ATE417039T1 - 3,4-dihydro-2-naphthoesäureamidderivate und deren therapeutische anwendungen - Google Patents
3,4-dihydro-2-naphthoesäureamidderivate und deren therapeutische anwendungenInfo
- Publication number
- ATE417039T1 ATE417039T1 AT06704278T AT06704278T ATE417039T1 AT E417039 T1 ATE417039 T1 AT E417039T1 AT 06704278 T AT06704278 T AT 06704278T AT 06704278 T AT06704278 T AT 06704278T AT E417039 T1 ATE417039 T1 AT E417039T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydro
- therapeutic applications
- acid amide
- amide derivatives
- naphtoic acid
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- VEBYIGGYOBSBCS-UHFFFAOYSA-N 3,4-dihydronaphthalene-2-carboxamide Chemical class C1=CC=C2CCC(C(=O)N)=CC2=C1 VEBYIGGYOBSBCS-UHFFFAOYSA-N 0.000 abstract 1
- 102000004073 Dopamine D3 Receptors Human genes 0.000 abstract 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003557 neuropsychological effect Effects 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290156A EP1683790A1 (de) | 2005-01-24 | 2005-01-24 | 3,4-Dihydro-2-Naphthamidderivate als selektive Dopamin-D3-Liganden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417039T1 true ATE417039T1 (de) | 2008-12-15 |
Family
ID=34941904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06704278T ATE417039T1 (de) | 2005-01-24 | 2006-01-20 | 3,4-dihydro-2-naphthoesäureamidderivate und deren therapeutische anwendungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7875617B2 (de) |
| EP (2) | EP1683790A1 (de) |
| AT (1) | ATE417039T1 (de) |
| DE (1) | DE602006004172D1 (de) |
| ES (1) | ES2318719T3 (de) |
| WO (1) | WO2006077487A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2949465B1 (fr) * | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
| US8722683B2 (en) * | 2011-02-17 | 2014-05-13 | Hoffmann La-Roche Inc. | Benzodioxole piperazine compounds |
| US8598357B2 (en) * | 2011-03-03 | 2013-12-03 | Hoffmann-La Roche Inc. | Benzodioxole piperidine compounds |
| US20250276066A1 (en) * | 2021-02-10 | 2025-09-04 | Gero Pte. Ltd. | Methods, compositions and compounds for treating age-related diseases and conditions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0189612B1 (de) | 1984-12-21 | 1992-11-04 | Duphar International Research B.V | Arzneimittel mit psychotroper Wirkung |
| FR2663638B2 (fr) | 1990-04-06 | 1995-02-10 | Institut Nal Sante Recherc Medic | Polypeptides ayant une activite de recepteur dopaminergique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides. |
| FR2668771B1 (fr) | 1990-11-06 | 1995-03-17 | Inst Nat Sante Rech Med | Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides. |
| FR2742149B1 (fr) * | 1995-12-11 | 1998-02-13 | Inst Nat Sante Rech Med | Nouveaux derives de 2-naphtamides et leurs applications therapeutiques |
| EP0900792B1 (de) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten |
| AR032711A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| EP1462117A1 (de) | 2003-03-28 | 2004-09-29 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Verfahren zur Entdeckung von Dopamin-D3 Rezeptor Liganden mit antipsykotisher Wirkung in-vivo |
-
2005
- 2005-01-24 EP EP05290156A patent/EP1683790A1/de not_active Withdrawn
-
2006
- 2006-01-20 WO PCT/IB2006/000088 patent/WO2006077487A1/en not_active Ceased
- 2006-01-20 DE DE602006004172T patent/DE602006004172D1/de not_active Expired - Lifetime
- 2006-01-20 EP EP06704278A patent/EP1841752B1/de not_active Expired - Lifetime
- 2006-01-20 AT AT06704278T patent/ATE417039T1/de not_active IP Right Cessation
- 2006-01-20 ES ES06704278T patent/ES2318719T3/es not_active Expired - Lifetime
- 2006-01-20 US US11/814,428 patent/US7875617B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006004172D1 (de) | 2009-01-22 |
| US20090124630A1 (en) | 2009-05-14 |
| EP1841752A1 (de) | 2007-10-10 |
| EP1841752B1 (de) | 2008-12-10 |
| US7875617B2 (en) | 2011-01-25 |
| WO2006077487A1 (en) | 2006-07-27 |
| EP1683790A1 (de) | 2006-07-26 |
| ES2318719T3 (es) | 2009-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |