MA30063B1 - Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fcg) - Google Patents

Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fcg)

Info

Publication number
MA30063B1
MA30063B1 MA31047A MA31047A MA30063B1 MA 30063 B1 MA30063 B1 MA 30063B1 MA 31047 A MA31047 A MA 31047A MA 31047 A MA31047 A MA 31047A MA 30063 B1 MA30063 B1 MA 30063B1
Authority
MA
Morocco
Prior art keywords
aryluree
fcg
pyrimidinyl
inhibitors
derivatives
Prior art date
Application number
MA31047A
Other languages
English (en)
Inventor
Guido Bold
Pascal Furet
Vito Guagnano
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30063B1 publication Critical patent/MA30063B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des hétéroarylarylurées de formule IA : dans laquelle les radicaux et les symboles ont les significations définies ici, l'utilisation de ces composés dans le traitement de maladies sous la dépendance de protéine-kinases, des préparations pharmaceutiques comprenant lesdites hétéroarylarylurées, des procédés de fabrication de ces nouveaux composés et des procédés de traitement comprenant l'utilisation de ces hétéroarylarylurées.
MA31047A 2005-12-21 2008-06-18 Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fcg) MA30063B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75271105P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
MA30063B1 true MA30063B1 (fr) 2008-12-01

Family

ID=37946774

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31047A MA30063B1 (fr) 2005-12-21 2008-06-18 Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fcg)

Country Status (22)

Country Link
US (2) US8293746B2 (fr)
EP (1) EP1976847B1 (fr)
JP (1) JP5153645B2 (fr)
KR (1) KR101406956B1 (fr)
CN (1) CN101336237B (fr)
AU (1) AU2006326989B2 (fr)
BR (1) BRPI0620408B8 (fr)
CA (1) CA2634047C (fr)
CR (1) CR10072A (fr)
EA (1) EA016438B1 (fr)
EC (1) ECSP088561A (fr)
GE (1) GEP20105074B (fr)
HN (1) HN2008000949A (fr)
IL (1) IL192093A0 (fr)
MA (1) MA30063B1 (fr)
ME (2) MEP3808A (fr)
NO (1) NO20083214L (fr)
SM (1) SMP200800041B (fr)
SV (1) SV2008002967A (fr)
TN (1) TNSN08276A1 (fr)
WO (1) WO2007071752A2 (fr)
ZA (1) ZA200805092B (fr)

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Also Published As

Publication number Publication date
IL192093A0 (en) 2008-12-29
BRPI0620408B1 (pt) 2020-09-15
JP5153645B2 (ja) 2013-02-27
SMP200800041B (it) 2009-07-14
US8759517B2 (en) 2014-06-24
MEP3808A (xx) 2010-02-10
JP2009520768A (ja) 2009-05-28
WO2007071752A3 (fr) 2007-11-08
BRPI0620408A2 (pt) 2011-11-08
BRPI0620408B8 (pt) 2021-05-25
KR20080090439A (ko) 2008-10-08
EP1976847A2 (fr) 2008-10-08
TNSN08276A1 (en) 2009-10-30
SMAP200800041A (it) 2008-07-23
ZA200805092B (en) 2009-09-30
HN2008000949A (es) 2010-11-11
EA200801565A1 (ru) 2008-12-30
WO2007071752A2 (fr) 2007-06-28
US8293746B2 (en) 2012-10-23
CN101336237A (zh) 2008-12-31
US20080312248A1 (en) 2008-12-18
ECSP088561A (es) 2008-07-30
CA2634047A1 (fr) 2007-06-28
AU2006326989A1 (en) 2007-06-28
EP1976847B1 (fr) 2015-06-17
ME00011A (fr) 2009-02-10
CR10072A (es) 2008-08-25
NO20083214L (no) 2008-09-01
GEP20105074B (en) 2010-09-10
EA016438B1 (ru) 2012-05-30
KR101406956B1 (ko) 2014-06-13
CN101336237B (zh) 2015-09-30
CA2634047C (fr) 2016-04-12
US20130030171A1 (en) 2013-01-31
SV2008002967A (es) 2011-01-24
AU2006326989B2 (en) 2011-11-24

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