ATE447626T1 - Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen - Google Patents

Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen

Info

Publication number
ATE447626T1
ATE447626T1 AT04762850T AT04762850T ATE447626T1 AT E447626 T1 ATE447626 T1 AT E447626T1 AT 04762850 T AT04762850 T AT 04762850T AT 04762850 T AT04762850 T AT 04762850T AT E447626 T1 ATE447626 T1 AT E447626T1
Authority
AT
Austria
Prior art keywords
oligonucleotide
molecule
target
encoded
structural information
Prior art date
Application number
AT04762850T
Other languages
English (en)
Inventor
Thomas Thisted
Mikkel Lundorf
Torben Rasmussen
Per-Ola Freskgard
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of ATE447626T1 publication Critical patent/ATE447626T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04762850T 2003-09-18 2004-09-17 Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen ATE447626T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200301356 2003-09-18
US50474803P 2003-09-22 2003-09-22
US50926803P 2003-10-08 2003-10-08
DKPA200301485 2003-10-08
PCT/DK2004/000630 WO2005026387A1 (en) 2003-09-18 2004-09-17 A method for obtaining structural information concerning an encoded molecule and method for selecting compounds

Publications (1)

Publication Number Publication Date
ATE447626T1 true ATE447626T1 (de) 2009-11-15

Family

ID=34317542

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04762850T ATE447626T1 (de) 2003-09-18 2004-09-17 Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen

Country Status (6)

