ATE418534T1 - Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe - Google Patents
Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffeInfo
- Publication number
- ATE418534T1 ATE418534T1 AT02793840T AT02793840T ATE418534T1 AT E418534 T1 ATE418534 T1 AT E418534T1 AT 02793840 T AT02793840 T AT 02793840T AT 02793840 T AT02793840 T AT 02793840T AT E418534 T1 ATE418534 T1 AT E418534T1
- Authority
- AT
- Austria
- Prior art keywords
- antimuscarinomic
- agents
- quaternary ammonium
- ammonium compounds
- trifluoromethyl
- Prior art date
Links
- 150000003856 quaternary ammonium compounds Chemical class 0.000 title 1
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 abstract 2
- FIZRZYUJJOUDHY-LJQANCHMSA-N 2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(trifluoromethyl)phenol Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C=2)C(F)(F)F)O)=CC=CC=C1 FIZRZYUJJOUDHY-LJQANCHMSA-N 0.000 abstract 1
- -1 compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940102396 methyl bromide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34893001P | 2001-10-26 | 2001-10-26 | |
| US36197902P | 2002-03-06 | 2002-03-06 | |
| US39152102P | 2002-06-25 | 2002-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE418534T1 true ATE418534T1 (de) | 2009-01-15 |
Family
ID=27407868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02793840T ATE418534T1 (de) | 2001-10-26 | 2002-10-25 | Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6890920B2 (de) |
| EP (1) | EP1461306B1 (de) |
| JP (1) | JP3981357B2 (de) |
| AT (1) | ATE418534T1 (de) |
| BR (1) | BR0206207A (de) |
| CA (1) | CA2464223C (de) |
| CY (1) | CY1109898T1 (de) |
| DE (1) | DE60230546D1 (de) |
| DK (1) | DK1461306T3 (de) |
| ES (1) | ES2315425T3 (de) |
| MX (1) | MXPA04003865A (de) |
| MY (1) | MY130316A (de) |
| NO (1) | NO20032938L (de) |
| PT (1) | PT1461306E (de) |
| SG (1) | SG168451A1 (de) |
| WO (1) | WO2003035599A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957073A1 (de) | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | 3,3-Diphenylpropylaminderivate |
| ATE418534T1 (de) * | 2001-10-26 | 2009-01-15 | Pharmacia & Upjohn Co Llc | Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe |
| US7754242B2 (en) * | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| CA2483827C (en) * | 2002-04-29 | 2012-01-24 | Amir H. Shojaei | Pharmaceutical formulations with improved bioavailability |
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| CA2522102A1 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Quaternary ammonium compounds and their use as antimuscarinic agents |
| BRPI0409492A (pt) * | 2003-04-18 | 2006-05-02 | Pharmacia & Up John Company Ll | terapias de combinação |
| EP1620389A1 (de) | 2003-04-25 | 2006-02-01 | Pharmacia & Upjohn Company LLC | Halogen-substituierte 3,3-diphenylpropylamine (tolterodin) mit antimuscarinerger wirkung |
| WO2005046663A1 (en) | 2003-11-04 | 2005-05-26 | Shire Laboratories, Inc. | Compositions of quaternary ammonium containing bioavailability enhancers |
| DK2210605T3 (en) * | 2003-11-04 | 2017-05-22 | Tcd Royalty Sub Llc | Daily single dose doses of trospium. |
| ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| JP5250205B2 (ja) * | 2003-12-24 | 2013-07-31 | シプラ・リミテッド | トルテロジン、その組成物及び使用、及びその製造方法 |
| US20070179131A1 (en) * | 2004-03-11 | 2007-08-02 | Jian Jin | Novel M3 Muscarinic Acetylcholine Receptor Antagonists |
| WO2006066931A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Process for preparation of 3-(2-hydroxy-5-methylphenyl)-n,n-diisopropyl-3phenylpropylamine |
| CA2653105A1 (en) * | 2006-05-24 | 2007-11-29 | Boehringer Ingelheim International Gmbh | Novel medicament combinations for the treatment of respiratory diseases |
| EP1908502A1 (de) * | 2006-10-02 | 2008-04-09 | Koninklijke Philips Electronics N.V. | Modulares Interaktivenfliesensystem |
| US7731604B2 (en) * | 2006-10-31 | 2010-06-08 | Taylor Made Golf Company, Inc. | Golf club iron head |
| EP2114972A2 (de) * | 2006-12-13 | 2009-11-11 | Gilead Sciences, Inc. | Monophosphate als gemeinsame prodrugs für muskarinrezeptorantagonisten und beta-agonisten für die behandlung von copd und chronischer bronchitis |
| CA2675942C (en) * | 2007-02-23 | 2016-04-12 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| US20090246146A1 (en) * | 2008-01-25 | 2009-10-01 | Botond Banfi | Halides in the treatment of pathogenic infection |
