529583C (en) | 2013-07-23 |
| DE10327454A1 (de) | 2005-01-20 |
| PT1633779E (pt) | 2011-01-18 |
| US20070243594A1 (en) | 2007-10-18 |
| DE502004011781D1 (de) | 2010-11-25 |
| US7575909B2 (en) | 2009-08-18 |
| ATE484518T1 (de) | 2010-10-15 |
| EP1633779A2 (de) | 2006-03-15 |
| ES2357113T3 (es) | 2011-04-18 |
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