Country Link
US (2) US11118215B2 (de)
EP (1) EP1670939B1 (de)
AT (1) ATE447626T1 (de)
DE (1) DE602004023960D1 (de)
DK (1) DK1670939T3 (de)
WO (1) WO2005026387A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
EP1545762A2 (de) 2002-09-27 2005-06-29 Carlsberg A/S Räumlich kodierte polymermatrix
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
DK1608748T3 (da) 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
CN1898257B (zh) 2003-12-17 2010-06-23 普雷西斯药品公司 合成编码文库的方法
WO2005090566A2 (en) 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
US20090163371A1 (en) * 2005-05-31 2009-06-25 Stern Andrew M Anchor-Assisted Fragment Selection and Directed Assembly
KR101346432B1 (ko) * 2005-06-09 2014-02-14 프래시스 파마슈티컬즈 인코포레이티드 코드된 라이브러리를 합성하는 방법
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
WO2007016488A2 (en) * 2005-07-29 2007-02-08 Ensemble Discovery Corporation Analysis of encoded chemical libraries
JP2009513135A (ja) 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
WO2007054515A1 (en) * 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Method for detecting microorganisms
LT3018206T (lt) * 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20110245101A1 (en) * 2010-04-05 2011-10-06 Prognosys Biosciences, Inc. Co-localization affinity assays
KR101866401B1 (ko) 2010-04-05 2018-06-11 프로그노시스 바이오사이언스, 인코포레이티드 공간적으로 엔코딩된 생물학적 검정
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
WO2012019765A1 (en) * 2010-08-10 2012-02-16 European Molecular Biology Laboratory (Embl) Methods and systems for tracking samples and sample combinations
CN103119165B (zh) * 2010-09-27 2017-04-12 威泊根私人有限公司 制备富集文库的方法
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DK2748357T3 (en) 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
EP3901280B1 (de) 2012-10-17 2025-03-12 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
CA2907050C (en) 2013-03-15 2023-09-26 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
JP6262848B2 (ja) 2013-05-21 2018-01-17 成都先導薬物開発有限公司 薬物標的の捕獲方法
CN111500680B (zh) 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US10288608B2 (en) 2013-11-08 2019-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
GB201322692D0 (en) * 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
EP4321627A3 (de) 2015-04-10 2024-04-17 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
WO2017031378A1 (en) 2015-08-18 2017-02-23 Krusemark Casey J Systems and methods for proteomic activity analysis using dna-encoded probes
KR102516168B1 (ko) 2016-05-02 2023-03-30 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP3472376A4 (de) 2016-06-16 2019-12-18 Richard Edward Watts Oligonukleotidgesteuerte und aufgezeichnete kombinatorische synthese von codierten sondenmolekülen
WO2018166532A1 (en) 2017-03-17 2018-09-20 Hitgen Ltd. Methods and compositions for synthesis of encoded libraries
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
MX2020004559A (es) 2017-10-31 2020-10-05 Encodia Inc Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
US20210355483A1 (en) * 2017-10-31 2021-11-18 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
EP3894585A2 (de) 2018-12-10 2021-10-20 10X Genomics, Inc. Erzeugung von erfassungssonden zur räumlichen analyse
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3127137A1 (en) 2019-01-22 2020-07-30 Vipergen Aps A method for screening of an in vitro display library within a cell
EP3938566A4 (de) * 2019-03-14 2023-02-08 Haystack Sciences Corporation Verfahren und systeme zur verarbeitung oder analyse von oligonukleotid-codierten molekülen
CA3137716A1 (en) 2019-04-23 2020-10-29 Encodia, Inc. Methods for spatial analysis of proteins and related kits
EP3963070A4 (de) 2019-04-30 2023-02-22 Encodia, Inc. Verfahren zur herstellung von analyten und zugehörige kits
EP3976820A1 (de) 2019-05-30 2022-04-06 10X Genomics, Inc. Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
EP4081656A1 (de) 2019-12-23 2022-11-02 10X Genomics, Inc. Zusammensetzungen und verfahren zur verwendung von fixierten biologischen proben bei partitionsbasierten tests
CN121022991A (zh) 2019-12-23 2025-11-28 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
EP4752521A3 (de) 2019-12-23 2026-08-12 10X Genomics, Inc. Reversible fixierreagenzien und verfahren zur verwendung davon
US11169157B2 (en) 2020-01-07 2021-11-09 Encodia, Inc. Methods for stable complex formation and related kits
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
CN116157533A (zh) 2020-02-21 2023-05-23 10X基因组学有限公司 使用杂交方法捕获遗传靶标
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
EP4139485B1 (de) 2020-04-22 2023-09-06 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4153775B1 (de) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
EP4446430A3 (de) 2020-06-10 2024-12-18 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
EP4450639B1 (de) 2020-06-25 2025-10-15 10X Genomics, Inc. Räumliche analyse der dna-methylierung
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
CN116685725A (zh) 2020-08-19 2023-09-01 Encodia 公司 顺序编码方法和相关试剂盒
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
EP4320271B1 (de) 2021-05-06 2025-03-19 10X Genomics, Inc. Verfahren zur erhöhung der auflösung von räumlicher analyse
ES3030033T3 (en) 2021-06-03 2025-06-26 10X Genomics Inc Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4419707A1 (de) 2021-11-10 2024-08-28 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position eines analyten in einer biologischen probe
EP4305195A2 (de) 2021-12-01 2024-01-17 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme für verbesserten in-situ-nachweis von analyten und raumanalyse
EP4206674B1 (de) 2021-12-28 2025-10-22 Encodia, Inc. Serotypisierungs- und antikörperprofilierungsassays mit hohem durchsatz
AU2023308308A1 (en) 2022-07-12 2025-02-13 Abrus Bio, Inc. Determination of protein information by recoding amino acid polymers into dna polymers
WO2024040236A2 (en) 2022-08-19 2024-02-22 Abrus Bio, Inc. Determination of protein information by recoding amino acid polymers into dna polymers
AU2023366930A1 (en) * 2022-10-26 2025-06-05 Allchemy, Inc. Closed-loop optimization of general reaction conditions for heteroaryl suzuki-miyaura coupling
EP4685239A1 (de) 2022-11-09 2026-01-28 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe

Family Cites Families (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EP0260032B1 (de) 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
WO1990005785A1 (en) 1988-11-18 1990-05-31 The Regents Of The University Of California Method for site-specifically incorporating unnatural amino acids into proteins
US5324829A (en) 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
ES2118066T3 (es) 1989-10-05 1998-09-16 Optein Inc Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos.
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992002536A1 (en) 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5432272A (en) * 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
WO1993003172A1 (en) 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
JP2780572B2 (ja) 1991-09-13 1998-07-30 株式会社島津製作所 オリゴヌクレオチドの酵素的合成法及びオリゴヌクレオチドのプライマーとしての使用
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
EP0604552B1 (de) 1991-09-18 1997-02-12 Affymax Technologies N.V. Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US6197556B1 (en) * 1991-12-20 2001-03-06 The University Of Chicago Nucleic acid amplification using modular branched primers
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
HUT72495A (en) 1992-10-01 1996-05-28 Cold Spring Harbor Lab Complex combinatorial chemical libraries encoded with tags
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6503759B1 (en) * 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5684169A (en) 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
WO1994013623A1 (en) 1992-12-11 1994-06-23 Chiron Corporation Synthesis of encoded polymers
DE4244584A1 (de) * 1992-12-28 1994-07-07 Krone Ag Verfahren und Anordnung zur Vernetzung von elektro-optischen Bildwandmodulen
ES2204913T3 (es) 1993-04-12 2004-05-01 Northwestern University Metodo para formacion de oligonucleotidos.
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
CA2163637C (en) * 1993-05-27 2008-05-06 Michal Lebl Topologically segregated, encoded solid phase libraries
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
EP0706531A4 (de) 1993-07-02 1998-11-25 Lynx Therapeutics Inc Synthese verzweigter nukleinsäuren
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DK96093D0 (da) 1993-08-25 1993-08-25 Symbicom Ab Improvements in molecular modelling and drug design
CN1525171A (zh) 1993-10-01 2004-09-01 ŦԼ�и��ױ��Ǵ�ѧ���� 用标示物编码的多元组合化学库
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
JPH09508353A (ja) 1993-11-02 1997-08-26 アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ 分子多様性の合成及びスクリーニング
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
CA2179315A1 (en) * 1993-12-17 1995-06-22 Roger S. Cubicciotti Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
JPH09511486A (ja) * 1994-01-13 1997-11-18 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 合成レセプター、ライブラリー及びこれらの使用
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5449613A (en) * 1994-03-01 1995-09-12 The University Of Iowa Research Foundation Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent
US6936477B2 (en) * 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
JPH08268A (ja) 1994-06-16 1996-01-09 Koichi Nishigaki 連結した2本鎖dnaの製造方法
US5663046A (en) * 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
US5739386A (en) * 1994-06-23 1998-04-14 Affymax Technologies N.V. Photolabile compounds and methods for their use
US20030059826A1 (en) 1994-07-26 2003-03-27 Kim Janda Soluble combinatorial libraries
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
WO1996024847A1 (en) 1995-02-10 1996-08-15 Smithkline Beecham Corporation A process for identifiying pharmaceutically active agents using an epitope-tagged library
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6210900B1 (en) * 1995-05-23 2001-04-03 Smithkline Beecham Corporation Method of encoding a series of combinatorial libraries and developing structure activity relationships
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5824471A (en) 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
US5910408A (en) * 1995-06-07 1999-06-08 The General Hospital Corporation Catalytic DNA having ligase activity
EP0832287B1 (de) 1995-06-07 2007-10-10 Solexa, Inc Oligonukleotid-tags zur sortierung und identifizierung
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
WO1997004131A1 (en) * 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US5780613A (en) * 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US5795976A (en) * 1995-08-08 1998-08-18 The Board Of Trustees Of The Leland Stanford Junior University Detection of nucleic acid heteroduplex molecules by denaturing high-performance liquid chromatography and methods for comparative sequencing
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
WO1997011958A1 (en) 1995-09-29 1997-04-03 The Scripps Research Institute Protein signature analysis
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
WO1997019039A1 (en) 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6613508B1 (en) * 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
EP0904540A1 (de) 1996-03-22 1999-03-31 Ontogen Corporation Methoden für die synthese von räumlich verteilten kombinatorischen bibliotheken mit festgelegten positionen
US6294325B1 (en) 1996-07-05 2001-09-25 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of thermostable multi genes and proteins and uses thereof
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
EP1477561B1 (de) 1996-10-17 2008-12-10 Mitsubishi Chemical Corporation Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen
US5954874A (en) 1996-10-17 1999-09-21 Hunter; Charles Eric Growth of bulk single crystals of aluminum nitride from a melt
IL131016A (en) 1997-01-21 2004-12-15 Gen Hospital Corp Selection of proteins using RNA-protein blends
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US6127533A (en) 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US5739314A (en) 1997-04-25 1998-04-14 Hybridon, Inc. Method for synthesizing 2'-O-substituted pyrimidine nucleosides
DK0985032T4 (da) * 1997-05-28 2009-08-31 Crescendo Biolog Ltd Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
AU8147798A (en) 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US6607878B2 (en) * 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6348322B1 (en) 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US20030004122A1 (en) * 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20020006604A1 (en) 1998-02-21 2002-01-17 Alan W Schwabacher One dimensional compound arrays and a method for assaying them
US6316616B1 (en) 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
EP1068356B8 (de) 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Adressierbare protein arrays
EP1073730A1 (de) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
DE69913509T2 (de) * 1998-05-15 2004-09-23 Oxford Gene Technology Ip Ltd., Kidlington Bibliotheken von Oligomeren, die mit unterschiedlichen Markierungen (TAGS) markiert sind
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6372712B1 (en) * 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
US6096875A (en) * 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
US5948648A (en) * 1998-05-29 1999-09-07 Khan; Shaheer H. Nucleotide compounds including a rigid linker
EP1086064A2 (de) 1998-06-10 2001-03-28 Glycodesign Inc. Gerichtete kombinatorische verbindungsbibliothek und hochdurchsatz assays für deren screening
WO2000020639A1 (en) 1998-10-05 2000-04-13 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
EP1119530A2 (de) 1998-10-09 2001-08-01 Pharmacopeia, Inc. Auswahl von codes für die codierung von kombinatorischen bibliotheken
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
US7479472B1 (en) * 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
WO2000023548A1 (en) * 1998-10-20 2000-04-27 The Procter & Gamble Company Laundry detergents comprising modified alkylbenzene sulfonates
EP1124948A1 (de) 1998-10-28 2001-08-22 Novozymes A/S Verfahren zur herstellung einer genbibliothek
US5942609A (en) * 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
CA2350417C (en) * 1998-12-02 2010-02-09 Bristol-Myers Squibb Company Dna-protein fusions and uses thereof
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
AU2225000A (en) 1999-01-08 2000-07-24 Ceres, Inc. Sequence-determined dna fragments and corresponding polypeptides encoded thereby
US6831071B2 (en) 1999-04-08 2004-12-14 Pavel Sergeev Synthesis of biologically active compounds in cells
AU7569600A (en) * 1999-05-20 2000-12-28 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
ATE502117T1 (de) 1999-06-25 2011-04-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
GB9920194D0 (en) 1999-08-27 1999-10-27 Advanced Biotech Ltd A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
EP1125945B1 (de) * 1999-08-27 2003-05-21 Japan Science and Technology Corporation Reversibel photokuppelnde nukleinsäure und phosphoramidit
US20020048760A1 (en) * 1999-12-10 2002-04-25 Hyseq, Inc. Use of mismatch cleavage to detect complementary probes
EP1250463B1 (de) 2000-01-24 2006-04-05 Compound Therapeutics, Inc. Sensible und multiplexe diagnostische tests zur proteinanalyse
US6799120B2 (en) 2000-02-03 2004-09-28 Nanoscale Combinatorial Synthesis, Inc. Nonredundant split/pool synthesis of combinatorial libraries
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US20020127598A1 (en) * 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
HK1054410B (en) 2000-05-19 2008-03-07 Richard B. Williams In vitro evolution of nucleic acids and encoded polypeptide
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
PT1297338E (pt) * 2000-06-05 2007-05-31 Novartis Vaccines & Diagnostic Microarrays para efectuar análises proteómicas
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
CA2415098A1 (en) 2000-07-03 2002-01-10 Merck & Co., Inc. Methods for encoding combinatorial libraries
WO2002010186A1 (en) 2000-07-27 2002-02-07 California Institute Of Technology A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping
US20020072887A1 (en) 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
WO2004007529A2 (en) 2002-07-15 2004-01-22 The Trustees Of Princeton University Iap binding compounds
WO2002034948A2 (en) 2000-10-25 2002-05-02 City Of Hope Candidate region mismatch scanning for genotyping and mutation detection
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
PT1423400E (pt) * 2001-03-19 2006-12-29 Harvard College Evolução de nova função molecular
US7678554B2 (en) 2001-03-19 2010-03-16 President And Fellows Of Harvard College Nucleic acid shuffling
WO2002083951A1 (en) * 2001-04-10 2002-10-24 Northeastern University Multiplexed ligand/protein binding assays with pna labels
WO2002090581A2 (en) 2001-05-03 2002-11-14 Genevision Inc. A molecular tag code for monitoring a product and process using same
AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