| US20090318396A1 (en) * | 2008-06-10 | 2009-12-24 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| US20110171274A1 (en) * | 2008-07-21 | 2011-07-14 | Actavis Group Ptc Ehf | Fesoterodine Substantially Free of Dehydroxy Impurity |
| JP5801997B2 (ja) | 2009-07-07 | 2015-10-28 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器 |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
| CN110845357B (zh) * | 2019-11-22 | 2022-09-30 | 华东理工大学 | 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用 |
| WO2021260441A1 (en) | 2020-06-26 | 2021-12-30 | Mylan Pharma Uk Limited | Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE106643C (de) | ||||
| US2592191A (en) | 1949-09-16 | 1952-04-08 | Sterling Drug Inc | Quaternary ammonium salts of nu-(3, 3-diphenylpropyl) pyrrolidine |
| NL267508A (de) | 1960-07-26 | |||
| NL6717123A (de) * | 1966-12-29 | 1968-07-01 | ||
| US3505337A (en) * | 1967-12-22 | 1970-04-07 | Boehringer Sohn Ingelheim | N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof |
| US5382600A (en) * | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| IL91377A (en) * | 1988-09-14 | 1996-09-12 | Nippon Shinyaku Co Ltd | Derivatives of botinylamine glycolate |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SE9203318D0 (sv) * | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
| AU7971394A (en) | 1993-10-08 | 1995-05-04 | Sepracor, Inc. | Method for treating urinary incontinence using optically pure s-terodiline |
| US5492933A (en) | 1993-10-08 | 1996-02-20 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof |
| KR20000057548A (ko) | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
| SE9701144D0 (sv) * | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| PE20020547A1 (es) * | 2000-10-24 | 2002-06-12 | Upjohn Co | Uso de la tolterodina en tratamientos del asma |
| WO2002035245A1 (en) | 2000-10-26 | 2002-05-02 | Koninklijke Philips Electronics N.V. | Electronic device |
| ATE418534T1 (de) * | 2001-10-26 | 2009-01-15 | Pharmacia & Upjohn Co Llc | Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe |
| CA2522102A1 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Quaternary ammonium compounds and their use as antimuscarinic agents |
| EP1620389A1 (de) * | 2003-04-25 | 2006-02-01 | Pharmacia & Upjohn Company LLC | Halogen-substituierte 3,3-diphenylpropylamine (tolterodin) mit antimuscarinerger wirkung |
-
2002
- 2002-10-25 AT AT02793840T patent/ATE418534T1/de active
- 2002-10-25 MX MXPA04003865A patent/MXPA04003865A/es active IP Right Grant
- 2002-10-25 SG SG200905309-1A patent/SG168451A1/en unknown
- 2002-10-25 JP JP2003538115A patent/JP3981357B2/ja not_active Expired - Fee Related
- 2002-10-25 US US10/280,906 patent/US6890920B2/en not_active Expired - Fee Related
- 2002-10-25 WO PCT/US2002/034529 patent/WO2003035599A1/en not_active Ceased
- 2002-10-25 CA CA002464223A patent/CA2464223C/en not_active Expired - Fee Related
- 2002-10-25 MY MYPI20024003A patent/MY130316A/en unknown
- 2002-10-25 DE DE60230546T patent/DE60230546D1/de not_active Expired - Lifetime
- 2002-10-25 DK DK02793840T patent/DK1461306T3/da active
- 2002-10-25 BR BR0206207-0A patent/BR0206207A/pt not_active Application Discontinuation
- 2002-10-25 PT PT02793840T patent/PT1461306E/pt unknown
- 2002-10-25 ES ES02793840T patent/ES2315425T3/es not_active Expired - Lifetime
- 2002-10-25 EP EP02793840A patent/EP1461306B1/de not_active Expired - Lifetime
-
2003
- 2003-06-26 NO NO20032938A patent/NO20032938L/no not_active Application Discontinuation
-
2005
- 2005-03-08 US US11/074,914 patent/US7439397B2/en not_active Expired - Fee Related
-
2009
- 2009-02-03 CY CY20091100122T patent/CY1109898T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1461306T3 (da) | 2009-03-09 |
| US6890920B2 (en) | 2005-05-10 |
| PT1461306E (pt) | 2009-04-01 |
| DE60230546D1 (de) | 2009-02-05 |
| EP1461306B1 (de) | 2008-12-24 |
| SG168451A1 (en) | 2011-02-28 |
| WO2003035599A1 (en) | 2003-05-01 |
| NO20032938L (no) | 2003-08-25 |
| US20030158176A1 (en) | 2003-08-21 |
| MXPA04003865A (es) | 2004-07-08 |
| CA2464223C (en) | 2009-05-26 |
| JP2005524605A (ja) | 2005-08-18 |
| CY1109898T1 (el) | 2014-09-10 |
| BR0206207A (pt) | 2003-12-23 |
| ES2315425T3 (es) | 2009-04-01 |
| NO20032938D0 (no) | 2003-06-26 |
| EP1461306A1 (de) | 2004-09-29 |
| MY130316A (en) | 2007-06-29 |
| US20050148672A1 (en) | 2005-07-07 |
| JP3981357B2 (ja) | 2007-09-26 |
| US7439397B2 (en) | 2008-10-21 |
| CA2464223A1 (en) | 2003-05-01 |
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