ATE419274T1 - Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung - Google Patents

Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung

Info

Publication number
ATE419274T1
ATE419274T1 AT03777907T AT03777907T ATE419274T1 AT E419274 T1 ATE419274 T1 AT E419274T1 AT 03777907 T AT03777907 T AT 03777907T AT 03777907 T AT03777907 T AT 03777907T AT E419274 T1 ATE419274 T1 AT E419274T1
Authority
AT
Austria
Prior art keywords
transmembrane receptor
receptor agonists
tmr
reduced internalization
identifying
Prior art date
Application number
AT03777907T
Other languages
English (en)
Inventor
Carson Loomis
Robert Oakley
Shuntai Wang
Allen Eckhardt
Original Assignee
Mds Analytical Technologies Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Analytical Technologies Us filed Critical Mds Analytical Technologies Us
Application granted granted Critical
Publication of ATE419274T1 publication Critical patent/ATE419274T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03777907T 2002-10-25 2003-10-24 Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung ATE419274T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42153802P 2002-10-25 2002-10-25

Publications (1)

Publication Number Publication Date
ATE419274T1 true ATE419274T1 (de) 2009-01-15

Family

ID=32176725

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03777907T ATE419274T1 (de) 2002-10-25 2003-10-24 Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung

Country Status (7)

Country Link
US (1) US7297503B2 (de)
EP (1) EP1579212B1 (de)
AT (1) ATE419274T1 (de)
AU (1) AU2003286697A1 (de)
DE (1) DE60325640D1 (de)
TW (1) TW200413722A (de)
WO (1) WO2004038005A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
ATE534900T1 (de) * 2003-07-09 2011-12-15 Life Technologies Corp Verfahren zum testen einer protein-protein- wechselwirkung
JP5176188B2 (ja) 2006-04-21 2013-04-03 ディーエスエム アイピー アセッツ ビー．ブイ． オピオイド受容体拮抗薬の使用
WO2009149560A1 (en) * 2008-06-12 2009-12-17 Centre For Addiction And Mental Health Compositions and methods for modulating d1-d2 dopamine receptor interaction and function
CN104781280A (zh) 2012-11-13 2015-07-15 瑞泽恩制药公司 抗前动力蛋白受体(prokr)抗体及其使用
KR20180086438A (ko) * 2015-11-20 2018-07-31 에이전시 포 사이언스, 테크놀로지 앤드 리서치 다양한 화학 구조를 가지는 생체이물질의 세포 유형 특이적 독성을 예측하기 위한 고처리량 영상화 기반 방법
CN108962208A (zh) * 2018-09-01 2018-12-07 哈尔滨工程大学 一种共形驱动三瓣形弯张换能器

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3249997A (en) 1996-07-01 1998-01-21 Biosignal Inc. Method of assaying compounds which affect the activity of g protein-coupled receptors based on measurement of receptor oligomerization
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
CA2335305C (en) 1998-06-16 2006-05-23 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) system and its use
FR2788602B1 (fr) * 1999-01-20 2002-06-07 Inst Nat Sante Rech Med Procede de criblage utile pour identifier des ligands potentiels pour un recepteur capable de s'internaliser
WO2001042786A2 (en) * 1999-12-09 2001-06-14 Cellomics, Inc. System for cell based screening : cell spreading
WO2001046694A2 (en) 1999-12-22 2001-06-28 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) fusion molecule and method of use
WO2001046691A1 (en) 1999-12-22 2001-06-28 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) system with broad spectral resolution between donor and acceptor emission wavelengths and its use
US6893827B1 (en) 2000-02-07 2005-05-17 Applera Corporation Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
WO2002046763A1 (en) 2000-12-04 2002-06-13 Novo Nordisk A/S Method of identifying compounds capable of acting as agonists or antagonists of g-protein coupled receptors
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
US20030013137A1 (en) 2001-03-13 2003-01-16 Barak Larry S. Automated methods of detecting receptor activity
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
CA2483692A1 (en) 2002-05-13 2003-11-27 Molecular Devices Corporation Constitutively translocating cell line
AU2003251759A1 (en) 2002-07-03 2004-01-23 Duke University Methods of screening compounds for grk6 modulating activity

Also Published As

Publication number Publication date
US7297503B2 (en) 2007-11-20
AU2003286697A1 (en) 2004-05-13
TW200413722A (en) 2004-08-01
WO2004038005A3 (en) 2005-02-03
US20050009111A1 (en) 2005-01-13
AU2003286697A8 (en) 2004-05-13
EP1579212B1 (de) 2008-12-31
DE60325640D1 (de) 2009-02-12
EP1579212A2 (de) 2005-09-28
WO2004038005A2 (en) 2004-05-06
EP1579212A4 (de) 2007-02-14

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