AU2002312389A1 (en) 2001-06-05 2002-12-16 Irm Llc Functional proteomic profiling
US7727713B2 (en) * 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US20060234231A1 (en) 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
CN1539014A (zh) 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US20040241688A1 (en) * 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
WO2003038558A2 (en) * 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
WO2003062417A1 (fr) 2002-01-22 2003-07-31 Mitsubishi Chemical Corporation Produit de ligation arn-adn, et utilisation correspondante
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
EA006965B1 (ru) 2002-03-08 2006-06-30 Айдгенёссише Текнише Хохшуле Цюрих Закодированные самособирающиеся химические библиотеки
EP1487850A2 (de) 2002-03-15 2004-12-22 Nuevolution A/S Ein baublock zur c-c bindungsbildung oder c-heteroatom bindungsbildung
AU2003218630A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
EP1488009A4 (de) 2002-03-22 2007-07-11 Univ Emory Schablonengesteuerte verfahren zur synthese von polymeren und mit solchen verfahren assoziierte komponenten
GB0213816D0 (en) 2002-06-14 2002-07-24 Univ Aston Method of producing DNA and protein libraries
EP1520040A2 (de) 2002-06-20 2005-04-06 Nuevolution A/S Mikroarrays zur darstellung von kodierten molekülen
US20060099589A1 (en) 2002-07-23 2006-05-11 Nuevolution A/S Gene shuffling by template switching
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
US20040197845A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
WO2004024929A2 (en) 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
JP2006500959A (ja) * 2002-09-30 2006-01-12 パラレル バイオサイエンス, インコーポレイテッド 動的サンプリング結合によるポリヌクレオチド合成および標識化
CA2504443A1 (en) 2002-10-30 2004-05-13 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
CN102838654B (zh) * 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
WO2004050899A2 (en) 2002-12-03 2004-06-17 Archemix Corporation Method for in vitro selection of 2’-substituted nucleic acids
DE60330406D1 (de) * 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
DE602004026033D1 (de) * 2003-01-29 2010-04-29 454 Corp Zweiendige sequenzierung
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US20060269920A1 (en) 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
JP4054871B2 (ja) 2003-02-24 2008-03-05 独立行政法人産業技術総合研究所 耐熱性dnaリガーゼ
DK1608748T3 (da) * 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
EP1625230A2 (de) 2003-05-09 2006-02-15 Thorleif Möller Selektion und evolution von chemischen biobliotheken
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
EP1652123A2 (de) 2003-07-03 2006-05-03 Biogen Idec MA Inc. Fingerabdruck zur strukturellen interaktion (sift)
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US7972994B2 (en) * 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
CN1898257B (zh) 2003-12-17 2010-06-23 普雷西斯药品公司 合成编码文库的方法
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
WO2005090566A2 (en) 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
WO2005116213A2 (en) 2004-04-15 2005-12-08 President And Fellows Of Harvard College Directed evolution of proteins
EP1809743B1 (de) 2004-11-08 2008-12-31 Vipergen APS Strukturelle nukleinsäure-geführte chemische synthese
US8168381B2 (en) 2004-11-22 2012-05-01 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
MX2007007195A (es) 2004-12-20 2007-10-08 Genentech Inc Inhibidores de pirrolidina de iap.
WO2006079061A2 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
JP2008541698A (ja) 2005-05-03 2008-11-27 アンサンブル ディスカバリー コーポレイション 核酸検出のためのターンオーバープローブおよびその使用
BRPI0611474A2 (pt) 2005-05-26 2010-09-14 Ensemble Discovery Corp biodetecção por quìmica modelada com ácido nucléico
US20090163371A1 (en) 2005-05-31 2009-06-25 Stern Andrew M Anchor-Assisted Fragment Selection and Directed Assembly
US20090149347A1 (en) * 2005-06-07 2009-06-11 President And Fellows Of Harvard College Ordered Multi-Step Synthesis by Nucleic Acid-Mediated Chemistry
WO2006135654A2 (en) 2005-06-07 2006-12-21 President And Fellows Of Harvard College Polymer evolution via templated synthesis related applications
KR101346432B1 (ko) 2005-06-09 2014-02-14 프래시스 파마슈티컬즈 인코포레이티드 코드된 라이브러리를 합성하는 방법
WO2006138560A2 (en) 2005-06-17 2006-12-28 President And Fellows Of Harvard College Nucleic acid-templated chemistry in organic solvents
WO2006138666A2 (en) 2005-06-17 2006-12-28 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
WO2007016488A2 (en) 2005-07-29 2007-02-08 Ensemble Discovery Corporation Analysis of encoded chemical libraries
JP2009513135A (ja) * 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
US7928211B2 (en) 2006-05-03 2011-04-19 Vipergen Pharmaceuticals Aps Method for preparing compounds by nucleic acid directed synthesis
US20100143499A1 (en) 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
EP2064348B1 (de) 2006-09-18 2012-02-08 Ensemble Therapeutics Corporation Profilierung einer rezeptorfamilie
JP2010504983A (ja) 2006-09-28 2010-02-18 アンサンブル ディスカバリー コーポレイション 核酸を鋳型とする化学による生物学的検出のための組成物および方法
US8383370B2 (en) 2007-01-30 2013-02-26 The Rockefeller University Modified RNA ligase for efficient 3′ modification of RNA
AU2008282557A1 (en) 2007-07-27 2009-02-05 Ensemble Discovery Corporation Detection assays and use thereof
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
JP2021531255A (ja) 2018-07-23 2021-11-18 アベクサ バイオロジクス,インク. 非古典的hla−iおよびネオアンチゲンを含む複合体を標的とする抗体、およびその使用方法

Also Published As

Publication number Publication date
US20220205027A1 (en) 2022-06-30
WO2005026387A1 (en) 2005-03-24
DK1670939T3 (da) 2010-03-01
EP1670939B1 (de) 2009-11-04
US20080305957A1 (en) 2008-12-11
US11965209B2 (en) 2024-04-23
US11118215B2 (en) 2021-09-14
EP1670939A1 (de) 2006-06-21
DE602004023960D1 (de) 2009-12-17

Similar Documents

Publication Publication Date Title
DE602004023960D1 (de) Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
Gohl et al. Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies
US8945844B2 (en) Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample
US20160024558A1 (en) Nucleic acid binding proteins and uses thereof
DE602005017370D1 (de) Ligationscodierung unter verwendung von oligonukleotidbausteinen
EP3134536A1 (de) Systeme und verfahren zur barcodierung von nukleinsäuren
US20060057595A1 (en) Compositions, methods, and kits for identifying and quantitating small RNA molecules
WO2004016767A3 (en) Evolving new molecular function
Sahoo et al. Role of next‐generation sequencing in revolutionizing healthcare for cancer management
CA2398107A1 (en) Methods for analysis of gene expression
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
CN118421758A (zh) 一种扩增靶核酸的引物的制备方法
AU2016356395A1 (en) Methods for obtaining and correcting biological sequence information
EP3052645B1 (de) Dna-adaptermoleküle zur herstellung von dna-bibliotheken und herstellungs- und verwendungsverfahren dafür
Antunes et al. Forensic discrimination of vaginal epithelia by DNA methylation analysis through pyrosequencing
Zhang et al. Hairpin structure facilitates multiplex high-fidelity DNA amplification in real-time polymerase chain reaction
Hall et al. Base composition profiling of human mitochondrial DNA using polymerase chain reaction and direct automated electrospray ionization mass spectrometry
CN110892079B (zh) 用于检测核酸标识符污染的测定方法和组合物
JP2023503349A (ja) 標的の分析に関する組成物、セット、および方法
Wang et al. Sanger Sequencing of Xeno‐Nucleic Acid
Renders et al. Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase
WO2021258032A9 (en) Methylated dna fragment enrichment, methods, compositions and kits
EP3090049B1 (de) Anreicherung vollständiger oligonukleotide über transkriptions-/translationsvermittelte reinigung
Kim et al. Simultaneous determination of multiple microRNA levels utilizing biotinylated dideoxynucleotides and mass spectrometry
Zuckerman et al. Automation of hybridization and capture based next generation sequencing library preparation requires reduction of on-deck bead binding and heated wash temperatures

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties