ATE418991T1 - Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker - Google Patents

Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker

Info

Publication number: ATE418991T1
Authority: AT; Austria
Prior art keywords: beta blocker; cardiac rhythm; rhythm disorders; treating cardiac; adenosine agonist
Prior art date: 2002-04-18

Application number

AT03724098T

Other languages

English (en)

Inventor

Luiz Belardinelli

Arvinder Dhalla

Original Assignee

Cv Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-18

Filing date

2003-04-18

Publication date

2009-01-15

2003-04-18 Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE418991T1 publication Critical patent/ATE418991T1/de

Links

239000003379 purinergic P1 receptor agonist Substances 0.000 title abstract 2
230000000747 cardiac effect Effects 0.000 title 1
230000033764 rhythmic process Effects 0.000 title 1
101150007969 ADORA1 gene Proteins 0.000 abstract 1
229940122614 Adenosine receptor agonist Drugs 0.000 abstract 1
229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
229940097320 beta blocking agent Drugs 0.000 abstract 1
239000000480 calcium channel blocker Substances 0.000 abstract 1
229940097217 cardiac glycoside Drugs 0.000 abstract 1
239000002368 cardiac glycoside Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 abstract 1
229930002534 steroid glycoside Natural products 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

AT03724098T 2002-04-18 2003-04-18 Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker ATE418991T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37376602P	2002-04-18	2002-04-18

Publications (1)

Publication Number	Publication Date
ATE418991T1 true ATE418991T1 (de)	2009-01-15

Family

ID=29251078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03724098T ATE418991T1 (de)	2002-04-18	2003-04-18	Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker

Country Status (17)

Country	Link
US (3)	US7005425B2 (de)
EP (1)	EP1494685B1 (de)
JP (1)	JP2005530736A (de)
KR (1)	KR20040106354A (de)
CN (2)	CN101385738A (de)
AT (1)	ATE418991T1 (de)
AU (1)	AU2003235466C1 (de)
CA (1)	CA2482928A1 (de)
DE (1)	DE60325572D1 (de)
ES (1)	ES2318129T3 (de)
IL (1)	IL164652A0 (de)
MX (1)	MXPA04010285A (de)
NO (1)	NO20045005L (de)
NZ (1)	NZ536001A (de)
RU (1)	RU2332220C2 (de)
WO (1)	WO2003088978A1 (de)
ZA (1)	ZA200408411B (de)

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JP2013516495A (ja)	2010-01-11	2013-05-13	イノテックファーマシューティカルズコーポレイション	眼圧を低下させる組合せ、キット、および方法
PT2555776T (pt) *	2010-03-19	2017-02-01	Inotek Pharmaceuticals Corp	Composições de combinação de agonistas de adenosina a1 e bloqueadores não selectivos dos receptores adrenérgicos beta para redução da pressão intra-ocular
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2003
- 2003-04-18 AT AT03724098T patent/ATE418991T1/de not_active IP Right Cessation
- 2003-04-18 EP EP03724098A patent/EP1494685B1/de not_active Expired - Lifetime
- 2003-04-18 AU AU2003235466A patent/AU2003235466C1/en not_active Ceased
- 2003-04-18 KR KR10-2004-7016764A patent/KR20040106354A/ko not_active Abandoned
- 2003-04-18 RU RU2004130826/14A patent/RU2332220C2/ru not_active IP Right Cessation
- 2003-04-18 CN CNA2008101711378A patent/CN101385738A/zh active Pending
- 2003-04-18 US US10/418,654 patent/US7005425B2/en not_active Expired - Fee Related
- 2003-04-18 NZ NZ536001A patent/NZ536001A/en not_active IP Right Cessation
- 2003-04-18 CN CNA038086999A patent/CN1646142A/zh active Pending
- 2003-04-18 CA CA002482928A patent/CA2482928A1/en not_active Abandoned
- 2003-04-18 ES ES03724098T patent/ES2318129T3/es not_active Expired - Lifetime
- 2003-04-18 WO PCT/US2003/012043 patent/WO2003088978A1/en not_active Ceased
- 2003-04-18 JP JP2003585730A patent/JP2005530736A/ja active Pending
- 2003-04-18 MX MXPA04010285A patent/MXPA04010285A/es active IP Right Grant
- 2003-04-18 DE DE60325572T patent/DE60325572D1/de not_active Expired - Lifetime
2004
- 2004-10-18 ZA ZA200408411A patent/ZA200408411B/en unknown
- 2004-10-18 IL IL16465204A patent/IL164652A0/xx unknown
- 2004-11-17 NO NO20045005A patent/NO20045005L/no not_active Application Discontinuation
2005
- 2005-10-28 US US11/262,025 patent/US7479485B2/en not_active Expired - Fee Related
2009
- 2009-01-09 US US12/351,731 patent/US20090118221A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20030216349A1 (en)	2003-11-20
US7005425B2 (en)	2006-02-28
CA2482928A1 (en)	2003-10-30
KR20040106354A (ko)	2004-12-17
NZ536001A (en)	2006-05-26
US7479485B2 (en)	2009-01-20
US20090118221A1 (en)	2009-05-07
WO2003088978A1 (en)	2003-10-30
NO20045005L (no)	2004-11-17
RU2004130826A (ru)	2005-05-10
ZA200408411B (en)	2006-02-22
ES2318129T3 (es)	2009-05-01
EP1494685A1 (de)	2005-01-12
CN101385738A (zh)	2009-03-18
JP2005530736A (ja)	2005-10-13
AU2003235466A1 (en)	2003-11-03
DE60325572D1 (de)	2009-02-12
MXPA04010285A (es)	2005-02-03
US20060052333A1 (en)	2006-03-09
AU2003235466C1 (en)	2008-03-20
EP1494685B1 (de)	2008-12-31
IL164652A0 (en)	2005-12-18
RU2332220C2 (ru)	2008-08-27
CN1646142A (zh)	2005-07-27

Legal Events

Date	Code	Title	Description
2009-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60325572D1 (de)	2009-02-12	Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker
ZA200409388B (en)	2006-05-31	Methods and compositions using immunodulatory compounds for treatment and management of cancers and other diseases
SV1995000007A (es)	1996-02-28	Derivados del acido micofenolico 5-substituidos.
TW200500355A (en)	2005-01-01	Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
MY124853A (en)	2006-07-31	4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives.
BR0316157A (pt)	2005-09-27	Derivados de 4-amino-5-fenil-7-ciclohexil-pirrolo[2,3-d]pirimidina
IL157841A0 (en)	2004-03-28	Activation of natural killer cells by adenosine a3 receptor agonists
EA200900272A1 (ru)	2009-10-30	Комбинации для лечения заболеваний, связанных с клеточной пролиферацией, миграцией или апоптозом клеток миеломы или с ангиогенезом
MXPA05012155A (es)	2006-02-22	Metodos y composiciones que utilizan compuestos inmunomoduladores para el tratamiento y manejo de canceres y otras enfermedades.
MY169308A (en)	2019-03-21	Treatment of tnf? related disorders
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ATE318135T1 (de)	2006-03-15	Verwendung von dapoxetin, a selektiver serotonin- aufnahme inhibitor mit schnellem wirkungseintritt,zur behandlung von sexueller dysfunction
EA200600921A1 (ru)	2006-10-27	Способы и композиции с применением талидомида для лечения и менеджмента рака и других заболеваний
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