ATE418555T1 - A2a-adenosinrezeptorantagonisten - Google Patents
A2a-adenosinrezeptorantagonistenInfo
- Publication number
- ATE418555T1 ATE418555T1 AT04759359T AT04759359T ATE418555T1 AT E418555 T1 ATE418555 T1 AT E418555T1 AT 04759359 T AT04759359 T AT 04759359T AT 04759359 T AT04759359 T AT 04759359T AT E418555 T1 ATE418555 T1 AT E418555T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- formula
- adenosin
- adenosin receptor
- antagonists
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46148403P | 2003-04-09 | 2003-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE418555T1 true ATE418555T1 (de) | 2009-01-15 |
Family
ID=33299825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759359T ATE418555T1 (de) | 2003-04-09 | 2004-04-09 | A2a-adenosinrezeptorantagonisten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7834014B2 (de) |
| EP (1) | EP1633756B1 (de) |
| AT (1) | ATE418555T1 (de) |
| DE (1) | DE602004018637D1 (de) |
| WO (1) | WO2004092173A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060106040A1 (en) | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| EP2258372B8 (de) | 2005-06-07 | 2012-12-19 | Kyowa Hakko Kirin Co., Ltd. | A2A Antagonisten zur Behandlung von motorischen Störungen |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| EP1939197A1 (de) | 2006-12-22 | 2008-07-02 | Schwarz Pharma Ag | 8-Ethinylxanthinderivate als selektive Antagonisten des A2A-Rezeptors |
| CN101809021B (zh) | 2007-09-11 | 2013-04-24 | 雅培制药有限公司 | 八氢-吡咯并[3,4-b]吡咯n-氧化物 |
| KR20110040856A (ko) * | 2008-07-23 | 2011-04-20 | 교와 핫꼬 기린 가부시키가이샤 | 편두통 치료제 |
| US20130190327A1 (en) | 2010-02-26 | 2013-07-25 | Catabasis Pharmaceuticals Inc | Bis-fatty acid conjugates and their uses |
| US9216224B2 (en) | 2010-03-05 | 2015-12-22 | Catabasis Pharmaceuticals, Inc. | Fatty acid COX inhibitor derivatives and their uses |
| WO2011116312A1 (en) | 2010-03-19 | 2011-09-22 | Catabasis Pharmaceuticals, Inc. | Fatty acid macrolide derivatives and their uses |
| CA2889919C (en) | 2012-11-16 | 2021-08-17 | University Health Network | Pyrazolopyrimidine compounds |
| WO2014101120A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| JP6832430B2 (ja) | 2016-08-31 | 2021-02-24 | アジオス ファーマシューティカルズ， インコーポレイテッド | 細胞代謝過程の阻害剤 |
| AU2018237598B2 (en) * | 2017-03-24 | 2023-12-14 | Piksci Inc. | Fused triazolo-pyrimidine compounds having useful pharmaceutical application |
| PL3611174T3 (pl) * | 2017-04-07 | 2022-08-08 | Medshine Discovery Inc. | Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a |
| CN109535161B (zh) * | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| GB201804922D0 (en) * | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
| EP3810610A1 (de) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren |
| KR102633145B1 (ko) * | 2018-06-26 | 2024-02-05 | 쩌지앙 빔그린 파머슈티컬스, 엘티디 | A2a 수용체 길항제로서의 트리아졸로 트리아진 유도체 |
| WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| JP2023508182A (ja) * | 2019-12-26 | 2023-03-01 | チェジン ヴィムグリーン ファーマシューティカルズ リミテッド | トリアゾロトリアジン誘導体の疾患治療への応用 |
| MX2023012338A (es) * | 2021-04-23 | 2023-10-30 | Chong Kun Dang Pharmaceutical Corp | Compuesto como antagonista del receptor de adenosina a2a y composicion farmaceutica que comprende al mismo. |
| WO2023191400A1 (ko) * | 2022-04-01 | 2023-10-05 | 에이치케이이노엔 주식회사 | 에틸 피페리딘 트리아졸로 트리아진 유도체, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7406641A (de) | 1973-05-22 | 1974-11-26 | ||
| JPS56131587A (en) | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | 7-substituted triazolopyrimidine derivative and its preparation |
| JPS56131586A (en) | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | Triazolopyrimidine derivative and its preparation |
| JPS5962595A (ja) | 1982-09-30 | 1984-04-10 | Ss Pharmaceut Co Ltd | ３，５，７―トリ置換―トリアゾロピリミジン誘導体 |
| DE3304330A1 (de) | 1983-02-09 | 1984-08-09 | Basf Ag, 6700 Ludwigshafen | Neue 2h-v-triazolyl(4,5-d)-pyrimidine und deren verwendung |
| JPS60140335A (ja) | 1983-12-28 | 1985-07-25 | Konishiroku Photo Ind Co Ltd | 熱現像カラ−感光材料 |
| US5204353A (en) | 1987-04-07 | 1993-04-20 | Ciba-Geigy Corporation | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith |
| WO1990008148A1 (en) | 1989-01-23 | 1990-07-26 | Pfizer Inc. | Bis-aza-bicyclic anxiolytic agents |
| ZA902280B (en) | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
| ES2079391T3 (es) | 1989-04-17 | 1996-01-16 | Bayer Ag | Procedimiento para la obtencion de 2,7-diazabiciclo(3.3.0)octanos. |
| GB2240102B (en) | 1990-01-22 | 1993-10-20 | Biochemie Gmbh | Improvements in or relating to beta lactam production |
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| EP0459702A1 (de) | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azolderivate |
| JPH0436284A (ja) | 1990-05-29 | 1992-02-06 | Sumitomo Chem Co Ltd | ジフェニルフロピリミジン誘導体、その製造法およびそれを有効成分とする除草剤 |
| CA2100863A1 (en) | 1991-01-23 | 1992-07-24 | David A. Bullough | Adenosine kinase inhibitors |
| GB9111130D0 (en) | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
| DE69230613T2 (de) | 1991-07-02 | 2000-12-28 | Inhale Inc | Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform |
| ES2150941T3 (es) | 1992-04-03 | 2000-12-16 | Upjohn Co | Aminas biciclicas-heterociclicas eficaces farmaceuticamente. |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| CZ284157B6 (cs) | 1992-12-17 | 1998-08-12 | Pfizer Inc. | Pyrazolové a pyrazolopyrimidinové sloučeniny jako takové a pro léčbu chorob a farmaceutické prostředky na jejich bázi |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| KR19990067704A (ko) | 1992-12-17 | 1999-08-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물 |
| IL108523A0 (en) | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
| WO1995003806A1 (en) | 1993-07-27 | 1995-02-09 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for parkinson's disease |
| CA2148502A1 (en) | 1993-09-06 | 1995-03-16 | Fumio Suzuki | Antidepressants |
| BR9407799A (pt) | 1993-10-12 | 1997-05-06 | Du Pont Merck Pharma | Composição de matéria método de tratamento e composição farmaceutica |
| TW427996B (en) | 1995-07-11 | 2001-04-01 | Astra Pharma Prod | Novel triazolopyrimidines and their use as medicaments |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| DE69820866T2 (de) | 1997-03-24 | 2004-12-30 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE |
| AU8181098A (en) | 1997-07-03 | 1999-01-25 | Du Pont Pharmaceuticals Company | Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists |
| PL337888A1 (en) | 1997-07-03 | 2000-09-11 | Du Pont Pharm Co | Imidazoprimidines and imidazopyridines for use in treating neurological disorders |
| US5939432A (en) | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| EP0975345A1 (de) | 1997-11-26 | 2000-02-02 | Cerebrus Pharmaceuticals Limited | (-)-mefloquine zur blockierung der purinrezeptoren und zur behandlung von bewegung- oder neurodegenerativen erkrankungen |
| AU1688599A (en) | 1998-01-05 | 1999-07-26 | Eisai Co. Ltd. | Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| AU2639299A (en) | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| JPH11279193A (ja) | 1998-03-24 | 1999-10-12 | Akira Matsuda | アデノシン誘導体 |
| JP4611524B2 (ja) | 1998-06-02 | 2011-01-12 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | ピロロ［２，３ｄ］ピリミジン組成物およびその使用 |
| GB9819384D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9819382D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
| WO2000017201A1 (en) | 1998-09-22 | 2000-03-30 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES |
| TW564247B (en) | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| GB9915437D0 (en) | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
| US6841549B1 (en) | 1999-07-02 | 2005-01-11 | Eisai Co., Ltd. | Condensed imidazole compounds and a therapeutic agent for diabetes mellitus |
| WO2001062233A2 (en) | 2000-02-25 | 2001-08-30 | F. Hoffmann La Roche Ag | Adenosine receptor modulators |
| JPWO2003020723A1 (ja) | 2001-08-30 | 2004-12-16 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体 |
| IL161573A0 (en) | 2001-11-30 | 2004-09-27 | Schering Corp | [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS |
| JPWO2003068776A1 (ja) * | 2002-02-15 | 2005-06-02 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| WO2004029056A1 (ja) | 2002-09-24 | 2004-04-08 | Kyowa Hakko Kogyo Co., Ltd. | [１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体 |
| WO2004092170A2 (en) * | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
-
2004
- 2004-04-09 WO PCT/US2004/011009 patent/WO2004092173A2/en not_active Ceased
- 2004-04-09 EP EP04759359A patent/EP1633756B1/de not_active Expired - Lifetime
- 2004-04-09 AT AT04759359T patent/ATE418555T1/de not_active IP Right Cessation
- 2004-04-09 US US10/552,304 patent/US7834014B2/en not_active Expired - Fee Related
- 2004-04-09 DE DE602004018637T patent/DE602004018637D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1633756A2 (de) | 2006-03-15 |
| HK1083838A1 (en) | 2006-07-14 |
| WO2004092173A3 (en) | 2004-12-09 |
| WO2004092173A2 (en) | 2004-10-28 |
| EP1633756B1 (de) | 2008-12-24 |
| US7834014B2 (en) | 2010-11-16 |
| DE602004018637D1 (de) | 2009-02-05 |
| US20070173505A1 (en) | 2007-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |