ATE419344T1 - Strukturelle nukleinsäure-geführte chemische synthese - Google Patents

Strukturelle nukleinsäure-geführte chemische synthese

Info

Publication number
ATE419344T1
ATE419344T1 AT05800754T AT05800754T ATE419344T1 AT E419344 T1 ATE419344 T1 AT E419344T1 AT 05800754 T AT05800754 T AT 05800754T AT 05800754 T AT05800754 T AT 05800754T AT E419344 T1 ATE419344 T1 AT E419344T1
Authority
AT
Austria
Prior art keywords
nucleic acid
composition
chemical synthesis
reaction
structural nucleic
Prior art date
Application number
AT05800754T
Other languages
English (en)
Inventor
Nils Jakob Vest Hansen
Peter Blakskjfr
Margit Haahr Hansen
Lars Kolster Petersen
Tara Renee Heitner
Original Assignee
Vipergen Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vipergen Aps filed Critical Vipergen Aps
Application granted granted Critical
Publication of ATE419344T1 publication Critical patent/ATE419344T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electroluminescent Light Sources (AREA)
  • Luminescent Compositions (AREA)
AT05800754T 2004-11-08 2005-11-08 Strukturelle nukleinsäure-geführte chemische synthese ATE419344T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04105597 2004-11-08
US68784905P 2005-06-07 2005-06-07
US72534705P 2005-10-11 2005-10-11

Publications (1)

Publication Number Publication Date
ATE419344T1 true ATE419344T1 (de) 2009-01-15

Family

ID=34929821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05800754T ATE419344T1 (de) 2004-11-08 2005-11-08 Strukturelle nukleinsäure-geführte chemische synthese

Country Status (16)

Country Link
US (2) US8202823B2 (de)
EP (1) EP1809743B1 (de)
JP (1) JP4931825B2 (de)
KR (1) KR101411361B1 (de)
CN (3) CN101914528B (de)
AT (1) ATE419344T1 (de)
AU (1) AU2005300886B2 (de)
CA (1) CA2587010C (de)
DE (1) DE602005012139D1 (de)
DK (1) DK1809743T3 (de)
EA (1) EA024849B1 (de)
ES (1) ES2320361T3 (de)
IL (1) IL183013A (de)
NZ (1) NZ555698A (de)
WO (1) WO2006048025A1 (de)
ZA (1) ZA200704520B (de)

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EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
DK1608748T3 (da) 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
ATE447020T1 (de) 2004-03-22 2009-11-15 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US7960357B2 (en) 2005-10-07 2011-06-14 California Institute Of Technology PKR activation via hybridization chain reaction
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
WO2007124758A1 (en) * 2006-05-03 2007-11-08 Vipergen Aps A method for preparing compounds by nucleic acid directed synthesis
WO2008106658A2 (en) 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
EP2241640B1 (de) * 2008-01-22 2016-06-22 Hiroshima University Nukleinsäurebindungsprotein-testverfahren und -kit
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
EP3653763A1 (de) 2009-02-13 2020-05-20 X-Chem, Inc. Verfahren zur erstellung und durchsuchung von dna-codierten bibliotheken
WO2010020892A2 (en) * 2009-07-07 2010-02-25 The Procter & Gamble Company Property-space similarity modeling
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
CN103119165B (zh) * 2010-09-27 2017-04-12 威泊根私人有限公司 制备富集文库的方法
DK2748357T3 (en) 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
US9078078B1 (en) * 2011-09-15 2015-07-07 Google Inc. Call forwarding methods and systems
CA2879018A1 (en) 2012-07-13 2014-01-16 X-Chem, Inc. Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
JP7283727B2 (ja) 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
EP3481843B1 (de) 2016-07-05 2022-01-26 California Institute of Technology Hybridisierungskettenreaktion mit fraktioniertem initiator
IL264831B (en) 2016-08-30 2022-09-01 California Inst Of Techn Immunohistochemistry via hybridization chain reaction
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
WO2019109046A1 (en) 2017-11-30 2019-06-06 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
GB201817321D0 (en) 2018-10-24 2018-12-05 Nanna Therapeutics Ltd Microbeads for tagless encoded chemical library screening
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
KR102890413B1 (ko) * 2019-01-22 2025-11-21 비퍼겐 에이피에스 세포 내에서 인 비트로 디스플레이 라이브러리를 스크리닝하는 방법
EP4284925A4 (de) 2021-01-26 2025-08-13 California Inst Of Techn Allosterische bedingte guide-rnas zur zellselektiven regulierung von crispr/cas

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EP0151631A1 (de) * 1983-08-03 1985-08-21 The Research Foundation Of State University Of New York Verzweigte verbindungen von nukleinsäure mit einer präzise bestimmten migration
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
CA2346989A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
AU2951599A (en) 1999-04-08 2000-11-14 Pavel Sergeev Synthesis of biologically active compounds in cells
CN1434726A (zh) * 2000-06-08 2003-08-06 拉卓拉药物公司 包含高分子量聚环氧乙烷的多价平台分子
IL158000A0 (en) 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
AU2003260291A1 (en) * 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
PT1558744E (pt) * 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
JP2006506395A (ja) 2002-11-01 2006-02-23 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ＣＮＳ疾患の治療のための、α７ニコチンアゴニスト活性及び５ＨＴ３アンタゴニスト活性を有する化合物
AU2002953366A0 (en) 2002-12-17 2003-01-09 Hearts And Minds Crm Pty Ltd A method of analysing a business network
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods

Also Published As

Publication number Publication date
CA2587010C (en) 2017-08-15
ES2320361T3 (es) 2009-05-21
US20110045990A1 (en) 2011-02-24
DK1809743T3 (da) 2009-05-04
US8202823B2 (en) 2012-06-19
CN101056980A (zh) 2007-10-17
KR20070085977A (ko) 2007-08-27
WO2006048025A1 (en) 2006-05-11
NZ555698A (en) 2010-07-30
EP1809743B1 (de) 2008-12-31
CN101914528A (zh) 2010-12-15
DE602005012139D1 (de) 2009-02-12
US9006150B2 (en) 2015-04-14
ZA200704520B (en) 2008-09-25
JP2008518607A (ja) 2008-06-05
CN101914528B (zh) 2013-04-03
IL183013A (en) 2011-12-29
AU2005300886B2 (en) 2009-11-12
CN101914527B (zh) 2012-06-27
AU2005300886A1 (en) 2006-05-11
EP1809743A1 (de) 2007-07-25
CN101914527A (zh) 2010-12-15
EA200701022A1 (ru) 2007-10-26
IL183013A0 (en) 2007-08-19
EA024849B1 (ru) 2016-10-31
KR101411361B1 (ko) 2014-06-25
CN101056980B (zh) 2012-05-23
CA2587010A1 (en) 2006-05-11
JP4931825B2 (ja) 2012-05-16
US20130005581A1 (en) 2013-01-03

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