ATE417921T1 - Herstellung von tacrolimus (fk-506) unter verwendung neuer streptomyces-spezies - Google Patents
Herstellung von tacrolimus (fk-506) unter verwendung neuer streptomyces-speziesInfo
- Publication number
- ATE417921T1 ATE417921T1 AT04791706T AT04791706T ATE417921T1 AT E417921 T1 ATE417921 T1 AT E417921T1 AT 04791706 T AT04791706 T AT 04791706T AT 04791706 T AT04791706 T AT 04791706T AT E417921 T1 ATE417921 T1 AT E417921T1
- Authority
- AT
- Austria
- Prior art keywords
- tacrolimus
- production
- streptomyces species
- new streptomyces
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1284DE2003 | 2003-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417921T1 true ATE417921T1 (de) | 2009-01-15 |
Family
ID=34452218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04791706T ATE417921T1 (de) | 2003-10-17 | 2004-10-15 | Herstellung von tacrolimus (fk-506) unter verwendung neuer streptomyces-spezies |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070191415A1 (de) |
| EP (1) | EP1751272B8 (de) |
| CN (1) | CN1867664A (de) |
| AT (1) | ATE417921T1 (de) |
| DE (1) | DE602004018547D1 (de) |
| ES (1) | ES2317066T3 (de) |
| WO (1) | WO2005038009A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100448984C (zh) * | 2006-03-07 | 2009-01-07 | 广东省微生物研究所 | 粤蓝链霉菌 |
| US7744717B2 (en) | 2006-07-17 | 2010-06-29 | E. I. Du Pont De Nemours And Company | Process for enhancing the resolution of a thermally transferred pattern |
| CN101486975B (zh) * | 2008-01-18 | 2012-04-18 | 浙江海正药业股份有限公司 | 一种链霉菌、用其产生他克莫司的方法及其应用 |
| EP2272963A1 (de) | 2009-07-09 | 2011-01-12 | LEK Pharmaceuticals d.d. | Verfahren zur Herstellung von Tacrolimus |
| KR101261131B1 (ko) | 2010-08-24 | 2013-05-06 | 이화여자대학교 산학협력단 | 신규 타크롤리무스 유도체, 상기 유도체를 포함하는 신경 보호용 조성물, 상기 유도체를 포함하는 면역 억제용 조성물, 상기 유도체의 생산 방법 및 상기 유도체의 생산 균주 |
| WO2012026665A1 (en) * | 2010-08-24 | 2012-03-01 | Ewha University - Industry Collaboration Foundation | Novel tacrolimus derivatives, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same |
| RU2495937C1 (ru) * | 2012-04-02 | 2013-10-20 | Общество с ограниченной ответственностью "Фарминс"/Pharmins Ltd. (ООО "Фарминс"/Pharmins Ltd.) | Способ получения такролимуса методом микробиологического синтеза |
| CN117088931A (zh) | 2014-08-12 | 2023-11-21 | 莫纳什大学 | 定向淋巴的前药 |
| KR101729251B1 (ko) * | 2015-04-28 | 2017-04-21 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| US11738087B2 (en) | 2015-09-08 | 2023-08-29 | Monash University | Lymph directing prodrugs |
| CN108384819B (zh) * | 2017-02-03 | 2021-06-25 | 上海医药工业研究院 | 一种用于发酵他克莫司的培养基以及发酵方法 |
| CA3077739A1 (en) | 2017-08-29 | 2019-03-07 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| WO2019126374A1 (en) * | 2017-12-19 | 2019-06-27 | Ariya Therapeutics, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| CN108929335B (zh) * | 2018-08-31 | 2021-07-20 | 福建省微生物研究所 | 一种他克莫司粗晶的制备方法 |
| IL295362A (en) | 2020-02-05 | 2022-10-01 | Puretech Lyt Inc | Lipid drug inhibitors of neurosteroids |
| CN112159826B (zh) * | 2020-09-14 | 2022-05-24 | 浙江工业大学 | 一种提高他克莫司产量的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137126A (en) * | 1975-05-03 | 1979-01-30 | Givaudan Corporation | Process for preparing glucose isomerase using streptomyces glaucescens mutants |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5116756A (en) * | 1991-01-28 | 1992-05-26 | Merck & Co., Inc. | Process for producing FK-506 |
| US5194378A (en) * | 1991-01-28 | 1993-03-16 | Merck & Co., Inc. | Process for producing fk-506 |
| US5264355A (en) * | 1992-07-02 | 1993-11-23 | Merck & Co., Inc. | Methlating enzyme from streptomyces MA6858 |
-
2004
- 2004-10-15 CN CNA2004800303827A patent/CN1867664A/zh active Pending
- 2004-10-15 EP EP04791706A patent/EP1751272B8/de not_active Expired - Lifetime
- 2004-10-15 AT AT04791706T patent/ATE417921T1/de not_active IP Right Cessation
- 2004-10-15 DE DE602004018547T patent/DE602004018547D1/de not_active Expired - Fee Related
- 2004-10-15 WO PCT/IB2004/003380 patent/WO2005038009A2/en not_active Ceased
- 2004-10-15 US US10/575,444 patent/US20070191415A1/en not_active Abandoned
- 2004-10-15 ES ES04791706T patent/ES2317066T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20070191415A1 (en) | 2007-08-16 |
| CN1867664A (zh) | 2006-11-22 |
| WO2005038009A3 (en) | 2005-06-16 |
| WO2005038009A2 (en) | 2005-04-28 |
| DE602004018547D1 (de) | 2009-01-29 |
| ES2317066T3 (es) | 2009-04-16 |
| EP1751272B8 (de) | 2009-04-15 |
| EP1751272B1 (de) | 2008-12-17 |
| EP1751272A2 (de) | 2007-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |