ATE463503T1 - Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden - Google Patents
Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptidenInfo
- Publication number
- ATE463503T1 ATE463503T1 AT05826671T AT05826671T ATE463503T1 AT E463503 T1 ATE463503 T1 AT E463503T1 AT 05826671 T AT05826671 T AT 05826671T AT 05826671 T AT05826671 T AT 05826671T AT E463503 T1 ATE463503 T1 AT E463503T1
- Authority
- AT
- Austria
- Prior art keywords
- formation
- polypeptides
- preventing
- trisulfide
- trisulfide derivatives
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229910052786 argon Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200402022 | 2004-12-29 | ||
| PCT/EP2005/056976 WO2006069940A1 (en) | 2004-12-29 | 2005-12-20 | Method for preventing formation of trisulfide derivatives of polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463503T1 true ATE463503T1 (de) | 2010-04-15 |
Family
ID=35986616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05826671T ATE463503T1 (de) | 2004-12-29 | 2005-12-20 | Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090131311A1 (de) |
| EP (1) | EP1833841B1 (de) |
| JP (1) | JP4865728B2 (de) |
| AT (1) | ATE463503T1 (de) |
| DE (1) | DE602005020505D1 (de) |
| ES (1) | ES2344120T3 (de) |
| WO (1) | WO2006069940A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2483289B2 (de) | 2009-10-02 | 2025-03-26 | Biogen MA Inc. | Verfahren zur vorbeugung und entfernung von trisulphid-bindungen |
| US9562252B2 (en) | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
| KR102463267B1 (ko) * | 2014-07-24 | 2022-11-03 | 제넨테크, 인크. | 적어도 하나의 트리설파이드 결합을 함유하는 단백질에서 티올 모이어티에 제제의 접합 방법 |
| JP7088912B2 (ja) | 2016-09-15 | 2022-06-21 | シティ・オブ・ホープ | ジチオｅｔｐ誘導体 |
| WO2018217811A1 (en) * | 2017-05-22 | 2018-11-29 | City Of Hope | Synthesis of etp derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL97339C (de) | 1956-03-02 | |||
| JPH0720980B2 (ja) | 1991-11-26 | 1995-03-08 | 株式会社島津製作所 | ペプチド合成装置 |
| JPH06220084A (ja) | 1993-01-23 | 1994-08-09 | Shimadzu Corp | ペプチド合成装置 |
| DK44593D0 (da) | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| US6299776B1 (en) * | 1997-12-23 | 2001-10-09 | General Signal Corporation | Biochemical oxidation system and process |
| SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| US20040048315A1 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
-
2005
- 2005-12-20 AT AT05826671T patent/ATE463503T1/de not_active IP Right Cessation
- 2005-12-20 JP JP2007548807A patent/JP4865728B2/ja not_active Expired - Fee Related
- 2005-12-20 EP EP05826671A patent/EP1833841B1/de not_active Expired - Lifetime
- 2005-12-20 US US11/813,045 patent/US20090131311A1/en not_active Abandoned
- 2005-12-20 WO PCT/EP2005/056976 patent/WO2006069940A1/en not_active Ceased
- 2005-12-20 ES ES05826671T patent/ES2344120T3/es not_active Expired - Lifetime
- 2005-12-20 DE DE602005020505T patent/DE602005020505D1/de not_active Expired - Lifetime
-
2010
- 2010-03-01 US US12/714,900 patent/US8530191B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100160236A1 (en) | 2010-06-24 |
| JP4865728B2 (ja) | 2012-02-01 |
| EP1833841A1 (de) | 2007-09-19 |
| US8530191B2 (en) | 2013-09-10 |
| EP1833841B1 (de) | 2010-04-07 |
| WO2006069940A1 (en) | 2006-07-06 |
| DE602005020505D1 (de) | 2010-05-20 |
| ES2344120T3 (es) | 2010-08-18 |
| US20090131311A1 (en) | 2009-05-21 |
| JP2008525517A (ja) | 2008-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |